LV5618A3 - Panemiens 2-oksoindol-1-karboksamida atvasinajumu iegusanai - Google Patents

Panemiens 2-oksoindol-1-karboksamida atvasinajumu iegusanai

Info

Publication number
LV5618A3
LV5618A3 LV931200A LV931200A LV5618A3 LV 5618 A3 LV5618 A3 LV 5618A3 LV 931200 A LV931200 A LV 931200A LV 931200 A LV931200 A LV 931200A LV 5618 A3 LV5618 A3 LV 5618A3
Authority
LV
Latvia
Prior art keywords
alkyl
optionally substituted
bicyclo
compounds
formula
Prior art date
Application number
LV931200A
Other languages
English (en)
Latvian (lv)
Inventor
Sol Bernard Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of LV5618A3 publication Critical patent/LV5618A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
LV931200A 1984-03-19 1993-11-11 Panemiens 2-oksoindol-1-karboksamida atvasinajumu iegusanai LV5618A3 (lv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59065984A 1984-03-19 1984-03-19
US06/684,634 US4556672A (en) 1984-03-19 1984-12-21 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
SU853869754A SU1445556A3 (ru) 1984-03-19 1985-03-18 Способ получени производных 2-оксоиндол-1-карбоксамида

Publications (1)

Publication Number Publication Date
LV5618A3 true LV5618A3 (lv) 1994-05-10

Family

ID=27080909

Family Applications (1)

Application Number Title Priority Date Filing Date
LV931200A LV5618A3 (lv) 1984-03-19 1993-11-11 Panemiens 2-oksoindol-1-karboksamida atvasinajumu iegusanai

Country Status (36)

Country Link
US (1) US4556672A (ru)
EP (1) EP0156603B1 (ru)
JP (1) JPH04235165A (ru)
KR (1) KR860001873B1 (ru)
AT (1) ATE45731T1 (ru)
AU (1) AU549927B2 (ru)
BG (1) BG60347B2 (ru)
CA (2) CA1251441A (ru)
CS (1) CS249539B2 (ru)
CY (1) CY1668A (ru)
DE (1) DE3572481D1 (ru)
DK (1) DK162090C (ru)
EG (1) EG17795A (ru)
ES (1) ES8603408A1 (ru)
FI (2) FI82042C (ru)
GR (1) GR850668B (ru)
HK (1) HK78392A (ru)
HU (1) HU196178B (ru)
IE (1) IE57743B1 (ru)
IL (3) IL74631A (ru)
LV (1) LV5618A3 (ru)
MA (1) MA20380A1 (ru)
MY (1) MY101987A (ru)
NL (1) NL940025I2 (ru)
NO (1) NO165799C (ru)
NZ (2) NZ224134A (ru)
OA (1) OA07966A (ru)
PH (2) PH21323A (ru)
PL (1) PL145951B1 (ru)
PT (1) PT80117B (ru)
RO (1) RO90952B (ru)
SI (1) SI8510440A8 (ru)
SU (1) SU1445556A3 (ru)
UA (1) UA6343A1 (ru)
YU (1) YU43870B (ru)
ZW (1) ZW4785A1 (ru)

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DE3568776D1 (en) * 1984-02-07 1989-04-20 Pfizer 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
DE3681358D1 (de) * 1985-07-09 1991-10-17 Pfizer Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel.
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
UA25898A1 (uk) * 1987-02-02 1999-02-26 Пфайзер Інк. Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
US4885370A (en) * 1987-03-11 1989-12-05 Pfizer Inc. Synthetic method for indol-2(3H)-ones
US4761485A (en) * 1987-03-11 1988-08-02 Pfizer Inc. Synthetic method for indol-2(3H)-ones
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
DE68923673T2 (de) * 1988-10-18 1996-01-18 Pfizer Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden.
SK278175B6 (en) * 1988-10-18 1996-03-06 Pfizer 3-acyl-2-oxindole-1-carboxamides and method of their preparation
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
WO1991009598A1 (en) * 1990-01-05 1991-07-11 Pfizer Inc. Azaoxindole derivatives
US5006547A (en) * 1990-03-19 1991-04-09 Pfizer Inc. Tenidap as an inhibitor of the release of elastase by neutrophils
US5008283A (en) * 1990-03-19 1991-04-16 Pfizer Inc. Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
US5122534A (en) * 1991-02-08 1992-06-16 Pfizer Inc. Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111306C2 (de) * 1991-04-08 1994-06-01 Mack Chem Pharm Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
DE4111305C2 (de) * 1991-04-08 1994-12-01 Mack Chem Pharm Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5166401A (en) * 1991-06-25 1992-11-24 Pfizer Inc Intermediates for 5-fluoro-6-chlorooxindole
US5210212A (en) * 1991-06-25 1993-05-11 Pfizer Inc Process for 5-fluoro-6-chlorooxindole
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
CN1116822A (zh) * 1993-01-22 1996-02-14 美国辉瑞有限公司 6-氯-5-氟-3-(2-噻吩甲酰)-2-羟吲哚-1-羰酰胺的赖氨酸盐
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5270331A (en) * 1993-01-26 1993-12-14 Pfizer, Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
CA2155664C (en) * 1993-02-09 1999-06-15 Ralph P. Robinson Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as antiinflammatory agents
ES2076106B1 (es) * 1993-08-26 1996-06-16 Pfizer Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas
US5449788A (en) * 1994-01-28 1995-09-12 Catalytica, Inc. Process for preparing 2-oxindole-1-carboxamides
EP0679396A1 (en) * 1994-03-02 1995-11-02 Pfizer Inc. Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury
US6469181B1 (en) 1995-01-30 2002-10-22 Catalytica, Inc. Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles
US5545656A (en) * 1995-04-05 1996-08-13 Pfizer Inc. 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
US6051588A (en) * 1995-04-19 2000-04-18 Nitromed Inc Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
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Also Published As

Publication number Publication date
FI82449B (fi) 1990-11-30
HUT37398A (en) 1985-12-28
KR860001873B1 (ko) 1986-10-24
UA6343A1 (ru) 1994-12-29
DK121385A (da) 1985-09-20
NZ211486A (en) 1988-10-28
CS249539B2 (en) 1987-03-12
FI82449C (fi) 1991-03-11
DK162090C (da) 1992-02-24
NL940025I2 (nl) 2000-01-03
IL85130A (en) 1988-07-31
AU549927B2 (en) 1986-02-20
GR850668B (ru) 1985-07-16
HK78392A (en) 1992-10-23
NO165799B (no) 1991-01-02
EG17795A (en) 1990-08-30
RO90952A (ro) 1987-02-27
CA1288422C (en) 1991-09-03
EP0156603B1 (en) 1989-08-23
DK121385D0 (da) 1985-03-18
HU196178B (en) 1988-10-28
IL74631A0 (en) 1985-06-30
PT80117B (pt) 1987-10-20
FI851069A0 (fi) 1985-03-18
FI894540A0 (fi) 1989-09-26
OA07966A (fr) 1987-01-31
YU43870B (en) 1989-12-31
YU44085A (en) 1988-02-29
SI8510440A8 (sl) 1996-06-30
JPH04235165A (ja) 1992-08-24
FI82042C (fi) 1991-01-10
IL74631A (en) 1988-07-31
NZ224134A (en) 1988-10-28
FI851069L (fi) 1985-09-20
PT80117A (en) 1985-04-01
AU4005985A (en) 1985-09-26
ES541372A0 (es) 1985-12-16
DK162090B (da) 1991-09-16
IE57743B1 (en) 1993-03-24
NO851054L (no) 1985-09-20
PH21470A (en) 1987-10-28
SU1445556A3 (ru) 1988-12-15
EP0156603A3 (en) 1986-02-12
PH21323A (en) 1987-09-28
PL252434A1 (en) 1985-12-03
IL85130A0 (en) 1988-06-30
CA1251441A (en) 1989-03-21
MA20380A1 (fr) 1985-10-01
NL940025I1 (nl) 1995-02-01
NO165799C (no) 1991-04-10
MY101987A (en) 1992-02-29
FI82042B (fi) 1990-09-28
FI894540A (fi) 1989-09-26
US4556672A (en) 1985-12-03
KR850006173A (ko) 1985-10-02
IE850684L (en) 1985-09-19
BG60347B2 (bg) 1994-06-30
JPH0561269B2 (ru) 1993-09-06
ATE45731T1 (de) 1989-09-15
RO90952B (ro) 1987-03-01
PL145951B1 (en) 1988-12-31
CY1668A (en) 1993-05-14
ES8603408A1 (es) 1985-12-16
ZW4785A1 (en) 1985-06-19
EP0156603A2 (en) 1985-10-02
DE3572481D1 (en) 1989-09-28

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