LV10094B - Novel pilocarpine derivatives and process for their preparation - Google Patents

Novel pilocarpine derivatives and process for their preparation Download PDF

Info

Publication number
LV10094B
LV10094B LVP-93-436A LV930436A LV10094B LV 10094 B LV10094 B LV 10094B LV 930436 A LV930436 A LV 930436A LV 10094 B LV10094 B LV 10094B
Authority
LV
Latvia
Prior art keywords
formula
compound
acid
bispilocarpate
mmoles
Prior art date
Application number
LVP-93-436A
Other languages
English (en)
Latvian (lv)
Other versions
LV10094A (lv
Inventor
Tomi J Rvinen
Pekka Peura
Pekka Suhonen
Arto Urtti
Hannu Hanhij Rvi
Esko Pohjala
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of LV10094A publication Critical patent/LV10094A/xx
Publication of LV10094B publication Critical patent/LV10094B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LVP-93-436A 1990-11-30 1993-05-28 Novel pilocarpine derivatives and process for their preparation LV10094B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI905930A FI98815C (fi) 1990-11-30 1990-11-30 Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi
PCT/FI1991/000359 WO1992009583A1 (en) 1990-11-30 1991-11-27 Novel pilocarpine derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
LV10094A LV10094A (lv) 1994-05-10
LV10094B true LV10094B (en) 1995-02-20

Family

ID=8531500

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-436A LV10094B (en) 1990-11-30 1993-05-28 Novel pilocarpine derivatives and process for their preparation

Country Status (19)

Country Link
EP (1) EP0559700B1 (fi)
JP (1) JP3094232B2 (fi)
KR (1) KR930703264A (fi)
AT (1) ATE192144T1 (fi)
AU (1) AU664958B2 (fi)
CA (1) CA2096444A1 (fi)
CZ (1) CZ282229B6 (fi)
DE (1) DE69132143T2 (fi)
EE (1) EE9400143A (fi)
FI (1) FI98815C (fi)
HU (1) HUT67273A (fi)
LT (1) LT3532B (fi)
LV (1) LV10094B (fi)
NO (1) NO304228B1 (fi)
NZ (1) NZ240781A (fi)
PL (2) PL168715B1 (fi)
RU (1) RU2100352C1 (fi)
SK (1) SK52393A3 (fi)
WO (1) WO1992009583A1 (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0642501A1 (en) * 1992-05-29 1995-03-15 Leiras Oy Novel pilocarpine derivatives and process for their preparation
GB9310965D0 (en) * 1993-05-27 1993-07-14 Ucb Sa 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
SE9302201D0 (sv) 1993-06-24 1993-06-24 Leiras Oy Composition for ophthalmic use
SE501482C2 (sv) 1993-06-24 1995-02-27 Leiras Oy Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning
WO1995000143A1 (en) * 1993-06-24 1995-01-05 Leiras Oy Composition for ophthalmic use
DE4334135A1 (de) * 1993-10-07 1995-04-13 Merck Patent Gmbh Verfahren zur Herstellung von Pilocarpin-Derivaten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061722A (en) 1976-04-26 1977-12-06 Interx Research Corporation Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
IL69593A (en) * 1982-09-17 1988-09-30 Bundegaard Hans Pilocarpine prodrugs,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI98815C (fi) 1997-08-25
EP0559700A1 (en) 1993-09-15
SK52393A3 (en) 1994-01-12
LTIP577A (en) 1994-12-27
EE9400143A (et) 1995-12-15
EP0559700B1 (en) 2000-04-26
FI98815B (fi) 1997-05-15
AU664958B2 (en) 1995-12-07
NO931960D0 (no) 1993-05-28
JP3094232B2 (ja) 2000-10-03
HU9301569D0 (en) 1993-09-28
LV10094A (lv) 1994-05-10
RU2100352C1 (ru) 1997-12-27
FI905930A0 (fi) 1990-11-30
PL167773B1 (pl) 1995-11-30
CZ102593A3 (en) 1994-04-13
JPH06504270A (ja) 1994-05-19
NO931960L (no) 1993-05-28
CZ282229B6 (cs) 1997-06-11
NO304228B1 (no) 1998-11-16
WO1992009583A1 (en) 1992-06-11
CA2096444A1 (en) 1992-05-31
AU8939891A (en) 1992-06-25
DE69132143D1 (de) 2000-05-31
FI905930A (fi) 1992-05-31
PL168715B1 (pl) 1996-03-29
ATE192144T1 (de) 2000-05-15
DE69132143T2 (de) 2000-12-14
LT3532B (en) 1995-11-27
NZ240781A (en) 1993-12-23
HUT67273A (en) 1995-03-28
KR930703264A (ko) 1993-11-29

Similar Documents

Publication Publication Date Title
US4593044A (en) Injectable solution for the treatment of inflammations
JPH0524135B2 (fi)
EP0338291A1 (en) Antiinflammatory Gel
KR20090114398A (ko) (ｅ)-2,6-다이알콕시스티릴 4-치환된 벤질설폰의 비경구 투여용 제형
CA2001574A1 (en) Pharmaceutical preparation for percutaneous administration containing bunazosin or its salts
KR20200011485A (ko) 섬유증 치료를 위한 조성물
EP0403578A1 (en) STABLE PHARMACEUTICAL COMPOSITION.
LV10094B (en) Novel pilocarpine derivatives and process for their preparation
CH683427A5 (fr) Composé d'isoquinoléine comme agents de blocage neuromusculaire.
US3886278A (en) Ammonium carboxylate sebum inhibition process
CN115175665B (zh) 含有索吡溴铵的药物
EP0440811B1 (en) Composition for percutaneous administration
EP0106541A2 (en) Pilocarpine prodrugs
US5436350A (en) Bispilocarpic acid ester derivatives and process for their preparation
LV10257B (en) Novel pilocarpine derivatives and process for their preparation
KR900006124B1 (ko) Gem-디할로 및 테트라할로-1,12-디아미노-4,9-디아자-도데칸 및 이들의 제조방법
JP2623580B2 (ja) 消炎鎮痛クリーム剤
FI98910C (fi) Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi
US4124723A (en) Method for suppressing histamine release
FI98911C (fi) Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi
CA1148165A (en) Esters of arylpropionic acids endowed with an anti- inflammatory activity, process for their preparation, and related pharmaceutical compositions
JP3098275B2 (ja) トルナフテート含有液剤
FR2466249A1 (fr) Composition therapeutique pour reduire la pression intraoculaire de l'oeil humain, procede de preparation de cette composition et application au traitement du glaucome
JPH09110685A (ja) 消炎鎮痛クリーム剤
EP0693481A1 (en) Prodrugs of 5,5-diphenylhydantoin as antiepileptic and antiarrhythmic agents