CY1112633T1 - Μεθοδοι για κινητοποιηση προγονων/βλαστικων κυτταρων - Google Patents
Μεθοδοι για κινητοποιηση προγονων/βλαστικων κυτταρωνInfo
- Publication number
- CY1112633T1 CY1112633T1 CY20121100223T CY121100223T CY1112633T1 CY 1112633 T1 CY1112633 T1 CY 1112633T1 CY 20121100223 T CY20121100223 T CY 20121100223T CY 121100223 T CY121100223 T CY 121100223T CY 1112633 T1 CY1112633 T1 CY 1112633T1
- Authority
- CY
- Cyprus
- Prior art keywords
- atoms
- nitrogen
- formula
- fused
- compounds
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 abstract 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 abstract 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
Abstract
Αποκαλύπτονται μέθοδοι αύξησης των μετρήσεων προγόνου και βλαστικού κυττάρου σε ζωικά υποκείμενα χρησιμοποιώντας ενώσεις οι οποίες συνδέονται προς τον υποδοχέα χημειοκίνης CXCR4. Προτιμώμενες πραγματοποιήσεις τέτοιων ενώσεων είναι του τύπου Ζ-συνδετήρας-Ζ' (1) ή φαρμακευτικώς αποδεκτό άλας αυτών όπου το Ζ είναι κυκλική πολυαμίνη περιέχουσα 9-32 μέλη δακτυλίου από τα οποία 3-8 είναι άτομα αζώτου, τα εν λόγω δε άτομα αζώτου διαχωρίζονται μεταξύ τους με τουλάχιστον 2 άτομα άνθρακα και όπου ο εν λόγω ετερόκυκλος μπορεί προαιρετικά να περιέχει επιπρόσθετα ετεροάτομα πέραν του αζώτου ή/και μπορεί να είναι συντηγμένος προς ένα επιπρόσθετο σύστημα δακτυλίου ή το Ζ είναι του τύπου (a), όπου το Α περιλαμβάνει μονοκυκλικό ή δικυκλικό σύστημα συντηγμένου δακτυλίου που περιέχει τουλάχιστον ένα Ν και το Β είναι Η ή μια οργανική χαρακτηριστική ομάδα 1-20 ατόμων, το Ζ' μπορεί να πραγματοποιείται σε μια μορφή όπως ορίζεται από το Ζ ανωτέρω ή εναλλακτικώς μπορεί να είναι του τύπου -Ν(R)-(CR2)n-Χ όπου έκαστο R ανεξαρτήτως είναι Η ή ευθύ ή διακλαδισμένο ή κυκλικό αλκύλ (1-6C), το n είναι 1 ή 2 και το Χ είναι αρωματικός δακτύλιος, που συμπεριλαμβάνει ετεροαρωματικούς δακτυλίους ή είναι μια μερκαπτάνη, το "συνδετήρας" αντιπροσωπεύει δεσμό, αλκυλένο (1-6C) ή μπορεί να περιλαμβάνει αρύλ, συντηγμένο αρύλ, άτομα οξυγόνου που περιέχονται σε μια αλκυλένο άλυσο ή μπορεί να περιέχει κέτο ομάδες ή άτομα αζώτου ή θείου.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30919601P | 2001-07-31 | 2001-07-31 | |
US38215502P | 2002-05-20 | 2002-05-20 | |
EP02750370A EP1411918B1 (en) | 2001-07-31 | 2002-07-30 | Methods to mobilize progenitor/stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112633T1 true CY1112633T1 (el) | 2015-08-05 |
Family
ID=26976666
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100223T CY1112633T1 (el) | 2001-07-31 | 2012-03-07 | Μεθοδοι για κινητοποιηση προγονων/βλαστικων κυτταρων |
CY2012017C CY2012017I1 (el) | 2001-07-31 | 2012-06-27 | Μεθοδοι για κινητοποιηση προγονων/βλαστικων κυτταρων |
CY20191100889T CY1122199T1 (el) | 2001-07-31 | 2019-08-20 | Μεθοδοι για την κινητοποιηση κυτταρων προγεννητορων/βλαστοκυτταρων |
CY2019038C CY2019038I1 (el) | 2001-07-31 | 2019-10-14 | Μεθοδοι για την κινητοποιηση κυτταρων προγεννητορων/βλαστοκυτταρων |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2012017C CY2012017I1 (el) | 2001-07-31 | 2012-06-27 | Μεθοδοι για κινητοποιηση προγονων/βλαστικων κυτταρων |
CY20191100889T CY1122199T1 (el) | 2001-07-31 | 2019-08-20 | Μεθοδοι για την κινητοποιηση κυτταρων προγεννητορων/βλαστοκυτταρων |
CY2019038C CY2019038I1 (el) | 2001-07-31 | 2019-10-14 | Μεθοδοι για την κινητοποιηση κυτταρων προγεννητορων/βλαστοκυτταρων |
Country Status (29)
Country | Link |
---|---|
US (9) | US6987102B2 (el) |
EP (3) | EP1411918B1 (el) |
JP (2) | JP5137288B2 (el) |
KR (2) | KR100996378B1 (el) |
CN (2) | CN102302493B (el) |
AT (1) | ATE538785T1 (el) |
AU (1) | AU2002318927B2 (el) |
BE (1) | BE2019C544I2 (el) |
BR (1) | BRPI0211570B8 (el) |
CA (1) | CA2455559C (el) |
CY (4) | CY1112633T1 (el) |
DK (2) | DK1411918T3 (el) |
ES (2) | ES2742730T3 (el) |
FR (2) | FR12C0042I1 (el) |
HK (1) | HK1063005A1 (el) |
HU (1) | HUP0402360A2 (el) |
IL (2) | IL159312A0 (el) |
LT (2) | LT2371361T (el) |
LU (2) | LU92033I2 (el) |
MX (1) | MXPA04000982A (el) |
NL (2) | NL300537I2 (el) |
NO (4) | NO336989B1 (el) |
NZ (1) | NZ530169A (el) |
PL (1) | PL364673A1 (el) |
PT (2) | PT1411918E (el) |
RU (1) | RU2309741C2 (el) |
SI (2) | SI1411918T1 (el) |
WO (1) | WO2003011277A2 (el) |
ZA (1) | ZA200400658B (el) |
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KR100996378B1 (ko) | 2001-07-31 | 2010-11-25 | 아노르메드 인코포레이티드 | 선조/줄기 세포를 이동시킴으로써 이식에 사용하기 위한 약제학적 조성물 |
US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
US7354932B2 (en) * | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
IL161784A0 (en) | 2001-12-21 | 2005-11-20 | Anormed Inc | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
KR101160698B1 (ko) * | 2003-06-27 | 2012-06-28 | 아사히 가세이 가부시키가이샤 | 세포 분화 억제제, 이것을 이용하는 세포 배양 방법, 배양 배지 및 배양된 세포주 |
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US20050069553A1 (en) | 2003-08-13 | 2005-03-31 | Yi Zheng | Chimeric peptides for the regulation of GTPases |
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IL158868A0 (en) * | 2003-11-13 | 2004-05-12 | Yeda Res & Dev | Methods of generating and using stem cells enriched with immature primitive progenitor |
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