MA30260B1 - Acides 4-phenyl-thiazole-5-carboxyliques et amides d'acide 4-phenyl-thiazole-5-carboxylique en tant qu'inhibiteurs de plk 1 - Google Patents

Acides 4-phenyl-thiazole-5-carboxyliques et amides d'acide 4-phenyl-thiazole-5-carboxylique en tant qu'inhibiteurs de plk 1

Info

Publication number
MA30260B1
MA30260B1 MA31208A MA31208A MA30260B1 MA 30260 B1 MA30260 B1 MA 30260B1 MA 31208 A MA31208 A MA 31208A MA 31208 A MA31208 A MA 31208A MA 30260 B1 MA30260 B1 MA 30260B1
Authority
MA
Morocco
Prior art keywords
thiazole
phenyl
acid amides
carboxylic acid
carboxylic acids
Prior art date
Application number
MA31208A
Other languages
English (en)
Inventor
John Frederick Boylan
Jianping Cai
Nader Fotouhi
Paul Gillespie
Robert Alan Goodnow Jr
Kang Le
Christophe Michoud
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA30260B1 publication Critical patent/MA30260B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

L'invention concerne un composé de formule (I) une composition comprenant un composé de formule (I), un procédé pour traiter un sujet atteint d'une maladie ou affection qui répond à une modulation de l'activité de Plk1, un procédé pour préparer un composé de formule (1) et l'utilisation d'un composé de formule (1) pour la fabrication de médicaments pour le traitement du cancer, en particulier de tumeurs solides.
MA31208A 2006-02-27 2008-09-04 Acides 4-phenyl-thiazole-5-carboxyliques et amides d'acide 4-phenyl-thiazole-5-carboxylique en tant qu'inhibiteurs de plk 1 MA30260B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27

Publications (1)

Publication Number Publication Date
MA30260B1 true MA30260B1 (fr) 2009-03-02

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31208A MA30260B1 (fr) 2006-02-27 2008-09-04 Acides 4-phenyl-thiazole-5-carboxyliques et amides d'acide 4-phenyl-thiazole-5-carboxylique en tant qu'inhibiteurs de plk 1

Country Status (19)

Country Link
US (1) US7504513B2 (fr)
EP (1) EP1991543A1 (fr)
JP (1) JP2009528284A (fr)
KR (1) KR101060539B1 (fr)
CN (1) CN101415704A (fr)
AR (1) AR059621A1 (fr)
AU (1) AU2007217575A1 (fr)
BR (1) BRPI0710473A2 (fr)
CA (1) CA2642921A1 (fr)
CR (1) CR10206A (fr)
EC (1) ECSP088700A (fr)
IL (1) IL193481A0 (fr)
MA (1) MA30260B1 (fr)
MX (1) MX2008010884A (fr)
NO (1) NO20083708L (fr)
RU (1) RU2008138163A (fr)
TW (1) TW200745097A (fr)
WO (1) WO2007096315A1 (fr)
ZA (1) ZA200807074B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5246158B2 (ja) * 2007-06-08 2013-07-24 日本電気株式会社 半導体集積回路及びフィルタ制御方法
US9029411B2 (en) 2008-01-25 2015-05-12 Millennium Pharmaceuticals, Inc. Thiophenes and uses thereof
WO2009128805A1 (fr) * 2008-04-17 2009-10-22 The Johns Hopkins University Analogue nucléotidique améliorant l'activité d'agent chimiothérapeutique dans des tumeurs résistantes aux médicaments
ES2388570T3 (es) * 2008-09-10 2012-10-16 Datalase Ltd Medio de almacenamiento de datos
WO2010077295A1 (fr) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Hétérocycles tricycliques substitués et leurs utilisations pour traiter des tumeurs et des troubles prolifératifs
JP2012512223A (ja) * 2008-12-18 2012-05-31 エフ．ホフマン−ラ ロシュ アーゲー チアゾリル−ベンズイミダゾール類
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
CN102395585A (zh) * 2009-01-30 2012-03-28 米伦纽姆医药公司 杂芳基化合物和其作为pi3k抑制剂的用途
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
JP2013533318A (ja) 2010-08-11 2013-08-22 ミレニアム ファーマシューティカルズ， インコーポレイテッド ヘテロアリールおよびその使用
PE20131304A1 (es) 2010-08-11 2013-11-14 Millennium Pharm Inc Heteroarilos y sus usos
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
UY33671A (es) 2010-10-13 2012-04-30 Millenium Pharmaceuticals Inc Heteroarilos y sus usos

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322429A (en) 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
EA006381B1 (ru) 2000-08-10 2005-12-29 Фармация Италия С.П.А. Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
AU2003206946A1 (en) 2002-02-22 2003-09-09 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
WO2003072554A1 (fr) * 2002-02-28 2003-09-04 Takeda Chemical Industries, Ltd. Composes d'azole
IL163607A0 (en) 2002-02-28 2005-12-18 Univ Temple Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders
US20060079503A1 (en) 2002-05-03 2006-04-13 Schering Aktiengesellschaft Thiazolidinones and the use therof as polo-like kinase inhibitors
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
WO2004014899A1 (fr) * 2002-08-08 2004-02-19 Smithkline Beecham Corporation Composes de benzimidazole-1-yl-thiophene utilises en cancerotherapie
AU2003284399A1 (en) 2002-11-14 2004-06-03 Kyowa Hakko Kogyo Co., Ltd. Plk inhibitors
WO2004046317A2 (fr) 2002-11-14 2004-06-03 Massachusetts Institue Of Technology Produits et procedes pour moduler les interactions entre domaines de liaison de peptide a peptide
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
ES2325440T3 (es) 2003-02-20 2009-09-04 Smithkline Beecham Corporation Compuestos de pirimidina.
ATE432936T1 (de) 2003-04-01 2009-06-15 Smithkline Beecham Corp Imidazotriazin verbindungen zur behandlung von krebserkrankungen
JP2007516168A (ja) 2003-06-24 2007-06-21 ファイザー・プロダクツ・インク １−［２−（ベンゾイミダゾル−１−イル）キノリン−８−イル］−ピペリジン−４−イルアミン誘導体の製造方法
WO2005019193A2 (fr) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Composés de phényl-urée
CA2542880A1 (fr) 2003-10-21 2005-05-12 Cyclacel Limited Composes de pyrimidin-4-yl-3, 4-thione et leur utilisation a des fins therapeutiques
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
WO2005075470A1 (fr) 2004-01-28 2005-08-18 Smithkline Beecham Corporation Composes thiazole

Also Published As

Publication number Publication date
ECSP088700A (es) 2008-09-29
KR101060539B1 (ko) 2011-08-30
TW200745097A (en) 2007-12-16
WO2007096315A1 (fr) 2007-08-30
AR059621A1 (es) 2008-04-16
IL193481A0 (en) 2009-05-04
CR10206A (es) 2008-09-22
CN101415704A (zh) 2009-04-22
NO20083708L (no) 2008-09-23
RU2008138163A (ru) 2010-04-10
BRPI0710473A2 (pt) 2011-08-16
KR20080090550A (ko) 2008-10-08
JP2009528284A (ja) 2009-08-06
CA2642921A1 (fr) 2007-08-30
MX2008010884A (es) 2008-09-03
US7504513B2 (en) 2009-03-17
US20070203210A1 (en) 2007-08-30
ZA200807074B (en) 2009-10-28
EP1991543A1 (fr) 2008-11-19
AU2007217575A1 (en) 2007-08-30

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