LUC00139I1 - - Google Patents
Info
- Publication number
- LUC00139I1 LUC00139I1 LUC00139C LUC00139I1 LU C00139 I1 LUC00139 I1 LU C00139I1 LU C00139 C LUC00139 C LU C00139C LU C00139 I1 LUC00139 I1 LU C00139I1
- Authority
- LU
- Luxembourg
- Prior art keywords
- sub
- atoms
- nitrogen
- formula
- fused
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30919601P | 2001-07-31 | 2001-07-31 | |
US38215502P | 2002-05-20 | 2002-05-20 | |
PCT/US2002/024212 WO2003011277A2 (fr) | 2001-07-31 | 2002-07-30 | Methodes de mobilisation de cellules souches/embryonnaires |
EP02750370A EP1411918B1 (fr) | 2001-07-31 | 2002-07-30 | Methodes de mobilisation de cellules souches/embryonnaires |
Publications (2)
Publication Number | Publication Date |
---|---|
LUC00139I1 true LUC00139I1 (fr) | 2019-11-27 |
LUC00139I2 LUC00139I2 (fr) | 2021-02-10 |
Family
ID=26976666
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU92033C LU92033I2 (fr) | 2001-07-31 | 2012-06-27 | Plerixafor et ses dérivés pharmaceutiquement acceptables (MOZOBIL®) |
LU00139C LUC00139I2 (fr) | 2001-07-31 | 2019-11-26 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU92033C LU92033I2 (fr) | 2001-07-31 | 2012-06-27 | Plerixafor et ses dérivés pharmaceutiquement acceptables (MOZOBIL®) |
Country Status (29)
Country | Link |
---|---|
US (9) | US6987102B2 (fr) |
EP (3) | EP1411918B1 (fr) |
JP (2) | JP5137288B2 (fr) |
KR (2) | KR20040020075A (fr) |
CN (2) | CN1561208B (fr) |
AT (1) | ATE538785T1 (fr) |
AU (1) | AU2002318927B2 (fr) |
BE (1) | BE2019C544I2 (fr) |
BR (1) | BRPI0211570B8 (fr) |
CA (1) | CA2455559C (fr) |
CY (4) | CY1112633T1 (fr) |
DK (2) | DK1411918T3 (fr) |
ES (2) | ES2380009T3 (fr) |
FR (2) | FR12C0042I1 (fr) |
HK (1) | HK1063005A1 (fr) |
HU (1) | HUP0402360A2 (fr) |
IL (2) | IL159312A0 (fr) |
LT (2) | LT2371361T (fr) |
LU (2) | LU92033I2 (fr) |
MX (1) | MXPA04000982A (fr) |
NL (2) | NL300537I2 (fr) |
NO (4) | NO336989B1 (fr) |
NZ (1) | NZ530169A (fr) |
PL (1) | PL364673A1 (fr) |
PT (2) | PT2371361T (fr) |
RU (1) | RU2309741C2 (fr) |
SI (2) | SI2371361T1 (fr) |
WO (1) | WO2003011277A2 (fr) |
ZA (1) | ZA200400658B (fr) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
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US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
IL159312A0 (en) * | 2001-07-31 | 2004-06-01 | Anormed Inc | Methods to mobilize progenitor/stem cells |
US7354932B2 (en) * | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
RU2325387C2 (ru) | 2001-12-21 | 2008-05-27 | Анормед Инк. | Гетероциклические соединения с повышенной эффективностью, связывающиеся с рецептором хемокина |
WO2005007838A1 (fr) * | 2003-06-27 | 2005-01-27 | Asahi Kasei Kabushiki Kaisha | Inhibiteur de differenciation cellulaire, procede de culture de cellules utilisant celui-ci, milieu de culture liquide et lignee de cellules cultivees |
WO2005002522A2 (fr) * | 2003-06-30 | 2005-01-13 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Compositions et methodes pour traiter une ischemie tissulaire |
EP1656156A2 (fr) | 2003-08-13 | 2006-05-17 | Children's Hospital Medical Center | Mobilisation de cellules hematopoietques |
EP1656451A2 (fr) | 2003-08-13 | 2006-05-17 | Children's Hospital Medical Center | Peptides chimeriques pour regulation de gtpases |
IL158868A0 (en) * | 2003-11-13 | 2004-05-12 | Yeda Res & Dev | Methods of generating and using stem cells enriched with immature primitive progenitor |
WO2005103721A1 (fr) * | 2004-04-20 | 2005-11-03 | Bayer Healthcare Ag | Moyens diagnostiques et therapeutiques pour maladies associees au recepteur 4 de la chimiokine cxc (cxcr4) |
WO2006020891A2 (fr) * | 2004-08-13 | 2006-02-23 | Anormed Inc. | Combinaisons de chimiokines pour mobiliser des cellules progenitrices/souches |
US8182806B2 (en) * | 2004-09-07 | 2012-05-22 | Johnson Lanny L | Synovial villi for use with tissue engineering |
US7785582B2 (en) * | 2004-09-07 | 2010-08-31 | Johnson Lanny L | Use of synovium and omentum for tissue engineering |
US9789171B2 (en) | 2004-11-05 | 2017-10-17 | The General Hospital Corporation | Anti-fugetactic agents for the treatment of ovarian cancer |
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AU2006280945A1 (en) * | 2005-08-19 | 2007-02-22 | Genzyme Corporation | Methods to enhance chemotherapy |
WO2007025166A2 (fr) * | 2005-08-25 | 2007-03-01 | Repair Technologies, Inc. | Dispositifs, compositions et methodes de protection et de reparation de cellules et de tissus |
US7927630B2 (en) * | 2005-09-12 | 2011-04-19 | Johnson Lanny L | Use of autologous sediment from fluid aspirates as vehicles for drug delivery |
US8518349B2 (en) | 2005-09-12 | 2013-08-27 | Lanny Johnson | Use of autologous sediment from fluid aspirates as vehicles for drug delivery |
US20070116680A1 (en) * | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
WO2007106063A2 (fr) * | 2006-02-24 | 2007-09-20 | Genzyme Corporation | Procédés servant à accroître le débit sanguin et/ou à favoriser la régénération d'un tissu |
WO2007108689A2 (fr) * | 2006-03-21 | 2007-09-27 | Stichting Skeletal Tissue Engineering | Nouveau procede d'induction de la differenciation de cellules souches et progenitrices |
EP2056853A1 (fr) * | 2006-08-07 | 2009-05-13 | Genzyme Corporation | Thérapie combinée |
US7883698B2 (en) * | 2007-01-17 | 2011-02-08 | Maria Michejda | Isolation and preservation of fetal hematopoietic and mesencymal system cells from non-controversial materials and/or tissues resulting from miscarriages and methods of therapeutic use |
WO2010025416A1 (fr) * | 2008-08-29 | 2010-03-04 | Genzyme Corporation | Antagonistes du cxcr4 pour des lésions rénales |
US20130039882A1 (en) * | 2009-10-28 | 2013-02-14 | Henry Ford Health System | Method to mitigate injury from radiation exposure |
CN101716167B (zh) * | 2009-12-08 | 2011-12-28 | 中国人民解放军军事医学科学院野战输血研究所 | 一类饱和胺类化合物在制备外周血造血干细胞动员药物中的应用 |
EP3578205A1 (fr) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | Compositions pharmaceutiques a base d'acides nucléiques modifiés et leur utilisation medicale |
PL2709991T3 (pl) | 2011-05-16 | 2021-04-06 | Genzyme Corporation | Zastosowanie antagonistów CXCR4 w leczeniu zespołu WHIM, mielokateksji, neutropenii i limfocytopenii |
EP2968563A4 (fr) * | 2013-03-15 | 2016-11-30 | Leonard B Miller | Traitement combiné pour améliorer la cicatrisation de tissu mou, la cicatrisation de greffe de tissu adipeux, la cicatrisation osseuse endochondrale et l'ostéointégration |
US9988973B2 (en) | 2015-01-06 | 2018-06-05 | Hamilton Sundstrand Corporation | Water injector for aviation cooling system |
US11890348B2 (en) | 2015-09-18 | 2024-02-06 | The General Hospital Corporation | Localized delivery of anti-fugetactic agent for treatment of cancer |
ES2907489T3 (es) | 2015-12-14 | 2022-04-25 | X4 Pharmaceuticals Inc | Métodos para el tratamiento del cáncer |
WO2017106332A1 (fr) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Méthodes de traitement du cancer |
US11433136B2 (en) | 2015-12-18 | 2022-09-06 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
CN108883091A (zh) | 2015-12-22 | 2018-11-23 | X4 制药有限公司 | 用于治疗免疫缺陷病的方法 |
US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
EP3471716A1 (fr) * | 2016-06-16 | 2019-04-24 | Centre National De La Recherche Scientifique | Composés de liaison au récepteur cxcr4 utiles pour augmenter le taux d'interféron |
US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
EP3808748A1 (fr) | 2016-06-21 | 2021-04-21 | X4 Pharmaceuticals, Inc. | Piperidines substutues comme inhibiteurs de cxcr4 |
US11332470B2 (en) | 2016-06-21 | 2022-05-17 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
US11364264B2 (en) | 2016-09-09 | 2022-06-21 | The General Hospital Corporation | Ex vivo antigen-presenting cells or activated CD-positive T cells for treatment of cancer |
WO2018049124A1 (fr) | 2016-09-09 | 2018-03-15 | The General Hospital Corporation | Protéine de fusion hsp avec un agent anti-chimiorépulsion pour le traitement d'une maladie infectieuse |
JP2019534249A (ja) | 2016-09-09 | 2019-11-28 | ザ ジェネラル ホスピタル コーポレイション | 癌の治療のための抗化学忌避剤とのhsp融合タンパク質 |
WO2018106738A1 (fr) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Polymères en étoile à bras en brosse, conjugués et particules, et leurs utilisations |
US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
US10058573B1 (en) | 2017-12-06 | 2018-08-28 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem cells |
JP2021505172A (ja) * | 2017-12-06 | 2021-02-18 | マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. | 造血幹細胞及び前駆細胞を動員させるための投薬レジメン |
KR20200103018A (ko) * | 2017-12-19 | 2020-09-01 | 주식회사 지피씨알 | Gpcr 헤테로머 억제제 및 이의 용도 |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
US20230193212A1 (en) | 2020-05-06 | 2023-06-22 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
CA3234340A1 (fr) | 2021-10-01 | 2023-04-06 | Janssen Pharmaceutica N.V. | Procedes d'augmentation de la production de cellules progenitrices |
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