NO20040631L - 2,4,5-trisubstituerte tiazolylderivater og deres antiinflammatoriske aktivitet - Google Patents

2,4,5-trisubstituerte tiazolylderivater og deres antiinflammatoriske aktivitet

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Publication number
NO20040631L
NO20040631L NO20040631A NO20040631A NO20040631L NO 20040631 L NO20040631 L NO 20040631L NO 20040631 A NO20040631 A NO 20040631A NO 20040631 A NO20040631 A NO 20040631A NO 20040631 L NO20040631 L NO 20040631L
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NO
Norway
Prior art keywords
aminocarbonyl
mono
amino
optionally substituted
calkyl
Prior art date
Application number
NO20040631A
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English (en)
Other versions
NO327345B1 (no
Inventor
Jean Pierre Frans Van Wauwe
Ludwig Paul Cooymans
Gaston Stanislas Marcell Diels
Christopher John Love
Marc J De Brabander
Roger Clive Moses
Mykhaylo Goncharenko
Caterina Noula
Nele Vandermaesen
Anthony William Sibley
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20040631L publication Critical patent/NO20040631L/no
Publication of NO327345B1 publication Critical patent/NO327345B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
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Abstract

Denne oppfinnelse vedrører anvendelsen av en forbindelse med formel (I). et //-oksid, et farmasøytisk akseptabelt addisjonssalt, et kvaternært amin og en stereokjemisk isomer form derav, hvori Z er halo; Calkyl; Calkyl substituert med hydroksy, karboksyl, cyano, amino, mono- eller di(Calkyl)amino, aminokarbonyl, mono- eller di(C|alkyl)aminokarbonyl, Calkyloksykarbonyl eller Calkyloksy; polyhaloCalkyl; Calkyloksy; cyano; amino; aminokarbonyl; mono- eller di(Q.alkyl)aminokarbonyl; Calkyloksykarbonyl; Calkylkarbonyloksy, HN-S(=0)-; mono- eller di(Calkyl)amino-S(=0); -C(=N-R)NRR; Q er en eventuelt substituert karbocykel eller en eventuelt substituert heterocykel; L er substituert fenyl eller en eventuelt substituert monocyklisk 5- eller 6-leddet delvis mettet eller aromatisk heterocykel eller en bicyklisk delvis mettet eller aromatisk heterocykel; aryl er eventuelt substituert fenyl; for fremstillingen av et medikament for forebyggingen eller behandlingen av sykdommer mediert gjennom TNF-a og/eller IL-12.
NO20040631A 2001-08-13 2004-02-12 2,4,5-trisubstituerte tiazolylderivater og deres antiinflammatoriske aktivitet NO327345B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203088 2001-08-13
PCT/EP2002/008956 WO2003015776A1 (en) 2001-08-13 2002-08-09 2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity

Publications (2)

Publication Number Publication Date
NO20040631L true NO20040631L (no) 2004-03-12
NO327345B1 NO327345B1 (no) 2009-06-15

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ID=8180791

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NO20040631A NO327345B1 (no) 2001-08-13 2004-02-12 2,4,5-trisubstituerte tiazolylderivater og deres antiinflammatoriske aktivitet

Country Status (26)

Country Link
US (1) US7138403B2 (no)
EP (1) EP1418911B1 (no)
JP (1) JP4491231B2 (no)
KR (1) KR100922538B1 (no)
CN (1) CN100502863C (no)
AR (1) AR037232A1 (no)
AT (1) ATE325608T1 (no)
AU (1) AU2002331227B2 (no)
BR (1) BR0211910A (no)
CA (1) CA2451981C (no)
DE (1) DE60211348T2 (no)
EA (1) EA007933B1 (no)
ES (1) ES2264734T3 (no)
HK (1) HK1077507A1 (no)
HR (1) HRP20040098B1 (no)
HU (1) HUP0401160A3 (no)
IL (2) IL160327A0 (no)
MX (1) MXPA04001400A (no)
MY (1) MY130780A (no)
NO (1) NO327345B1 (no)
NZ (1) NZ530772A (no)
PL (1) PL210475B1 (no)
TW (1) TWI268152B (no)
UA (1) UA79756C2 (no)
WO (1) WO2003015776A1 (no)
ZA (1) ZA200401164B (no)

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WO2003015776A1 (en) 2003-02-27
EP1418911A1 (en) 2004-05-19
EA200400305A1 (ru) 2004-08-26
KR100922538B1 (ko) 2009-10-21
ZA200401164B (en) 2005-07-27
HUP0401160A3 (en) 2008-01-28
CA2451981C (en) 2012-02-21
CN100502863C (zh) 2009-06-24
DE60211348D1 (de) 2006-06-14
US7138403B2 (en) 2006-11-21
JP4491231B2 (ja) 2010-06-30
JP2005504767A (ja) 2005-02-17
ATE325608T1 (de) 2006-06-15
EA007933B1 (ru) 2007-02-27
MXPA04001400A (es) 2004-05-27
CA2451981A1 (en) 2003-02-27
UA79756C2 (en) 2007-07-25
IL160327A (en) 2010-05-17
IL160327A0 (en) 2004-07-25
HK1077507A1 (en) 2006-02-17
DE60211348T2 (de) 2007-02-08
TWI268152B (en) 2006-12-11
US20040254192A1 (en) 2004-12-16
ES2264734T3 (es) 2007-01-16
AR037232A1 (es) 2004-11-03
EP1418911B1 (en) 2006-05-10
KR20040043134A (ko) 2004-05-22
HRP20040098B1 (en) 2012-08-31
MY130780A (en) 2007-07-31
PL368241A1 (en) 2005-03-21
HUP0401160A2 (hu) 2004-09-28
HRP20040098A2 (en) 2004-06-30
CN1633294A (zh) 2005-06-29
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BR0211910A (pt) 2004-10-19
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