ZA200807074B - 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors - Google Patents

4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors

Info

Publication number
ZA200807074B
ZA200807074B ZA200807074A ZA200807074A ZA200807074B ZA 200807074 B ZA200807074 B ZA 200807074B ZA 200807074 A ZA200807074 A ZA 200807074A ZA 200807074 A ZA200807074 A ZA 200807074A ZA 200807074 B ZA200807074 B ZA 200807074B
Authority
ZA
South Africa
Prior art keywords
thiazole
phenyl
acid amides
carboxylic acid
carboxylic acids
Prior art date
Application number
ZA200807074A
Other languages
English (en)
Inventor
Boylan John Frederick
Cai Jianping
Fotouhi Nader
Gillespie Paul
Goodnow Robert Alan Jr
Le Kang
Michoud Christophe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200807074B publication Critical patent/ZA200807074B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ZA200807074A 2006-02-27 2008-08-15 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors ZA200807074B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27

Publications (1)

Publication Number Publication Date
ZA200807074B true ZA200807074B (en) 2009-10-28

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200807074A ZA200807074B (en) 2006-02-27 2008-08-15 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors

Country Status (19)

Country Link
US (1) US7504513B2 (xx)
EP (1) EP1991543A1 (xx)
JP (1) JP2009528284A (xx)
KR (1) KR101060539B1 (xx)
CN (1) CN101415704A (xx)
AR (1) AR059621A1 (xx)
AU (1) AU2007217575A1 (xx)
BR (1) BRPI0710473A2 (xx)
CA (1) CA2642921A1 (xx)
CR (1) CR10206A (xx)
EC (1) ECSP088700A (xx)
IL (1) IL193481A0 (xx)
MA (1) MA30260B1 (xx)
MX (1) MX2008010884A (xx)
NO (1) NO20083708L (xx)
RU (1) RU2008138163A (xx)
TW (1) TW200745097A (xx)
WO (1) WO2007096315A1 (xx)
ZA (1) ZA200807074B (xx)

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US8412867B2 (en) * 2007-06-08 2013-04-02 Nec Corporation Semiconductor integrated circuit and filter and informational delivery method using same
WO2009094224A1 (en) 2008-01-25 2009-07-30 Millennium Pharmaceuticals, Inc. Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
CA2721722C (en) * 2008-04-17 2015-12-08 The Johns Hopkins University On01910.na enhances chemotherapeutic agent activity in drug-resistant tumors
EP2324477B1 (en) * 2008-09-10 2012-07-25 DataLase Ltd Data storage medium
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
JP2012512223A (ja) * 2008-12-18 2012-05-31 エフ．ホフマン−ラ ロシュ アーゲー チアゾリル−ベンズイミダゾール類
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
CN102395585A (zh) * 2009-01-30 2012-03-28 米伦纽姆医药公司 杂芳基化合物和其作为pi3k抑制剂的用途
EP2603216A4 (en) 2010-08-11 2013-12-18 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
CA2807971A1 (en) 2010-08-11 2012-02-16 Millenium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
UY33671A (es) 2010-10-13 2012-04-30 Millenium Pharmaceuticals Inc Heteroarilos y sus usos

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US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
AU2001287654B2 (en) 2000-08-10 2006-12-14 Pfizer Italia S.R.I. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
US20050107316A1 (en) 2002-02-22 2005-05-19 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
US7183276B2 (en) * 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
IL163607A0 (en) 2002-02-28 2005-12-18 Univ Temple Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
RS95404A (xx) 2002-05-03 2006-10-27 Schering Aktiengesellschaft Tiazolidinoni i njihova primena kao inhibitora polo like kinaze
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
CA2493908A1 (en) 2002-08-08 2004-02-19 Smithkline Beecham Corporation Thiophene compounds
CA2506246A1 (en) 2002-11-14 2004-06-03 Massachusetts Institute Of Technology Products and processes for modulating peptide-peptide binding domain interactions
JPWO2004043936A1 (ja) 2002-11-14 2006-03-09 協和醗酵工業株式会社 Ｐｌｋ阻害剤
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
DE602004021472D1 (en) 2003-02-20 2009-07-23 Smithkline Beecham Corp Pyrimiidinverbindungen
ES2326808T3 (es) 2003-04-01 2009-10-20 Smithkline Beecham Corporation Compuestos de imidazotriazina para el tratamiento de enfermedades cancerosas.
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DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
JP2007519720A (ja) 2004-01-28 2007-07-19 スミスクライン ビーチャム コーポレーション チアゾール化合物

Also Published As

Publication number Publication date
NO20083708L (no) 2008-09-23
BRPI0710473A2 (pt) 2011-08-16
TW200745097A (en) 2007-12-16
CA2642921A1 (en) 2007-08-30
US20070203210A1 (en) 2007-08-30
JP2009528284A (ja) 2009-08-06
KR20080090550A (ko) 2008-10-08
ECSP088700A (es) 2008-09-29
AR059621A1 (es) 2008-04-16
MX2008010884A (es) 2008-09-03
RU2008138163A (ru) 2010-04-10
CR10206A (es) 2008-09-22
WO2007096315A1 (en) 2007-08-30
US7504513B2 (en) 2009-03-17
CN101415704A (zh) 2009-04-22
EP1991543A1 (en) 2008-11-19
MA30260B1 (fr) 2009-03-02
KR101060539B1 (ko) 2011-08-30
IL193481A0 (en) 2009-05-04
AU2007217575A1 (en) 2007-08-30

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