JPS5732255A - Trimethoxyphenyl derivative - Google Patents

Trimethoxyphenyl derivative

Info

Publication number
JPS5732255A
JPS5732255A JP10743980A JP10743980A JPS5732255A JP S5732255 A JPS5732255 A JP S5732255A JP 10743980 A JP10743980 A JP 10743980A JP 10743980 A JP10743980 A JP 10743980A JP S5732255 A JPS5732255 A JP S5732255A
Authority
JP
Japan
Prior art keywords
formula
compound shown
trimethoxyphenyl
derivative
actions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10743980A
Other languages
Japanese (ja)
Other versions
JPS6323986B2 (en
Inventor
Tomio Ota
Yoshio Takahashi
Masahiko Nagakura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP10743980A priority Critical patent/JPS5732255A/en
Publication of JPS5732255A publication Critical patent/JPS5732255A/en
Publication of JPS6323986B2 publication Critical patent/JPS6323986B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula I [A is CH=CH-CO, CH= CH-CH2, group shown by the formula II, COO-(CH3)2; R1 and R2 are alkyl, form ethylene or propylene; R is pyrrolidinoalkyl-carbonyl, pyrrolidinocarbonylalkyl, alkoxycarbonylalkyl, trimethoxycinnamyl, etc.].
EXAMPLE: N,N'-Dimethyl-N-(1-pyrrolidinocarbonylmethyl)-N'-(3,4,5-trimethoxycinnamoyl)-ethylenediamine.
USE: Having vasodilating actions, antiarrhythmic actions, etc., useful as a circulatory organ type drug.
PROCESS: A compound shown by the formula III (X is halogen) is reacted with a compound shown by the formula IV in a proper solvent (e.g., benzene, THF, etc.) in the presence of a deoxidizer, e.g., triethylamine, K2CO3, etc., to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP10743980A 1980-08-05 1980-08-05 Trimethoxyphenyl derivative Granted JPS5732255A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10743980A JPS5732255A (en) 1980-08-05 1980-08-05 Trimethoxyphenyl derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10743980A JPS5732255A (en) 1980-08-05 1980-08-05 Trimethoxyphenyl derivative

Publications (2)

Publication Number Publication Date
JPS5732255A true JPS5732255A (en) 1982-02-20
JPS6323986B2 JPS6323986B2 (en) 1988-05-18

Family

ID=14459169

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10743980A Granted JPS5732255A (en) 1980-08-05 1980-08-05 Trimethoxyphenyl derivative

Country Status (1)

Country Link
JP (1) JPS5732255A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2522325A1 (en) * 1982-02-26 1983-09-02 Delalande Sa NOVEL ARYLIC DERIVATIVES OF PIPERAZINE, HOMOPIPERAZINE AND N, N'-DIALKYL DIAMINO-1,2 ETHANE, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC USE
EP0136945A2 (en) * 1983-09-30 1985-04-10 Delalande S.A. Cinnamoyl compounds, process for their preparation and their therapeutical use
US4780560A (en) * 1986-03-05 1988-10-25 Terumo Corporation Nitrate derivatives and vasodilators containing the same
WO1992002487A1 (en) * 1989-05-30 1992-02-20 Kowa Co., Ltd. New diamine compound and brain protecting agent containing the same
EP0774257A3 (en) * 1995-11-20 1997-08-27 Kowa Co Use of piperazine and homopiperazine compounds for the inhibition of cellular adhesion and infiltration
WO1998007702A1 (en) * 1996-08-23 1998-02-26 Kowa Co., Ltd. Diamide compounds and drugs containing the same

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2522325A1 (en) * 1982-02-26 1983-09-02 Delalande Sa NOVEL ARYLIC DERIVATIVES OF PIPERAZINE, HOMOPIPERAZINE AND N, N'-DIALKYL DIAMINO-1,2 ETHANE, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC USE
JPS58159484A (en) * 1982-02-26 1983-09-21 ドウラランドウ・ソシエテ・アノニム Novel piperazine derivative and manufacture
JPH0518830B2 (en) * 1982-02-26 1993-03-15 Delalande Sa
EP0136945A2 (en) * 1983-09-30 1985-04-10 Delalande S.A. Cinnamoyl compounds, process for their preparation and their therapeutical use
US4780560A (en) * 1986-03-05 1988-10-25 Terumo Corporation Nitrate derivatives and vasodilators containing the same
WO1992002487A1 (en) * 1989-05-30 1992-02-20 Kowa Co., Ltd. New diamine compound and brain protecting agent containing the same
US5389630A (en) * 1989-05-30 1995-02-14 Kowa Co., Ltd. Diamine compound and brain protecting agent containing the same
EP0774257A3 (en) * 1995-11-20 1997-08-27 Kowa Co Use of piperazine and homopiperazine compounds for the inhibition of cellular adhesion and infiltration
WO1998007702A1 (en) * 1996-08-23 1998-02-26 Kowa Co., Ltd. Diamide compounds and drugs containing the same
US6340682B1 (en) * 1996-08-23 2002-01-22 Kowa Co., Ltd. Diamide compound and drugs containing the same
US6828316B2 (en) 1996-08-23 2004-12-07 Kowa Co., Ltd. Diamide compound and medicine containing the same
EP0926138A4 (en) * 1996-08-23 2006-04-12 Kowa Co Diamide compounds and drugs containing the same

Also Published As

Publication number Publication date
JPS6323986B2 (en) 1988-05-18

Similar Documents

Publication Publication Date Title
JPS5432460A (en) Cycloalkylidenemethylphenylacetic acid derivative and their preparation
JPS5732255A (en) Trimethoxyphenyl derivative
JPS5271444A (en) Synthesis of phenyl-onn-azoxycyanides
JPS5731671A (en) Preparation of homopiperazine derivative
JPS5424882A (en) Novel heterocyclic compounds and their preparation
JPS5346989A (en) Novel dibenzo(b,f)thiepin derivatives and their preparation
JPS5210266A (en) Pyrrolidine series herbicides
JPS57102957A (en) Dye-dissolving aid
JPS5414956A (en) Novel 3-amino-4-homoisotwistan derivative
JPS554329A (en) Imidazolonecarboxamide derivative and its preparation
JPS52151191A (en) Novel antibiotics neoviridogriseins and their preparation
JPS52122358A (en) Novel methano-anthracene derivatives
JPS55104274A (en) Isoxazolin-3-one derivative and its preparation
JPS5732260A (en) Mercaptofatty acid derivative and its preparation
JPS5555168A (en) Novel 4-carboxy-2-phenyl-1-phthalazone derivative
JPS5368751A (en) Thiocyclopentanol derivatives and their preparation
JPS52139075A (en) Novel morpholine derivatives
JPS5629578A (en) Novel cyclic urethane compound and its preparation
JPS5527142A (en) Novel 1-phthalazone derivative
JPS5212161A (en) Succinimide compounds and fungicides for agricultural and gardening us e
JPS5271478A (en) Synthesis of novel derivatives of kanamycin b
JPS5651461A (en) Novel 3-phenyl-4-quinazolone derivative
JPS523031A (en) Novel tyrosinol derivatives
JPS52131590A (en) Bis-trimethoxybenzylpiperazino-alkanes
JPS5283706A (en) Novel propargyl alcohol derivatives and preparation thereof