LV10344B - Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies - Google Patents

Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies Download PDF

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Publication number
LV10344B
LV10344B LVP-93-438.1A LV934381A LV10344B LV 10344 B LV10344 B LV 10344B LV 934381 A LV934381 A LV 934381A LV 10344 B LV10344 B LV 10344B
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LV
Latvia
Prior art keywords
hcv
domain
cvh
avh
antigen
Prior art date
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LVP-93-438.1A
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English (en)
Inventor
Houghton Michael
Choo Qui-Lim
Kuo George
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Chiron Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24005897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV10344(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of LV10344B publication Critical patent/LV10344B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pinball Game Machines (AREA)
  • Thermistors And Varistors (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (10)

  1. LV 10344 Izgudrojuma formula 1. Kompozīcija no hepatīta C vīrusa (HCV) epitopa secībām vienā vai vairākos polipeptīdos, kas iegūti ar ķīmisko sintēzi vai rekombinantā ekspresijā, imobilizēti uz cietas nesējvielas un paredzēti HCV noteikšanai ar imūnanalīzi,kas atšķiras ar to, ka tā satur: a) pirmo epitopa secību no HCV poliproteīna C domēna; b) otro epitopa secību no HCV poliproteīna otra domēna, kurš var būt - I) HCV poliproteīna NS3 domēns; II) HCV poliproteīna NS4 domēns, vai III) HCV poliproteīna NS5 domēns; c) trešo epitopa secību no HCV poliproteīna trešā domēna, kurš var būt - I) HCV poliproteīna NS3 domēns; II) HCV poliproteīna NS4 domēns, vai III) HCV poliproteīna NS5 domēns; pie kam trešais domēns atšķiras no otrā domēna.
  2. 2. Kompozīcija pēc 1. punkta, kas atšķiras ar to, ka otrais domēns ir NS3.
  3. 3. Kompozīcija pēc 1. punkta, kas atšķiras ar to, ka otrais domēns ir NS4.
  4. 4. Kompozīcija pēc 1. punkta, kas atšķiras ar to, ka tā satur: a) pirmo epitopa secību no HCV poliproteīna C domēna; b) otro epitopa secību no HCV poliproteīna NS3 domēna; c) trešo epitopa secību no HCV poliproteīna NS4 domēna. 1
  5. 5. Kompozīcija pēc jebkura no iepriekšējiem punktiem, kas atšķiras ar to, ka cietā nesējviela ir mikrotitrēšanas plates šūnas virsma, lodītes virsma vai indikatora nūjiņas virsma.
  6. 6. Kompozīcija pēc jebkura no iepriekšējiem punktiem, kas atšķiras ar to, ka pirmā, otrā un trešā epitopa secība ir ietvertas attiecīgi pirmajā, otrajā un trešajā polipeptīdā , kas katrs atsevišķi piesaistīts cietās nesējvielas virsmai.
  7. 7. Kompozīcija pēc 6. punkta, kas atšķiras ar to, ka cietā nesējviela ir indikatora nūjiņa un polipeptīdi ir uzklāti uz tās atsevišķi viens no otra tādā veidā, ka pirmā, otrā vai trešā polipeptīdā saistīšanos var novērot atsevišķi.
  8. 8. Kompozīcija pēc jebkura no 1.-5. punktiem, kas atšķiras ar to, ka kompozīcija ir savienota polipeptīdā formā.
  9. 9. Paņēmiens hepatīta C vīrusa (HCV) antivielu noteikšanai tādās zīdītāja organisma sastāvdaļās, kuras varētu saturēt minētās antivielas, kas atšķiras ar to, ka minēto organisma sastāvdaļu kontaktē ar kompozīciju pēc jebkura no iepriekšējiem punktiem tādos apstākļos, kas dod iespēju notikt antivielas reakcijai ar antigēnu, un nosaka minēto antivielu un minēto polipeptīdu epitopa secību imūno kompleksu veidošanos.
  10. 10. Diagnostikas reaģentu komplekts hepatīta C vīrusa (HCV) antivielu noteikšanai tādās zīdītāja organisma sastāvdaļās, kuras varētu saturēt minētās antivielas, kas iesaiņotā veidā satur: a) HCV epitopa secību kompozīciju pēc jebkūra no iepriekšējiem punktiem; b) parastos analītiskos reaģentus un c) instrukcijas analīzes veikšanai. 2
LVP-93-438.1A 1990-04-04 1993-05-31 Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies LV10344B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50435290A 1990-04-04 1990-04-04

Publications (1)

Publication Number Publication Date
LV10344B true LV10344B (en) 1996-02-20

Family

ID=24005897

Family Applications (2)

Application Number Title Priority Date Filing Date
LV930038D LV10344A (lv) 1990-04-04 1993-05-31 Kompozicija antivielu noteiksanas panemiens diagnostikas reagentu komplekss
LVP-93-438.1A LV10344B (en) 1990-04-04 1993-05-31 Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LV930038D LV10344A (lv) 1990-04-04 1993-05-31 Kompozicija antivielu noteiksanas panemiens diagnostikas reagentu komplekss

Country Status (25)

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EP (2) EP0693687B2 (lv)
JP (1) JP2733138B2 (lv)
KR (1) KR100206150B1 (lv)
AT (2) ATE139343T1 (lv)
BG (1) BG61291B1 (lv)
BR (1) BR9106309A (lv)
CY (1) CY1881A (lv)
DE (2) DE69131488T2 (lv)
DK (2) DK0450931T3 (lv)
ES (2) ES2088465T3 (lv)
FI (1) FI106317B (lv)
GB (1) GB2257784B (lv)
GR (2) GR3020964T3 (lv)
HU (1) HU217025B (lv)
IE (1) IE911105A1 (lv)
IL (2) IL97741A0 (lv)
LT (1) LT3808B (lv)
LV (2) LV10344A (lv)
MY (1) MY107499A (lv)
NO (1) NO310241B1 (lv)
PL (1) PL172133B1 (lv)
RO (1) RO109916B1 (lv)
RU (1) RU2130969C1 (lv)
UA (1) UA41266C2 (lv)
WO (1) WO1991015771A1 (lv)

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Publication number Publication date
GR3020964T3 (en) 1996-12-31
HUT62706A (en) 1993-05-28
DK0693687T4 (da) 2008-09-22
LTIP1747A (en) 1995-07-25
EP0693687B1 (en) 1999-07-28
RU2130969C1 (ru) 1999-05-27
GB2257784B (en) 1995-01-04
DE69120138D1 (de) 1996-07-18
NO923839D0 (no) 1992-10-01
MY107499A (en) 1995-12-30
UA41266C2 (uk) 2001-09-17
FI924349A0 (fi) 1992-09-28
ES2134388T5 (es) 2008-12-01
NO310241B1 (no) 2001-06-11
DE69131488T2 (de) 1999-11-18
DK0693687T3 (da) 1999-11-29
KR100206150B1 (ko) 1999-07-01
EP0450931B1 (en) 1996-06-12
LT3808B (en) 1996-03-25
CY1881A (en) 1996-04-05
GB2257784A (en) 1993-01-20
BG96943A (bg) 1993-12-24
ATE139343T1 (de) 1996-06-15
FI106317B (fi) 2001-01-15
EP0693687B2 (en) 2008-06-04
DE69131488D1 (de) 1999-09-02
EP0693687A1 (en) 1996-01-24
WO1991015771A1 (en) 1991-10-17
IE911105A1 (en) 1991-10-09
RO109916B1 (ro) 1995-07-28
IL170719A (en) 2011-04-28
DE69120138T2 (de) 1996-11-14
DK0450931T3 (da) 1996-07-01
GR3031361T3 (en) 2000-01-31
IL97741A0 (en) 1992-06-21
ES2134388T3 (es) 1999-10-01
BG61291B1 (en) 1997-04-30
ATE182684T1 (de) 1999-08-15
AU7651091A (en) 1991-10-30
FI924349A (fi) 1992-09-28
BR9106309A (pt) 1993-04-20
NO923839L (no) 1992-11-19
HU9203146D0 (en) 1992-12-28
HU217025B (hu) 1999-11-29
EP0450931A1 (en) 1991-10-09
LV10344A (lv) 1994-10-20
ES2088465T3 (es) 1996-08-16
GB9220480D0 (en) 1992-11-25
JPH05508219A (ja) 1993-11-18
JP2733138B2 (ja) 1998-03-30
AU639560B2 (en) 1993-07-29
PL172133B1 (pl) 1997-08-29

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