LTIP577A - Novel pilocarpine derivatives and process for their preparation - Google Patents
Novel pilocarpine derivatives and process for their preparationInfo
- Publication number
- LTIP577A LTIP577A LTIP577A LTIP577A LTIP577A LT IP577 A LTIP577 A LT IP577A LT IP577 A LTIP577 A LT IP577A LT IP577 A LTIP577 A LT IP577A LT IP577 A LTIP577 A LT IP577A
- Authority
- LT
- Lithuania
- Prior art keywords
- same
- preparation
- novel
- group
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The object of the invention are novel bispilocarpates useful in the treatment of glaucoma and having general formula (I), wherein A) Y is hydrogen or the acyl group (II), and W is the group -O-A-O-Z-Y', wherein Y' is hydrogen or the acyl group (III), the groups R and R' having different meanings and may be the same or different and A is an aliphatic or aromatic bridging group, and -Z-Y' is (IV), or B) W is OR, wherein R has the same meaning as above, Y is (V), where R' has the same meaning as above, B means the same as A and Z'-OR' is (VI) or C) W and Y together mean -A-O-Z-C-B-C-, where the symbols have the same meanings as above.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI905930A FI98815C (en) | 1990-11-30 | 1990-11-30 | Process for the preparation of novel pharmacologically useful ester derivatives of bispilocarpic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP577A true LTIP577A (en) | 1994-12-27 |
| LT3532B LT3532B (en) | 1995-11-27 |
Family
ID=8531500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP577A LT3532B (en) | 1990-11-30 | 1993-05-28 | Novel pilocarpine derivatives and process for their preparation |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0559700B1 (en) |
| JP (1) | JP3094232B2 (en) |
| KR (1) | KR930703264A (en) |
| AT (1) | ATE192144T1 (en) |
| AU (1) | AU664958B2 (en) |
| CA (1) | CA2096444A1 (en) |
| CZ (1) | CZ282229B6 (en) |
| DE (1) | DE69132143T2 (en) |
| EE (1) | EE9400143A (en) |
| FI (1) | FI98815C (en) |
| HU (1) | HUT67273A (en) |
| LT (1) | LT3532B (en) |
| LV (1) | LV10094B (en) |
| NO (1) | NO304228B1 (en) |
| NZ (1) | NZ240781A (en) |
| PL (2) | PL168715B1 (en) |
| RU (1) | RU2100352C1 (en) |
| SK (1) | SK52393A3 (en) |
| WO (1) | WO1992009583A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4071993A (en) * | 1992-05-29 | 1993-12-30 | Leiras Oy | Novel pilocarpine derivatives and process for their preparation |
| GB9310965D0 (en) * | 1993-05-27 | 1993-07-14 | Ucb Sa | 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides |
| AU6973094A (en) * | 1993-06-24 | 1995-01-17 | Leiras Oy | Composition for ophthalmic use |
| SE9302201D0 (en) | 1993-06-24 | 1993-06-24 | Leiras Oy | COMPOSITION FOR OPHTHALMIC USE |
| SE501482C2 (en) | 1993-06-24 | 1995-02-27 | Leiras Oy | Composition for topical administration of bispilocarpic acid diesters to the eye in the form of an aqueous solution |
| DE4334135A1 (en) * | 1993-10-07 | 1995-04-13 | Merck Patent Gmbh | Process for the preparation of pilocarpine derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061722A (en) | 1976-04-26 | 1977-12-06 | Interx Research Corporation | Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals |
| IL69593A (en) * | 1982-09-17 | 1988-09-30 | Bundegaard Hans | Pilocarpine prodrugs,their preparation and pharmaceutical compositions containing them |
-
1990
- 1990-11-30 FI FI905930A patent/FI98815C/en not_active IP Right Cessation
-
1991
- 1991-11-27 JP JP04500392A patent/JP3094232B2/en not_active Expired - Fee Related
- 1991-11-27 EP EP91920512A patent/EP0559700B1/en not_active Expired - Lifetime
- 1991-11-27 CA CA002096444A patent/CA2096444A1/en not_active Abandoned
- 1991-11-27 RU RU93041054/04A patent/RU2100352C1/en not_active IP Right Cessation
- 1991-11-27 PL PL91308270A patent/PL168715B1/en unknown
- 1991-11-27 DE DE69132143T patent/DE69132143T2/en not_active Expired - Fee Related
- 1991-11-27 HU HU9301569A patent/HUT67273A/en unknown
- 1991-11-27 PL PL91299375A patent/PL167773B1/en unknown
- 1991-11-27 WO PCT/FI1991/000359 patent/WO1992009583A1/en not_active Ceased
- 1991-11-27 AT AT91920512T patent/ATE192144T1/en not_active IP Right Cessation
- 1991-11-27 KR KR1019930701611A patent/KR930703264A/en not_active Withdrawn
- 1991-11-27 AU AU89398/91A patent/AU664958B2/en not_active Ceased
- 1991-11-27 SK SK523-93A patent/SK52393A3/en unknown
- 1991-11-27 CZ CS931025A patent/CZ282229B6/en not_active IP Right Cessation
- 1991-11-28 NZ NZ240781A patent/NZ240781A/en unknown
-
1993
- 1993-05-28 LT LTIP577A patent/LT3532B/en not_active IP Right Cessation
- 1993-05-28 NO NO931960A patent/NO304228B1/en not_active IP Right Cessation
- 1993-05-28 LV LVP-93-436A patent/LV10094B/en unknown
-
1994
- 1994-11-16 EE EE9400143A patent/EE9400143A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI98815C (en) | 1997-08-25 |
| LT3532B (en) | 1995-11-27 |
| NO931960L (en) | 1993-05-28 |
| HU9301569D0 (en) | 1993-09-28 |
| RU2100352C1 (en) | 1997-12-27 |
| LV10094A (en) | 1994-05-10 |
| JP3094232B2 (en) | 2000-10-03 |
| CA2096444A1 (en) | 1992-05-31 |
| EP0559700A1 (en) | 1993-09-15 |
| DE69132143D1 (en) | 2000-05-31 |
| JPH06504270A (en) | 1994-05-19 |
| AU664958B2 (en) | 1995-12-07 |
| ATE192144T1 (en) | 2000-05-15 |
| FI98815B (en) | 1997-05-15 |
| KR930703264A (en) | 1993-11-29 |
| CZ102593A3 (en) | 1994-04-13 |
| PL168715B1 (en) | 1996-03-29 |
| LV10094B (en) | 1995-02-20 |
| EE9400143A (en) | 1995-12-15 |
| WO1992009583A1 (en) | 1992-06-11 |
| CZ282229B6 (en) | 1997-06-11 |
| EP0559700B1 (en) | 2000-04-26 |
| DE69132143T2 (en) | 2000-12-14 |
| HUT67273A (en) | 1995-03-28 |
| NO931960D0 (en) | 1993-05-28 |
| NZ240781A (en) | 1993-12-23 |
| SK52393A3 (en) | 1994-01-12 |
| AU8939891A (en) | 1992-06-25 |
| NO304228B1 (en) | 1998-11-16 |
| PL167773B1 (en) | 1995-11-30 |
| FI905930A7 (en) | 1992-05-31 |
| FI905930A0 (en) | 1990-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TK9A | Rectifications: patents |
Free format text: 5. JUNGINIU, TURINCIU FORMULE I PAGAL 1 PUNKTA, GAVIMO BUDAS, B E S I S K I R I A N T I S TUO, KADA) SIEKIANT PAGAMINTI JUNGINI, KURIO FORMULE YRA I , (I ),KURIOJE A TURI REIKSMES, MINETAS 1 PUNKTE,PILOKARPINO RUGSTIS, KURIOS FORMULE YRAARBA JOS DRUSKA REAGUOJA SU JUNGINIU, KURIO FORMULE YRA X-A-X , KAI X IR X NEPRIKLAUSOMAI VIENAS NUO KITO YRA HIDROKSILAS, ARBA PALIEKANTI GRUPE, PAVYZDZIUI, HALOGENAS, ACILOKSIGRUPE, ARBA ALKIL- ARBA ARILSULFONILOKSIGRUPE, SIEKIANT PAGAMINTI JUNGINI, KURIO FORMULE YRA (II) (II),KURIS, JEI TO PAGEIDA |
|
| PC9A | Transfer of patents |
Free format text: SANTEN OY,NIITTYHAANKATU 20, FIN-33720 TAMPERE,FI,971017 |
|
| MM9A | Lapsed patents |
Effective date: 19990528 |