ES2192671T3 - Compuestos triciclicos que tienen actividad como inhibidores de ras-fpt. - Google Patents

Compuestos triciclicos que tienen actividad como inhibidores de ras-fpt.

Info

Publication number
ES2192671T3
ES2192671T3 ES97911596T ES97911596T ES2192671T3 ES 2192671 T3 ES2192671 T3 ES 2192671T3 ES 97911596 T ES97911596 T ES 97911596T ES 97911596 T ES97911596 T ES 97911596T ES 2192671 T3 ES2192671 T3 ES 2192671T3
Authority
ES
Spain
Prior art keywords
hydrogen
lower alkyl
group
ras
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97911596T
Other languages
English (en)
Inventor
Adriano Afonso
Joseph M Kelly
Stuart Rosenblum
Ronald L Wolin
Jay Weinstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2192671T3 publication Critical patent/ES2192671T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuesto de Fórmula I **fórmula** en la que: X1 es hidrógeno, halógeno, CF3, nitro, NH2, o alquilo inferior; cada X2 se selecciona independientemente del grupo que consiste en hidrógeno, halógeno, alcoxi inferior o alquilo inferior; n es 1 ó 2; Y se selecciona del grupo que consiste en S(O)p, O, y NR5, en los que p es 0, 1 ó 2, y R5 es hidrógeno, alquilo, arilo, cicloalquilo, alcoxi inferior-carbonilo, aminocarbonilo o acilo; R1 y R2 son iguales o diferentes y se seleccionan del grupo que consiste en hidrógeno o grupos alquilo inferiores, ó R1 y R2 tomados juntos pueden formar un átomo de oxígeno cuando Y es NR5, la línea discontinua indica un enlace sencillo o doble; A es un átomo de C (cuando la línea discontinua indica un doble enlace) o CH o un átomo de N (cuando la línea discontinua indica un enlace sencillo); R es CZ-Y1-Y2-R3
ES97911596T 1996-10-09 1997-10-07 Compuestos triciclicos que tienen actividad como inhibidores de ras-fpt. Expired - Lifetime ES2192671T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72810496A 1996-10-09 1996-10-09

Publications (1)

Publication Number Publication Date
ES2192671T3 true ES2192671T3 (es) 2003-10-16

Family

ID=24925436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97911596T Expired - Lifetime ES2192671T3 (es) 1996-10-09 1997-10-07 Compuestos triciclicos que tienen actividad como inhibidores de ras-fpt.

Country Status (8)

Country Link
EP (1) EP1021448B1 (es)
JP (1) JP2001505189A (es)
AT (1) ATE239020T1 (es)
AU (1) AU4892297A (es)
CA (1) CA2267800C (es)
DE (1) DE69721588T2 (es)
ES (1) ES2192671T3 (es)
WO (1) WO1998015556A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69930120T2 (de) * 1998-06-16 2006-11-02 The Government of the United States of America, as represented by the Secretary National Institute of Health, Office of Technology Transfer Annellierte azepinone als inhibitoren cyclin-abhängiger kinasen
US6740406B2 (en) * 2000-12-15 2004-05-25 Kimberly-Clark Worldwide, Inc. Coated activated carbon
EP1656156A2 (en) 2003-08-13 2006-05-17 Children's Hospital Medical Center Mobilization of hematopoietic cells
MX2007007074A (es) * 2004-12-13 2007-09-04 Schering Corp Inhibidores novedosos de proteina transferasa de farnesilo y su uso para tratar cancer.
JP5503877B2 (ja) * 2009-01-30 2014-05-28 住友化学株式会社 ジベンゾオキセピン化合物の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164716T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de carbamato utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
ATE239020T1 (de) 2003-05-15
EP1021448B1 (en) 2003-05-02
DE69721588D1 (de) 2003-06-05
AU4892297A (en) 1998-05-05
CA2267800A1 (en) 1998-04-16
EP1021448A1 (en) 2000-07-26
CA2267800C (en) 2003-12-23
DE69721588T2 (de) 2004-05-19
JP2001505189A (ja) 2001-04-17
WO1998015556A1 (en) 1998-04-16

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