ATE192144T1 - NEW PILOCARPNINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF - Google Patents

NEW PILOCARPNINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Info

Publication number
ATE192144T1
ATE192144T1 AT91920512T AT91920512T ATE192144T1 AT E192144 T1 ATE192144 T1 AT E192144T1 AT 91920512 T AT91920512 T AT 91920512T AT 91920512 T AT91920512 T AT 91920512T AT E192144 T1 ATE192144 T1 AT E192144T1
Authority
AT
Austria
Prior art keywords
same
pilocarpnine
derivatives
new
production
Prior art date
Application number
AT91920512T
Other languages
German (de)
Inventor
Tomi Jaervinen
Pekka Peura
Pekka Suhonen
Arto Urtti
Hannu Hanhijaervi
Esko Pohjala
Original Assignee
Santen Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Oy filed Critical Santen Oy
Application granted granted Critical
Publication of ATE192144T1 publication Critical patent/ATE192144T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

The object of the invention are novel bispilocarpates useful in the treatment of glaucoma and having general formula (I), wherein A) Y is hydrogen or the acyl group (II), and W is the group -O-A-O-Z-Y', wherein Y' is hydrogen or the acyl group (III), the groups R and R' having different meanings and may be the same or different and A is an aliphatic or aromatic bridging group, and -Z-Y' is (IV), or B) W is OR, wherein R has the same meaning as above, Y is (V), where R' has the same meaning as above, B means the same as A and Z'-OR' is (VI) or C) W and Y together mean -A-O-Z-C-B-C-, where the symbols have the same meanings as above.
AT91920512T 1990-11-30 1991-11-27 NEW PILOCARPNINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF ATE192144T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI905930A FI98815C (en) 1990-11-30 1990-11-30 Process for the preparation of new pharmacologically useful ester derivatives of bispilocarpic acid
PCT/FI1991/000359 WO1992009583A1 (en) 1990-11-30 1991-11-27 Novel pilocarpine derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
ATE192144T1 true ATE192144T1 (en) 2000-05-15

Family

ID=8531500

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91920512T ATE192144T1 (en) 1990-11-30 1991-11-27 NEW PILOCARPNINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Country Status (19)

Country Link
EP (1) EP0559700B1 (en)
JP (1) JP3094232B2 (en)
KR (1) KR930703264A (en)
AT (1) ATE192144T1 (en)
AU (1) AU664958B2 (en)
CA (1) CA2096444A1 (en)
CZ (1) CZ282229B6 (en)
DE (1) DE69132143T2 (en)
EE (1) EE9400143A (en)
FI (1) FI98815C (en)
HU (1) HUT67273A (en)
LT (1) LT3532B (en)
LV (1) LV10094B (en)
NO (1) NO304228B1 (en)
NZ (1) NZ240781A (en)
PL (2) PL168715B1 (en)
RU (1) RU2100352C1 (en)
SK (1) SK52393A3 (en)
WO (1) WO1992009583A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0642501A1 (en) * 1992-05-29 1995-03-15 Leiras Oy Novel pilocarpine derivatives and process for their preparation
GB9310965D0 (en) * 1993-05-27 1993-07-14 Ucb Sa 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
SE501482C2 (en) 1993-06-24 1995-02-27 Leiras Oy Composition for topical administration of bispilocarpic acid diesters to the eye in the form of an aqueous solution
WO1995000143A1 (en) * 1993-06-24 1995-01-05 Leiras Oy Composition for ophthalmic use
SE9302201D0 (en) 1993-06-24 1993-06-24 Leiras Oy COMPOSITION FOR OPHTHALMIC USE
DE4334135A1 (en) * 1993-10-07 1995-04-13 Merck Patent Gmbh Process for the preparation of pilocarpine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061722A (en) 1976-04-26 1977-12-06 Interx Research Corporation Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
IL69593A (en) * 1982-09-17 1988-09-30 Bundegaard Hans Pilocarpine prodrugs,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI905930A (en) 1992-05-31
DE69132143T2 (en) 2000-12-14
CZ282229B6 (en) 1997-06-11
AU664958B2 (en) 1995-12-07
LV10094B (en) 1995-02-20
LTIP577A (en) 1994-12-27
KR930703264A (en) 1993-11-29
FI98815C (en) 1997-08-25
LV10094A (en) 1994-05-10
WO1992009583A1 (en) 1992-06-11
RU2100352C1 (en) 1997-12-27
CZ102593A3 (en) 1994-04-13
NO304228B1 (en) 1998-11-16
EP0559700A1 (en) 1993-09-15
NO931960D0 (en) 1993-05-28
JPH06504270A (en) 1994-05-19
DE69132143D1 (en) 2000-05-31
AU8939891A (en) 1992-06-25
PL167773B1 (en) 1995-11-30
FI905930A0 (en) 1990-11-30
LT3532B (en) 1995-11-27
PL168715B1 (en) 1996-03-29
HUT67273A (en) 1995-03-28
SK52393A3 (en) 1994-01-12
NZ240781A (en) 1993-12-23
EP0559700B1 (en) 2000-04-26
HU9301569D0 (en) 1993-09-28
CA2096444A1 (en) 1992-05-31
NO931960L (en) 1993-05-28
FI98815B (en) 1997-05-15
EE9400143A (en) 1995-12-15
JP3094232B2 (en) 2000-10-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee