ZA200807074B - 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors - Google Patents

4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors

Info

Publication number
ZA200807074B
ZA200807074B ZA200807074A ZA200807074A ZA200807074B ZA 200807074 B ZA200807074 B ZA 200807074B ZA 200807074 A ZA200807074 A ZA 200807074A ZA 200807074 A ZA200807074 A ZA 200807074A ZA 200807074 B ZA200807074 B ZA 200807074B
Authority
ZA
South Africa
Prior art keywords
thiazole
phenyl
acid amides
carboxylic acid
carboxylic acids
Prior art date
Application number
ZA200807074A
Other languages
English (en)
Inventor
Boylan John Frederick
Cai Jianping
Fotouhi Nader
Gillespie Paul
Goodnow Robert Alan Jr
Le Kang
Michoud Christophe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200807074B publication Critical patent/ZA200807074B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ZA200807074A 2006-02-27 2008-08-15 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors ZA200807074B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27

Publications (1)

Publication Number Publication Date
ZA200807074B true ZA200807074B (en) 2009-10-28

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200807074A ZA200807074B (en) 2006-02-27 2008-08-15 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors

Country Status (19)

Country Link
US (1) US7504513B2 (xx)
EP (1) EP1991543A1 (xx)
JP (1) JP2009528284A (xx)
KR (1) KR101060539B1 (xx)
CN (1) CN101415704A (xx)
AR (1) AR059621A1 (xx)
AU (1) AU2007217575A1 (xx)
BR (1) BRPI0710473A2 (xx)
CA (1) CA2642921A1 (xx)
CR (1) CR10206A (xx)
EC (1) ECSP088700A (xx)
IL (1) IL193481A0 (xx)
MA (1) MA30260B1 (xx)
MX (1) MX2008010884A (xx)
NO (1) NO20083708L (xx)
RU (1) RU2008138163A (xx)
TW (1) TW200745097A (xx)
WO (1) WO2007096315A1 (xx)
ZA (1) ZA200807074B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8412867B2 (en) * 2007-06-08 2013-04-02 Nec Corporation Semiconductor integrated circuit and filter and informational delivery method using same
EP2250160B1 (en) 2008-01-25 2015-11-11 Millennium Pharmaceuticals, Inc. Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
RU2476239C2 (ru) * 2008-04-17 2013-02-27 Де Джонс Хопкинс Юниверсити On01910.na, усиливающий активность химиотерапевтического агента в резистентных к лекарственным средствам опухолях
BRPI0918427A2 (pt) * 2008-09-10 2018-05-22 Datalase Ltd meio de armazenamento de dados
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
SG172229A1 (en) * 2008-12-18 2011-07-28 Hoffmann La Roche Thiazolyl-benzimidazoles
WO2010090716A1 (en) * 2009-01-30 2010-08-12 Millennium Pharmaceuticals, Inc. Heteroaryls and their use as pi3k inhibitors
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US8796271B2 (en) 2010-08-11 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US8859768B2 (en) 2010-08-11 2014-10-14 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
AR083450A1 (es) 2010-10-13 2013-02-27 Millennium Pharm Inc Heteroarilos y sus usos en el tratamiento de enfermedades proliferativas, inflamatorias o cardiovasculares

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
EP1320531B1 (en) 2000-08-10 2010-09-08 Pfizer Italia S.r.l. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
US20050107316A1 (en) 2002-02-22 2005-05-19 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
WO2003072554A1 (en) * 2002-02-28 2003-09-04 Takeda Chemical Industries, Ltd. Azole compounds
KR100972131B1 (ko) 2002-02-28 2010-07-26 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 증식성 질병 치료용 아미노-치환（ｅ）-2,6-디알콕시스티릴 4-치환-벤질설폰
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
CN1649853A (zh) 2002-05-03 2005-08-03 舍林股份公司 噻唑烷酮类化合物、其制备方法以及作为药物的应用
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
AU2003265348B2 (en) * 2002-08-08 2007-08-16 Smithkline Beecham Corporation Thiophene compounds
AU2003284399A1 (en) 2002-11-14 2004-06-03 Kyowa Hakko Kogyo Co., Ltd. Plk inhibitors
EP1576128A4 (en) 2002-11-14 2008-02-13 Massachusetts Inst Technology PRODUCTS AND METHODS FOR MODULATING INTERACTIONS BETWEEN PEPTIDE PEPTIDE BINDING DOMAINS
WO2004054186A1 (ja) 2002-12-12 2004-06-24 Fujitsu Limited データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
WO2004074244A2 (en) 2003-02-20 2004-09-02 Smithkline Beecham Corporation Pyrimidine compounds
EP1608656B1 (en) 2003-04-01 2009-06-03 SmithKline Beecham Corporation Imidazotriazine compounds for the treatment of cancer diseases
BRPI0411794A (pt) 2003-06-24 2006-08-08 Pfizer Prod Inc processos para a preparação de derivados de 1-[(benzoimidazol-1-il)quinolin-8-il]piperidin-4-ilamina
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
AU2004285745A1 (en) 2003-10-21 2005-05-12 Cyclacel Limited Pyrimidin-4-YL-3, 4-thione compounds and their use in therapy
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
EP1711496A4 (en) 2004-01-28 2009-02-11 Smithkline Beecham Corp THIAZOLE COMPOUNDS

Also Published As

Publication number Publication date
ECSP088700A (es) 2008-09-29
AU2007217575A1 (en) 2007-08-30
KR20080090550A (ko) 2008-10-08
TW200745097A (en) 2007-12-16
WO2007096315A1 (en) 2007-08-30
US7504513B2 (en) 2009-03-17
IL193481A0 (en) 2009-05-04
NO20083708L (no) 2008-09-23
RU2008138163A (ru) 2010-04-10
CR10206A (es) 2008-09-22
US20070203210A1 (en) 2007-08-30
BRPI0710473A2 (pt) 2011-08-16
AR059621A1 (es) 2008-04-16
CA2642921A1 (en) 2007-08-30
KR101060539B1 (ko) 2011-08-30
MX2008010884A (es) 2008-09-03
CN101415704A (zh) 2009-04-22
EP1991543A1 (en) 2008-11-19
JP2009528284A (ja) 2009-08-06
MA30260B1 (fr) 2009-03-02

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