MA31780B1 - Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée - Google Patents

Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée

Info

Publication number
MA31780B1
MA31780B1 MA32777A MA32777A MA31780B1 MA 31780 B1 MA31780 B1 MA 31780B1 MA 32777 A MA32777 A MA 32777A MA 32777 A MA32777 A MA 32777A MA 31780 B1 MA31780 B1 MA 31780B1
Authority
MA
Morocco
Prior art keywords
glypican
plasma
antibody
enhanced
life
Prior art date
Application number
MA32777A
Other languages
Arabic (ar)
English (en)
Inventor
Tomoyuki Igawa
Taichi Kuramochi
Hirotake Shiraiwa
Hiroyuki Tsunoda
Tatsuhiko Tachibana
Takahiro Ishiguro
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40510966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31780(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MA31780B1 publication Critical patent/MA31780B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé de régulation de la demi-vie d'un anticorps anti-glypican-3 dans le plasma, une composition pharmaceutique comprenant, comme ingrédient actif, un anticorps anti-glypican-3 dont la demi-vie dans le plasma est régulée, un procédé de production de l'anticorps anti-glypican-3, et un procédé de production d'une composition pharmaceutique comprenant, comme ingrédient actif, l'anticorps anti-glypican-3. Elle concerne un procédé de régulation de la demi-vie d'un anticorps anti-glypican-3 dans le plasma par modification d'un résidu d'acide aminé exposé à la surface de l'anticorps anti-glypican-3, un anticorps anti-glypican-3 dont la demi-vie dans le plasma est régulée par modification d'un résidu d'acide aminé, une composition pharmaceutique comprenant l'anticorps comme ingrédient actif, et un procédé de production de la composition pharmaceutique.
MA32777A 2007-09-28 2010-04-14 Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée MA31780B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007256063 2007-09-28
PCT/JP2008/002690 WO2009041062A1 (fr) 2007-09-28 2008-09-26 Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée

Publications (1)

Publication Number Publication Date
MA31780B1 true MA31780B1 (fr) 2010-10-01

Family

ID=40510966

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32777A MA31780B1 (fr) 2007-09-28 2010-04-14 Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée

Country Status (26)

Country Link
US (3) US8497355B2 (fr)
EP (3) EP2584043A3 (fr)
JP (3) JP4535406B2 (fr)
KR (2) KR20100085067A (fr)
CN (1) CN101809162B (fr)
AR (1) AR066172A1 (fr)
AU (1) AU2008305851B2 (fr)
BR (1) BRPI0817637A2 (fr)
CA (1) CA2700986A1 (fr)
CL (1) CL2008002873A1 (fr)
CO (1) CO6270266A2 (fr)
CR (1) CR11369A (fr)
DK (1) DK2196541T3 (fr)
EC (1) ECSP10010135A (fr)
ES (1) ES2394471T3 (fr)
HK (1) HK1144702A1 (fr)
IL (1) IL204754A0 (fr)
MA (1) MA31780B1 (fr)
MX (1) MX2010003158A (fr)
MY (1) MY148637A (fr)
NZ (1) NZ584769A (fr)
PE (1) PE20091218A1 (fr)
RU (2) RU2445366C2 (fr)
TW (1) TWI418363B (fr)
WO (1) WO2009041062A1 (fr)
ZA (1) ZA201002741B (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3050963B1 (fr) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production de polypeptide au moyen de la régulation d'un ensemble
US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
ES2654040T3 (es) 2006-03-31 2018-02-12 Chugai Seiyaku Kabushiki Kaisha Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos
WO2007114319A1 (fr) 2006-03-31 2007-10-11 Chugai Seiyaku Kabushiki Kaisha Procédé de régulation de la cinétique sanguine d'un anticorps
WO2009041613A1 (fr) 2007-09-26 2009-04-02 Chugai Seiyaku Kabushiki Kaisha Région constante d'anticorps modifié
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
ES2834741T3 (es) * 2007-12-05 2021-06-18 Chugai Pharmaceutical Co Ltd Anticuerpo anti-NR10 y uso del mismo
US8124725B2 (en) 2007-12-19 2012-02-28 General Electric Company PDGF-Rβ binders
US8937047B2 (en) 2007-12-19 2015-01-20 General Electric Company Biokinetics of fast-clearing polypeptides
CL2009000647A1 (es) * 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
LT2708559T (lt) 2008-04-11 2018-06-11 Chugai Seiyaku Kabushiki Kaisha Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
EP2409991B1 (fr) 2009-03-19 2017-05-03 Chugai Seiyaku Kabushiki Kaisha Variant d'une région constante d'anticorps
TWI544077B (zh) 2009-03-19 2016-08-01 Chugai Pharmaceutical Co Ltd Antibody constant region change body
BRPI1011145A2 (pt) 2009-05-15 2016-03-15 Chugai Pharmaceutical Co Ltd anticorpo anti-axl
GB0914691D0 (en) 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
JP5837821B2 (ja) 2009-09-24 2015-12-24 中外製薬株式会社 抗体定常領域改変体
US10435458B2 (en) 2010-03-04 2019-10-08 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variants with reduced Fcgammar binding
AU2011225716A1 (en) * 2010-03-11 2012-09-27 Pfizer Inc. Antibodies with pH dependent antigen binding
AU2011283694B2 (en) * 2010-07-29 2017-04-13 Xencor, Inc. Antibodies with modified isoelectric points
KR101398363B1 (ko) 2010-11-17 2014-05-22 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
EP2647706B1 (fr) * 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Molécule de liaison à l'antigène, apte à se lier de façon répétée à une pluralité de molécules d'antigène
WO2012132067A1 (fr) * 2011-03-30 2012-10-04 中外製薬株式会社 Rétention de molécules de liaison d'antigène dans le plasma sanguin et procédé pour modifier l'immunogénicité
MX352889B (es) 2011-02-25 2017-12-13 Chugai Pharmaceutical Co Ltd Anticuerpo de fc especifico para fcyriib.
CN113999307A (zh) * 2011-03-30 2022-02-01 中外制药株式会社 改变抗原结合分子的血浆中滞留性和免疫原性的方法
EP2698431B1 (fr) 2011-03-30 2020-09-09 Chugai Seiyaku Kabushiki Kaisha Rétention de molécules de liaison à l'antigène dans le plasma sanguin et procédé de modification du caractère immunogène
BR112013032630B1 (pt) 2011-06-30 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Polipeptídeo heterodimerizado compreendendo região fc de igg
TW201817745A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
US20150050269A1 (en) 2011-09-30 2015-02-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
JP6284766B2 (ja) 2011-09-30 2018-02-28 中外製薬株式会社 イオン濃度依存性結合分子ライブラリ
MX358220B (es) 2011-11-30 2018-08-10 Chugai Pharmaceutical Co Ltd Portador que contiene fármaco en la célula para formar el inmunocomplejo.
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
SG11201407972RA (en) 2012-06-01 2015-01-29 Us Health High-affinity monoclonal antibodies to glypican-3 and use thereof
JP6628966B2 (ja) 2012-06-14 2020-01-15 中外製薬株式会社 改変されたＦｃ領域を含む抗原結合分子
PE20150361A1 (es) 2012-07-13 2015-03-14 Roche Glycart Ag Anticuerpos biespecificos anti-vegf/anti-ang-2 y su utilizacion en el tratamiento de enfermedades vasculares oculares
AU2013306700B2 (en) 2012-08-24 2019-05-02 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIb-specific Fc region variant
TWI693073B (zh) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
EP4119947A1 (fr) 2012-12-21 2023-01-18 Chugai Seiyaku Kabushiki Kaisha Médicament de ciblage gpc3 administré à un patient en réponse à une thérapie médicamenteuse de ciblage gpc3
US10766960B2 (en) 2012-12-27 2020-09-08 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
AU2014250434B2 (en) 2013-04-02 2019-08-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
CN105517571A (zh) 2013-06-24 2016-04-20 中外制药株式会社 含有人源化抗上皮调节蛋白抗体作为有效成分的腺癌以外的非小细胞肺癌的治疗药
EP3050896B1 (fr) 2013-09-27 2021-07-07 Chugai Seiyaku Kabushiki Kaisha Procédé de production d'un hétéromultimère polypeptidique
CN111402950B (zh) * 2013-11-29 2024-03-19 豪夫迈·罗氏有限公司 抗体选择装置和方法
AR100353A1 (es) 2014-05-08 2016-09-28 Chugai Pharmaceutical Co Ltd Droga de direccionamiento a glipicano 3 (gpc3) que se administra a un paciente que responde a la terapia con drogas de direccionamiento a gpc3
CN106414499A (zh) * 2014-05-22 2017-02-15 基因泰克公司 抗gpc3抗体和免疫偶联物
US9926377B2 (en) 2014-05-22 2018-03-27 Genentech, Inc. Anti-GPC3 antibodies and immunoconjugates
WO2016036973A1 (fr) * 2014-09-04 2016-03-10 The Trustees Of The University Of Pennsylvania Anticorps anti-glypican-3 et ses utilisations
MA40764A (fr) * 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
ME03806B (fr) 2014-11-21 2021-04-20 Bristol Myers Squibb Co Anticorps anti-cd73 et leurs utilisations
CN107208025A (zh) 2014-11-25 2017-09-26 康宁股份有限公司 延续细胞培养基的材料和方法
SG11201700841QA (en) 2014-12-19 2017-03-30 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
MY183415A (en) 2014-12-19 2021-02-18 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
KR102605798B1 (ko) 2015-02-05 2023-11-23 추가이 세이야쿠 가부시키가이샤 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
BR112017014067B1 (pt) 2015-02-27 2021-01-12 Chugai Seiyaku Kabushiki Kaisha usos de um anticorpo receptor de il-6 para no tratamento de doenças relacionadas a il-6
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
US11376326B2 (en) 2015-07-01 2022-07-05 Chugai Seiyaku Kabushiki Kaisha GPC3-targeting therapeutic agent which is administered to patient for whom the GPC3-targeting therapeutic agent is effective
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
WO2017115773A1 (fr) 2015-12-28 2017-07-06 中外製薬株式会社 Procédé pour favoriser l'efficacité de purification d'un polypeptide contenant une région fc
MX2018010988A (es) 2016-03-14 2019-01-21 Chugai Pharmaceutical Co Ltd Farmaco terapeutico que induce lesion celular para usarse en terapia de cancer.
CA3016552A1 (fr) 2016-03-15 2017-09-21 Genentech, Inc. Procedes de traitement de cancers au moyen d'antagonistes se liant a l'axe pd-1 et d'anticorps anti-gpc3
CN105820250B (zh) * 2016-04-29 2019-04-30 中国人民解放军第四军医大学 一种抗basigin人源化抗体及其应用
MX2019001448A (es) 2016-08-05 2019-09-13 Chugai Pharmaceutical Co Ltd Composicion para profilaxis o tratamiento de enfermedades relacionadas con interleucina 8 (il-8).
EP3502250B1 (fr) 2016-08-22 2024-04-24 Chugai Seiyaku Kabushiki Kaisha Rongeurs génétiquement modifiés exprimant un polypeptide gpc3 humain
MA46952A (fr) 2016-12-01 2019-10-09 Regeneron Pharma Anticorps anti-pd-l1 radiomarqués pour imagerie immuno-pet
JP7191833B2 (ja) 2017-01-30 2022-12-19 中外製薬株式会社 抗スクレロスチン抗体およびその使用
EP3586872A4 (fr) 2017-02-24 2020-12-30 Chugai Seiyaku Kabushiki Kaisha Composition pharmaceutique, molécules de liaison à l'antigène, méthode de traitement et procédé de criblage
JP7185884B2 (ja) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
JP7382922B2 (ja) 2017-09-20 2023-11-17 中外製薬株式会社 Ｐｄ－１系結合アンタゴニストおよびｇｐｃ３標的化剤を使用する併用療法のための投与レジメン
WO2021236546A1 (fr) * 2020-05-18 2021-11-25 Bristol-Myers Squibb Company Variants d'anticorps ayant des propriétés pharmacocinétiques améliorées
JPWO2022025030A1 (fr) 2020-07-28 2022-02-03
WO2023030539A1 (fr) * 2021-09-06 2023-03-09 Nanjing Legend Biotech Co., Ltd. Récepteur antigénique chimérique anti-gpc3 et ses procédés d'utilisation
WO2023091909A1 (fr) 2021-11-16 2023-05-25 Sotio Biotech Inc. Traitement de patients atteints de liposarcome myxoïde/à cellules rondes
WO2024011186A2 (fr) * 2022-07-08 2024-01-11 Imaginab, Inc. Anticorps, leurs procédés de fabrication et leurs méthodes d'utilisation
GB202212077D0 (en) 2022-08-18 2022-10-05 Tribune Therapeutics Ab Agents that inhibit ccn ligand-induced signalling for treating disease

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JPS6459878A (en) 1987-08-31 1989-03-07 Matsushita Electric Ind Co Ltd Semiconductor laser protective circuit
US5322678A (en) 1988-02-17 1994-06-21 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU665190B2 (en) 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
WO1993006213A1 (fr) 1991-09-23 1993-04-01 Medical Research Council Production d'anticorps chimeriques - une approche combinatoire
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
JPH07503132A (ja) 1991-12-17 1995-04-06 ジェンファーム　インターナショナル，インコーポレイティド 異種抗体を産生することができるトランスジェニック非ヒト動物
EP0656941B1 (fr) 1992-03-24 2005-06-01 Cambridge Antibody Technology Limited Procedes de production d'elements de paires de liaison specifiques
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
US6214613B1 (en) 1993-12-03 2001-04-10 Ashai Kasei Kogyo Kabushiki Kaisha Expression screening vector
AU690171B2 (en) 1993-12-03 1998-04-23 Medical Research Council Recombinant binding proteins and peptides
KR100261941B1 (ko) 1994-07-13 2000-07-15 나가야마 오사무 사람의 인터루킨-8에 대한 재구성 사람항체
DE69637481T2 (de) 1995-04-27 2009-04-09 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP0938499A1 (fr) * 1996-07-19 1999-09-01 Amgen Inc. Analogues de proteines cationiques
BR9713294A (pt) 1996-09-26 2000-10-17 Chugai Pharmaceutical Co Ltd "anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano"
FR2761994B1 (fr) 1997-04-11 1999-06-18 Centre Nat Rech Scient Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
DE69838454T2 (de) 1997-10-03 2008-02-07 Chugai Seiyaku K.K. Natürlicher menschlicher antikörper
EP2275541B1 (fr) * 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Procédé de contrôle de l'activité d'une molécule fonctionnelle immunologiquement
GB0017635D0 (en) 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
DK2208784T3 (da) 2001-06-22 2013-03-18 Chugai Pharmaceutical Co Ltd Celleproliferationsinhibitorer indeholdende anti-glypican-3-antistof
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
WO2004023145A1 (fr) * 2002-09-04 2004-03-18 Perseus Proteomics Inc. Procede de detection du cancer par detection du gpc3
EP3502133A1 (fr) * 2002-09-27 2019-06-26 Xencor, Inc. Variantes fc optimisées et leurs procédés de génération
US7217797B2 (en) * 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
AU2003286467B2 (en) 2002-10-15 2009-10-01 Abbvie Biotherapeutics Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
EP1761281A1 (fr) 2004-06-04 2007-03-14 Pfizer Products Incorporated Methode de traitement de croissances cellulaires anormales
DE102004032634A1 (de) 2004-07-06 2006-02-16 Sms Demag Ag Verfahren und Einrichtung zum Messen und Regeln der Planheit und/oder der Bandspannungen eines Edelstahlbandes oder einer Edelstahlfolie beim Kaltwalzen in einem Vielwalzengerüst, insbesondere in einem 20-Walzen-Sendizimir-Walzwerk
UA94019C2 (ru) * 2004-07-09 2011-04-11 Чугаи Сейяку Кабусики Кайся Антитело, которое специфически связывается с глипиканом 3 (gpc3)
WO2006022407A1 (fr) 2004-08-24 2006-03-02 Chugai Seiyaku Kabushiki Kaisha Thérapie adjuvante utilisant des anticorps anti-glypicane 3
JP4455236B2 (ja) * 2004-09-02 2010-04-21 本田技研工業株式会社 芝刈機
US7867734B2 (en) 2004-10-26 2011-01-11 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody having modified sugar chain
EP1829961A4 (fr) 2004-12-22 2008-06-04 Chugai Pharmaceutical Co Ltd Procede de preparation d'un anticorps a l'aide d'une cellule dont la fonction de transporteur du fucose est inhibee
CA2614181A1 (fr) 2005-07-01 2007-01-11 Medimmune, Inc. Approche integree permettant de generer des applications therapeutiques a base de proteine multidomaine
US20070087005A1 (en) * 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
CA2627873A1 (fr) 2005-10-31 2007-05-10 Scott Wilhelm Traitement du cancer au moyen de sorafenib
US20070185069A1 (en) * 2005-11-14 2007-08-09 Plum Stacy M Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
WO2007059782A1 (fr) * 2005-11-28 2007-05-31 Genmab A/S Anticorps monovalents recombines et leurs procedes de production
TW200800181A (en) 2006-02-09 2008-01-01 Sankyo Co Pharmaceutical composition for anticancer
WO2007099988A1 (fr) 2006-02-28 2007-09-07 Kyowa Hakko Kogyo Co., Ltd. mutant de α-1,6-FUCOSYLTRANSFERASE et son utilisation
JP2007256063A (ja) 2006-03-23 2007-10-04 Seiko Epson Corp 表示装置、および、電子機器
WO2007114319A1 (fr) * 2006-03-31 2007-10-11 Chugai Seiyaku Kabushiki Kaisha Procédé de régulation de la cinétique sanguine d'un anticorps
ES2654040T3 (es) * 2006-03-31 2018-02-12 Chugai Seiyaku Kabushiki Kaisha Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos
WO2007137170A2 (fr) 2006-05-20 2007-11-29 Seattle Genetics, Inc. Conjugués médicamenteux d'anticorps anti-glypicane-3
EP2178921B1 (fr) * 2007-07-17 2016-01-06 E. R. Squibb & Sons, L.L.C. Anticorps monoclonaux contre le glypicane-3
CN101874042B9 (zh) * 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
CL2009000647A1 (es) * 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.

Also Published As

Publication number Publication date
BRPI0817637A2 (pt) 2015-09-08
EP2196541A1 (fr) 2010-06-16
RU2445366C2 (ru) 2012-03-20
TWI418363B (zh) 2013-12-11
EP2196541A4 (fr) 2010-11-03
US20150315278A1 (en) 2015-11-05
JP2014005292A (ja) 2014-01-16
EP2584043A2 (fr) 2013-04-24
AU2008305851B2 (en) 2014-12-18
CO6270266A2 (es) 2011-04-20
MX2010003158A (es) 2010-04-14
EP2617736A1 (fr) 2013-07-24
ECSP10010135A (es) 2010-07-30
JPWO2009041062A1 (ja) 2011-01-20
JP4535406B2 (ja) 2010-09-01
CL2008002873A1 (es) 2010-02-19
EP2584043A3 (fr) 2013-10-02
ZA201002741B (en) 2011-10-26
JP5382873B2 (ja) 2014-01-08
KR20150126724A (ko) 2015-11-12
CN101809162B (zh) 2013-06-05
CN101809162A (zh) 2010-08-18
JP2010200768A (ja) 2010-09-16
WO2009041062A1 (fr) 2009-04-02
EP2196541B1 (fr) 2012-11-07
CA2700986A1 (fr) 2009-04-02
KR20100085067A (ko) 2010-07-28
US8497355B2 (en) 2013-07-30
ES2394471T3 (es) 2013-02-01
DK2196541T3 (da) 2012-11-26
RU2010116756A (ru) 2011-11-10
TW200930406A (en) 2009-07-16
HK1144702A1 (en) 2011-03-04
AR066172A1 (es) 2009-07-29
PE20091218A1 (es) 2009-08-14
NZ584769A (en) 2011-09-30
MY148637A (en) 2013-05-15
US20100239577A1 (en) 2010-09-23
IL204754A0 (en) 2010-11-30
JP6101611B2 (ja) 2017-03-22
RU2010125605A (ru) 2011-12-20
AU2008305851A1 (en) 2009-04-02
US20130295612A1 (en) 2013-11-07
CR11369A (es) 2010-08-12

Similar Documents

Publication Publication Date Title
MA31780B1 (fr) Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée
MX2010003443A (es) Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
MA34837B1 (fr) Composés indoliques ou analogues de ceux-ci utiles dans le traitement de la dégénérescence maculaire liée à l'âge (dmla)
MA29171B1 (fr) Formulation a compression directe et procede associe
MA30345B1 (fr) Formulation d'anticorps monoclonal humain anti-igf-1r
MA31797B1 (fr) Compositions pharmaceutiques
CL2007001388A1 (es) Co-cristal de maleato de 2{etil[3-({4-[(5-{2-[(3-fluorfenil)amino]-2-oxoetil}-1h-pirazol-3-il)amino]quinazolin-7-il}oxi)propil]amino}fosfato dihidrogeno de etilo (azd1152), inhibidor de aurora quinasa; metodo de preparacion; composicion farmaceutica; y uso para el tratamiento de enfermedades hiperproliferativas como el cancer.
EA200970296A1 (ru) Содержащие диариловый эфир соединения мочевины
BR112013002764A8 (pt) formulações esatabilizadas contendo anticorpos anti-ngf
EA200700096A1 (ru) Производные 2-карбамид-4-фенилтиазола, способ их получения и их применение в терапии
MX2011004324A (es) Proceso novedoso para la preparacion de derivados de aminoacidos.
MA33299B1 (fr) Nouvelle formulation de naproxène
MA38330A1 (fr) Dérivés d'acide phosphonique butanoïque de bisphénol substitués en qualité d'inhibiteurs de nep (endopeptidase neutre)
TW200833682A (en) Pharmaceutical compounds
WO2003099338A3 (fr) Conjugues d'acides amines permettant d'obtenir des concentrations systemiques prolongees d'analogues gaba
UY27548A1 (es) Sales de ácido succínico de 5,7,14-triazatetraciclo (10.3.1.02.11.04,9) exadeca-2 (11),3,5,7,9-pentaeno y composiciones farmacéuticas
MA27670A1 (fr) Composition pharmaceutique contenant de l'acide 5-methyl-2-2'-(chloro-6'-fluoroanilino)phenylacetique
MA30260B1 (fr) Acides 4-phenyl-thiazole-5-carboxyliques et amides d'acide 4-phenyl-thiazole-5-carboxylique en tant qu'inhibiteurs de plk 1
HK1111168A1 (en) A PROCESS FOR THE PREPARATION OF 17-HYDROXY-6 ß,7ß,15 ß,16 ß - BISMETHYLENE-17a-PREGN-4-ENE-3-ONE-21-CARBOXYLIC ACID Y-LACTONE AND KEY-INTERMEDIATES FOR THIS PROCESS
MA33676B1 (fr) Compositions pharmaceutiques comprenant des dérivés de bisphosphonate et du cholécalciférol à dose élevée
MA37317A1 (fr) Formulation d'anticorps il-17
MY151183A (en) Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof
TW200745155A (en) Preparation of pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl)betulinic acid
BR0309298A (pt) Método para estabilizar comprimidos de cloreto de bupropion
Jiracek et al. S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase