MC1884A1 - Variants de l'hirudine,leur utilisation et leur preparation - Google Patents

Variants de l'hirudine,leur utilisation et leur preparation

Info

Publication number
MC1884A1
MC1884A1 MC871932A MC1932A MC1884A1 MC 1884 A1 MC1884 A1 MC 1884A1 MC 871932 A MC871932 A MC 871932A MC 1932 A MC1932 A MC 1932A MC 1884 A1 MC1884 A1 MC 1884A1
Authority
MC
Monaco
Prior art keywords
hirudin
variant
gly
glu
asn
Prior art date
Application number
MC871932A
Other languages
English (en)
French (fr)
Inventor
Michael Courtney
Eric Degryse
Gerard Loison
Yves Lemoine
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of MC1884A1 publication Critical patent/MC1884A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Control Of Multiple Motors (AREA)
MC871932A 1986-12-01 1987-12-01 Variants de l'hirudine,leur utilisation et leur preparation MC1884A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR868616723A FR2607517B2 (fr) 1986-12-01 1986-12-01 Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu

Publications (1)

Publication Number Publication Date
MC1884A1 true MC1884A1 (fr) 1989-01-24

Family

ID=9341393

Family Applications (1)

Application Number Title Priority Date Filing Date
MC871932A MC1884A1 (fr) 1986-12-01 1987-12-01 Variants de l'hirudine,leur utilisation et leur preparation

Country Status (24)

Country Link
US (1) US5650301A (enExample)
EP (1) EP0273800B1 (enExample)
JP (1) JP2567263B2 (enExample)
KR (1) KR960011918B1 (enExample)
AT (1) ATE73462T1 (enExample)
AU (1) AU617989B2 (enExample)
BG (1) BG49719A3 (enExample)
CA (1) CA1341416C (enExample)
CS (1) CS276245B6 (enExample)
DE (1) DE3777367D1 (enExample)
DK (1) DK173247B1 (enExample)
ES (1) ES2032465T3 (enExample)
FI (1) FI99211C (enExample)
FR (1) FR2607517B2 (enExample)
GR (1) GR3004556T3 (enExample)
HU (1) HU213871B (enExample)
IE (1) IE60544B1 (enExample)
MC (1) MC1884A1 (enExample)
NO (1) NO177500C (enExample)
PL (1) PL157254B1 (enExample)
PT (1) PT86233B (enExample)
RO (1) RO106890B1 (enExample)
SU (1) SU1687032A3 (enExample)
ZA (1) ZA879011B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins
GB8817161D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Modified proteins
US5284768A (en) * 1988-08-24 1994-02-08 Sanofi Signal peptide, DNA sequences coding for the latter, expression vectors carrying one of these sequences, gram-negative bacteria transformed by these vectors, and process for the periplasmic production of a polypeptide
US5879926A (en) * 1989-03-31 1999-03-09 Transgene S.A. Yeast strains for the production of mature heterologous proteins, especially hirudin
FR2645175B1 (fr) * 1989-03-31 1994-02-18 Transgene Sa Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
FR2645174B1 (fr) * 1989-03-31 1994-01-07 Transgene Sa Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
FR2646437B1 (fr) * 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
FR2656531B1 (fr) * 1989-12-29 1992-04-24 Sanofi Sa Promoteur artificiel pour l'expression de proteines dans le levure.
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
DK0511393T3 (da) * 1990-11-08 1996-12-09 Japan Energy Corp Hirudin-mutant, fremstilling af denne, antikoagulant, sekretorisk vektor, mikroorganisme transformeret af vektoren og fremstilling af produkt ud fra mikroorganismen
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
US5407822A (en) * 1991-10-02 1995-04-18 Sanofi Artificial promoter for the expression of proteins in yeast
WO2020210965A1 (zh) * 2019-04-16 2020-10-22 广东双骏生物科技有限公司 水蛭素突变体的提取纯化方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158564B1 (fr) * 1984-03-27 1992-07-15 Transgene S.A. Vecteurs d'expression de l'hirudine, cellules transformées et procédé de préparation de l'hirudine
ATE64956T1 (de) * 1984-06-14 1991-07-15 Ciba Geigy Ag Verfahren zur herstellung von thrombininhibitoren.
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
FR2593518B1 (fr) * 1985-05-02 1989-09-08 Transgene Sa Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.

Also Published As

Publication number Publication date
EP0273800B1 (fr) 1992-03-11
FI99211B (fi) 1997-07-15
HUT45564A (en) 1988-07-28
JPS63152987A (ja) 1988-06-25
FI99211C (fi) 1997-10-27
SU1687032A3 (ru) 1991-10-23
EP0273800A2 (fr) 1988-07-06
ES2032465T3 (es) 1993-02-16
PT86233A (fr) 1987-12-01
GR3004556T3 (enExample) 1993-04-28
RO106890B1 (ro) 1993-07-30
ATE73462T1 (de) 1992-03-15
DE3777367D1 (de) 1992-04-16
IE873239L (en) 1988-06-01
ZA879011B (en) 1988-05-27
FI875295A0 (fi) 1987-12-01
CS276245B6 (en) 1992-05-13
PL157254B1 (pl) 1992-05-29
IE60544B1 (en) 1994-07-27
FI875295L (fi) 1988-06-02
KR960011918B1 (ko) 1996-09-04
CA1341416C (fr) 2003-01-21
FR2607517A2 (fr) 1988-06-03
CS8708732A2 (en) 1991-07-16
DK627687D0 (da) 1987-11-30
JP2567263B2 (ja) 1996-12-25
NO874905L (no) 1988-06-02
NO177500B (no) 1995-06-19
NO177500C (no) 1995-09-27
PT86233B (pt) 1990-11-07
AU617989B2 (en) 1991-12-12
DK627687A (da) 1988-06-02
DK173247B1 (da) 2000-05-22
NO874905D0 (no) 1987-11-25
AU8188087A (en) 1988-06-02
EP0273800A3 (en) 1988-07-20
FR2607517B2 (fr) 1989-12-22
HU213871B (en) 1997-11-28
KR880007729A (ko) 1988-08-29
PL269164A1 (en) 1988-08-18
BG49719A3 (bg) 1992-01-15
US5650301A (en) 1997-07-22

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