LTIP577A - Novel pilocarpine derivatives and process for their preparation - Google Patents

Novel pilocarpine derivatives and process for their preparation

Info

Publication number
LTIP577A
LTIP577A LTIP577A LTIP577A LTIP577A LT IP577 A LTIP577 A LT IP577A LT IP577 A LTIP577 A LT IP577A LT IP577 A LTIP577 A LT IP577A LT IP577 A LTIP577 A LT IP577A
Authority
LT
Lithuania
Prior art keywords
same
preparation
novel
group
hydrogen
Prior art date
Application number
LTIP577A
Inventor
Tomi Jaervinen
Pekka Peura
Pekka Suhonen
Arto Urtti
Hannu Hanhijaervi
Esko Pohjala
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of LTIP577A publication Critical patent/LTIP577A/en
Publication of LT3532B publication Critical patent/LT3532B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The object of the invention are novel bispilocarpates useful in the treatment of glaucoma and having general formula (I), wherein A) Y is hydrogen or the acyl group (II), and W is the group -O-A-O-Z-Y', wherein Y' is hydrogen or the acyl group (III), the groups R and R' having different meanings and may be the same or different and A is an aliphatic or aromatic bridging group, and -Z-Y' is (IV), or B) W is OR, wherein R has the same meaning as above, Y is (V), where R' has the same meaning as above, B means the same as A and Z'-OR' is (VI) or C) W and Y together mean -A-O-Z-C-B-C-, where the symbols have the same meanings as above.
LTIP577A 1990-11-30 1993-05-28 Novel pilocarpine derivatives and process for their preparation LT3532B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI905930A FI98815C (en) 1990-11-30 1990-11-30 Process for the preparation of new pharmacologically useful ester derivatives of bispilocarpic acid

Publications (2)

Publication Number Publication Date
LTIP577A true LTIP577A (en) 1994-12-27
LT3532B LT3532B (en) 1995-11-27

Family

ID=8531500

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP577A LT3532B (en) 1990-11-30 1993-05-28 Novel pilocarpine derivatives and process for their preparation

Country Status (19)

Country Link
EP (1) EP0559700B1 (en)
JP (1) JP3094232B2 (en)
KR (1) KR930703264A (en)
AT (1) ATE192144T1 (en)
AU (1) AU664958B2 (en)
CA (1) CA2096444A1 (en)
CZ (1) CZ282229B6 (en)
DE (1) DE69132143T2 (en)
EE (1) EE9400143A (en)
FI (1) FI98815C (en)
HU (1) HUT67273A (en)
LT (1) LT3532B (en)
LV (1) LV10094B (en)
NO (1) NO304228B1 (en)
NZ (1) NZ240781A (en)
PL (2) PL168715B1 (en)
RU (1) RU2100352C1 (en)
SK (1) SK52393A3 (en)
WO (1) WO1992009583A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4071993A (en) * 1992-05-29 1993-12-30 Leiras Oy Novel pilocarpine derivatives and process for their preparation
GB9310965D0 (en) * 1993-05-27 1993-07-14 Ucb Sa 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
AU6973094A (en) * 1993-06-24 1995-01-17 Leiras Oy Composition for ophthalmic use
SE9302201D0 (en) 1993-06-24 1993-06-24 Leiras Oy COMPOSITION FOR OPHTHALMIC USE
SE501482C2 (en) 1993-06-24 1995-02-27 Leiras Oy Composition for topical administration of bispilocarpic acid diesters to the eye in the form of an aqueous solution
DE4334135A1 (en) * 1993-10-07 1995-04-13 Merck Patent Gmbh Process for the preparation of pilocarpine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061722A (en) 1976-04-26 1977-12-06 Interx Research Corporation Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
IL69593A (en) * 1982-09-17 1988-09-30 Bundegaard Hans Pilocarpine prodrugs,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HUT67273A (en) 1995-03-28
CA2096444A1 (en) 1992-05-31
NO304228B1 (en) 1998-11-16
JP3094232B2 (en) 2000-10-03
RU2100352C1 (en) 1997-12-27
PL168715B1 (en) 1996-03-29
EP0559700A1 (en) 1993-09-15
LV10094B (en) 1995-02-20
SK52393A3 (en) 1994-01-12
KR930703264A (en) 1993-11-29
NO931960L (en) 1993-05-28
WO1992009583A1 (en) 1992-06-11
AU664958B2 (en) 1995-12-07
DE69132143D1 (en) 2000-05-31
AU8939891A (en) 1992-06-25
FI905930A0 (en) 1990-11-30
NO931960D0 (en) 1993-05-28
FI905930A (en) 1992-05-31
LT3532B (en) 1995-11-27
CZ102593A3 (en) 1994-04-13
PL167773B1 (en) 1995-11-30
EE9400143A (en) 1995-12-15
NZ240781A (en) 1993-12-23
ATE192144T1 (en) 2000-05-15
HU9301569D0 (en) 1993-09-28
EP0559700B1 (en) 2000-04-26
JPH06504270A (en) 1994-05-19
CZ282229B6 (en) 1997-06-11
FI98815C (en) 1997-08-25
LV10094A (en) 1994-05-10
DE69132143T2 (en) 2000-12-14
FI98815B (en) 1997-05-15

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Legal Events

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TK9A Rectifications: patents

Free format text: 5. JUNGINIU, TURINCIU FORMULE I PAGAL 1 PUNKTA, GAVIMO BUDAS, B E S I S K I R I A N T I S TUO, KADA) SIEKIANT PAGAMINTI JUNGINI, KURIO FORMULE YRA I , (I ),KURIOJE A TURI REIKSMES, MINETAS 1 PUNKTE,PILOKARPINO RUGSTIS, KURIOS FORMULE YRAARBA JOS DRUSKA REAGUOJA SU JUNGINIU, KURIO FORMULE YRA X-A-X , KAI X IR X NEPRIKLAUSOMAI VIENAS NUO KITO YRA HIDROKSILAS, ARBA PALIEKANTI GRUPE, PAVYZDZIUI, HALOGENAS, ACILOKSIGRUPE, ARBA ALKIL- ARBA ARILSULFONILOKSIGRUPE, SIEKIANT PAGAMINTI JUNGINI, KURIO FORMULE YRA (II) (II),KURIS, JEI TO PAGEIDA

PC9A Transfer of patents

Free format text: SANTEN OY,NIITTYHAANKATU 20, FIN-33720 TAMPERE,FI,971017

MM9A Lapsed patents

Effective date: 19990528