LU92301I2 - "Nepafenac - suspension ophtalmique" - Google Patents

"Nepafenac - suspension ophtalmique"

Info

Publication number
LU92301I2
LU92301I2 LU92301C LU92301C LU92301I2 LU 92301 I2 LU92301 I2 LU 92301I2 LU 92301 C LU92301 C LU 92301C LU 92301 C LU92301 C LU 92301C LU 92301 I2 LU92301 I2 LU 92301I2
Authority
LU
Luxembourg
Prior art keywords
nepafenac
ophthalmic suspension
compositions
eye
ophthalmic
Prior art date
Application number
LU92301C
Other languages
English (en)
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21988983&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU92301(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of LU92301I2 publication Critical patent/LU92301I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LU92301C 1997-07-29 2013-10-31 "Nepafenac - suspension ophtalmique" LU92301I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5413297P 1997-07-29 1997-07-29

Publications (1)

Publication Number Publication Date
LU92301I2 true LU92301I2 (fr) 2013-12-31

Family

ID=21988983

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92301C LU92301I2 (fr) 1997-07-29 2013-10-31 "Nepafenac - suspension ophtalmique"

Country Status (20)

Country Link
US (6) US6403609B1 (fr)
EP (2) EP1348427B1 (fr)
JP (2) JP3979783B2 (fr)
KR (1) KR100507984B1 (fr)
CN (3) CN1762381B (fr)
AR (1) AR013272A1 (fr)
AT (2) ATE391492T1 (fr)
AU (1) AU737442B2 (fr)
BR (1) BR9811574B1 (fr)
CA (1) CA2296080C (fr)
CY (2) CY1110365T1 (fr)
DE (2) DE69818675T2 (fr)
DK (2) DK0999825T3 (fr)
ES (2) ES2206965T3 (fr)
HK (2) HK1026618A1 (fr)
LU (1) LU92301I2 (fr)
PT (2) PT999825E (fr)
TW (2) TWI233801B (fr)
WO (1) WO1999006023A1 (fr)
ZA (1) ZA986533B (fr)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
WO1999006023A1 (fr) * 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Compositions ophtalmologiques contenant des polymeres de galactomannan et du borate
DK1203808T3 (da) 1997-07-29 2005-01-31 Alcon Lab Inc Konditioneringsoplösninger til pleje af hårde kontaktlinser
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
US6878694B2 (en) 2000-12-20 2005-04-12 Alcon, Inc. Ophthalmic irrigating solution adapted for use in lasik surgery
JP4169596B2 (ja) * 2000-12-20 2008-10-22 アルコン、インコーポレイテッド 白内障を液化破壊により取り除くための溶液
US6919321B2 (en) 2000-12-20 2005-07-19 Alcon, Inc. Ophthalmic lubricating solution adapted for use in lasik surgery
DE60141477D1 (de) * 2000-12-20 2010-04-15 Alcon Inc Intraoculare irrigationslösung mit verbesserten fliesseigenschaften
US20090258955A1 (en) * 2000-12-20 2009-10-15 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
WO2003001030A1 (fr) * 2001-06-22 2003-01-03 Bj Services Company Fluides de fracturation et leurs procedes de preparation et d'utilisation
FR2832223B1 (fr) 2001-11-15 2005-01-14 Cit Alcatel Composant monolithique electro-optique multisections
WO2003059194A2 (fr) 2001-12-21 2003-07-24 Alcon, Inc. Utilisation de nanoparticules synthetiques inorganiques comme vecteurs de medicaments ophtalmiques et otiques
CA2467759C (fr) * 2001-12-21 2012-04-03 Alcon, Inc. Utilisation de nanoparticules en tant qu'excipients pour biocides dans des compositions ophtalmiques
US20050002970A1 (en) * 2001-12-21 2005-01-06 Ketelson Howard Allen Inorganic nanopartices to modify the viscosity and physical properties of ophthalmic and otic compositions
CA2477044A1 (fr) 2002-02-22 2003-09-04 Pharmacia Corporation Formulation ophtalmique contenant un systeme de gomme
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE529447T1 (de) * 2002-06-25 2011-11-15 Rhodia Propfpolymerisation von guar durch elektronenstrahlen
WO2004000885A2 (fr) 2002-06-25 2003-12-31 Rhodia, Inc. Reduction du poids moleculaire de polysaccharides par des faisceaux d'electrons
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
EP1525884B1 (fr) 2002-07-31 2011-10-12 Senju Pharmaceutical Co., Ltd. Preparations liquides aqueuses et preparations liquides aqueuses photostabilisees
CA2810477C (fr) 2002-12-13 2013-09-17 Durect Corporation Systeme d'administration de medicaments par voie orale
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
KR101131056B1 (ko) * 2003-06-13 2012-04-23 알콘, 인코퍼레이티드 시너지성의 2개의 폴리머 배합물을 포함하는 안과용 조성물
US7947295B2 (en) * 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
US7914803B2 (en) * 2003-06-13 2011-03-29 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers
AU2012205283B2 (en) * 2003-06-13 2014-08-07 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
AU2004305539B2 (en) * 2003-12-11 2010-09-02 Alcon, Inc. Ophthalmic compositions containing a polysaccharide/borate gelling system
US20050129770A1 (en) * 2003-12-11 2005-06-16 Alcon, Inc. Ophthalmic compositions containing a PVA/borate gelling system
US20050137166A1 (en) * 2003-12-19 2005-06-23 Alcon, Inc. Use of cooling agents to relieve mild ocular irritation and enhance comfort
JP2007524690A (ja) * 2004-02-17 2007-08-30 ヴェーリ・インター・アーゲー 活性物質の生体内利用効率を高めるためのガラクトマンナン及び／又はグルコマンナン
TWI339659B (en) * 2004-03-18 2011-04-01 R Tech Ueno Ltd Aqueous composition comprising thiazole derivative
US7022740B2 (en) * 2004-04-29 2006-04-04 Leonard Mackles Lubricious ophthalmic solutions
KR100665299B1 (ko) * 2004-06-10 2007-01-04 서울반도체 주식회사 발광물질
EP1890670B1 (fr) * 2004-08-03 2011-06-29 Rhodia, Inc. Copolymeres greffes de polysaccharide et leur utilisation dans des applications de soins de la chevèlure
JP4771044B2 (ja) * 2004-09-15 2011-09-14 大正製薬株式会社 粘膜適用液剤
SI2767292T1 (sl) 2004-09-17 2017-01-31 Durect Corporation Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem
US20070059274A1 (en) * 2004-12-01 2007-03-15 Bahram Asgharian Ophthalmic compositions containing a PVA/borate gelling system
US8318210B2 (en) 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
WO2007025142A2 (fr) * 2005-08-26 2007-03-01 Ladd Byron S Compositions et procedes pour le traitement de surface dans des procedures medicales et chirurgicales
US20100130580A1 (en) * 2006-01-25 2010-05-27 Aciex Therapeutics, Inc. Formulations and Methods for Treating Dry Eye
CA2636646A1 (fr) * 2006-01-25 2007-08-02 Aciex, Inc. Compositions et procedes de traitement de la secheresse ophtalmique
US20070259021A1 (en) * 2006-05-01 2007-11-08 Friedlaender Mitchell H Compositions, Methods, and Kits for Treating Dry Eye
TWI394564B (zh) * 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
WO2008036855A2 (fr) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Compositions pharmaceutiques aqueuses auto-conservées
JP5394927B2 (ja) * 2006-09-28 2014-01-22 アルコン リサーチ， リミテッド 自己保存性水性医薬品組成物
ES2388355T3 (es) 2006-11-03 2012-10-11 Durect Corporation Sistemas de suministro transdémico que comprenden bupivacaína
US9157063B2 (en) * 2007-01-16 2015-10-13 Texas Tech University System Method and apparatus for gender selection based on pH
KR101555291B1 (ko) * 2007-02-09 2015-09-30 알콘, 인코퍼레이티드 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물
JP2010520765A (ja) * 2007-03-09 2010-06-17 コーニング インコーポレイテッド 細胞培養用ガムコーティング、製造方法および使用方法
JP2010520766A (ja) * 2007-03-09 2010-06-17 コーニング インコーポレイテッド 細胞培養用三次元ガムマトリックス、製造方法および使用方法
JP2010528014A (ja) * 2007-05-24 2010-08-19 アーシエックス セラピューティックス， インコーポレイテッド ドライアイを処置するための処方物および方法
US20090131303A1 (en) * 2007-11-16 2009-05-21 Bor-Shyue Hong Methods and compositions for treating dry eye
EP3326621A1 (fr) 2007-12-06 2018-05-30 Durect Corporation Formes orales de dosage pharmaceutique
US7795316B1 (en) 2007-12-19 2010-09-14 Alcon Research, Ltd. Topical ophthalmic compositions containing tobramycin and dexamethasone
MX2010009336A (es) * 2008-03-17 2010-09-24 Alcon Res Ltd Composiciones farmaceuticas acuosas que contienen complejos de borato-poliol.
TWI526213B (zh) * 2008-04-26 2016-03-21 愛爾康研究有限公司 聚合性人工淚液系統
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
EP2393837A1 (fr) * 2009-02-05 2011-12-14 Alcon Research, Ltd. Procédé de purification de guar
TW201039815A (en) 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
TWI489997B (zh) 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
TWI547522B (zh) * 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
TWI478730B (zh) * 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
PL2965749T3 (pl) * 2009-12-03 2018-10-31 Novartis Ag Zawiesiny nanocząsteczkowe zawierające polimer karboksywinylowy
BR112012028308B1 (pt) * 2010-05-05 2021-09-28 Alcon Inc. Formulações oftálmicas de galactomanano estabilizadas, e seu método de fabricação
WO2011162752A1 (fr) * 2010-06-23 2011-12-29 Alcon Research, Ltd. Suspensions ophtalmiques locales contenant de la tobramycine et de la dexaméthasone
PL2632927T3 (pl) 2010-10-26 2016-09-30 Boroniany jako inhibitory arginazy
CA2833591A1 (fr) 2011-04-22 2012-10-26 Alcon Research, Ltd. Composition ophtalmique comprenant un systeme d'amelioration de la viscosite constitue de deux agents d'amelioration de la viscosite differents
CA2833596A1 (fr) 2011-04-22 2012-10-26 Alcon Research, Ltd. Composition ophtalmique comprenant un systeme d'amelioration de la viscosite constitue de deux agents d'amelioration de la viscosite differents
JP6031527B2 (ja) 2011-11-21 2016-11-24 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼのヘテロ環式阻害剤
TW201336527A (zh) * 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
UA113434C2 (uk) 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
CN102860949B (zh) * 2012-08-31 2014-07-02 马应龙药业集团股份有限公司 眼部抗皱护肤品及其制备方法
WO2014078645A1 (fr) 2012-11-16 2014-05-22 Calithera Biosciences, Inc. Inhibiteurs de glutaminase hétérocycliques
AU2014233453A1 (en) 2013-03-15 2015-10-01 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
WO2014207769A1 (fr) 2013-06-27 2014-12-31 Mylan Laboratories Ltd Procédé pour la préparation de népafénac
EP3973954A1 (fr) 2013-10-15 2022-03-30 Pharmathen S.A. Compositions pharmaceutiques sans conservateur pour l'administration ophtalmique
FR3000391B3 (fr) 2013-11-12 2015-02-20 Pharmathen Sa Compositions pharmaceutiques sans conservateur pour administration ophtalmique
CN103572651B (zh) * 2013-11-25 2016-05-04 齐鲁工业大学 一种改性塔拉胶及其制备方法与应用
EP3119392A4 (fr) * 2014-03-17 2017-10-11 Encompass Development Inc. Formulations oculaires
SG11201610333VA (en) 2014-06-13 2017-01-27 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors
MX2017001620A (es) 2014-08-07 2017-05-10 Calithera Biosciences Inc Formas cristalinas de inhibidores de glutaminasa.
UY36272A (es) 2014-08-13 2016-02-29 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores de los receptores de orexinas
WO2016061147A1 (fr) 2014-10-13 2016-04-21 John Eric Paderi Revêtement d'une lumière vasculaire en vue d'une fistule artério-veineuse
WO2016061145A1 (fr) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Protéoglycanes synthétiques pour empêcher l'adhérence tissulaire
WO2016065083A1 (fr) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycanes comprenant des peptides se fixant au collagène pour le traitement d'une lésion gastro-œsophagienne
EP4023645A1 (fr) 2015-03-10 2022-07-06 Aurigene Discovery Technologies Limited Composés 1,2,4-oxadiazoles et thiadiazoles utilisés comme immunomodulateurs
AU2016281620B2 (en) 2015-06-23 2021-07-22 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US20170037303A1 (en) 2015-08-03 2017-02-09 Ecolab Usa Inc. Compositions and methods for delayed crosslinking in hydraulic fracturing fluids
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
EP3359150A4 (fr) 2015-10-05 2019-11-06 Calithera Biosciences, Inc. Polythérapie à l'aide d'inhibiteurs de glutaminase et agents immuno-oncologiques
TW201718028A (zh) 2015-10-13 2017-06-01 賽米克Ｉｐ有限責任公司 Ve-鈣黏蛋白結合性生物結合物
CN107847604B (zh) 2015-10-25 2020-11-10 艾威药业(珠海)有限公司 眼用原位凝胶处方
RS60695B1 (sr) 2015-10-30 2020-09-30 Calithera Biosciences Inc Supstance i postupci za inhibiranje aktivnosti arginaze
BR112018009946A8 (pt) 2015-11-16 2019-02-26 Ichorion Therapeutics Inc pró-fármacos de ácido nucleico
JP6703408B2 (ja) * 2016-01-30 2020-06-03 国立大学法人 筑波大学 ポリイオンコンプレックスを有効成分とするドライアイ処置用組成物
EA036542B9 (ru) 2016-02-12 2020-12-22 Астразенека Аб Галоген-замещенные пиперидины в качестве модуляторов орексинового рецептора
US10087363B2 (en) * 2016-03-15 2018-10-02 Baker Hughes, A Ge Company, Llc Using borated galactomannan to enhance swelling of superabsorbents for fracturing applications
US10793590B2 (en) 2016-06-03 2020-10-06 President And Fellows Of Harvard College Antifungal compounds
WO2018013816A1 (fr) 2016-07-15 2018-01-18 Ecolab USA, Inc. Compositions et procédés pour une réticulation retardée dans des fluides de fracturation hydraulique
EP3509583B1 (fr) 2016-09-09 2021-06-30 The Regents of the University of California Ligands du récepteur des oestrogènes, compositions et méthodes associées
EP3510040A4 (fr) 2016-09-09 2020-06-03 Calithera Biosciences, Inc. Inhibiteurs d'éctonucléotidase et leurs procédés d'utilisation
CN109952293A (zh) 2016-09-14 2019-06-28 范德比尔特大学 Bmp信号转导的抑制、化合物、组合物及其用途
AU2017330443B2 (en) 2016-09-26 2023-08-24 Dana-Farber Cancer Institute, Inc. Chromobox protein inhibitors and uses thereof
MA46793A (fr) 2016-11-08 2019-09-18 Calithera Biosciences Inc Polythérapies faisant appel à un inhibiteur d'arginase
US10287303B2 (en) 2016-12-22 2019-05-14 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
BR112019014759A2 (pt) 2017-01-18 2020-03-03 Vanderbilt University Compostos heterocíclicos fundidos como inibidores seletivos de bmp
BR112019017567A2 (pt) 2017-02-24 2020-03-24 Merck Patent Gmbh Derivados de 1,4,6-trissubstituído-2-alquil-1h-benzo[d]imidazol como inibidores da di-hidro-orotato oxigenase
RS64411B1 (sr) 2017-03-31 2023-09-29 Aurigene Oncology Ltd Jedinjenja i kompozicije za lečenje hematoloških poremećaja
US10994025B2 (en) 2017-05-12 2021-05-04 Massachusetts Institute Of Technology Argonaute protein-double stranded RNA complexes and uses related thereto
US11325943B2 (en) 2017-06-02 2022-05-10 Stealth Biotherapeutics Inc. Crystalline salt forms of SBT-20
WO2019018539A1 (fr) 2017-07-19 2019-01-24 California Institute Of Technology Procédés de préparation de composés contenant bis-tétrahydroisoquinoline
EA202090536A1 (ru) 2017-10-11 2020-07-22 Ориджен Дискавери Текнолоджис Лимитед Кристаллические формы 3-замещенного 1,2,4-оксадиазола
CA3076820A1 (fr) 2017-10-19 2019-04-25 Signpath Pharma, Inc. Effet protecteur de dmpc, dmpg, dmpc/dmpg, lysopg et lysopc contre des medicaments provoquant des canalopathies
FI3704108T3 (fi) 2017-10-31 2024-05-23 Curis Inc Irak4-estäjä yhdistelmässä bcl-2-estäjän kanssa käytettäväksi syövän hoitoon
EA202090746A1 (ru) 2017-11-03 2020-08-17 Ориджен Дискавери Текнолоджис Лимитед Двойные ингибиторы путей tim-3 и pd-1
AU2018360389A1 (en) 2017-11-06 2020-05-07 Aurigene Oncology Limited Conjoint therapies for immunomodulation
CA3085097A1 (fr) 2017-12-22 2019-06-27 Medimmune Limited Modulateurs a petites molecules du domaine btb de keap1
TW201938141A (zh) 2018-02-21 2019-10-01 瑞士商諾華公司 基於脂質的眼用乳劑
EP3765460A1 (fr) 2018-03-14 2021-01-20 Vanderbilt University Inhibition de la signalisation bmp, composés, compositions et leurs utilisations
KR20210062626A (ko) 2018-07-27 2021-05-31 캘리포니아 인스티튜트 오브 테크놀로지 Cdk 억제제 및 이의 용도
CN110787126A (zh) * 2018-08-03 2020-02-14 武汉武药科技有限公司 一种盐酸莫西沙星眼用凝胶及其制备方法
US20220218652A1 (en) 2018-09-05 2022-07-14 The General Hospital Corporation Methods of treating cytokine release syndrome
CN114269345A (zh) 2018-10-26 2022-04-01 科乐斯疗法公司 Alk2抑制剂的晶体形式
MX2021006869A (es) 2018-12-10 2021-07-02 Massachusetts Gen Hospital Esteres de cromolin y usos de los mismos.
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.
CN113573709A (zh) 2019-03-14 2021-10-29 阿斯利康(瑞典)有限公司 用于体重减轻的兰比斯特
JP6890865B1 (ja) 2019-06-03 2021-06-18 株式会社大分大学先端医学研究所 狂犬病治療のための環状アミド化合物およびその方法
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
CN114727954A (zh) 2019-09-18 2022-07-08 爱尔康公司 湿包装的软水凝胶眼睛插入物
CN114981243A (zh) 2019-11-12 2022-08-30 健赞公司 用于治疗由cftr活性缺陷介导的疾病和病状的6元杂芳基氨基磺酰胺
WO2021113809A1 (fr) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides et leurs procédés d'utilisation
WO2021113806A1 (fr) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides et leurs procédés d'utilisation
EP4079309A4 (fr) 2019-12-16 2024-01-10 Ulsan National Institute Of Science And Tech Unist Composé destiné à inhiber le facteur d'angiogenèse et son utilisation
CA3167217A1 (fr) 2020-01-13 2021-07-22 Durect Corporation Systemes d'administration de medicament a liberation prolongee avec impuretes reduites et procedes associes
US20220363696A1 (en) 2021-04-13 2022-11-17 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
WO2023034946A1 (fr) 2021-09-03 2023-03-09 Genzyme Corporation Composés indoles et leurs utilisations dans le traitement de la fibrose kystique
CA3230259A1 (fr) 2021-09-03 2023-03-09 Junkai Liao Composes indoles et procedes d'utilisation
WO2023056431A1 (fr) 2021-10-01 2023-04-06 Nuvalent, Inc. Méthodes de traitement d'une tumeur solide à l'aide de composés éther macrocycliques hétéroaromatiques
AU2022357554A1 (en) 2021-10-01 2024-04-11 Nuvalent, Inc. Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
US20230310615A1 (en) 2022-03-31 2023-10-05 Alcon Inc. Ophthalmic compositions
WO2023196910A1 (fr) 2022-04-07 2023-10-12 Nuvalent, Inc Méthodes de traitement d'une tumeur solide à l'aide de (19r)-5-chloro-3-éthyl-16-fluoro-10,19-diméthyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6. 08,12.013,18]pentacosa-1(24), 2(6),4,8,11,13,15,17,21(25),22-décaén-22-amine
WO2023196900A1 (fr) 2022-04-07 2023-10-12 Nuvalent, Inc. Formes solides, compositions pharmaceutiques et préparation de composés éther macrocycliques hétéroaromatiques
WO2023224961A1 (fr) 2022-05-16 2023-11-23 Exelixis, Inc. Thérapie anticancéreuse utilisant une association d'un inhibiteur de cdk7 avec un serd oral
WO2024036097A1 (fr) 2022-08-12 2024-02-15 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques et isotopologues de ceux-ci
WO2024036098A1 (fr) 2022-08-12 2024-02-15 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques
WO2024086634A1 (fr) 2022-10-19 2024-04-25 Nuvalent, Inc. Agents chimiothérapeutiques à base d'éther macrocyclique hétéroaromatique

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944427A (en) * 1970-04-06 1976-03-16 Itek Corporation Gelable and gelled compositions
US3843782A (en) 1971-07-26 1974-10-22 Flow Pharma Inc Eye solution and method of using same
US4136178A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Locust bean gum therapeutic compositions
US4136177A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4255415A (en) 1978-11-22 1981-03-10 Schering Corporation Polyvinyl alcohol ophthalmic gel
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
US4436730A (en) 1979-06-25 1984-03-13 Polymer Technology Corporation Ionic opthalmic cellulose polymer solutions
US4624868A (en) * 1979-12-17 1986-11-25 Colgate-Palmolive Company Borated polysaccharide absorbents and absorbent products
US4323467A (en) 1980-11-24 1982-04-06 Syntex (U.S.A.) Inc. Contact lens cleaning, storing and wetting solutions
JPS57186733A (en) 1981-05-13 1982-11-17 Toyo Contact Lens Co Ltd Agent for use in contact lenses
US4362781A (en) * 1981-09-21 1982-12-07 Scott Paper Company Flushable premoistened wiper
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US5188826A (en) 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5607698A (en) 1988-08-04 1997-03-04 Ciba-Geigy Corporation Method of preserving ophthalmic solution and compositions therefor
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
CA2011423A1 (fr) 1989-03-07 1990-09-07 Peter M. Taylor Composes pharmaceutiques utiles comme vehicules de medicaments et (ou) pansement
US5082579A (en) * 1990-01-16 1992-01-21 Bj Services Company Method and composition for delaying the gellation of borated galactomannans
US5160643A (en) * 1990-01-16 1992-11-03 Bj Services Company Method for delaying the gellation of borated galactomannans with a delay additive such as glyoxal
US5145590A (en) 1990-01-16 1992-09-08 Bj Services Company Method for improving the high temperature gel stability of borated galactomannans
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5376693A (en) 1990-08-07 1994-12-27 Mediventures Inc. Thermo-irreversible gel corneal contact lens formed in situ
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5372732A (en) 1992-10-21 1994-12-13 Halliburton Company Delayed release borate crosslinking agent
AU5599594A (en) 1992-11-16 1994-06-08 Ciba-Geigy Ag Polyvinyl alcohol/borate ophthalmic drug delivery system
JPH06345653A (ja) 1993-06-08 1994-12-20 Asahi Chem Ind Co Ltd 点眼液
US5773025A (en) 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5603929A (en) 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
GB9603146D0 (en) 1996-02-15 1996-04-17 Innovative Tech Ltd Hydrogels
JP3989054B2 (ja) 1996-07-29 2007-10-10 株式会社メニコン コンタクトレンズ用洗浄材
JPH10221654A (ja) 1997-02-07 1998-08-21 Seiko Epson Corp コンタクトレンズ用溶液
DK1203808T3 (da) * 1997-07-29 2005-01-31 Alcon Lab Inc Konditioneringsoplösninger til pleje af hårde kontaktlinser
WO1999006023A1 (fr) * 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Compositions ophtalmologiques contenant des polymeres de galactomannan et du borate
PT999854E (pt) 1997-07-29 2003-12-31 Alcon Mfg Ltd Sistemas viscoelasticos comutaveis contendo polimeros de galactomanano e borato
AU2004305539B2 (en) * 2003-12-11 2010-09-02 Alcon, Inc. Ophthalmic compositions containing a polysaccharide/borate gelling system

Also Published As

Publication number Publication date
BR9811574B1 (pt) 2010-11-30
ES2206965T3 (es) 2004-05-16
TW577751B (en) 2004-03-01
TWI233801B (en) 2005-06-11
CN100408100C (zh) 2008-08-06
ATE391492T1 (de) 2008-04-15
AU8570598A (en) 1999-02-22
US20070098677A1 (en) 2007-05-03
ES2302881T3 (es) 2008-08-01
US6403609B1 (en) 2002-06-11
CY2013040I1 (el) 2015-11-04
AR013272A1 (es) 2000-12-13
US20020183280A1 (en) 2002-12-05
CN1229110C (zh) 2005-11-30
WO1999006023A1 (fr) 1999-02-11
EP1348427A1 (fr) 2003-10-01
US6486138B1 (en) 2002-11-26
CY2013040I2 (el) 2015-11-04
KR20010022286A (ko) 2001-03-15
DK0999825T3 (da) 2004-02-09
US20050075313A1 (en) 2005-04-07
DE69839355T2 (de) 2009-06-04
CN1544092A (zh) 2004-11-10
CN1762381A (zh) 2006-04-26
US6583124B2 (en) 2003-06-24
PT999825E (pt) 2004-02-27
EP1348427B1 (fr) 2008-04-09
JP2007197461A (ja) 2007-08-09
US7169767B2 (en) 2007-01-30
CY1110365T1 (el) 2015-04-29
CN1302201A (zh) 2001-07-04
HK1026618A1 (en) 2000-12-22
BR9811574A (pt) 2000-08-29
EP0999825A1 (fr) 2000-05-17
HK1055392A1 (en) 2004-01-09
DE69818675T2 (de) 2004-07-29
US6838449B2 (en) 2005-01-04
ZA986533B (en) 1999-02-05
AU737442B2 (en) 2001-08-16
DE69839355D1 (de) 2008-05-21
PT1348427E (pt) 2008-05-26
JP4673339B2 (ja) 2011-04-20
ATE250923T1 (de) 2003-10-15
EP0999825B1 (fr) 2003-10-01
CN1762381B (zh) 2012-07-11
KR100507984B1 (ko) 2005-08-17
JP3979783B2 (ja) 2007-09-19
US20030206970A1 (en) 2003-11-06
DE69818675D1 (de) 2003-11-06
CA2296080A1 (fr) 1999-02-11
CA2296080C (fr) 2005-02-01
DK1348427T3 (da) 2008-06-30
JP2003528797A (ja) 2003-09-30

Similar Documents

Publication Publication Date Title
LU92301I2 (fr) "Nepafenac - suspension ophtalmique"
CA2031382A1 (fr) Composition de traitement capillaire
NO975331D0 (no) Anvendelse av R-enantiomer av N-propargyl-1-aminoindan salter og sammensetninger derav
CA2154950A1 (fr) Nouvelles composition et methode de fracturation
PT1028707E (pt) Formulacoes oftalmicas de libertacao controlada contendo medicamentos soluveis em agua
FR2719769B1 (fr) Composition cosmétique ou dermatologique sous forme d'huile gélifiée contenant un mélange d'acide hydroxy-12 stéarique ou d'un dialkylamide de l'acide N-lauroylglutamique et d'un copolymère styrène/alcadiène hydrogéné.
DE3581768D1 (de) Tensidepraeparate.
FI953915A (fi) Dupuytrenin taudin lievittämiseen
MA22352A1 (fr) Compositions de type gel ayant une regulation perfectionnee de l'huile
ATE215821T1 (de) Entzündungshemmende augentropfen
DE69325493D1 (de) Künstliche Speichelzusammensetzungen
BG102342A (en) Optical active derivative of phenylpyrimidine as an anlgesics
ATE195055T1 (de) Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
YU48341B (sh) Preparat herbicida
BR9303862A (pt) Mesofase esmetica preparada "in vitro" e composicao cosmetica
NO974551L (no) Bruk av sulbutiamin for å fremskaffe farmasöytiske sammensetninger nyttige i behandling av visse psykomotoriske- og psyko-intellektuelle sykdommer
IT9002117A0 (it) Procedimento per l'applicazione dello sperone e calzature costruite secondo il procedimento.
AUPM656494A0 (en) Organism's light computer & games of triangles
FR2743494B1 (fr) Composition aqueuse dentaire a base d'un melange de gomme xanthane et de gomme de guar comme agent epaississant
AU123610S (en) Range hood adaptor
KR960007370U (ko) 앞 현가장치의 펜둘럼의 하부캡
IT1282704B1 (it) Uso topico dell'invertasi nella prevenzione o nella cura della carie e delle patologie parodontali
ITPG950031U1 (it) Manico per cappuccio di siringa
YU84491A (sh) Skrobni hidrolizati