MA34042B1 - Pyrrolo [2, 3. b ]pyridines qui inhibent la protéeine kinase raf - Google Patents

Pyrrolo [2, 3. b ]pyridines qui inhibent la protéeine kinase raf

Info

Publication number
MA34042B1
MA34042B1 MA34424A MA34424A MA34042B1 MA 34042 B1 MA34042 B1 MA 34042B1 MA 34424 A MA34424 A MA 34424A MA 34424 A MA34424 A MA 34424A MA 34042 B1 MA34042 B1 MA 34042B1
Authority
MA
Morocco
Prior art keywords
compounds
formulas
cancer
pyridines
pyrrolo
Prior art date
Application number
MA34424A
Other languages
Arabic (ar)
English (en)
Inventor
Prabha N Ibrahim
Wayne Spevak
Hanna Cho
Songyuan Shi
Guoxian Wu
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42236712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34042(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of MA34042B1 publication Critical patent/MA34042B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

L'invention porte sur des composés (i) et des sels de ceux-ci, sur des formulations de ceux-ci, sur des conjugués de ceux-ci, sur des dérivés de ceux-ci, sur des formes de ceux-ci et sur leurs utilisations. Sous certains aspects et modes de réalisation, les composés décrits ou sels de ceux-ci, formulations de ceux-ci, conjugués de ceux-ci, dérivés de ceux-ci et formes de ceux-ci sont actifs sur chacune des protéines kinases braf et c-raf-1, et peuvent également être actifs sur l'une ou l'autre protéine kinase a-raf ou b-raf v600e ou sur les deux. L'invention porte également sur des procédés d'utilisation des composés pour traiter des maladies et des états pathologiques, tels qu'un mélanome, un cancer colorectal, un cancer de la thyroïde, un cancer de l'ovaire et un cancer du tractus biliaire.
MA34424A 2009-05-06 2010-05-04 Pyrrolo [2, 3. b ]pyridines qui inhibent la protéeine kinase raf MA34042B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17605409P 2009-05-06 2009-05-06
PCT/US2010/033571 WO2010129567A1 (fr) 2009-05-06 2010-05-04 Pyrrolo [2, 3. b] pyridines qui inhibent la protéine kinase raf

Publications (1)

Publication Number Publication Date
MA34042B1 true MA34042B1 (fr) 2013-03-05

Family

ID=42236712

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34424A MA34042B1 (fr) 2009-05-06 2010-05-04 Pyrrolo [2, 3. b ]pyridines qui inhibent la protéeine kinase raf

Country Status (23)

Country Link
US (3) US8198273B2 (fr)
EP (2) EP2427462A1 (fr)
JP (2) JP2012526127A (fr)
KR (1) KR20140014386A (fr)
CN (1) CN102459262A (fr)
AR (1) AR076749A1 (fr)
AU (1) AU2010246005A1 (fr)
BR (1) BRPI1013843A2 (fr)
CA (1) CA2759997A1 (fr)
CL (1) CL2011002739A1 (fr)
CR (1) CR20110562A (fr)
EC (1) ECSP11011437A (fr)
IL (1) IL215908A0 (fr)
MA (1) MA34042B1 (fr)
MX (1) MX2011011737A (fr)
NI (1) NI201100189A (fr)
NO (1) NO20111508A1 (fr)
PE (1) PE20120518A1 (fr)
RU (1) RU2011149485A (fr)
SG (1) SG175810A1 (fr)
TW (1) TW201041888A (fr)
WO (2) WO2010129567A1 (fr)
ZA (1) ZA201108124B (fr)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0611863B1 (pt) * 2005-06-22 2021-11-23 Plexxikon, Inc Composto, bem como composição e kit compreendendo o mesmo, composto intermediário na preparação do mesmo, método para tratamento e uso do mesmo
WO2008063888A2 (fr) 2006-11-22 2008-05-29 Plexxikon, Inc. Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées
EP2170830B1 (fr) 2007-07-17 2014-10-15 Plexxikon, Inc. COMPOSÉS DE 2-FLUORO-BENZÈNESULFONAMIDE COMME MODULATEURS DE LA KINASE Raf
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MY172424A (en) 2009-04-03 2019-11-25 Hoffmann La Roche Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
BR112012012156A2 (pt) 2009-11-06 2015-09-08 Plexxikon Inc compostos e métodos para modulação de cinase, e indicações para esta
ES2627911T3 (es) * 2009-11-18 2017-08-01 Plexxikon, Inc. Derivados de N-[2-fluoro-3-(4-amino-7H-pirrolo[2,3-d]pirimidin-5-carbonil)-fenil]-4-bencenosulfonamida como moduladores de la proteína quinasa Raf para el tratamiento del cáncer
AU2010336524B2 (en) * 2009-12-23 2015-10-08 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
TWI619713B (zh) 2010-04-21 2018-04-01 普雷辛肯公司 用於激酶調節的化合物和方法及其適應症
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
WO2012075210A2 (fr) * 2010-12-01 2012-06-07 Niiki Pharma Inc. Méthode de traitement du cancer réfractaire
US8889684B2 (en) * 2011-02-02 2014-11-18 Boehringer Ingelheim International Gmbh Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
WO2012106559A1 (fr) * 2011-02-02 2012-08-09 Translational Genomics Research Institute Biomarqueurs et leurs procédés d'utilisation
TR201816421T4 (tr) 2011-02-07 2018-11-21 Plexxikon Inc Kinaz modülasyonu için bileşikler ve metotlar ve bunların endikasyonları.
AR085279A1 (es) * 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
EP2710137B1 (fr) 2011-03-10 2018-09-19 Provectus Pharmatech, Inc. Une combinaison de rose bengale et un antikorps anti-ctla4 pour le traitement du cancer
WO2012138809A1 (fr) * 2011-04-05 2012-10-11 Dawei Zhang Utilisation de composés hétérocycliques en tant qu'inhibiteurs des kinases
AU2012255275B2 (en) 2011-05-17 2016-01-28 Plexxikon Inc. Kinase modulation and indications therefor
WO2013032951A1 (fr) 2011-08-26 2013-03-07 Neupharma, Inc. Entités chimiques, compositions et procédés
CN102993199A (zh) * 2011-09-09 2013-03-27 山东轩竹医药科技有限公司 杂环取代的吡啶并吡咯激酶抑制剂
JP6093768B2 (ja) 2011-09-14 2017-03-08 ニューファーマ， インコーポレイテッド 特定の化学的実体、組成物、および方法
WO2013043935A1 (fr) 2011-09-21 2013-03-28 Neupharma, Inc. Entités chimiques, compositions, et procédés spécifiques
WO2013049701A1 (fr) 2011-09-30 2013-04-04 Neupharma, Inc. Certaines entités chimiques, compositions et procédés
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
WO2013112950A2 (fr) 2012-01-25 2013-08-01 Neupharma, Inc. Entités chimiques particulières, compositions et procédés
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
JP6013029B2 (ja) * 2012-05-25 2016-10-25 千葉県 抗癌剤
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
JP2015522037A (ja) * 2012-07-03 2015-08-03 ラシオファルム ゲーエムベーハー ベムラフェニブコリン塩の固体形態
DE102012016908A1 (de) * 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
TWI601725B (zh) 2012-08-27 2017-10-11 加拓科學公司 取代的氮雜吲哚化合物及其鹽、組合物和用途
US10227357B2 (en) 2012-09-06 2019-03-12 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2014047648A1 (fr) 2012-09-24 2014-03-27 Neupharma, Inc. Entités chimiques particulières, compositions et procédés
CN105712992B (zh) * 2012-09-29 2018-10-26 上海科州药物研发有限公司 作为cMet抑制剂的化合物及其制备方法和用途
EP2916838B1 (fr) 2012-11-12 2019-03-13 Neupharma, Inc. Certaines entités chimiques, compositions et certains procédés
EP2922538B1 (fr) 2012-11-20 2016-10-19 Principia Biopharma Inc. Dérivés d'azaindole en tant qu'inhibiteurs de jak3
KR102212923B1 (ko) 2012-12-21 2021-02-04 플렉시콘 인코퍼레이티드 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
MX2015009270A (es) * 2013-01-18 2015-10-30 Hoffmann La Roche Pirazoles sustituidos en posicion 3 y uso de los mismos como inhibidores de la cinasa cremallera de leucinas dual (dlk).
EP2970270A1 (fr) * 2013-03-14 2016-01-20 ratiopharm GmbH Formes solides de chlorhydrate de vémurafénib
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
KR102244719B1 (ko) 2013-03-15 2021-04-26 플렉시콘 인코퍼레이티드 헤테로시클릭 화합물 및 그의 용도
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
SG11201509338QA (en) * 2013-05-30 2015-12-30 Plexxikon Inc Compounds for kinase modulation, and indications therefor
WO2015075749A1 (fr) * 2013-11-22 2015-05-28 Laurus Labs Private Limited Nouveaux procédés de préparation de vemurafenib
CZ2013943A3 (cs) 2013-11-27 2015-06-03 Zentiva, K.S. Krystalické formy vemurafenibu
US9771369B2 (en) 2014-03-04 2017-09-26 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
HUE053654T2 (hu) 2014-03-26 2021-07-28 Astex Therapeutics Ltd FGFR- és CMET-inhibitorok kombinációi a rák kezelésére
JP6980385B2 (ja) 2014-03-26 2021-12-15 アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited Ｆｇｆｒ阻害剤とｉｇｆ１ｒ阻害剤の組合せ
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
NO2714752T3 (fr) * 2014-05-08 2018-04-21
EP3194392B1 (fr) 2014-09-15 2020-01-01 Plexxikon, Inc. Composés hétérocycliques et leurs utilisations
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CZ2015250A3 (cs) 2015-04-14 2016-10-26 Zentiva, K.S. Amorfní formy vemurafenibu
WO2017019804A2 (fr) 2015-07-28 2017-02-02 Plexxikon Inc. Composés et procédés de modulation des kinases, et indications associées
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
KR20180052757A (ko) 2015-09-21 2018-05-18 플렉시콘 인코퍼레이티드 헤테로시클릭 화합물 및 그의 용도
BR112018005637B1 (pt) 2015-09-23 2023-11-28 Janssen Pharmaceutica Nv Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos
KR20180052631A (ko) 2015-09-23 2018-05-18 얀센 파마슈티카 엔.브이. 비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도
US9938273B2 (en) 2015-12-07 2018-04-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
EP3430005B1 (fr) 2016-03-16 2021-12-08 Plexxikon Inc. Composes et procedes de modulation des kinases, et indications associees
US10195188B2 (en) 2016-06-13 2019-02-05 Chemocentryx, Inc. Method of treating pancreatic cancer
AU2017283491B2 (en) * 2016-06-13 2021-06-03 Chemocentryx, Inc. Methods of treating pancreatic cancer
CN107722013B (zh) * 2016-08-11 2021-01-12 中国科学院上海药物研究所 去氮嘌呤类化合物及其药物组合物、制备方法和用途
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
AU2017363299B2 (en) 2016-11-23 2022-12-22 Chemocentryx, Inc. Method of treating focal segmental glomerulosclerosis
CA3047580A1 (fr) 2016-12-23 2018-07-26 Plexxikon Inc. Composes et procedes pour la modulation de cdk8, et indications associees
NZ755835A (en) * 2017-01-17 2023-12-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
US10577366B2 (en) 2017-03-20 2020-03-03 Plexxikon Inc. Crystalline forms of a compound that inhibits bromodomain
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
US10435404B2 (en) 2017-07-25 2019-10-08 Plexxikon Inc. Formulations of a compound modulating kinases
JP2020536919A (ja) 2017-10-11 2020-12-17 ケモセントリックス， インコーポレイテッド Ｃｃｒ２アンタゴニストによる巣状分節性糸球体硬化症の治療
WO2019075243A1 (fr) 2017-10-13 2019-04-18 Plexxikon Inc. Formes solides d'un composé pour la modulation de kinases
CA3080197C (fr) 2017-10-27 2023-12-19 Plexxikon Inc. Formulation d'un compose modulant les kinases
EP3737382A1 (fr) * 2018-01-10 2020-11-18 Cura Therapeutics, LLC Compositions pharmaceutiques comprenant des phénylsulfonamides, et leurs applications thérapeutiques
WO2019149738A1 (fr) 2018-01-31 2019-08-08 Heparegenix Gmbh Inhibiteurs de protéine kinase mkk4 pour favoriser la régénération hépatique ou pour réduire ou prévenir la mort des hépatocytes
CN112119072A (zh) 2018-03-20 2020-12-22 普莱希科公司 用于ido和tdo调节的化合物和方法，以及其适应症
EP3810139A1 (fr) 2018-06-21 2021-04-28 HepaRegeniX GmbH Inhibiteurs de protéine kinase tricycliques pour favoriser la régénération du foie ou réduire ou prévenir la mort des hépatocytes
AU2019303986B2 (en) * 2018-07-16 2024-02-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101476067B1 (ko) 2002-09-06 2014-12-23 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
BRPI0611863B1 (pt) * 2005-06-22 2021-11-23 Plexxikon, Inc Composto, bem como composição e kit compreendendo o mesmo, composto intermediário na preparação do mesmo, método para tratamento e uso do mesmo
DE102005034406A1 (de) * 2005-07-22 2007-02-01 Ratiopharm Gmbh Neue Salze von Rosiglitazon
WO2008063888A2 (fr) 2006-11-22 2008-05-29 Plexxikon, Inc. Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées
GB0624084D0 (en) 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
WO2008079909A1 (fr) 2006-12-21 2008-07-03 Plexxikon, Inc. Composés et méthodes de modulation des kinases, et indications connexes
PE20121126A1 (es) 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
EP2170830B1 (fr) * 2007-07-17 2014-10-15 Plexxikon, Inc. COMPOSÉS DE 2-FLUORO-BENZÈNESULFONAMIDE COMME MODULATEURS DE LA KINASE Raf

Also Published As

Publication number Publication date
IL215908A0 (en) 2012-01-31
NO20111508A1 (no) 2011-12-02
JP2012526127A (ja) 2012-10-25
CA2759997A1 (fr) 2010-11-11
ECSP11011437A (es) 2011-12-30
EP2427462A1 (fr) 2012-03-14
RU2011149485A (ru) 2013-06-20
CL2011002739A1 (es) 2012-04-09
US20100286142A1 (en) 2010-11-11
ZA201108124B (en) 2014-04-30
WO2010129567A1 (fr) 2010-11-11
NI201100189A (es) 2012-01-11
BRPI1013843A2 (pt) 2016-04-12
WO2010129570A1 (fr) 2010-11-11
US8198273B2 (en) 2012-06-12
CN102459262A (zh) 2012-05-16
PE20120518A1 (es) 2012-05-24
CR20110562A (es) 2012-02-09
AR076749A1 (es) 2011-07-06
US20120245174A1 (en) 2012-09-27
MX2011011737A (es) 2011-12-08
JP2012526128A (ja) 2012-10-25
KR20140014386A (ko) 2014-02-06
EP2427433A1 (fr) 2012-03-14
SG175810A1 (en) 2011-12-29
US20120122860A1 (en) 2012-05-17
AU2010246005A1 (en) 2011-12-01
TW201041888A (en) 2010-12-01

Similar Documents

Publication Publication Date Title
MA34042B1 (fr) Pyrrolo [2, 3. b ]pyridines qui inhibent la protéeine kinase raf
MX363950B (es) Derivados de urea utiles como inhibidores de quinasa.
CO6270257A2 (es) Derivados de piridazinona
EA201000325A1 (ru) Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ
MX2015002044A (es) Pirazolil-ureas como inhibidores de quinasa.
MY150136A (en) Picolinamide derivatives as kinase inhibitors
EA201070667A1 (ru) 8-замещенные пиридо[2,3-в]пиразины и их применение
EA201001242A1 (ru) ПИРРОЛО[2,3-d]ПИРИДИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ТИРОЗИНКИНАЗЫ
MX2009010728A (es) Compuestos de imidazo[1,2-a]piridina como inhibidores de la tirosina-cinasa repectora.
BR112015022011A2 (pt) derivados de imidazo[4,5-c]piridina e pirrolo[2,3-c] piridina como inibidores de ssao
UA111604C2 (uk) ЗАМІЩЕНІ 2,3-ДИГІДРОІМІДАЗО[1,2-c]ХІНАЗОЛІНОВІ СОЛІ
EA201100426A1 (ru) Бициклические ингибиторы киназы
NZ596571A (en) Pyrazolopyrimidines and related heterocycles as kinase inhibitors
EA201070618A1 (ru) 4-пиразолил-n-арилпиримидин-2-амины и 4-пиразолил-n-гетероарилпиримидин-2-амины в качестве ингибиторов киназ janus
WO2014033447A3 (fr) Inhibiteurs de kinase
MY156210A (en) Compounds and methods for kinase modulation, and indications therefor
SG158112A1 (en) Hepatocyte growth factor (hgf) binding proteins
ATE512146T1 (de) Phenylharnstoffderivate als hemmstoffe von tyrosinkinasen zur behandlung von tumorerkrankungen
MX2009012708A (es) Derivados de piridazinona.
EA200600689A1 (ru) Замещённые бензазолы и их применение в качестве ингибиторов raf киназы
WO2012016133A3 (fr) Inhibiteurs de la ros1 kinase pour le traitement de glioblastome et d'autres cancers déficients en p53
ATE534292T1 (de) Spiroverbindungen und anwendungsverfahren dafür
BR112013021675A2 (pt) compostos de triazolopiridina como inibidores de pim cinase
MY155719A (en) 2-benzylpyridazinone derivatives as met kinase inhibitors
SG155931A1 (en) Wnt proteins and detection and treatment of cancer