NI201600145A - Derivados de nucleósido 4'-sustituidos como inhibidores de la transcriptasa reversa de vih - Google Patents
Derivados de nucleósido 4'-sustituidos como inhibidores de la transcriptasa reversa de vihInfo
- Publication number
- NI201600145A NI201600145A NI201600145A NI201600145A NI201600145A NI 201600145 A NI201600145 A NI 201600145A NI 201600145 A NI201600145 A NI 201600145A NI 201600145 A NI201600145 A NI 201600145A NI 201600145 A NI201600145 A NI 201600145A
- Authority
- NI
- Nicaragua
- Prior art keywords
- reverse transcriptase
- derivatives
- substituted
- nucleoside
- inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Abstract
La presente invención se refiere a derivados de nucleósidos 4' sustituidos de fórmula I y su uso en la inhibición de la transcriptasa reversa de VIH, la profilaxis de la infección por VIH, el tratamiento de la infección por el VIH, y la profilaxis , tratamiento, y retraso en la aparición o pregresión de SIDA y/o ARC.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2014/074294 WO2015143712A1 (en) | 2014-03-28 | 2014-03-28 | 4'-substituted nucleoside reverse transcriptase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201600145A true NI201600145A (es) | 2016-10-27 |
Family
ID=52824598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201600145A NI201600145A (es) | 2014-03-28 | 2016-09-26 | Derivados de nucleósido 4'-sustituidos como inhibidores de la transcriptasa reversa de vih |
Country Status (41)
Families Citing this family (38)
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CR20180101A (es) | 2015-08-13 | 2018-04-12 | Merck Sharp & Dohme | Compuestos di-nucleóticos cíclicos como agonistas de sting |
CA2998646C (en) | 2015-09-23 | 2021-05-18 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
JOP20170038B1 (ar) * | 2016-02-12 | 2021-08-17 | Merck Sharp & Dohme | مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه |
TW201803871A (zh) | 2016-06-24 | 2018-02-01 | 英塞特公司 | 作為PI3K-γ抑制劑之雜環化合物 |
JOP20190070B1 (ar) | 2016-10-04 | 2023-09-17 | Merck Sharp And Dohme Llc | مركبات بنزو[b] ثيوفين كناهضات محفزة لبروتين جينات الإنترفيرون |
WO2018110591A1 (ja) * | 2016-12-13 | 2018-06-21 | ヤマサ醤油株式会社 | 抗ウイルス活性を有する2'-デオキシ-7-デアザプリンヌクレオシド誘導体 |
EP3621624B1 (en) | 2017-05-12 | 2023-08-30 | Merck Sharp & Dohme LLC | Cyclic di-nucleotide compounds as sting agonists |
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JP2020530838A (ja) | 2017-08-04 | 2020-10-29 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト |
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US11685761B2 (en) | 2017-12-20 | 2023-06-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
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EP3762396A1 (en) * | 2018-03-07 | 2021-01-13 | GlaxoSmithKline Intellectual Property (No.2) Limited | Compounds useful in hiv therapy |
MA52189A (fr) | 2018-04-03 | 2021-02-17 | Merck Sharp & Dohme | Benzothiophènes et composés associés utilisés en tant qu'agonistes de sting |
EP3774765A4 (en) | 2018-04-03 | 2021-12-29 | Merck Sharp & Dohme Corp. | Aza-benzothiophene compounds as sting agonists |
CA3105823C (en) * | 2018-07-09 | 2023-07-25 | Merck Sharp & Dohme Corp. | Enzymatic synthesis of 4'-ethynyl nucleoside analogs |
WO2020031131A1 (en) * | 2018-08-09 | 2020-02-13 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds useful in hiv therapy |
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AR118240A1 (es) * | 2019-03-06 | 2021-09-22 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY Nº 2 LTD | Compuestos útiles en la terapia del vih |
CN110054654B (zh) * | 2019-05-27 | 2022-12-27 | 武汉百科药物开发有限公司 | 一种地西他滨中间体α-取代脱氧核糖的合成方法 |
JP2022547558A (ja) * | 2019-09-11 | 2022-11-14 | ザ スクリプス リサーチ インスティテュート | 抗ウイルスプロドラッグ及びその医薬組成物 |
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2014
- 2014-03-28 WO PCT/CN2014/074294 patent/WO2015143712A1/en active Application Filing
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2015
- 2015-03-18 AR ARP150100818A patent/AR099788A1/es active IP Right Grant
- 2015-03-19 JO JOP/2015/0049A patent/JO3636B1/ar active
- 2015-03-20 TW TW104109078A patent/TWI660967B/zh active
- 2015-03-26 MA MA39809A patent/MA39809B1/fr unknown
- 2015-03-26 SG SG11201608031PA patent/SG11201608031PA/en unknown
- 2015-03-26 AP AP2016009482A patent/AP2016009482A0/en unknown
- 2015-03-26 HR HRP20211622TT patent/HRP20211622T1/hr unknown
- 2015-03-26 US US14/669,398 patent/US9777035B2/en active Active
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- 2015-03-26 EA EA201691931A patent/EA031476B1/ru not_active IP Right Cessation
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- 2015-03-26 ES ES15715934T patent/ES2894228T3/es active Active
- 2015-03-26 EP EP15715934.4A patent/EP3122752B1/en active Active
- 2015-03-26 UA UAA201610777A patent/UA120758C2/uk unknown
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- 2015-03-26 KR KR1020167029801A patent/KR101961009B1/ko active IP Right Grant
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- 2015-03-26 WO PCT/US2015/022621 patent/WO2015148746A1/en active Application Filing
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2016
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2017
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2021
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