LU84658A1 - Nouveaux derives aryliques de la piperazine,leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives aryliques de la piperazine,leur procede de preparation et leur application en therapeutique Download PDF

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Publication number
LU84658A1
LU84658A1 LU84658A LU84658A LU84658A1 LU 84658 A1 LU84658 A1 LU 84658A1 LU 84658 A LU84658 A LU 84658A LU 84658 A LU84658 A LU 84658A LU 84658 A1 LU84658 A1 LU 84658A1
Authority
LU
Luxembourg
Prior art keywords
phenyl
formula
compounds
hydroxy
group
Prior art date
Application number
LU84658A
Other languages
English (en)
French (fr)
Inventor
Alain Platel
Alain Lacour
Guy Bourgery
Original Assignee
Delalande Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande Sa filed Critical Delalande Sa
Publication of LU84658A1 publication Critical patent/LU84658A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LU84658A 1982-02-26 1983-02-24 Nouveaux derives aryliques de la piperazine,leur procede de preparation et leur application en therapeutique LU84658A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8203256A FR2522325B1 (fr) 1982-02-26 1982-02-26 Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique
FR8203256 1982-02-26

Publications (1)

Publication Number Publication Date
LU84658A1 true LU84658A1 (fr) 1984-11-08

Family

ID=9271396

Family Applications (1)

Application Number Title Priority Date Filing Date
LU84658A LU84658A1 (fr) 1982-02-26 1983-02-24 Nouveaux derives aryliques de la piperazine,leur procede de preparation et leur application en therapeutique

Country Status (16)

Country Link
US (1) US4639452A (sv)
JP (1) JPS58159484A (sv)
AU (1) AU1188983A (sv)
BE (1) BE896009A (sv)
CA (1) CA1246076A (sv)
CH (1) CH657615A5 (sv)
DE (1) DE3306302A1 (sv)
ES (2) ES8403881A1 (sv)
FR (1) FR2522325B1 (sv)
GB (4) GB2116967B (sv)
GR (1) GR77936B (sv)
IT (1) IT1193684B (sv)
LU (1) LU84658A1 (sv)
NL (1) NL8300720A (sv)
SE (1) SE460788B (sv)
ZA (1) ZA831134B (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2552762B1 (fr) * 1983-09-30 1986-07-25 Delalande Sa Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
GB8530602D0 (en) * 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
ATE60328T1 (de) * 1986-03-29 1991-02-15 Suntory Ltd Derivate vom benzoquinonylphenylalkansaeure-amid.
MY102447A (en) * 1986-06-16 1992-06-30 Ciba Geigy Ag Disubtituted piperazines
US5232923A (en) * 1988-03-18 1993-08-03 Mitsui Toatsu Chemicals, Incorporated Catechol derivatives and pharmaceutical preparations containing same
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO2001062749A1 (en) * 2000-02-22 2001-08-30 Cv Therapeutics, Inc. Substituted piperazine compounds
JPWO2004046110A1 (ja) * 2002-11-15 2006-03-16 アステラス製薬株式会社 メラニン凝集ホルモン受容体拮抗剤
ZA200507486B (en) * 2003-03-07 2007-03-28 Astellas Pharma Inc Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl
BRPI0514812A (pt) * 2004-09-01 2008-06-24 Astellas Pharma Inc derivado de piperidina ou seu sal farmaceuticamente aceitável
CN101754957A (zh) 2007-07-19 2010-06-23 弗·哈夫曼-拉罗切有限公司 新的杂环基化合物和它们作为趋化因子拮抗剂的用途
CN101591310B (zh) * 2008-12-19 2012-03-21 王绍杰 一种马来酸桂哌齐特的制备方法
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CN101906085B (zh) * 2009-06-04 2013-12-11 天津药物研究院 治疗心脑血管疾病的化合物、组合物、制备方法及用途
CN101921247B (zh) * 2009-06-12 2016-04-20 福州璐珈医药科技有限公司 1-(肉桂酰基)-4-哌啶基酰胺哌嗪化合物及其制备方法
US9073882B2 (en) 2010-10-27 2015-07-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058134A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CN103874493A (zh) 2011-08-19 2014-06-18 默沙东公司 肾外髓质钾通道的抑制剂
WO2013039802A1 (en) 2011-09-16 2013-03-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013062900A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8999990B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013066714A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2773351B1 (en) 2011-10-31 2017-08-23 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2773206B1 (en) 2011-10-31 2018-02-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013090271A1 (en) 2011-12-16 2013-06-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
WO2014085210A1 (en) 2012-11-29 2014-06-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2934533B1 (en) 2012-12-19 2017-11-15 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9604998B2 (en) 2013-02-18 2017-03-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2968288B1 (en) 2013-03-15 2018-07-04 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1139934A (en) * 1966-08-18 1969-01-15 Delalande Sa Cinnamylpiperazine preparations
GB1168108A (en) * 1967-09-29 1969-10-22 Delalande Sa Amide Derivatives of 1-Piperazine Acetic Acid and Process for their Preparation
GB1218591A (en) * 1968-04-03 1971-01-06 Delalande Sa Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
FR2068407A6 (sv) * 1969-10-17 1971-08-27 Delalande Sa
US3753984A (en) * 1971-05-26 1973-08-21 Delalande Sa Amides derived from the esters of 1-piperazine propionic acid, their method of preparation and their application to therapeutics
FR2262521A1 (en) * 1973-08-08 1975-09-26 Delalande Sa 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity
FR2244518A1 (en) * 1973-08-10 1975-04-18 Delalande Sa N-sinapyl-N'-alkoxyalkyl or-aminocarbonylmethyl-piperazines - as vasodilators, diuretics, antihypertensive and antiulcer agents
FR2240734A1 (en) * 1973-08-13 1975-03-14 Delalande Sa N-(dihydro sinapyl) piperazine derivs - having antiulcer, hypertensive and diuretic props
DK405775A (da) * 1974-09-12 1976-03-13 American Cyanamid Co Fremgangsmade til fremstilling af alkanolaminer
GB1473262A (en) * 1974-11-20 1977-05-11 Delalande Sa Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application
JPS5210284A (en) * 1975-07-11 1977-01-26 Tanabe Seiyaku Co Ltd Process for preparing piperazine derivatives
US4166116A (en) * 1977-11-11 1979-08-28 Canadian Patents And Development Limited Pharmaceutical compositions containing piperazinyl acylhydroxamic acid derivatives to treat inflammation or anaphylactic allergy conditions
JPS5732255A (en) * 1980-08-05 1982-02-20 Kowa Co Trimethoxyphenyl derivative

Also Published As

Publication number Publication date
BE896009A (fr) 1983-08-24
FR2522325A1 (fr) 1983-09-02
JPS58159484A (ja) 1983-09-21
ES520089A0 (es) 1984-04-16
FR2522325B1 (fr) 1985-08-09
GB8517121D0 (en) 1985-08-14
DE3306302C2 (sv) 1992-04-02
ES8403881A1 (es) 1984-04-16
IT8319764A0 (it) 1983-02-25
ZA831134B (en) 1983-11-30
AU1188983A (en) 1983-09-01
DE3306302A1 (de) 1983-09-08
GB2116967B (en) 1986-07-16
CH657615A5 (fr) 1986-09-15
GB2163152A (en) 1986-02-19
GB8517122D0 (en) 1985-08-14
GB2163152B (en) 1986-07-23
GB2163153B (en) 1986-07-16
ES8500254A1 (es) 1984-10-01
GB2163151B (en) 1986-07-23
US4639452A (en) 1987-01-27
GB2163153A (en) 1986-02-19
GB2163151A (en) 1986-02-19
ES529265A0 (es) 1984-10-01
GB2116967A (en) 1983-10-05
SE8300987L (sv) 1983-08-27
IT1193684B (it) 1988-07-21
SE8300987D0 (sv) 1983-02-23
GR77936B (sv) 1984-09-25
GB8517123D0 (en) 1985-08-14
JPH0518830B2 (sv) 1993-03-15
CA1246076A (en) 1988-12-06
SE460788B (sv) 1989-11-20
NL8300720A (nl) 1983-09-16
GB8304846D0 (en) 1983-03-23

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