EA200501083A1 - Соединения, активные в ингибировании пролилолигопептидазы - Google Patents

Соединения, активные в ингибировании пролилолигопептидазы

Info

Publication number
EA200501083A1
EA200501083A1 EA200501083A EA200501083A EA200501083A1 EA 200501083 A1 EA200501083 A1 EA 200501083A1 EA 200501083 A EA200501083 A EA 200501083A EA 200501083 A EA200501083 A EA 200501083A EA 200501083 A1 EA200501083 A1 EA 200501083A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
proliligopeptidase
inhibition
compounds active
prolyl oligopeptidase
Prior art date
Application number
EA200501083A
Other languages
English (en)
Other versions
EA010022B1 (ru
Inventor
Юкка Гюнтер
Эрик Валлен
Элина Ярхо
Пекка Мяннисте
Маркус Форсберг
Антти Посо
Йоханнес Кристиаанс
Яркко Веняляйнен
Йоуко Вепсяляйнен
Тайя Сааринен
Томи Ярвинен
Original Assignee
Орион Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орион Корпорейшн filed Critical Орион Корпорейшн
Publication of EA200501083A1 publication Critical patent/EA200501083A1/ru
Publication of EA010022B1 publication Critical patent/EA010022B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Изобретение предлагает соединение формулы (I)в котором X, R, Rи Rв формуле определены в п.1, или его фармацевтически приемлемую соль, или сложный эфир, применяемые в качестве ингибитора пролилолигопептидазы. Соединения формулы (I) можно использовать для лечения заболеваний или состояний, при которых показаны ингибиторы пролилолигопептидазы, например для лечения нейродегенеративных заболеваний, например болезни Альцгеймера или старческого слабоумия.Отчет о международном поиске был опубликован 2004.11.25.
EA200501083A 2003-01-03 2004-01-02 Соединения, активные в ингибировании пролилолигопептидазы EA010022B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20030014A FI20030014A0 (fi) 2003-01-03 2003-01-03 Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
PCT/FI2004/000001 WO2004060862A2 (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity

Publications (2)

Publication Number Publication Date
EA200501083A1 true EA200501083A1 (ru) 2006-02-24
EA010022B1 EA010022B1 (ru) 2008-06-30

Family

ID=8565256

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501083A EA010022B1 (ru) 2003-01-03 2004-01-02 Соединения, активные в ингибировании пролилолигопептидазы

Country Status (18)

Country Link
US (1) US20060229254A1 (ru)
EP (1) EP1581489A2 (ru)
JP (1) JP2006516557A (ru)
KR (1) KR20060027789A (ru)
CN (1) CN1747930A (ru)
AU (1) AU2004203788A1 (ru)
BR (1) BRPI0406618A (ru)
CA (1) CA2511856A1 (ru)
EA (1) EA010022B1 (ru)
FI (1) FI20030014A0 (ru)
HR (1) HRP20050693A2 (ru)
IS (1) IS7963A (ru)
MX (1) MXPA05007262A (ru)
NO (1) NO20053726L (ru)
PL (1) PL378329A1 (ru)
RS (1) RS20050514A (ru)
WO (1) WO2004060862A2 (ru)
ZA (1) ZA200505183B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101827529B1 (ko) 2009-12-18 2018-02-09 오게다 에스.에이. 피롤리딘 카르복실산 유도체, 대사장애 치료시 ｇ-단백질 커플링된 수용체 43(ｇｐｒ43)의 아고니스트로서 사용되기 위한 그의 의약 조성물 및 사용방법
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
DK3074008T3 (da) * 2013-11-27 2019-10-21 Epics Therapeutics Forbindelser, farmaceutisk sammensætning og fremgangsmåder til anvendelse i behandling af inflammation
KR101913506B1 (ko) * 2017-07-18 2018-10-30 경상대학교산학협력단 프롤릴 올리고펩티다아제 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물
EP4178945B1 (en) 2020-07-07 2024-08-28 Accure Therapeutics, S.L. 1-[1-(4-benzyloxy-3,5-difluoro-benzoyl)-4-fluoro-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
DE3680578D1 (de) * 1985-04-16 1991-09-05 Suntory Ltd Dipeptid-derivate, verfahren zur herstellung, pharmazeutische zusammensetzungen und ihre anwendung.
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
JPH0696563B2 (ja) * 1986-02-04 1994-11-30 サントリー株式会社 アシルアミノ酸誘導体、その製法並びに用途
EP0536163A1 (en) * 1990-06-04 1993-04-14 Pfizer Inc. Aromatic pyrrolidine and thiazolidine amides
ATE133407T1 (de) * 1990-06-07 1996-02-15 Zeria Pharm Co Ltd Neue arylalkanoylaminderivate und diese enthaltendes arzneimittel
PT915088E (pt) * 1997-10-31 2003-01-31 Hoffmann La Roche Derivados de d-prolina

Also Published As

Publication number Publication date
PL378329A1 (pl) 2006-03-20
CA2511856A1 (en) 2004-07-22
IS7963A (is) 2005-07-28
BRPI0406618A (pt) 2005-12-06
EP1581489A2 (en) 2005-10-05
HRP20050693A2 (en) 2005-10-31
EA010022B1 (ru) 2008-06-30
KR20060027789A (ko) 2006-03-28
US20060229254A1 (en) 2006-10-12
NO20053726D0 (no) 2005-08-03
ZA200505183B (en) 2006-04-26
AU2004203788A1 (en) 2004-07-22
NO20053726L (no) 2005-09-28
MXPA05007262A (es) 2005-09-08
CN1747930A (zh) 2006-03-15
JP2006516557A (ja) 2006-07-06
RS20050514A (en) 2007-12-31
FI20030014A0 (fi) 2003-01-03
WO2004060862A3 (en) 2004-11-25
WO2004060862A2 (en) 2004-07-22

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU