MD4812B1 - Derivaţi nucleozidici 4'-substituiţi în calitate de inhibitori ai transcriptazei inverse a HIV - Google Patents
Derivaţi nucleozidici 4'-substituiţi în calitate de inhibitori ai transcriptazei inverse a HIVInfo
- Publication number
- MD4812B1 MD4812B1 MDA20160117A MD20160117A MD4812B1 MD 4812 B1 MD4812 B1 MD 4812B1 MD A20160117 A MDA20160117 A MD A20160117A MD 20160117 A MD20160117 A MD 20160117A MD 4812 B1 MD4812 B1 MD 4812B1
- Authority
- MD
- Moldova
- Prior art keywords
- reverse transcriptase
- substituted nucleoside
- hiv reverse
- transcriptase inhibitors
- nucleoside derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Invenţia se referă la derivaţi nucleozidici 4'-substituiţi cu formula IIIIsau la săruri farmaceutic acceptabile ale acestora, în care substituenţii sunt definiţi în descriere. Invenţia de asemenea se referă la utilizarea acestora pentru inhibarea transcriptazei inverse a HIV, profilaxia infecţiei cu HIV, tratamentul infecţiei cu HIV şi profilaxia, tratamentul şi întârzierea debutului sau a evoluţiei SIDA şi/sau ARC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2014/074294 WO2015143712A1 (en) | 2014-03-28 | 2014-03-28 | 4'-substituted nucleoside reverse transcriptase inhibitors |
PCT/US2015/022621 WO2015148746A1 (en) | 2014-03-28 | 2015-03-26 | 4'-substituted nucleoside-derivatives as hiv reverse transcriptase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20160117A2 MD20160117A2 (ro) | 2017-02-28 |
MD4812B1 true MD4812B1 (ro) | 2022-06-30 |
MD4812C1 MD4812C1 (ro) | 2023-01-31 |
Family
ID=52824598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160117A MD4812C1 (ro) | 2014-03-28 | 2015-03-26 | Derivaţi nucleozidici 4'-substituiţi în calitate de inhibitori ai transcriptazei inverse a HIV |
Country Status (41)
Families Citing this family (39)
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US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
WO2017053216A2 (en) * | 2015-09-23 | 2017-03-30 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
JOP20170038B1 (ar) | 2016-02-12 | 2021-08-17 | Merck Sharp & Dohme | مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه |
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JP2020529421A (ja) | 2017-08-04 | 2020-10-08 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | がんの処置のためのPD−1アンタゴニストおよびベンゾ[b]チオフェンSTINGアゴニストの組み合わせ |
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EP3820473A4 (en) * | 2018-07-09 | 2022-05-11 | Merck Sharp & Dohme Corp. | ENZYMATIC SYNTHESIS OF 4'-ETHINYL NUCLEOSIDE ANALOGUES |
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2014
- 2014-03-28 WO PCT/CN2014/074294 patent/WO2015143712A1/en active Application Filing
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2015
- 2015-03-18 AR ARP150100818A patent/AR099788A1/es active IP Right Grant
- 2015-03-19 JO JOP/2015/0049A patent/JO3636B1/ar active
- 2015-03-20 TW TW104109078A patent/TWI660967B/zh active
- 2015-03-26 ES ES15715934T patent/ES2894228T3/es active Active
- 2015-03-26 MY MYPI2016001741A patent/MY194635A/en unknown
- 2015-03-26 AU AU2015236018A patent/AU2015236018B2/en active Active
- 2015-03-26 JP JP2016559266A patent/JP6182680B2/ja active Active
- 2015-03-26 MA MA39809A patent/MA39809B1/fr unknown
- 2015-03-26 HR HRP20211622TT patent/HRP20211622T1/hr unknown
- 2015-03-26 SI SI201531716T patent/SI3122752T1/sl unknown
- 2015-03-26 CR CR20160451A patent/CR20160451A/es unknown
- 2015-03-26 NZ NZ724343A patent/NZ724343A/en unknown
- 2015-03-26 UA UAA201610777A patent/UA120758C2/uk unknown
- 2015-03-26 PE PE2016001816A patent/PE20170197A1/es unknown
- 2015-03-26 GE GEAP201514307A patent/GEP20197009B/en unknown
- 2015-03-26 AP AP2016009482A patent/AP2016009482A0/en unknown
- 2015-03-26 SG SG11201608031PA patent/SG11201608031PA/en unknown
- 2015-03-26 DK DK15715934.4T patent/DK3122752T3/da active
- 2015-03-26 PL PL15715934T patent/PL3122752T3/pl unknown
- 2015-03-26 WO PCT/US2015/022621 patent/WO2015148746A1/en active Application Filing
- 2015-03-26 US US14/669,398 patent/US9777035B2/en active Active
- 2015-03-26 KR KR1020167029801A patent/KR101961009B1/ko active IP Right Grant
- 2015-03-26 MD MDA20160117A patent/MD4812C1/ro active IP Right Grant
- 2015-03-26 HU HUE15715934A patent/HUE056913T2/hu unknown
- 2015-03-26 PT PT157159344T patent/PT3122752T/pt unknown
- 2015-03-26 CA CA2943792A patent/CA2943792C/en active Active
- 2015-03-26 RS RS20211236A patent/RS62418B1/sr unknown
- 2015-03-26 EA EA201691931A patent/EA031476B1/ru not_active IP Right Cessation
- 2015-03-26 EP EP15715934.4A patent/EP3122752B1/en active Active
- 2015-03-26 LT LTEPPCT/US2015/022621T patent/LT3122752T/lt unknown
- 2015-03-26 MX MX2016012659A patent/MX367058B/es active IP Right Grant
- 2015-03-26 CN CN201580029472.2A patent/CN106795199B/zh active Active
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2016
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- 2016-09-26 CL CL2016002414A patent/CL2016002414A1/es unknown
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- 2016-09-26 NI NI201600145A patent/NI201600145A/es unknown
- 2016-09-28 GT GT201600201A patent/GT201600201A/es unknown
- 2016-09-28 SV SV2016005290A patent/SV2016005290A/es unknown
- 2016-09-28 DO DO2016000265A patent/DOP2016000265A/es unknown
- 2016-10-28 EC ECIEPI201685206A patent/ECSP16085206A/es unknown
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2017
- 2017-08-24 US US15/685,824 patent/US20180002366A1/en not_active Abandoned
- 2017-09-07 AU AU2017225090A patent/AU2017225090B2/en active Active
-
2021
- 2021-10-25 CY CY20211100925T patent/CY1124829T1/el unknown
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Legal Events
Date | Code | Title | Description |
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FG4A | Patent for invention issued | ||
TC4A | Change of name of proprietor (patent for invention) |
Owner name: MERCK SHARP & DOHME LLC, US126 EAST LINCOLN AVENUE, RAHWAY, NEW JERSEY 07065, STATELE UNITE ALE AMERICII Free format text: PREVIOUS NAME OF PROPRIETOR: MERCK SHARP & DOHME CORP, US126 EAST LINCOLN AVENUE, RAHWAY,NEW JERSEY 07065-0907, STATELE UNITE ALE AMERICII |