RU93041054A - NEW DERIVATIVES PILOKARPINA, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION - Google Patents

NEW DERIVATIVES PILOKARPINA, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION

Info

Publication number
RU93041054A
RU93041054A RU93041054/04A RU93041054A RU93041054A RU 93041054 A RU93041054 A RU 93041054A RU 93041054/04 A RU93041054/04 A RU 93041054/04A RU 93041054 A RU93041054 A RU 93041054A RU 93041054 A RU93041054 A RU 93041054A
Authority
RU
Russia
Prior art keywords
pilokarpina
production
pharmaceutical composition
new derivatives
same
Prior art date
Application number
RU93041054/04A
Other languages
Russian (ru)
Other versions
RU2100352C1 (en
Inventor
Ярвинен Томи
Пэура Пекка
Сюнонен Пекка
Уртти Арто
Ханхиярви Ханну
Похьяла Эско
Jarvinen Tomi
Pehura Pekka
Sjunonen Pekka
Urtti Arto
Khankhijarvi Khannu
Pokh'jala Ehsko
Original Assignee
Лейрас Ой
Lejras Oj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI905930A external-priority patent/FI98815C/en
Application filed by Лейрас Ой, Lejras Oj filed Critical Лейрас Ой
Publication of RU93041054A publication Critical patent/RU93041054A/en
Application granted granted Critical
Publication of RU2100352C1 publication Critical patent/RU2100352C1/en

Links

Claims (1)

Целью данного изобретения являются новые биспилокарпаты, используемые при лечении глаукомы, и имеющие общую формулу (I), в которой А) У - водород или ацильная группа (II), W - группа -O-A-O-Z-У', где У' - водород или ацильная группа (III), группы R и R', имеющие различные значения, и могут быть одинаковыми или различными, А - алифатическая или ароматическая мостиковая группа, и -Z-У' - (IV), или В) W - OR, в котором R имеет то же самое значение, как выше, У - (V), где R' имеет то же самое значение, как выше, В означает то же самое, как А, и Z'-OR' - (VI), или С) W и У вместе означают -A-O-Z-C-B-C-, где символы имеют те же самые значения, как выше.The purpose of this invention is a new bispilocarpates used in the treatment of glaucoma, and having the general formula (I), in which A) Y is hydrogen or acyl group (II), W is the group —OAOZ-U ', where hydrogen is hydrogen or acyl group (III), R and R 'groups having different meanings, and may be the same or different, A is an aliphatic or aromatic bridging group, and —Z-Y' is (IV), or B) W is OR, in which R has the same meaning as above, Y - (V), where R 'has the same meaning as above, B means the same as A, and Z'-OR' - (VI) or C ) W and Y together mean -AOZCB -C-, where the characters have the same meanings as above.
RU93041054/04A 1990-11-30 1991-11-27 Bis-pilocarpic acid ester derivatives and method of their synthesis RU2100352C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI905930 1990-11-30
FI905930A FI98815C (en) 1990-11-30 1990-11-30 Process for the preparation of new pharmacologically useful ester derivatives of bispilocarpic acid
PCT/FI1991/000359 WO1992009583A1 (en) 1990-11-30 1991-11-27 Novel pilocarpine derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
RU93041054A true RU93041054A (en) 1996-08-10
RU2100352C1 RU2100352C1 (en) 1997-12-27

Family

ID=8531500

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93041054/04A RU2100352C1 (en) 1990-11-30 1991-11-27 Bis-pilocarpic acid ester derivatives and method of their synthesis

Country Status (19)

Country Link
EP (1) EP0559700B1 (en)
JP (1) JP3094232B2 (en)
KR (1) KR930703264A (en)
AT (1) ATE192144T1 (en)
AU (1) AU664958B2 (en)
CA (1) CA2096444A1 (en)
CZ (1) CZ282229B6 (en)
DE (1) DE69132143T2 (en)
EE (1) EE9400143A (en)
FI (1) FI98815C (en)
HU (1) HUT67273A (en)
LT (1) LT3532B (en)
LV (1) LV10094B (en)
NO (1) NO304228B1 (en)
NZ (1) NZ240781A (en)
PL (2) PL167773B1 (en)
RU (1) RU2100352C1 (en)
SK (1) SK52393A3 (en)
WO (1) WO1992009583A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024466A1 (en) * 1992-05-29 1993-12-09 Leiras Oy Novel pilocarpine derivatives and process for their preparation
GB9310965D0 (en) * 1993-05-27 1993-07-14 Ucb Sa 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
SE501482C2 (en) * 1993-06-24 1995-02-27 Leiras Oy Composition for topical administration of bispilocarpic acid diesters to the eye in the form of an aqueous solution
WO1995000143A1 (en) * 1993-06-24 1995-01-05 Leiras Oy Composition for ophthalmic use
SE9302201D0 (en) 1993-06-24 1993-06-24 Leiras Oy COMPOSITION FOR OPHTHALMIC USE
DE4334135A1 (en) * 1993-10-07 1995-04-13 Merck Patent Gmbh Process for the preparation of pilocarpine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061722A (en) 1976-04-26 1977-12-06 Interx Research Corporation Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
AU557083B2 (en) * 1982-09-17 1986-12-04 Hans Bundgaard Pilocarpine prodrugs

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