MA29171B1 - Formulation a compression directe et procede associe - Google Patents
Formulation a compression directe et procede associeInfo
- Publication number
- MA29171B1 MA29171B1 MA30104A MA30104A MA29171B1 MA 29171 B1 MA29171 B1 MA 29171B1 MA 30104 A MA30104 A MA 30104A MA 30104 A MA30104 A MA 30104A MA 29171 B1 MA29171 B1 MA 29171B1
- Authority
- MA
- Morocco
- Prior art keywords
- tablets
- direct compression
- formulations
- new
- vildaglipin
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
CETTE INVENTION CONCERNE DES COMPRIMÉS, EN PARTICULIER DES COMPRIMÉS RÉALISÉS PAR COMPRESSION DIRECTE D'UN COMPOSÉ INHIBITEUR DE LA DIPEPTIDYLPEPTIDASE IV (DPP-IV), UN PROCÉDÉ DE PRÉPARATION AFFÉRENT, DE NOUVELLES FORMULATIONS PHARMACEUTIQUES ET DE NOUVELLES POUDRES DE FABRICATION DE COMPRIMÉS RENFERMANT DES FORMULATIONS À BASE D'INHIBITEUR DE DPP-IV CAPABLES D'ÊTRE DIRECTEMENT PRÉPARÉES SOUS FORME DE COMPRIMÉS. L'INVENTION CONCERNE ÉGALEMENT UN PROCÉDÉ DE PRÉPARATION DES COMPRIMÉS QUI CONSISTE À MÉLANGER L'INGRÉDIENT ACTIF AVEC DES EXCIPIENTS SPÉCIFIQUES DANS LES NOUVELLES FORMULATIONS PUIS À PRÉPARER DIRECTEMENT LES FORMULATIONS DANS LES COMPRIMÉS À COMPRESSION DIRECTE. L'INVENTION CONCERNE ÉGALEMENT UNE DISTRIBUTION GRANULOMÉTRIQUE DE VILDAGLIPTINE ET UNE NOUVELLE FORME CRISTALLINE DE VILDAGLIPTINE CONVENANT PARTICULIÈREMENT À LA PRÉPARATION DE COMPRIMÉS AMÉLIORÉS AINSI QUE D'AUTRES COMPOSITIONS PHARMACEUTIQUES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64464505P | 2005-01-18 | 2005-01-18 | |
US69048405P | 2005-06-14 | 2005-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29171B1 true MA29171B1 (fr) | 2008-01-02 |
Family
ID=36581880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30104A MA29171B1 (fr) | 2005-01-18 | 2007-07-26 | Formulation a compression directe et procede associe |
Country Status (19)
Country | Link |
---|---|
US (3) | US20080299190A1 (fr) |
EP (1) | EP1841413A2 (fr) |
JP (1) | JP2008527004A (fr) |
KR (1) | KR20070100291A (fr) |
AR (1) | AR052878A1 (fr) |
AU (2) | AU2006206670B2 (fr) |
BR (1) | BRPI0606731A2 (fr) |
CA (1) | CA2593359A1 (fr) |
GT (1) | GT200600008A (fr) |
IL (1) | IL183762A0 (fr) |
MA (1) | MA29171B1 (fr) |
MX (1) | MX2007008679A (fr) |
NO (1) | NO20074048L (fr) |
NZ (1) | NZ555576A (fr) |
PE (1) | PE20061017A1 (fr) |
RU (1) | RU2007131503A (fr) |
TN (1) | TNSN07274A1 (fr) |
TW (1) | TW200637616A (fr) |
WO (1) | WO2006078593A2 (fr) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
CN101684089A (zh) * | 2004-02-05 | 2010-03-31 | 杏林制药株式会社 | 双环酯类衍生物 |
EA011290B1 (ru) * | 2004-06-17 | 2009-02-27 | Мерц Фарма Гмбх Унд Ко. Кгаа | Препаративные формы пероральных лекарственных форм мемантина с немедленным высвобождением |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
JOP20180109A1 (ar) * | 2005-09-29 | 2019-01-30 | Novartis Ag | تركيبة جديدة |
AU2006306420A1 (en) * | 2005-10-25 | 2007-05-03 | Merck Sharp & Dohme Corp. | Combination of a dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension |
JP5165582B2 (ja) | 2005-12-16 | 2013-03-21 | メルク・シャープ・エンド・ドーム・コーポレイション | ジペプチジルペプチダーゼ−4インヒビターとメトホルミンとを組み合わせた医薬組成物 |
CA2645154C (fr) | 2006-03-08 | 2011-11-29 | Kyorin Pharmaceutical Co., Ltd. | Procede de production d'un derive aminoacetylpyrrolidinecarbonitrile et intermediaire utilise pour sa production |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
BRPI0711558A2 (pt) | 2006-05-04 | 2011-11-08 | Boeringer Ingelheim Internat Gmbh | polimorfos |
EP1852108A1 (fr) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Compositions d'inhibiteurs de la DPP IV |
JP2010518004A (ja) * | 2007-02-01 | 2010-05-27 | ネフロジェン, エルエルシー | 幹細胞ホーミングの増強および臓器機能障害または臓器不全の治療 |
EP2123636B1 (fr) | 2007-03-22 | 2012-03-21 | Kyorin Pharmaceutical Co., Ltd. | Procédé de préparation d'un dérivé d'aminoacétylpyrrolidinecarbonitrile |
CL2008002427A1 (es) * | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
DE102007040952A1 (de) * | 2007-08-30 | 2009-03-05 | Miele & Cie. Kg | Upright-Staubsauger |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
DK2275108T3 (da) * | 2008-05-14 | 2014-09-08 | Sanwa Kagaku Kenkyusho Co | Farmaceutisk præparat omfattende en dpp-iv-inhibitor og et andet diabetes-terapimiddel i konkomitant eller kombineret form |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
JP5476305B2 (ja) | 2008-08-07 | 2014-04-23 | 杏林製薬株式会社 | ビシクロ[2.2.2]オクチルアミン誘導体の製造方法 |
US20110152342A1 (en) * | 2008-08-14 | 2011-06-23 | Hiroshi Uchida | Stabilized pharmaceutical composition |
EP2326326B1 (fr) | 2008-08-15 | 2019-10-09 | Boehringer Ingelheim International GmbH | Inhibiteurs de dpp-4 destinés à l'utilisation dans la cicatrisation des lésions des diabétiques |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
TWI466672B (zh) | 2009-01-29 | 2015-01-01 | Boehringer Ingelheim Int | 小兒科病人糖尿病之治療 |
AP2011005794A0 (en) | 2009-02-13 | 2011-08-31 | Boehringer Ingelheim Int | Pharmaceutical composition comprising a SGLT2 inhibitor, a DPP-IV inhibitor and optionally a furtherantidiabetic agent and uses thereof. |
UY32427A (es) * | 2009-02-13 | 2010-09-30 | Boheringer Ingelheim Internat Gmbh | Composicion farmaceutica, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma |
EP2395968B1 (fr) * | 2009-02-13 | 2024-01-17 | Boehringer Ingelheim International GmbH | Composition pharmaceutique contenant des dérivés de glucopyranosyl diphényl-méthane, sa forme posologique galénique, son procédé de préparation et ses utilisations pour une régulation glycémique améliorée chez un patient |
US20120094894A1 (en) | 2009-02-13 | 2012-04-19 | Boehringer Ingelheim International Gmbh | Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics |
EP2412370A4 (fr) | 2009-03-27 | 2013-05-22 | Kyorin Seiyaku Kk | Préparation à libération prolongée de type matrice contenant un additif basique |
HUE026133T2 (en) | 2009-09-30 | 2016-05-30 | Boehringer Ingelheim Int | Process for the preparation of glycopyranosyl substituted benzylbenzene derivatives |
IN2012DN02756A (fr) * | 2009-09-30 | 2015-09-18 | Boehringer Ingelheim Int | |
UY32919A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos |
MX364651B (es) | 2009-11-27 | 2019-05-03 | Boehringer Ingelheim Int Gmbh Star | Inhibidores de dpp-iv, tales como la linagliptina, y composiciones farmacéuticas o combinaciones que comprenden los mismos, para usarse en el tratamiento de pacientes diabéticos tipificados genéticamente. |
WO2011113947A1 (fr) | 2010-03-18 | 2011-09-22 | Boehringer Ingelheim International Gmbh | Combinaisons d'agonistes de gpr119 et d'inhibiteurs de dpp-iv, linagliptine, pour le traitement du diabète et d'états apparentés |
EP2566469B1 (fr) | 2010-05-05 | 2022-12-21 | Boehringer Ingelheim International GmbH | Thérapie combinée |
EP2585101A1 (fr) | 2010-06-24 | 2013-05-01 | Boehringer Ingelheim International GmbH | Thérapie du diabète |
CA2816957A1 (fr) * | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions et procedes de traitement de la myelofibrose |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
TR201107482A1 (tr) | 2010-12-21 | 2012-07-23 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Vildagliptin ve gliklazidin iki tabakalı kombinasyon kompozisyonu. |
TR201010683A1 (tr) | 2010-12-21 | 2012-07-23 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Vildagliptin formülasyonları. |
EP2468268B1 (fr) | 2010-12-21 | 2017-12-13 | Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi | Composition de combinaison de vildagliptine et de gliclazide |
TR201101809A1 (tr) | 2010-12-21 | 2012-07-23 | Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | Vildagliptin ve glimepirid kombinasyonları. |
AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
US20140302150A1 (en) | 2011-09-07 | 2014-10-09 | Umit Cifter | Dpp-iv inhibitor formulations |
EP2572704A1 (fr) | 2011-09-22 | 2013-03-27 | Sanovel Ilac Sanayi ve Ticaret A.S. | Formulations orodispersibles de la vildagliptine |
EP2578208B1 (fr) | 2011-10-06 | 2014-05-21 | Sanovel Ilac Sanayi ve Ticaret A.S. | Formulations posologiques solides d'inhibiteurs DPP-IV |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
WO2013179300A2 (fr) | 2012-05-04 | 2013-12-05 | Megafine Pharma (P) Ltd. | Procédé de préparation de vildagliptine et de son intermédiaire |
EP3685839A1 (fr) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin pour son utilisation dans le traitement de l'albuminurie et des maladies liees au rein |
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AR092843A1 (es) | 2012-06-05 | 2015-05-06 | Takeda Pharmaceuticals Co | Preparacion solida |
WO2014013505A2 (fr) * | 2012-07-20 | 2014-01-23 | Hetero Research Foundation | Vildagliptine amorphe |
EP2769712A1 (fr) * | 2013-02-21 | 2014-08-27 | Siegfried International AG | Formulation pharmaceutique comportant des agglomérats d'inhibiteur DPP-IV et des particules d'inhibiteur DPP-IV |
US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
ES2702174T3 (es) | 2013-04-05 | 2019-02-27 | Boehringer Ingelheim Int | Usos terapéuticos de empagliflozina |
US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
DK2986304T3 (da) | 2013-04-18 | 2022-04-04 | Boehringer Ingelheim Int | Farmaceutisk sammensætning, fremgangsmåder til behandling og anvendelser deraf. |
EP3110449B1 (fr) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Utilisation médicale d'un inhibiteur de dpp-4 |
EP2915528A1 (fr) | 2014-03-06 | 2015-09-09 | Sanovel Ilac Sanayi ve Ticaret A.S. | Procédé de formulation de vildagliptine sous atmosphère de gaz inerte |
TR201402685A1 (tr) | 2014-03-06 | 2015-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Vildagliptinin farmasotik formulasyonları. |
EP3171710A1 (fr) | 2014-07-21 | 2017-05-31 | Roquette Frères | Compositions de sucre pour la fabrication de comprimés par compression directe |
EP3191024B1 (fr) * | 2014-09-11 | 2020-01-15 | Aprevent Medical Inc. | Appareil de traitement de l'insuffisance glottique |
CN104817482B (zh) * | 2015-03-17 | 2017-05-10 | 宁波百思佳医药科技有限公司 | 2‑取代吡咯烷类化合物、制备方法及其在制备维格列汀中的应用 |
WO2017211979A1 (fr) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinaisons de linagliptine et de metformine |
WO2018050892A1 (fr) | 2016-09-16 | 2018-03-22 | Galenicum Health S.L. | Compositions pharmaceutiques de vildagliptine |
WO2018092129A1 (fr) | 2016-11-15 | 2018-05-24 | The Medical Research,Infrastructure, And Health Services Fund Of The Tel-Aviv Medical Center | Dispositif et procédé de réparation de tissu |
GR1009406B (el) | 2017-10-03 | 2018-11-26 | Φαρματεν Αβεε | Φαρμακευτικο σκευασμα που περιλαμβανει βιλνταγλιπτινη και μεθοδος για την παρασκευη αυτου |
KR102622198B1 (ko) * | 2018-03-30 | 2024-01-09 | 한미약품 주식회사 | 빌다글립틴을 함유하는 경구용 고형제제 및 그의 제조 방법 |
WO2019217800A1 (fr) * | 2018-05-10 | 2019-11-14 | La'au Pono | Réduction en poudre d'extrait de cannabis à usage médical par l'intermédiaire d'une procédure de granulation par voie humide |
EP3793529A1 (fr) | 2018-05-18 | 2021-03-24 | Galenicum Health S.L.U. | Compositions pharmaceutiques stables d'inhibiteurs de dpp-iv en combinaison avec de la metformine sous la forme de comprimés à libération immédiate |
GR1009644B (el) | 2018-09-25 | 2019-11-12 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει βιλνταγλιπτινη και μετφορμινη και μεθοδος για την παρασκευη αυτου |
EP4045048A4 (fr) | 2019-10-14 | 2023-05-24 | Santa Farma Ilaç Sanayi A.S. | Formulations orales comprenant du monohydrate de hci de sitagliptine présentant des caractéristiques pharmaceutiques améliorées |
KR102362342B1 (ko) * | 2020-01-31 | 2022-02-14 | 주식회사 경보제약 | 빌다글립틴 및 메트포민 포함하는 복합 정제 |
WO2022003405A1 (fr) | 2020-07-03 | 2022-01-06 | Savoi Guilherme | Procédé monotope permettant d'obtenir un composé intermédiaire pyrrolidine-2-carbonitrile et procédé télescopique à l'échelle industrielle permettant de préparer du (2s)-1-[n-(3-hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile (vildagliptine) l'utilisant |
TR202010700A2 (tr) * | 2020-07-06 | 2022-01-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Vi̇ldagli̇pti̇n ve en az bi̇r farmasöti̇k olarak kabul edi̇lebi̇li̇r eksi̇pi̇yan i̇çeren bi̇r formülasyon |
CN114181129B (zh) * | 2021-11-09 | 2024-02-13 | 浙江国邦药业有限公司 | 一种制备不同粒度维格列汀的方法 |
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US5618845A (en) * | 1994-10-06 | 1997-04-08 | Cephalon, Inc. | Acetamide derivative having defined particle size |
CO5150173A1 (es) * | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
US6248359B1 (en) * | 2000-01-05 | 2001-06-19 | Laboratorios Phoenix U.S.A., Inc. | Multi-tablet oxybutynin system for treating incontinence |
GB0010188D0 (en) * | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
WO2003080056A2 (fr) * | 2002-03-21 | 2003-10-02 | Teva Pharmaceutical Industries Ltd. | Pioglitazone a particules de taille fine |
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US7109192B2 (en) * | 2002-12-03 | 2006-09-19 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions |
CA2519208A1 (fr) * | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Composition a liberation controlee |
PE20050021A1 (es) | 2003-04-16 | 2005-03-15 | Novartis Ag | Procedimiento para la preparacion de 2-cianopirrolidina n-sustituida |
ES2332920T3 (es) * | 2004-01-20 | 2010-02-15 | Novartis Ag | Proceso y formulacion de compresion directa. |
US20090017015A1 (en) * | 2004-02-20 | 2009-01-15 | Thomas Edward Hughes | Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders |
-
2006
- 2006-01-10 GT GT200600008A patent/GT200600008A/es unknown
- 2006-01-16 PE PE2006000068A patent/PE20061017A1/es not_active Application Discontinuation
- 2006-01-16 AR ARP060100167A patent/AR052878A1/es not_active Application Discontinuation
- 2006-01-17 MX MXMX07008679A patent/MX2007008679A/es not_active Application Discontinuation
- 2006-01-17 BR BRPI0606731-0A patent/BRPI0606731A2/pt not_active IP Right Cessation
- 2006-01-17 US US11/814,274 patent/US20080299190A1/en not_active Abandoned
- 2006-01-17 RU RU2007131503/15A patent/RU2007131503A/ru unknown
- 2006-01-17 CA CA002593359A patent/CA2593359A1/fr not_active Abandoned
- 2006-01-17 NZ NZ555576A patent/NZ555576A/en not_active IP Right Cessation
- 2006-01-17 US US11/333,582 patent/US20060210627A1/en not_active Abandoned
- 2006-01-17 KR KR1020077016309A patent/KR20070100291A/ko not_active Application Discontinuation
- 2006-01-17 TW TW095101743A patent/TW200637616A/zh unknown
- 2006-01-17 WO PCT/US2006/001473 patent/WO2006078593A2/fr active Application Filing
- 2006-01-17 EP EP06718534A patent/EP1841413A2/fr not_active Withdrawn
- 2006-01-17 AU AU2006206670A patent/AU2006206670B2/en not_active Ceased
- 2006-01-17 JP JP2007551457A patent/JP2008527004A/ja not_active Withdrawn
-
2007
- 2007-06-07 IL IL183762A patent/IL183762A0/en unknown
- 2007-07-17 TN TNP2007000274A patent/TNSN07274A1/en unknown
- 2007-07-26 MA MA30104A patent/MA29171B1/fr unknown
- 2007-08-06 NO NO20074048A patent/NO20074048L/no not_active Application Discontinuation
-
2010
- 2010-04-01 AU AU2010201312A patent/AU2010201312A1/en not_active Abandoned
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2011
- 2011-07-19 US US13/185,817 patent/US20120015029A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2593359A1 (fr) | 2006-07-27 |
EP1841413A2 (fr) | 2007-10-10 |
PE20061017A1 (es) | 2006-10-31 |
WO2006078593A2 (fr) | 2006-07-27 |
IL183762A0 (en) | 2008-04-13 |
MX2007008679A (es) | 2007-07-25 |
AU2006206670A1 (en) | 2006-07-27 |
NO20074048L (no) | 2007-10-11 |
US20060210627A1 (en) | 2006-09-21 |
AR052878A1 (es) | 2007-04-11 |
NZ555576A (en) | 2010-12-24 |
TW200637616A (en) | 2006-11-01 |
KR20070100291A (ko) | 2007-10-10 |
TNSN07274A1 (en) | 2008-12-31 |
RU2007131503A (ru) | 2009-05-10 |
GT200600008A (es) | 2006-08-09 |
AU2006206670B2 (en) | 2010-04-15 |
AU2010201312A1 (en) | 2010-04-22 |
US20080299190A1 (en) | 2008-12-04 |
US20120015029A1 (en) | 2012-01-19 |
BRPI0606731A2 (pt) | 2009-07-14 |
JP2008527004A (ja) | 2008-07-24 |
WO2006078593A3 (fr) | 2006-09-14 |
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