LT3532B - Novel pilocarpine derivatives and process for their preparation - Google Patents

Novel pilocarpine derivatives and process for their preparation Download PDF

Info

Publication number
LT3532B
LT3532B LTIP577A LTIP577A LT3532B LT 3532 B LT3532 B LT 3532B LT IP577 A LTIP577 A LT IP577A LT IP577 A LTIP577 A LT IP577A LT 3532 B LT3532 B LT 3532B
Authority
LT
Lithuania
Prior art keywords
formula
compound
bispilocarpate
acid
mmol
Prior art date
Application number
LTIP577A
Other languages
English (en)
Lithuanian (lt)
Inventor
Tomi Jaervinen
Pekka Peura
Pekka Suhonen
Arto Urtti
Hannu Hanhijaervi
Esko Pohjala
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of LTIP577A publication Critical patent/LTIP577A/xx
Publication of LT3532B publication Critical patent/LT3532B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTIP577A 1990-11-30 1993-05-28 Novel pilocarpine derivatives and process for their preparation LT3532B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI905930A FI98815C (fi) 1990-11-30 1990-11-30 Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi

Publications (2)

Publication Number Publication Date
LTIP577A LTIP577A (en) 1994-12-27
LT3532B true LT3532B (en) 1995-11-27

Family

ID=8531500

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP577A LT3532B (en) 1990-11-30 1993-05-28 Novel pilocarpine derivatives and process for their preparation

Country Status (19)

Country Link
EP (1) EP0559700B1 (fi)
JP (1) JP3094232B2 (fi)
KR (1) KR930703264A (fi)
AT (1) ATE192144T1 (fi)
AU (1) AU664958B2 (fi)
CA (1) CA2096444A1 (fi)
CZ (1) CZ282229B6 (fi)
DE (1) DE69132143T2 (fi)
EE (1) EE9400143A (fi)
FI (1) FI98815C (fi)
HU (1) HUT67273A (fi)
LT (1) LT3532B (fi)
LV (1) LV10094B (fi)
NO (1) NO304228B1 (fi)
NZ (1) NZ240781A (fi)
PL (2) PL168715B1 (fi)
RU (1) RU2100352C1 (fi)
SK (1) SK52393A3 (fi)
WO (1) WO1992009583A1 (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0642501A1 (en) * 1992-05-29 1995-03-15 Leiras Oy Novel pilocarpine derivatives and process for their preparation
GB9310965D0 (en) * 1993-05-27 1993-07-14 Ucb Sa 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
SE9302201D0 (sv) 1993-06-24 1993-06-24 Leiras Oy Composition for ophthalmic use
SE501482C2 (sv) 1993-06-24 1995-02-27 Leiras Oy Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning
WO1995000143A1 (en) * 1993-06-24 1995-01-05 Leiras Oy Composition for ophthalmic use
DE4334135A1 (de) * 1993-10-07 1995-04-13 Merck Patent Gmbh Verfahren zur Herstellung von Pilocarpin-Derivaten

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061722A (en) 1976-04-26 1977-12-06 Interx Research Corporation Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
EP0106541A2 (en) 1982-09-17 1984-04-25 Hans Bundgaard Pilocarpine prodrugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061722A (en) 1976-04-26 1977-12-06 Interx Research Corporation Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
EP0106541A2 (en) 1982-09-17 1984-04-25 Hans Bundgaard Pilocarpine prodrugs

Also Published As

Publication number Publication date
FI98815C (fi) 1997-08-25
EP0559700A1 (en) 1993-09-15
SK52393A3 (en) 1994-01-12
LTIP577A (en) 1994-12-27
EE9400143A (et) 1995-12-15
EP0559700B1 (en) 2000-04-26
FI98815B (fi) 1997-05-15
AU664958B2 (en) 1995-12-07
NO931960D0 (no) 1993-05-28
JP3094232B2 (ja) 2000-10-03
HU9301569D0 (en) 1993-09-28
LV10094A (lv) 1994-05-10
RU2100352C1 (ru) 1997-12-27
FI905930A0 (fi) 1990-11-30
PL167773B1 (pl) 1995-11-30
CZ102593A3 (en) 1994-04-13
JPH06504270A (ja) 1994-05-19
NO931960L (no) 1993-05-28
LV10094B (en) 1995-02-20
CZ282229B6 (cs) 1997-06-11
NO304228B1 (no) 1998-11-16
WO1992009583A1 (en) 1992-06-11
CA2096444A1 (en) 1992-05-31
AU8939891A (en) 1992-06-25
DE69132143D1 (de) 2000-05-31
FI905930A (fi) 1992-05-31
PL168715B1 (pl) 1996-03-29
ATE192144T1 (de) 2000-05-15
DE69132143T2 (de) 2000-12-14
NZ240781A (en) 1993-12-23
HUT67273A (en) 1995-03-28
KR930703264A (ko) 1993-11-29

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Free format text: 5. JUNGINIU, TURINCIU FORMULE I PAGAL 1 PUNKTA, GAVIMO BUDAS, B E S I S K I R I A N T I S TUO, KADA) SIEKIANT PAGAMINTI JUNGINI, KURIO FORMULE YRA I , (I ),KURIOJE A TURI REIKSMES, MINETAS 1 PUNKTE,PILOKARPINO RUGSTIS, KURIOS FORMULE YRAARBA JOS DRUSKA REAGUOJA SU JUNGINIU, KURIO FORMULE YRA X-A-X , KAI X IR X NEPRIKLAUSOMAI VIENAS NUO KITO YRA HIDROKSILAS, ARBA PALIEKANTI GRUPE, PAVYZDZIUI, HALOGENAS, ACILOKSIGRUPE, ARBA ALKIL- ARBA ARILSULFONILOKSIGRUPE, SIEKIANT PAGAMINTI JUNGINI, KURIO FORMULE YRA (II) (II),KURIS, JEI TO PAGEIDA

PC9A Transfer of patents

Free format text: SANTEN OY,NIITTYHAANKATU 20, FIN-33720 TAMPERE,FI,971017

MM9A Lapsed patents

Effective date: 19990528