LU91935I2 - Tafamidis et ses sels pharmaceutiquement acceptables, compernant le sel tafamidis méglumine (VYNDAQEL®) - Google Patents
Tafamidis et ses sels pharmaceutiquement acceptables, compernant le sel tafamidis méglumine (VYNDAQEL®)Info
- Publication number
- LU91935I2 LU91935I2 LU91935C LU91935C LU91935I2 LU 91935 I2 LU91935 I2 LU 91935I2 LU 91935 C LU91935 C LU 91935C LU 91935 C LU91935 C LU 91935C LU 91935 I2 LU91935 I2 LU 91935I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- tafamidis
- transthyretin
- vyndaqel
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43507902P | 2002-12-19 | 2002-12-19 | |
US46543503P | 2003-04-24 | 2003-04-24 | |
PCT/US2003/040567 WO2004056315A2 (en) | 2002-12-19 | 2003-12-19 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
Publications (2)
Publication Number | Publication Date |
---|---|
LU91935I2 true LU91935I2 (fr) | 2012-03-26 |
LU91935I9 LU91935I9 (de) | 2019-01-04 |
Family
ID=32685364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU91935C LU91935I2 (fr) | 2002-12-19 | 2012-01-25 | Tafamidis et ses sels pharmaceutiquement acceptables, compernant le sel tafamidis méglumine (VYNDAQEL®) |
Country Status (19)
Country | Link |
---|---|
US (6) | US7214695B2 (de) |
EP (3) | EP1988397B8 (de) |
JP (3) | JP4665076B2 (de) |
KR (1) | KR101089904B1 (de) |
CN (2) | CN100448852C (de) |
AT (2) | ATE405840T1 (de) |
AU (2) | AU2003303196C1 (de) |
BE (1) | BE2012C008I2 (de) |
BR (1) | BRPI0317463B8 (de) |
CA (2) | CA2800237C (de) |
CY (2) | CY1108467T1 (de) |
DE (2) | DE60323155D1 (de) |
DK (2) | DK1988397T3 (de) |
ES (3) | ES2373639T3 (de) |
FR (1) | FR12C0008I2 (de) |
LU (1) | LU91935I2 (de) |
PT (2) | PT1587821E (de) |
SI (1) | SI1587821T1 (de) |
WO (1) | WO2004056315A2 (de) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06105459B2 (ja) * | 1988-08-11 | 1994-12-21 | 日本電気株式会社 | ベクトル処理装置 |
SI1587821T1 (sl) * | 2002-12-19 | 2009-02-28 | Scripps Research Inst | Sestavki in postopki za stabiliziranje transtiretina in zaviranje napaäśnega zvijanja transtiretina |
AU2005222613B2 (en) * | 2004-03-12 | 2009-12-17 | Biodel, Inc. | Rapid acting drug delivery compositions |
CN101198598A (zh) | 2004-05-20 | 2008-06-11 | 弗尔德里克斯制药股份有限公司 | 2-((杂)芳基)-苯并噁唑化合物及其衍生物、组合物以及用于稳定和抑制甲状腺素转运蛋白错重叠的方法 |
ATE516813T1 (de) * | 2004-08-26 | 2011-08-15 | Biocrine Ab | Verfahren und verbindungen zur behandlung von diabetes |
US20070037875A1 (en) * | 2005-08-11 | 2007-02-15 | The Scripps Research Institute | Genistein inhibition of transthyretin amyloidosis |
EP2074223A4 (de) * | 2006-09-15 | 2010-03-10 | Foldrx Pharmaceuticals Inc | Testverfahren zum nachweis von proteinen im nativen zustand und zur identifizierung von die stabilität von proteinen im nativen zustand modulierenden verbindungen |
WO2010054127A1 (en) * | 2008-11-05 | 2010-05-14 | Elan Pharmaceuticals, Inc. | Methods and agents for stabilizing non-pathological amyloidogenic polypeptides |
JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
CA2751679C (en) | 2009-02-06 | 2018-02-27 | Women & Infants' Hospital Of Rhode Island | Compositions for treating preeclampsia-type disorders of pregnancy comprising transthyretin |
WO2011116123A1 (en) * | 2010-03-19 | 2011-09-22 | Irm Llc | Tafamidis for the treatment of ophthalmic diseases |
WO2011131661A1 (en) | 2010-04-21 | 2011-10-27 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis |
EP2566333A4 (de) | 2010-05-07 | 2014-04-02 | Univ Leland Stanford Junior | Identifikation von stabilisatoren multimerer proteine |
WO2014037832A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
RU2586330C2 (ru) | 2011-09-16 | 2016-06-10 | Пфайзер Инк. | Твердые формы ингибитора диссоциации транстиретина |
CN104603096A (zh) | 2012-05-07 | 2015-05-06 | 塞利克斯比奥私人有限公司 | 用于治疗神经肌肉障碍和神经退行性疾病的组合物和方法 |
WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
JP2015519333A (ja) | 2012-05-07 | 2015-07-09 | セリックスビオ プライヴェート リミテッド | 神経疾患の治療のための組成物および方法 |
US9403826B2 (en) | 2012-05-08 | 2016-08-02 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory disorders |
US9522884B2 (en) | 2012-05-08 | 2016-12-20 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic disorders |
US9309233B2 (en) | 2012-05-08 | 2016-04-12 | Cellix Bio Private Limited | Compositions and methods for the treatment of blood clotting disorders |
US9266823B2 (en) | 2012-05-08 | 2016-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of parkinson's disease |
US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
US9321775B2 (en) | 2012-05-10 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of moderate to severe pain |
US9346742B2 (en) | 2012-05-10 | 2016-05-24 | Cellix Bio Private Limited | Compositions and methods for the treatment of fibromyalgia pain |
WO2013168016A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome |
WO2013167997A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome |
WO2013168011A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of chronic pain |
US9499526B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
US9499527B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
US9242939B2 (en) | 2012-05-10 | 2016-01-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
WO2013168000A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
WO2013167999A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurologic diseases |
WO2013168005A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
WO2013168015A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of asthma and allergy |
WO2013168002A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological conditions |
US9434729B2 (en) | 2012-05-23 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
WO2013175347A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
AU2013264896A1 (en) | 2012-05-23 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
WO2013175357A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of inflammatory bowel disease |
US9492409B2 (en) | 2012-05-23 | 2016-11-15 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
WO2013175377A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
WO2014020480A2 (en) | 2012-08-03 | 2014-02-06 | Mahesh Kandula | Compositions and methods for the treatment migraine and neurologic diseases |
WO2014037833A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment inflammation and lipid disorders |
EP2892878A4 (de) | 2012-09-08 | 2016-02-24 | Cellix Bio Private Ltd | Zusammensetzungen und verfahren zur behandlung von entzündungen und lipidstörungen |
US9169214B2 (en) | 2012-12-21 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
JP2016514091A (ja) | 2013-02-08 | 2016-05-19 | ミスフォールディング ダイアグノスティクス, インコーポレイテッド | トランスサイレチン抗体およびその使用 |
US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
WO2014195961A1 (en) | 2013-06-04 | 2014-12-11 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
US20160045609A1 (en) | 2014-08-14 | 2016-02-18 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
SG11201700958YA (en) | 2014-09-08 | 2017-03-30 | Pfizer | Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole |
WO2016046835A1 (en) | 2014-09-26 | 2016-03-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
AU2014407862B2 (en) | 2014-09-29 | 2020-03-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
CN107108535B (zh) | 2014-10-27 | 2020-04-28 | 塞尔利克斯生物私人有限公司 | 用于治疗多发性硬化的富马酸单甲酯与哌嗪或乙二胺的三组分盐 |
US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
EP3242869B1 (de) | 2015-01-06 | 2021-10-27 | Cellixbio Private Limited | Zusammensetzungen und verfahren zur behandlung von entzündungen und schmerzen |
CN107344927A (zh) | 2016-05-05 | 2017-11-14 | 苏州晶云药物科技有限公司 | Tafamidis葡甲胺盐的晶型E及其制备方法和用途 |
CN106496014A (zh) * | 2016-10-17 | 2017-03-15 | 河北美星化工有限公司 | 一种二氟尼柳的制备方法 |
US11858974B2 (en) | 2017-05-22 | 2024-01-02 | Resq Biotech | Macrocyclic modulators of disease associated protein misfolding and aggregation |
GB2571950A (en) | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
CN108558599B (zh) * | 2018-03-29 | 2021-01-29 | 浦拉司科技(上海)有限责任公司 | 2-联苯基甲醇的合成工艺 |
US20220071965A1 (en) | 2018-12-20 | 2022-03-10 | Pfizer Inc. | Pharmaceutical Compositions and Methods Comprising A Combination of a Benzoxazole Transthyretin Stabilizer and an Additional Therapeutic Agent |
EP3953339B1 (de) | 2019-04-11 | 2024-09-04 | Inke, S.A. | Verfahren zur herstellung von 1-deoxy-1-methylamino-d-glucitol-2-(3,5-dichlorphenyl)-6-benzoxazolcarboxylat |
EP3969443A1 (de) | 2019-05-16 | 2022-03-23 | Teva Pharmaceuticals International GmbH | Feste formen von tafamidis und salze davon |
CN110215740B (zh) * | 2019-07-15 | 2021-05-04 | 大连医科大学 | 一种两性离子亲水前处理硅胶材料的制备方法 |
WO2021019448A1 (en) * | 2019-08-01 | 2021-02-04 | Honour (R&D) | Process for the preparation of transthyretin dissociation inhibitor |
JP2023503833A (ja) | 2019-11-15 | 2023-02-01 | ▲蘇▼州科睿思制▲葯▼有限公司 | タファミジスの結晶形及びその調製方法及びその使用 |
WO2021124158A1 (en) * | 2019-12-20 | 2021-06-24 | Pfizer Ireland Pharmaceuticals | Efficient process for making 6-carboxy benzoxazole derivatives |
WO2021152623A1 (en) * | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
CN115298168A (zh) | 2020-01-28 | 2022-11-04 | 普罗泰格生物制药公司 | 用于稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错误折叠的化合物、组合物和方法 |
WO2022112919A1 (en) | 2020-11-25 | 2022-06-02 | Pfizer Inc. | (aza)benzothiazolyl substituted pyrazole compounds |
CN112683844A (zh) * | 2020-12-07 | 2021-04-20 | 东华理工大学 | 一种振动对吲哚美辛-糖精共晶形成影响的研究方法 |
CN112858690B (zh) * | 2021-01-21 | 2023-11-10 | 宁波职业技术学院 | 一种尿白蛋白/尿肌酐复合质控品及其制备方法 |
CN114907283A (zh) * | 2021-02-07 | 2022-08-16 | 南京正大天晴制药有限公司 | 一种2-(3,5-二氯苯基)-苯并噁唑-6-羧酸的制备方法 |
EP4083027A1 (de) | 2021-04-26 | 2022-11-02 | Química Sintética, S.A. | Festkörperform von tafamidis und verfahren zu deren herstellung |
CN113372290A (zh) * | 2021-05-21 | 2021-09-10 | 遵义医科大学 | 一种药物Tafamidis的合成方法 |
CN113321627B (zh) * | 2021-06-06 | 2022-05-24 | 湖南第一师范学院 | 一种Tafamidis衍生物及其合成方法 |
EP4351541A2 (de) | 2021-06-08 | 2024-04-17 | Alnylam Pharmaceuticals, Inc. | Zusammensetzungen und verfahren zur behandlung oder prävention von erkrankungen im zusammenhang mit morbus stargardt und/oder retinal-bindendem protein 4 (rbp4) |
WO2023020762A1 (en) | 2021-08-16 | 2023-02-23 | Synthon B.V. | Crystalline forms of tafamidis nicotinamide adduct |
WO2023091534A1 (en) | 2021-11-17 | 2023-05-25 | Teva Pharmaceuticals International Gmbh | Solid state form of tafamidis |
CN114970600B (zh) * | 2022-04-11 | 2024-07-26 | 昆明理工大学 | 基于粒化散布熵和优化kelm的滚动轴承故障诊断方法、装置 |
WO2024023710A1 (en) | 2022-07-28 | 2024-02-01 | Pfizer Inc. | Tafamidis pharmaceutical compositions |
US11970468B1 (en) | 2023-10-23 | 2024-04-30 | King Faisal University | 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US435079A (en) | 1890-08-26 | Lock-nut for axles | ||
DE602336C (de) | 1933-03-09 | 1934-09-06 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von Kuepenfarbstoffen der Anthrachinonreihe |
US3551433A (en) * | 1967-06-21 | 1970-12-29 | Us Army | Preparation of 4-phenyl-4-acyloxypiperidine |
US3551443A (en) * | 1968-10-30 | 1970-12-29 | Ciba Ltd | 2-phenylbenzoxazole derivatives |
USRE29608E (en) * | 1972-05-18 | 1978-04-11 | Lilly Industries Limited | Benzoxazole derivatives |
DE2314238A1 (de) | 1973-03-22 | 1974-09-26 | Henkel & Cie Gmbh | Neue 2-(tetrazol-5'-yl)-benzoxazole, deren herstellung sowie verwendung als entzuendungshemmer in kosmetischen praeparationen |
US4025636A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles |
US4025637A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2,5 OR 2,6 Disubstituted benzoxazoles |
DE2619547A1 (de) * | 1976-05-04 | 1977-11-24 | Dynamit Nobel Ag | Verfahren zur herstellung von 2-aryl- benzoxazolen und 2-aryl-benzthiazolen |
US4416892A (en) | 1981-04-23 | 1983-11-22 | Lilly Industries Limited | Method of treating hypersensitivity disease with benzoxazole derivatives |
US5254692A (en) | 1990-04-06 | 1993-10-19 | Bayer Aktiengesellschaft | 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines |
DE4011106A1 (de) * | 1990-04-06 | 1991-10-10 | Bayer Ag | Neue heterocyclisch substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5037842A (en) * | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
CA2051518A1 (en) | 1990-10-01 | 1992-04-02 | Robert J. Perry | Synthesis of heterocyclic compounds |
JP3021028B2 (ja) | 1990-11-19 | 2000-03-15 | 株式会社日本化学工業所 | アゾール型カチオン染料 |
CH681806A5 (de) | 1991-03-19 | 1993-05-28 | Ciba Geigy Ag | |
JPH0517458A (ja) | 1991-07-04 | 1993-01-26 | Idemitsu Kosan Co Ltd | 芳香族化合物とその製造方法 |
US5354759A (en) | 1991-09-12 | 1994-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic compounds |
JPH0673051A (ja) | 1992-08-26 | 1994-03-15 | Asahi Glass Co Ltd | ベンズアゾール誘導体 |
JPH0673050A (ja) | 1992-08-26 | 1994-03-15 | Asahi Glass Co Ltd | ヘテロ環化合物 |
GB9218334D0 (en) | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
JPH06239849A (ja) | 1993-02-16 | 1994-08-30 | Canon Inc | 光学活性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法及び表示装置 |
DE4304650A1 (de) | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
JP3243887B2 (ja) | 1993-05-28 | 2002-01-07 | 三菱化学株式会社 | 有機電界発光素子 |
JPH0797379A (ja) | 1993-09-06 | 1995-04-11 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
US5441946A (en) | 1994-04-14 | 1995-08-15 | Rhone-Poulenc-Rorer Pharmaceuticals, Inc. | Phosphonate derivatives of lipophilic amines |
US5552426A (en) | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
US5837390A (en) | 1995-05-10 | 1998-11-17 | Sony Corporation | Metal complex, method for producing the same and optical device |
JP3861930B2 (ja) | 1995-12-15 | 2006-12-27 | ソニー株式会社 | 金属複核錯体、その製造方法及び光学的素子 |
JPH09227576A (ja) | 1996-02-23 | 1997-09-02 | Sony Corp | 金属複核錯体、その製造方法及び光学的素子 |
JP3760508B2 (ja) | 1996-06-10 | 2006-03-29 | 東洋インキ製造株式会社 | 有機エレクトロルミネッセンス素子材料およびそれを用いた有機エレクトロルミネッセンス素子 |
CA2257991A1 (en) | 1996-06-14 | 1997-12-18 | Progenics Pharmaceuticals, Inc. | Uses of a chemokine receptor for inhibiting hiv-1 infection |
AU5727798A (en) | 1996-12-23 | 1998-07-17 | Texas A & M University, The | Anti-amyloidogenic agents |
FR2767527B1 (fr) | 1997-08-25 | 1999-11-12 | Pf Medicament | Derives de piperazines indoliques, utiles comme medicaments et procede de preparation |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
US6156763A (en) | 1998-02-04 | 2000-12-05 | Board Of Regents, The University Of Texas System | Inhibition of human telomerase by a g-quadruplex-interaction compound |
US6107491A (en) | 1998-07-20 | 2000-08-22 | Ciba Specialty Chemicals Corporation | Polymerizable diketopyrrolopyrroles |
GB9816654D0 (en) | 1998-07-30 | 1998-09-30 | Zeneca Ltd | Chemical compounds |
JP2000100569A (ja) | 1998-09-22 | 2000-04-07 | Toray Ind Inc | 発光素子 |
JP2001055332A (ja) | 1999-06-07 | 2001-02-27 | Saitama Daiichi Seiyaku Kk | 芳香族アミジン誘導体類含有のイオントフォレ−シス用製剤 |
CN1356988A (zh) | 1999-06-18 | 2002-07-03 | 拜尔公司 | 苯氧基氟代嘧啶类化合物 |
JP2001064205A (ja) | 1999-06-25 | 2001-03-13 | Dai Ichi Seiyaku Co Ltd | 製剤組成物 |
JP2001064166A (ja) | 1999-06-25 | 2001-03-13 | Dai Ichi Seiyaku Co Ltd | 貼付剤 |
WO2001012183A1 (en) * | 1999-08-16 | 2001-02-22 | Merck & Co., Inc. | Heterocycle amides as cell adhesion inhibitors |
GB9919673D0 (en) | 1999-08-20 | 1999-10-20 | Cancer Res Campaign Tech | 2-Arlybenzazole compounds |
JP2001226358A (ja) | 1999-10-12 | 2001-08-21 | Japan Tobacco Inc | Lpl活性増強剤 |
JP2001242165A (ja) | 2000-02-25 | 2001-09-07 | Dai Ichi Seiyaku Co Ltd | 採血用試薬 |
AU5216801A (en) | 2000-03-16 | 2001-09-24 | Hoffmann La Roche | Carboxylic acid derivatives as ip antagonists |
GB0007934D0 (en) | 2000-03-31 | 2000-05-17 | Darwin Discovery Ltd | Chemical compounds |
JP3945123B2 (ja) | 2000-04-10 | 2007-07-18 | 三菱化学株式会社 | 有機電界発光素子 |
JP2001301329A (ja) | 2000-04-20 | 2001-10-31 | Mitsubishi Chemicals Corp | 光学記録媒体 |
JP2002003368A (ja) | 2000-06-23 | 2002-01-09 | Saitama Daiichi Seiyaku Kk | 経皮吸収又は経粘膜吸収用の製剤 |
BRPI0113470B8 (pt) | 2000-08-24 | 2021-05-25 | Univ Pittsburgh | composto de ligação amilóide, composição farmacêutica e métodos de síntese de composto, de detecção in vivo de depósitos amilóides num indivíduo e em tecido humano ou animal, de quantificação de depósito amilóide em tecido de biópsia ou postmortem e de distinção de um cérebro de doença de alzheimer de um cérebro normal |
MXPA03003829A (es) | 2000-11-04 | 2003-07-28 | Aventis Pharma Ltd | Acidos alcanoicos substituidos. |
AU2002221239A1 (en) | 2000-12-07 | 2002-06-18 | Astrazeneca Ab | Therapeutic benzimidazole compounds |
JP2004524289A (ja) | 2000-12-22 | 2004-08-12 | アストラゼネカ・アクチエボラーグ | 治療化合物 |
GB0118357D0 (en) | 2001-07-27 | 2001-09-19 | Syngenta Ltd | Chemical compounds |
WO2003020698A2 (en) | 2001-09-06 | 2003-03-13 | Prochon Biotech Ltd. | Protein tyrosine kinase inhibitors |
US6602619B2 (en) | 2001-10-19 | 2003-08-05 | Lightronik Technology Inc. | Organic EL device |
CN101092400A (zh) | 2001-11-16 | 2007-12-26 | 日本化学医药株式会社 | 黄嘌呤氧化酶抑制剂 |
EP1478631A1 (de) | 2001-11-28 | 2004-11-24 | AstraZeneca AB | Therapeutische verbindungen |
UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
MXPA04005864A (es) | 2001-12-19 | 2004-10-29 | Atherogenics Inc | Derivados de charcona y su uso para tratar enfermedades. |
US7202247B2 (en) | 2001-12-19 | 2007-04-10 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
GB0205256D0 (en) | 2002-03-06 | 2002-04-17 | Oxford Glycosciences Uk Ltd | Novel compounds |
ZA200407802B (en) | 2002-03-20 | 2006-11-29 | Metabolex Inc | Substituted phenylacetic acids |
UA79755C2 (en) | 2002-04-16 | 2007-07-25 | Bayer Pharmaceuticals Corp | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
GB0226822D0 (en) | 2002-11-16 | 2002-12-24 | Oxford Glycosciences Uk Ltd | Novel compounds |
SI1587821T1 (sl) * | 2002-12-19 | 2009-02-28 | Scripps Research Inst | Sestavki in postopki za stabiliziranje transtiretina in zaviranje napaäśnega zvijanja transtiretina |
WO2004064771A2 (en) | 2003-01-14 | 2004-08-05 | Merck & Co., Inc. | Geminally di-substituted nsaid derivatives as abeta 42 lowering agents |
JP2004250411A (ja) | 2003-02-21 | 2004-09-09 | Bf Kenkyusho:Kk | アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物 |
CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
AR044503A1 (es) | 2003-03-18 | 2005-09-14 | Merck & Co Inc | Triazoles sustituidos con biarilo como bloqueantes del canal de sodio |
JP2006521357A (ja) | 2003-03-24 | 2006-09-21 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネル遮断薬としてのビアリール置換6員複素環化合物 |
JP2004302049A (ja) | 2003-03-31 | 2004-10-28 | Hodogaya Chem Co Ltd | 感光性樹脂組成物 |
AU2004230854A1 (en) | 2003-04-03 | 2004-10-28 | Merck & Co., Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
JP2006523701A (ja) | 2003-04-18 | 2006-10-19 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャネルブロッカーとしてのビアリール置換チアゾール、オキサゾール、およびイミダゾール |
WO2004098494A2 (en) | 2003-04-30 | 2004-11-18 | Cytokinetics, Inc. | Compounds, compositions, and methods |
CN101198598A (zh) * | 2004-05-20 | 2008-06-11 | 弗尔德里克斯制药股份有限公司 | 2-((杂)芳基)-苯并噁唑化合物及其衍生物、组合物以及用于稳定和抑制甲状腺素转运蛋白错重叠的方法 |
-
2003
- 2003-12-19 SI SI200331330T patent/SI1587821T1/sl unknown
- 2003-12-19 AT AT03813782T patent/ATE405840T1/de active
- 2003-12-19 DK DK08014241.7T patent/DK1988397T3/da active
- 2003-12-19 AT AT08014241T patent/ATE524741T1/de not_active IP Right Cessation
- 2003-12-19 EP EP08014241A patent/EP1988397B8/de not_active Expired - Lifetime
- 2003-12-19 ES ES08014241T patent/ES2373639T3/es not_active Expired - Lifetime
- 2003-12-19 AU AU2003303196A patent/AU2003303196C1/en active Active
- 2003-12-19 PT PT03813782T patent/PT1587821E/pt unknown
- 2003-12-19 EP EP10180989.5A patent/EP2325651B1/de not_active Expired - Lifetime
- 2003-12-19 CN CNB2003801097362A patent/CN100448852C/zh not_active Expired - Lifetime
- 2003-12-19 EP EP03813782A patent/EP1587821B1/de not_active Expired - Lifetime
- 2003-12-19 KR KR1020057011676A patent/KR101089904B1/ko active Protection Beyond IP Right Term
- 2003-12-19 US US10/741,649 patent/US7214695B2/en not_active Expired - Lifetime
- 2003-12-19 PT PT08014241T patent/PT1988397E/pt unknown
- 2003-12-19 DE DE60323155T patent/DE60323155D1/de not_active Expired - Lifetime
- 2003-12-19 JP JP2005502649A patent/JP4665076B2/ja not_active Expired - Lifetime
- 2003-12-19 CN CN2008101738900A patent/CN101413143B/zh not_active Expired - Lifetime
- 2003-12-19 ES ES03813782T patent/ES2312857T3/es not_active Expired - Lifetime
- 2003-12-19 WO PCT/US2003/040567 patent/WO2004056315A2/en active Application Filing
- 2003-12-19 CA CA2800237A patent/CA2800237C/en not_active Expired - Fee Related
- 2003-12-19 BR BRPI0317463A patent/BRPI0317463B8/pt active IP Right Grant
- 2003-12-19 ES ES10180989.5T patent/ES2524803T3/es not_active Expired - Lifetime
- 2003-12-19 DK DK03813782T patent/DK1587821T3/da active
- 2003-12-19 CA CA2510455A patent/CA2510455C/en not_active Expired - Fee Related
-
2005
- 2005-10-21 US US11/256,026 patent/US7214696B2/en not_active Expired - Lifetime
-
2006
- 2006-09-25 US US11/527,020 patent/US7560488B2/en not_active Expired - Lifetime
-
2008
- 2008-10-30 CY CY20081101229T patent/CY1108467T1/el unknown
-
2009
- 2009-06-09 US US12/481,527 patent/US8168663B2/en not_active Expired - Lifetime
-
2010
- 2010-03-30 AU AU2010201263A patent/AU2010201263B8/en not_active Expired
- 2010-07-20 JP JP2010162800A patent/JP2010270134A/ja active Pending
-
2011
- 2011-11-22 US US13/303,060 patent/US8653119B2/en not_active Expired - Lifetime
-
2012
- 2012-01-17 DE DE201212000007 patent/DE122012000007I1/de active Pending
- 2012-01-25 LU LU91935C patent/LU91935I2/fr unknown
- 2012-01-30 CY CY2012005C patent/CY2012005I2/el unknown
- 2012-02-22 FR FR12C0008C patent/FR12C0008I2/fr active Active
- 2012-02-22 BE BE2012C008C patent/BE2012C008I2/fr unknown
-
2013
- 2013-08-21 JP JP2013170867A patent/JP5756151B2/ja not_active Expired - Lifetime
-
2014
- 2014-01-15 US US14/156,257 patent/US20140134753A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU91935I2 (fr) | Tafamidis et ses sels pharmaceutiquement acceptables, compernant le sel tafamidis méglumine (VYNDAQEL®) | |
DE602004007808D1 (de) | Neue gamma secretase inhibitoren | |
DE60317198D1 (de) | Proteinkinaseinhibitoren | |
DE60331187D1 (de) | Kinaseinhibitoren | |
EA200400073A1 (ru) | Пирролопиримидины как ингибиторы протеинкиназы | |
DOP2004001052A (es) | Inhibidores heterociclil amino de 11-beta-hidroxiesteroide deshidrogenasa tipo 1 | |
NO20053627L (no) | Malonamidderivater som gamma-sekretase inhibitorer | |
CY1109763T1 (el) | Υλικα και μεθοδος για τη θεραπεια διαταραχων πηξης | |
MXPA05012323A (es) | Sulfonamidas ciclicas para la inhibicion de gama-secretasa. | |
GB0223038D0 (en) | Therapeutic compounds | |
EA201691142A1 (ru) | Ингибиторы мек и способы их применения | |
EA200601584A1 (ru) | Замещённые глюкопиранозилом бензольные производные, содержащие эти соединения лекарственные средства, их применение и способ их получения | |
NO20040631L (no) | 2,4,5-trisubstituerte tiazolylderivater og deres antiinflammatoriske aktivitet | |
JO2282B1 (en) | Oxazole derivatives | |
DE60315146D1 (de) | Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase | |
EA200301216A1 (ru) | Замещенные хинуклидинами мультициклические гетероарилы для лечения заболевания | |
BRPI0410979A (pt) | composto, composição farmacêutica, e, métodos para tratar uma doença em um animal mediada pela catepsina s e para tratar um paciente submetido a uma terapia | |
IL171927A0 (en) | Use of tyrosine kinase inhibitor to treat diabetes | |
NO20064675L (no) | Polymorfe og amorfe former av 2,5-dimetyl-2H-pyrazol-3-karboksylsyre {2-fluoro-5-[3-((E)-2-pyridin-2-yl-vinyl)-1 H-indasol-6-ylamino]-fenyl]-amid | |
WO2004026930A3 (en) | The method for reducing inflammation using sti-571 or its salt | |
TW200505836A (en) | Cyclic sulfonamides for inhibition of gamma-secretase |