MA39809B1 - Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vih - Google Patents
Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vihInfo
- Publication number
- MA39809B1 MA39809B1 MA39809A MA39809A MA39809B1 MA 39809 B1 MA39809 B1 MA 39809B1 MA 39809 A MA39809 A MA 39809A MA 39809 A MA39809 A MA 39809A MA 39809 B1 MA39809 B1 MA 39809B1
- Authority
- MA
- Morocco
- Prior art keywords
- reverse transcriptase
- substituted nucleoside
- nucleoside derivatives
- hiv reverse
- transcriptase inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des dérivés nucléosidiques 4'-substitués de formule i (formule i) et leur utilisation pour l'inhibition de la transcriptase inverse du vih, la prévention d'une infection par le vih, le traitement d'une infection par le vih et la prévention, le traitement et le retardement de l'apparition ou de la progression du sida et/ou du complexe lié au sida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2014/074294 WO2015143712A1 (fr) | 2014-03-28 | 2014-03-28 | Inhibiteurs nucléosidiques substitués en 4' de la transcriptase inverse |
PCT/US2015/022621 WO2015148746A1 (fr) | 2014-03-28 | 2015-03-26 | Dérivés nucléosidiques 4'-substitués utilisés comme inhibiteurs de la transcriptase inverse du vih |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39809A MA39809A (fr) | 2021-04-07 |
MA39809B1 true MA39809B1 (fr) | 2021-10-29 |
Family
ID=52824598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39809A MA39809B1 (fr) | 2014-03-28 | 2015-03-26 | Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vih |
Country Status (41)
Families Citing this family (41)
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MA41213A (fr) * | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
CR20180101A (es) | 2015-08-13 | 2018-04-12 | Merck Sharp & Dohme | Compuestos di-nucleóticos cíclicos como agonistas de sting |
US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
RU2720811C2 (ru) * | 2015-09-23 | 2020-05-13 | Мерк Шарп И Доум Лимитед | 4'-замещенные нуклеозидные ингибиторы обратной транскриптазы и их получение |
JOP20170038B1 (ar) | 2016-02-12 | 2021-08-17 | Merck Sharp & Dohme | مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه |
TW201803871A (zh) | 2016-06-24 | 2018-02-01 | 英塞特公司 | 作為PI3K-γ抑制劑之雜環化合物 |
CN110036001B (zh) | 2016-10-04 | 2022-03-22 | 默沙东公司 | 作为STING激动剂的苯并[b]噻吩化合物 |
JP7125714B2 (ja) * | 2016-12-13 | 2022-08-25 | ヤマサ醤油株式会社 | 抗ウイルス活性を有する2’-デオキシ-7-デアザプリンヌクレオシド誘導体 |
EP3621624B1 (fr) | 2017-05-12 | 2023-08-30 | Merck Sharp & Dohme LLC | Composés dinucléotidiques cycliques en tant qu'agonistes sting |
US11312772B2 (en) | 2017-08-04 | 2022-04-26 | Merck Sharp & Dohme Corp. | Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment |
CA3071538A1 (fr) | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | Agonistes benzo[b]thiophene de sting pour le traitement du cancer |
MA50172A (fr) | 2017-09-18 | 2021-04-07 | Janssen Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
EP3727401A4 (fr) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | Composés dinucléotidiques cycliques utilisés comme agonistes sting |
CN111971284A (zh) * | 2017-12-27 | 2020-11-20 | 埃默里大学 | 核苷和/或nadph氧化酶(nox)抑制剂作为髓样特异性抗病毒剂的联合模式 |
WO2019171285A1 (fr) * | 2018-03-07 | 2019-09-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Composés utiles dans la thérapie du vih |
WO2019195063A1 (fr) | 2018-04-03 | 2019-10-10 | Merck Sharp & Dohme Corp. | Composés aza-benzothiophènes utilisés en tant qu'agonistes de sting |
BR112020020085A8 (pt) | 2018-04-03 | 2023-04-11 | Merck Sharp & Dohme | Composto, composição farmacêutica, e, métodos para induzir uma resposta imune, para induzir produção de interferons de tipo i dependentes de sting e para tratar um distúrbio de proliferação celular |
WO2020014041A1 (fr) * | 2018-07-09 | 2020-01-16 | Merck Sharp & Dohme Corp. | Synthèse enzymatique d'analogues de nucléosides de type 4'-éthynyle |
MA53280A (fr) * | 2018-08-09 | 2021-11-17 | Glaxosmithkline Ip No 2 Ltd | Composés utiles dans la thérapie du vih |
WO2020154656A1 (fr) | 2019-01-25 | 2020-07-30 | Brown University | Compositions et procédés pour traiter, prévenir ou inverser une inflammation et des troubles associés à l'âge |
EP3934760A1 (fr) * | 2019-03-06 | 2022-01-12 | GlaxoSmithKline Intellectual Property (No.2) Limited | Composés utiles dans la thérapie du vih |
CN110054654B (zh) * | 2019-05-27 | 2022-12-27 | 武汉百科药物开发有限公司 | 一种地西他滨中间体α-取代脱氧核糖的合成方法 |
CN114793421B (zh) * | 2019-09-11 | 2024-09-13 | 斯克里普斯研究所 | 抗病毒前体药物及其药物组合物 |
MX2022006940A (es) * | 2019-12-09 | 2022-07-11 | Viiv Healthcare Co | Composiciones farmaceuticas. |
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CN112321589B (zh) * | 2020-02-18 | 2022-05-03 | 山东科巢生物制药有限公司 | 一种抗病毒药物瑞德西韦及其中间体的合成方法 |
TW202322824A (zh) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
WO2021188959A1 (fr) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Promédicaments de nucléosides de 4'-c-substitué-2-halo-2'-désoxyadénosine et leurs procédés de fabrication et d'utilisation |
CN112778310A (zh) * | 2020-04-20 | 2021-05-11 | 中国科学院上海药物研究所 | 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用 |
CN113527303B (zh) * | 2020-04-21 | 2022-06-10 | 浙江工业大学 | 一种瑞德西韦母核中间体的制备工艺 |
CN113637041B (zh) * | 2020-05-11 | 2024-02-27 | 上海科胜药物研发有限公司 | 一种核糖核苷的制备方法 |
WO2022031894A1 (fr) | 2020-08-07 | 2022-02-10 | Gilead Sciences, Inc. | Promédicaments d'analogues nucléotidiques de phosphonamide et leur utilisation pharmaceutique |
WO2022074391A1 (fr) | 2020-10-08 | 2022-04-14 | Storm Therapeutics Limited | Composés inhibiteurs de mettl3 |
CN112300236A (zh) * | 2020-10-21 | 2021-02-02 | 佛山科学技术学院 | 核苷酸混合氨基磷酸酯化合物、其药物组合物及其应用 |
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2014
- 2014-03-28 WO PCT/CN2014/074294 patent/WO2015143712A1/fr active Application Filing
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2015
- 2015-03-18 AR ARP150100818A patent/AR099788A1/es active IP Right Grant
- 2015-03-19 JO JOP/2015/0049A patent/JO3636B1/ar active
- 2015-03-20 TW TW104109078A patent/TWI660967B/zh active
- 2015-03-26 EP EP15715934.4A patent/EP3122752B1/fr active Active
- 2015-03-26 KR KR1020167029801A patent/KR101961009B1/ko active IP Right Grant
- 2015-03-26 RS RS20211236A patent/RS62418B1/sr unknown
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- 2015-03-26 WO PCT/US2015/022621 patent/WO2015148746A1/fr active Application Filing
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2016
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- 2016-09-26 NI NI201600145A patent/NI201600145A/es unknown
- 2016-09-26 CL CL2016002414A patent/CL2016002414A1/es unknown
- 2016-09-28 GT GT201600201A patent/GT201600201A/es unknown
- 2016-09-28 SV SV2016005290A patent/SV2016005290A/es unknown
- 2016-09-28 DO DO2016000265A patent/DOP2016000265A/es unknown
- 2016-10-28 EC ECIEPI201685206A patent/ECSP16085206A/es unknown
-
2017
- 2017-08-24 US US15/685,824 patent/US20180002366A1/en not_active Abandoned
- 2017-09-07 AU AU2017225090A patent/AU2017225090B2/en active Active
-
2021
- 2021-10-25 CY CY20211100925T patent/CY1124829T1/el unknown
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