RS62418B1 - 4'-supstituisani nukleozidni-derivati kao inhibitori hiv reverzne transkriptaze - Google Patents
4'-supstituisani nukleozidni-derivati kao inhibitori hiv reverzne transkriptazeInfo
- Publication number
- RS62418B1 RS62418B1 RS20211236A RSP20211236A RS62418B1 RS 62418 B1 RS62418 B1 RS 62418B1 RS 20211236 A RS20211236 A RS 20211236A RS P20211236 A RSP20211236 A RS P20211236A RS 62418 B1 RS62418 B1 RS 62418B1
- Authority
- RS
- Serbia
- Prior art keywords
- derivatives
- reverse transcriptase
- transcriptase inhibitors
- hiv reverse
- substituted nucleoside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/074294 WO2015143712A1 (en) | 2014-03-28 | 2014-03-28 | 4'-substituted nucleoside reverse transcriptase inhibitors |
| PCT/US2015/022621 WO2015148746A1 (en) | 2014-03-28 | 2015-03-26 | 4'-substituted nucleoside-derivatives as hiv reverse transcriptase inhibitors |
| EP15715934.4A EP3122752B1 (en) | 2014-03-28 | 2015-03-26 | 4'-substituted nucleoside-derivatives as hiv reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS62418B1 true RS62418B1 (sr) | 2021-10-29 |
Family
ID=52824598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20211236A RS62418B1 (sr) | 2014-03-28 | 2015-03-26 | 4'-supstituisani nukleozidni-derivati kao inhibitori hiv reverzne transkriptaze |
Country Status (41)
Families Citing this family (43)
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| MA41213A (fr) * | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| MX2018001814A (es) | 2015-08-13 | 2018-05-07 | Merck Sharp & Dohme | Compuestos dinucleotidos ciclicos como agonistas del estimulador de genes de interferon. |
| MX2018003212A (es) | 2015-09-23 | 2018-07-06 | Merck Sharp & Dohme | Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos. |
| JOP20170038B1 (ar) | 2016-02-12 | 2021-08-17 | Merck Sharp & Dohme | مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه |
| WO2017223414A1 (en) | 2016-06-24 | 2017-12-28 | Incyte Corporation | HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS |
| CR20190168A (es) | 2016-10-04 | 2019-05-17 | Merck Sharp & Dohme | Compuestos de benzo[b]tiofeno como agonistas de sting |
| WO2018110591A1 (ja) * | 2016-12-13 | 2018-06-21 | ヤマサ醤油株式会社 | 抗ウイルス活性を有する２'－デオキシ－７－デアザプリンヌクレオシド誘導体 |
| US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| EP3661498A4 (en) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme Corp. | BENZO [B] THIOPHEN STING ANTAGONISTS FOR CANCER TREATMENT |
| MA49773A (fr) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
| CA3075950A1 (en) | 2017-09-18 | 2019-03-21 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3727401A4 (en) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | CYCLIC DINUCLEOTIDE COMPOUNDS USED AS STING AGONISTS |
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| WO2019171285A1 (en) * | 2018-03-07 | 2019-09-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds useful in hiv therapy |
| TWI793294B (zh) | 2018-04-03 | 2023-02-21 | 美商默沙東有限責任公司 | Sting促效劑化合物 |
| US11702430B2 (en) | 2018-04-03 | 2023-07-18 | Merck Sharp & Dohme Llc | Aza-benzothiophene compounds as STING agonists |
| CN112996511B (zh) | 2018-07-09 | 2024-08-09 | 默沙东有限责任公司 | 4’-乙炔基核苷类似物的酶促合成 |
| KR20210044806A (ko) * | 2018-08-09 | 2021-04-23 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Hiv 요법에 유용한 화합물 |
| EP3914604A4 (en) | 2019-01-25 | 2022-10-19 | Brown University | COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING INFLAMMATION AND AGE-RELATED DISORDERS |
| PE20212089A1 (es) * | 2019-03-06 | 2021-11-04 | Glaxosmithkline Ip No 2 Ltd | Compuestos utiles en la terapia del vih |
| CN110054654B (zh) * | 2019-05-27 | 2022-12-27 | 武汉百科药物开发有限公司 | 一种地西他滨中间体α-取代脱氧核糖的合成方法 |
| AU2020346908A1 (en) * | 2019-09-11 | 2022-03-24 | The Scripps Research Institute | Antiviral prodrugs and formulations thereof |
| WO2021116872A1 (en) * | 2019-12-09 | 2021-06-17 | Viiv Healthcare Company | Pharmaceutical compositions comprising cabotegravir |
| CN118598916A (zh) | 2020-02-18 | 2024-09-06 | 吉利德科学公司 | 抗病毒化合物 |
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| CN113527303B (zh) * | 2020-04-21 | 2022-06-10 | 浙江工业大学 | 一种瑞德西韦母核中间体的制备工艺 |
| CN113637041B (zh) * | 2020-05-11 | 2024-02-27 | 上海科胜药物研发有限公司 | 一种核糖核苷的制备方法 |
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2014
- 2014-03-28 WO PCT/CN2014/074294 patent/WO2015143712A1/en active Application Filing
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2015
- 2015-03-18 AR ARP150100818A patent/AR099788A1/es active IP Right Grant
- 2015-03-19 JO JOP/2015/0049A patent/JO3636B1/ar active
- 2015-03-20 TW TW104109078A patent/TWI660967B/zh active
- 2015-03-26 GE GEAP201514307A patent/GEP20197009B/en unknown
- 2015-03-26 MX MX2016012659A patent/MX367058B/es active IP Right Grant
- 2015-03-26 HR HRP20211622TT patent/HRP20211622T1/hr unknown
- 2015-03-26 CN CN201580029472.2A patent/CN106795199B/zh active Active
- 2015-03-26 MD MDA20160117A patent/MD4812C1/ro active IP Right Grant
- 2015-03-26 US US14/669,398 patent/US9777035B2/en active Active
- 2015-03-26 HU HUE15715934A patent/HUE056913T2/hu unknown
- 2015-03-26 RS RS20211236A patent/RS62418B1/sr unknown
- 2015-03-26 PE PE2016001816A patent/PE20170197A1/es unknown
- 2015-03-26 CR CR20160451A patent/CR20160451A/es unknown
- 2015-03-26 CA CA2943792A patent/CA2943792C/en active Active
- 2015-03-26 WO PCT/US2015/022621 patent/WO2015148746A1/en active Application Filing
- 2015-03-26 EP EP15715934.4A patent/EP3122752B1/en active Active
- 2015-03-26 NZ NZ724343A patent/NZ724343A/en unknown
- 2015-03-26 EA EA201691931A patent/EA031476B1/ru not_active IP Right Cessation
- 2015-03-26 UA UAA201610777A patent/UA120758C2/uk unknown
- 2015-03-26 AU AU2015236018A patent/AU2015236018B2/en active Active
- 2015-03-26 LT LTEPPCT/US2015/022621T patent/LT3122752T/lt unknown
- 2015-03-26 KR KR1020167029801A patent/KR101961009B1/ko active IP Right Grant
- 2015-03-26 DK DK15715934.4T patent/DK3122752T3/da active
- 2015-03-26 SG SG11201608031PA patent/SG11201608031PA/en unknown
- 2015-03-26 ES ES15715934T patent/ES2894228T3/es active Active
- 2015-03-26 PT PT157159344T patent/PT3122752T/pt unknown
- 2015-03-26 SI SI201531716T patent/SI3122752T1/sl unknown
- 2015-03-26 AP AP2016009482A patent/AP2016009482A0/en unknown
- 2015-03-26 MY MYPI2016001741A patent/MY194635A/en unknown
- 2015-03-26 PL PL15715934T patent/PL3122752T3/pl unknown
- 2015-03-26 MA MA39809A patent/MA39809B1/fr unknown
- 2015-03-26 JP JP2016559266A patent/JP6182680B2/ja active Active
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2016
- 2016-09-19 IL IL247923A patent/IL247923B/en active IP Right Grant
- 2016-09-26 PH PH12016501897A patent/PH12016501897A1/en unknown
- 2016-09-26 NI NI201600145A patent/NI201600145A/es unknown
- 2016-09-26 CL CL2016002414A patent/CL2016002414A1/es unknown
- 2016-09-28 GT GT201600201A patent/GT201600201A/es unknown
- 2016-09-28 DO DO2016000265A patent/DOP2016000265A/es unknown
- 2016-09-28 SV SV2016005290A patent/SV2016005290A/es unknown
- 2016-10-28 EC ECIEPI201685206A patent/ECSP16085206A/es unknown
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2017
- 2017-08-24 US US15/685,824 patent/US20180002366A1/en not_active Abandoned
- 2017-09-07 AU AU2017225090A patent/AU2017225090B2/en active Active
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2021
- 2021-10-25 CY CY20211100925T patent/CY1124829T1/el unknown
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