LU85796A1 - Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine - Google Patents
Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine Download PDFInfo
- Publication number
- LU85796A1 LU85796A1 LU85796A LU85796A LU85796A1 LU 85796 A1 LU85796 A1 LU 85796A1 LU 85796 A LU85796 A LU 85796A LU 85796 A LU85796 A LU 85796A LU 85796 A1 LU85796 A1 LU 85796A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- compound
- formula
- fluorophenyl
- compound according
- fluoro
- Prior art date
Links
- 0 *CC*CCN Chemical compound *CC*CCN 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Legs For Furniture In General (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58658084A | 1984-03-06 | 1984-03-06 | |
US58658084 | 1984-03-06 | ||
US06/683,309 US4605655A (en) | 1984-03-06 | 1984-12-18 | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
US68330984 | 1984-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
LU85796A1 true LU85796A1 (fr) | 1985-12-12 |
Family
ID=27079753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU85796A LU85796A1 (fr) | 1984-03-06 | 1985-03-05 | Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine |
Country Status (27)
Country | Link |
---|---|
US (1) | US4605655A (es) |
KR (3) | KR920005113B1 (es) |
AT (1) | AT390951B (es) |
AU (1) | AU576555B2 (es) |
BE (1) | BE901880A (es) |
CA (1) | CA1256871A (es) |
CH (1) | CH663022A5 (es) |
CY (1) | CY1545A (es) |
DE (1) | DE3507983A1 (es) |
DK (1) | DK166149C (es) |
ES (1) | ES8607254A1 (es) |
FI (1) | FI84478C (es) |
FR (1) | FR2560878B1 (es) |
GB (1) | GB2155925B (es) |
GR (1) | GR850561B (es) |
HK (1) | HK82890A (es) |
HU (1) | HU193949B (es) |
IE (1) | IE58338B1 (es) |
IT (1) | IT1183483B (es) |
LU (1) | LU85796A1 (es) |
MX (1) | MX9203177A (es) |
MY (1) | MY102240A (es) |
NL (1) | NL8500628A (es) |
PT (1) | PT80058B (es) |
SE (1) | SE462429B (es) |
SG (1) | SG35590G (es) |
ZA (1) | ZA851486B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
US4677104A (en) * | 1985-05-06 | 1987-06-30 | Bristol-Myers Company | Antipsychotic fused-ring pyridinylpiperazine derivatives |
US4766215A (en) * | 1987-02-27 | 1988-08-23 | American Home Products Corporation | Histamine H1 -receptor antagonists |
SE8701375D0 (sv) * | 1987-04-02 | 1987-04-02 | Leo Ab | Novel pyridyl- and pyrimidyl derivatives |
US4826844A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
MX173180B (es) * | 1987-10-26 | 1994-02-07 | Pfizer | Procedimiento para preparar agentes ansioliticos |
US4882432A (en) * | 1989-01-09 | 1989-11-21 | American Home Products Corporation | Polycyclic-carbamic acid piperazinoalkyl esters and amides |
GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
PT93824B (pt) * | 1989-04-22 | 1996-09-30 | Wyeth John & Brother Ltd | Processo para a preparacao de derivados de piperazina |
US5055470A (en) * | 1989-06-01 | 1991-10-08 | Bristol-Myers Squibb Co. | Method of treatment of ischemia in brain |
US4994460A (en) * | 1989-06-01 | 1991-02-19 | Bristol-Myers Squibb Co. | Agents for treatment of brain ischemia |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
US5656762A (en) * | 1990-12-28 | 1997-08-12 | Neurogen Corporation | 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands |
US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
EP0538693A3 (en) * | 1991-10-23 | 1994-08-17 | Squibb & Sons Inc | Stereoselective preparation of halophenyl alcohols |
TW217382B (es) * | 1991-10-24 | 1993-12-11 | Bristol Myers Squibb Co | |
SE9201239D0 (sv) * | 1992-04-21 | 1992-04-21 | Kabi Pharmacia Ab | Agents for treating substance abuse disorders |
US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
DE4243287A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
ES2074946B1 (es) * | 1993-07-19 | 1996-06-16 | Ferrer Int | Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida. |
DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
CA2187542C (en) * | 1994-04-18 | 2000-02-01 | Nobuyuki Takahashi | Adamantane derivative, process for producing the same, and use thereof |
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
ES2104509B1 (es) * | 1995-06-13 | 1998-07-01 | Ferrer Int | Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina. |
US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
US8541409B2 (en) * | 2007-05-14 | 2013-09-24 | Sk Biopharmaceuticals Co., Ltd. | Carbamoyloxy arylalkanoyl arylpiperazine analgesics |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
WO2021236879A1 (en) | 2020-05-20 | 2021-11-25 | The Board Of Trustees Of The University Of Illinois | Method for treating lysosomal storage diseases with histatin peptides |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2979508A (en) * | 1959-10-12 | 1961-04-11 | Paul A J Janssen | Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols |
US2985657A (en) * | 1959-10-12 | 1961-05-23 | Paul A J Janssen | 1-(aroylalkyl)-4-heterocyclylpiperazines |
US2973360A (en) * | 1959-10-12 | 1961-02-28 | Paul A J Janssen | Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines |
NL127996C (es) * | 1963-11-19 | |||
GB1259685A (en) * | 1969-04-03 | 1972-01-12 | Soc D Etudes Prod Chimique | Amino-pyrimidine derivatives |
BE758380A (fr) * | 1969-11-04 | 1971-04-16 | Sumitomo Chemical Co | Procede de preparation de derives d'aryl-cetones |
GB1307256A (en) * | 1970-09-15 | 1973-02-14 | Science Union & Cie | Piperazine derivatives and a process for their preparation |
BE882836A (fr) * | 1979-05-15 | 1980-08-18 | Soc D Etudes Prod Chimique | Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique |
US4316899A (en) * | 1979-08-24 | 1982-02-23 | Beecham Group Limited | Chromanone derivatives, a process for their preparation and compositions containing them |
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
-
1984
- 1984-12-18 US US06/683,309 patent/US4605655A/en not_active Expired - Lifetime
-
1985
- 1985-02-27 ZA ZA851486A patent/ZA851486B/xx unknown
- 1985-03-01 FI FI850850A patent/FI84478C/fi not_active IP Right Cessation
- 1985-03-04 ES ES540901A patent/ES8607254A1/es not_active Expired
- 1985-03-04 AU AU39449/85A patent/AU576555B2/en not_active Expired
- 1985-03-05 SE SE8501067A patent/SE462429B/sv not_active IP Right Cessation
- 1985-03-05 IT IT19773/85A patent/IT1183483B/it active
- 1985-03-05 AT AT0064985A patent/AT390951B/de not_active IP Right Cessation
- 1985-03-05 DK DK100685A patent/DK166149C/da not_active IP Right Cessation
- 1985-03-05 FR FR8503220A patent/FR2560878B1/fr not_active Expired
- 1985-03-05 LU LU85796A patent/LU85796A1/fr unknown
- 1985-03-05 GR GR850561A patent/GR850561B/el not_active IP Right Cessation
- 1985-03-05 CH CH991/85A patent/CH663022A5/de not_active IP Right Cessation
- 1985-03-05 BE BE0/214607A patent/BE901880A/fr not_active IP Right Cessation
- 1985-03-05 HU HU85831A patent/HU193949B/hu unknown
- 1985-03-05 IE IE54685A patent/IE58338B1/en not_active IP Right Cessation
- 1985-03-05 PT PT80058A patent/PT80058B/pt unknown
- 1985-03-05 GB GB08505662A patent/GB2155925B/en not_active Expired
- 1985-03-06 KR KR1019850001414A patent/KR920005113B1/ko not_active IP Right Cessation
- 1985-03-06 CA CA000475878A patent/CA1256871A/en not_active Expired
- 1985-03-06 DE DE19853507983 patent/DE3507983A1/de not_active Ceased
- 1985-03-06 NL NL8500628A patent/NL8500628A/nl active Search and Examination
-
1987
- 1987-10-01 MY MYPI87002690A patent/MY102240A/en unknown
-
1990
- 1990-05-19 SG SG355/90A patent/SG35590G/en unknown
- 1990-10-11 HK HK828/90A patent/HK82890A/xx not_active IP Right Cessation
-
1991
- 1991-03-22 CY CY1545A patent/CY1545A/xx unknown
-
1992
- 1992-05-09 KR KR1019920007855A patent/KR920005694B1/ko not_active IP Right Cessation
- 1992-05-09 KR KR1019920007854A patent/KR920005114B1/ko not_active IP Right Cessation
- 1992-06-23 MX MX9203177A patent/MX9203177A/es unknown
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