LTC2428508I2 - Heterociklinis diamino karboksamido junginys - Google Patents
Heterociklinis diamino karboksamido junginysInfo
- Publication number
- LTC2428508I2 LTC2428508I2 LTPA2020002C LTPA2020002C LTC2428508I2 LT C2428508 I2 LTC2428508 I2 LT C2428508I2 LT PA2020002 C LTPA2020002 C LT PA2020002C LT PA2020002 C LTPA2020002 C LT PA2020002C LT C2428508 I2 LTC2428508 I2 LT C2428508I2
- Authority
- LT
- Lithuania
- Prior art keywords
- carboxamide compound
- heterocyclic diamine
- diamine
- heterocyclic
- carboxamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009113936 | 2009-05-08 | ||
PCT/JP2010/057751 WO2010128659A1 (ja) | 2009-05-08 | 2010-05-06 | ジアミノへテロ環カルボキサミド化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
LTPA2020002I1 LTPA2020002I1 (lt) | 2020-02-10 |
LTC2428508I2 true LTC2428508I2 (lt) | 2020-12-28 |
Family
ID=43050157
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP15189570.3T LT3009428T (lt) | 2009-05-08 | 2010-05-06 | Diamino heterociklinis karboksamido junginys |
LTPA2020002C LTC2428508I2 (lt) | 2009-05-08 | 2020-01-21 | Heterociklinis diamino karboksamido junginys |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP15189570.3T LT3009428T (lt) | 2009-05-08 | 2010-05-06 | Diamino heterociklinis karboksamido junginys |
Country Status (29)
Country | Link |
---|---|
US (2) | US8969336B2 (lt) |
EP (2) | EP3009428B1 (lt) |
JP (1) | JP5364159B2 (lt) |
KR (1) | KR101614572B1 (lt) |
CN (1) | CN102421761B (lt) |
AU (1) | AU2010245545B2 (lt) |
BR (1) | BRPI1011838B8 (lt) |
CA (1) | CA2760061C (lt) |
CY (3) | CY1117546T1 (lt) |
DK (2) | DK2428508T3 (lt) |
ES (2) | ES2667706T3 (lt) |
FR (1) | FR20C1003I2 (lt) |
HK (1) | HK1219105A1 (lt) |
HR (2) | HRP20151435T8 (lt) |
HU (3) | HUE026647T2 (lt) |
IL (1) | IL216132A (lt) |
LT (2) | LT3009428T (lt) |
LU (1) | LUC00147I2 (lt) |
MX (1) | MX2011011875A (lt) |
NL (1) | NL301028I2 (lt) |
NO (2) | NO3009428T3 (lt) |
PL (2) | PL3009428T3 (lt) |
PT (2) | PT3009428T (lt) |
RS (2) | RS54552B1 (lt) |
SI (2) | SI3009428T1 (lt) |
SM (1) | SMT201600075B (lt) |
TW (1) | TWI484961B (lt) |
WO (1) | WO2010128659A1 (lt) |
ZA (1) | ZA201108642B (lt) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120208824A1 (en) * | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
EA019973B1 (ru) | 2008-04-16 | 2014-07-30 | Портола Фармасьютиклз, Инк. | ИНГИБИТОРЫ Syk ПРОТЕИНКИНАЗ |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
MX360970B (es) | 2008-06-27 | 2018-11-23 | Avila Therapeutics Inc | Compuestos de heteroarilo y usos de los mismos. |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
MY191934A (en) | 2010-05-20 | 2022-07-19 | Array Biopharma Inc | Macrocyclic compounds as trk kinase inhibitors |
EP2603081B1 (en) | 2010-08-10 | 2016-10-05 | Celgene Avilomics Research, Inc. | Besylate salt of a btk inhibitor |
JP2014005206A (ja) * | 2010-10-22 | 2014-01-16 | Astellas Pharma Inc | アリールアミノヘテロ環カルボキサミド化合物 |
ES2635713T3 (es) | 2010-11-01 | 2017-10-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
WO2012061415A1 (en) * | 2010-11-01 | 2012-05-10 | Portola Pharmaceuticals, Inc. | Oxypyrimidines as syk modulators |
NZ609957A (en) | 2010-11-01 | 2015-08-28 | Celgene Avilomics Res Inc | Heterocyclic compounds and uses thereof |
JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | 変異体選択的egfr阻害剤およびその使用 |
CN102285969B (zh) * | 2011-06-28 | 2013-06-19 | 山东大学 | N-1-取代哌啶-4-芳胺类衍生物及其制备方法与应用 |
EP3564261A1 (en) | 2011-08-23 | 2019-11-06 | Foundation Medicine, Inc. | Kif5b-ret fusion molecules and uses thereof |
WO2013063401A1 (en) | 2011-10-28 | 2013-05-02 | Celgene Avilomics Research, Inc. | Methods of treating a bruton's tyrosine kinase disease or disorder |
CA2856301C (en) | 2011-11-23 | 2020-10-06 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
EP2805940B1 (en) * | 2012-01-17 | 2016-11-23 | Astellas Pharma Inc. | Pyrazine carboxamide compound |
PL2825042T3 (pl) | 2012-03-15 | 2019-02-28 | Celgene Car Llc | Sole inhibitora kinazy receptora czynnika wzrostu naskórka |
CN104302178B (zh) | 2012-03-15 | 2018-07-13 | 西建卡尔有限责任公司 | 表皮生长因子受体激酶抑制剂的固体形式 |
WO2014071832A1 (en) * | 2012-11-06 | 2014-05-15 | Shanghai Fochon Pharmaceutical Co Ltd | Alk kinase inhibitors |
WO2014100748A1 (en) | 2012-12-21 | 2014-06-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
KR20150119012A (ko) | 2013-02-08 | 2015-10-23 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Erk 억제제 및 이의 용도 |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
CN104262328B (zh) * | 2013-09-18 | 2016-09-07 | 北京韩美药品有限公司 | 抑制btk和/或jak3激酶活性的化合物 |
AU2014331863C1 (en) | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2015061247A2 (en) | 2013-10-21 | 2015-04-30 | Merck Patent Gmbh | Heteroaryl compounds as btk inhibitors and uses thereof |
WO2015084998A1 (en) * | 2013-12-05 | 2015-06-11 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
CA2935944A1 (en) | 2014-01-09 | 2015-07-16 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Substituted benzoxazine and related compounds |
NZ715903A (en) * | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
KR102322338B1 (ko) * | 2014-02-04 | 2021-11-05 | 아스텔라스세이야쿠 가부시키가이샤 | 디아미노헤테로환 카르복스아미드 화합물을 유효 성분으로 하는 의약 조성물 |
CN104016977B (zh) * | 2014-06-13 | 2016-06-22 | 山东大学 | 一种取代噻二嗪二酮类衍生物及其制备方法与应用 |
WO2016025561A1 (en) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Forms and compositions of an erk inhibitor |
EP3233808B1 (en) | 2014-12-16 | 2021-07-14 | Signal Pharmaceuticals, LLC | Medical uses comprising methods for measurement of inhibition of c-jun n-terminal kinase in skin |
WO2016100310A1 (en) | 2014-12-16 | 2016-06-23 | Signal Pharmaceuticals, Llc | Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide |
CA2975260C (en) | 2015-01-29 | 2024-05-21 | Signal Pharmaceuticals Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
JP6132294B1 (ja) | 2015-07-03 | 2017-05-24 | アステラス製薬株式会社 | 安定な経口投与用医薬組成物 |
RS61485B1 (sr) | 2015-07-16 | 2021-03-31 | Array Biopharma Inc | Supstituisana pirazolo [1,5-a] piridinska jedinjenja kao inhibitori ret kinaze |
CN105001096B (zh) * | 2015-07-21 | 2017-07-21 | 沈阳化工研究院有限公司 | 一种制备4‑氨基‑n‑烷基苄胺的方法 |
MX2018001004A (es) | 2015-07-24 | 2018-06-07 | Celgene Corp | Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este. |
US10744134B2 (en) | 2015-11-04 | 2020-08-18 | Astellas Pharma Inc. | Pharmaceutical composition for cancer immunotherapy and/or immunological activation containing diamino heterocyclic carboxamide compound as active ingredient |
ES2896079T3 (es) | 2016-02-26 | 2022-02-23 | Ono Pharmaceutical Co | Fármaco para la terapia del cáncer, caracterizado por la administración de la combinación entre un inhibidor de Axl y un inhibidor del punto de control inmunitario |
CN106083821B (zh) * | 2016-06-22 | 2019-01-11 | 上海皓元生物医药科技有限公司 | 一种3,5-二取代-吡嗪-2-甲酰胺化合物的合成方法 |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
ES2948194T3 (es) | 2017-01-18 | 2023-09-01 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
EP3624780A1 (en) | 2017-05-17 | 2020-03-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 inhibitors for improving pain treatments by opioids |
CN109384774B (zh) * | 2017-08-11 | 2023-02-17 | 中国科学院上海药物研究所 | 一类多取代的吡嗪/三嗪酰胺类化合物及其制备方法和应用 |
EP3673907A4 (en) | 2017-08-23 | 2020-08-19 | ONO Pharmaceutical Co., Ltd. | CANCER TREATMENT PHARMACEUTICAL INCLUDING AX1 INHIBITOR AS AN EFFECTIVE INGREDIENT |
WO2019074116A1 (ja) | 2017-10-13 | 2019-04-18 | 小野薬品工業株式会社 | Axl阻害剤を有効成分として含む固形がん治療剤 |
CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
JP7061195B2 (ja) | 2018-01-18 | 2022-04-27 | アレイ バイオファーマ インコーポレイテッド | RETキナーゼ阻害剤としての置換ピラゾロ[3,4-d]ピリミジン化合物 |
JP7060694B2 (ja) | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Retキナーゼ阻害剤としての置換ピロロ[2,3-d]ピリミジン化合物 |
US11512074B2 (en) | 2018-03-28 | 2022-11-29 | Shenzhen Targetrx, Inc. | Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof |
CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
EP3858819A4 (en) * | 2018-09-30 | 2022-05-18 | Medshine Discovery Inc. | 3,9-DIAZASPIRO[5,5] UNDECAN COMPOUND AS FLT3 AND AXL INHIBITORS |
CA3117200A1 (en) * | 2018-10-22 | 2020-04-30 | Esker Therapeutics, Inc. | Tyk2 inhibitors and uses thereof |
EP3939954A4 (en) | 2019-03-13 | 2023-01-04 | Otsuka Pharmaceutical Co., Ltd. | METHOD FOR INTRODUCING A DEUTERED LOWER ALKYL INTO AN AMINE FRACTION OF A COMPOUND CONTAINING A SECONDARY AMINE |
US20220152020A1 (en) | 2019-04-03 | 2022-05-19 | Astellas Pharma Inc. | Pharmaceutical composition |
US20230141887A1 (en) * | 2020-03-30 | 2023-05-11 | Medshine Discovery Inc. | Crystal form of diazaspiropyran compound |
CN111423387B (zh) * | 2020-05-11 | 2022-03-08 | 苏州康纯医药科技有限公司 | 一种Gilteritinib关键中间体的制备方法 |
BR112022022220A2 (pt) * | 2020-06-01 | 2022-12-13 | Wigen Biomedicine Tech Shanghai Co Ltd | Composto, composição farmacêutica, uso do composto, e método para tratar, regular e/ou prevenir uma doença relacionada a uma proteína mutante de egfr |
WO2022009235A1 (en) * | 2020-07-10 | 2022-01-13 | Msn Laboratories Private Limited, R&D Center | Process for the preparation of gilteritinib fumarate |
CN113943288A (zh) * | 2020-07-17 | 2022-01-18 | 微境生物医药科技(上海)有限公司 | 5,6-二氢吡嗪并[2,3-c]异喹啉化合物 |
CN112225703B (zh) * | 2020-09-28 | 2022-03-11 | 广州智睿医药科技有限公司 | 一种治疗或预防与lrrk2激酶或异常lrrk2突变激酶活性相关疾病的药物 |
CN117355508A (zh) * | 2020-10-12 | 2024-01-05 | 西藏海思科制药有限公司 | 一种杂环衍生物及其在医药上的应用 |
WO2023027966A1 (en) * | 2021-08-24 | 2023-03-02 | Biomea Fusion, Inc. | Pyrazine compounds as irreversible inhibitors of flt3 |
WO2023129667A1 (en) * | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
WO2023178094A2 (en) * | 2022-03-14 | 2023-09-21 | Purdue Research Foundation | Spleen tyrosine kinase inhibitor, composition, and methods of use |
WO2023225005A1 (en) * | 2022-05-17 | 2023-11-23 | Biomea Fusion, Inc. | Flt3 combination therapy for cancer and compositions therefor |
CN115124590A (zh) * | 2022-07-05 | 2022-09-30 | 武汉大学中南医院 | 一种靶向降解flt3-itd突变蛋白的protac类化合物及其制备方法与应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5107900A (en) * | 1999-06-09 | 2000-12-28 | Yamanouchi Pharmaceutical Co., Ltd. | Novel heterocyclic carboxamide derivatives |
AU5108000A (en) * | 1999-06-10 | 2001-01-02 | Yamanouchi Pharmaceutical Co., Ltd. | Novel nitrogen-contaiing heterocyclic derivatives or salts thereof |
MXPA04012855A (es) | 2002-06-28 | 2005-04-19 | Yamanouchi Pharma Co Ltd | Derivado de diaminopirimidincarboxiamida. |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
JP2008013499A (ja) | 2006-07-06 | 2008-01-24 | Sankyo Co Ltd | 5−シアノニコチンアミド誘導体 |
WO2008016660A2 (en) * | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Imidazoacridine compounds for treating leukemias |
WO2008024974A1 (en) | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Pyrimidine and pyrazine derivatives |
EP1914240B1 (en) | 2006-10-11 | 2009-12-02 | Astellas Pharma Inc. | EML4-ALK fusion gene |
EP2222647B1 (en) | 2006-10-23 | 2015-08-05 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
PL2091918T3 (pl) | 2006-12-08 | 2015-02-27 | Novartis Ag | Związki i kompozycje jako inhibitory kinazy białkowej |
EP2109605B1 (en) | 2006-12-22 | 2013-02-20 | Boehringer Ingelheim International GmbH | 2- [(phenylamino) -pyrimidin-4ylamin0] -cyclopentane carboxamide derivatives and related compounds as inhibitors of kinases of the cell cycle for the treatment of cancer |
TWI389893B (zh) | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二(芳胺基)芳基化合物 |
JP5586460B2 (ja) | 2007-07-17 | 2014-09-10 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Pkc阻害剤としての環状アミン置換ピリミジンジアミン |
AR068054A1 (es) | 2007-08-08 | 2009-11-04 | Smithkline Beecham Corp | Compuestos de pirrolopirimidina |
AU2008296479A1 (en) | 2007-08-28 | 2009-03-12 | Dana Farber Cancer Institute | Amino substituted pyrimidine, pyrollopyridine and pyrazolopyrimidine derivatives useful as kinase inhibitors and in treating proliferative disorders and diseases associated with angiogenesis |
EP2203442B1 (en) | 2007-09-28 | 2012-06-20 | Nerviano Medical Sciences S.r.l. | Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors |
US20090270418A1 (en) | 2008-01-09 | 2009-10-29 | Marianne Sloss | Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith |
EA018484B1 (ru) | 2008-04-07 | 2013-08-30 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
MX2010010968A (es) | 2008-04-07 | 2010-10-26 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa de proteina. |
EA024109B1 (ru) | 2008-04-16 | 2016-08-31 | Портола Фармасьютиклз, Инк. | Ингибиторы протеинкиназ |
WO2009136995A2 (en) | 2008-04-16 | 2009-11-12 | Portola Pharmaceuticals, Inc. | Inhibitors of syk protein kinase |
WO2009143389A1 (en) | 2008-05-21 | 2009-11-26 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
-
2010
- 2010-05-06 BR BRPI1011838A patent/BRPI1011838B8/pt active IP Right Grant
- 2010-05-06 SI SI201031651T patent/SI3009428T1/en unknown
- 2010-05-06 HU HUE10772177A patent/HUE026647T2/en unknown
- 2010-05-06 SI SI201031107T patent/SI2428508T1/sl unknown
- 2010-05-06 NO NO15189570A patent/NO3009428T3/no unknown
- 2010-05-06 PT PT151895703T patent/PT3009428T/pt unknown
- 2010-05-06 ES ES15189570.3T patent/ES2667706T3/es active Active
- 2010-05-06 ES ES10772177.1T patent/ES2559230T3/es active Active
- 2010-05-06 TW TW099114522A patent/TWI484961B/zh active
- 2010-05-06 RS RS20160032A patent/RS54552B1/en unknown
- 2010-05-06 HU HUE15189570A patent/HUE038515T2/hu unknown
- 2010-05-06 DK DK10772177.1T patent/DK2428508T3/en active
- 2010-05-06 PL PL15189570T patent/PL3009428T3/pl unknown
- 2010-05-06 MX MX2011011875A patent/MX2011011875A/es active IP Right Grant
- 2010-05-06 JP JP2011512353A patent/JP5364159B2/ja active Active
- 2010-05-06 DK DK15189570.3T patent/DK3009428T3/en active
- 2010-05-06 US US13/266,164 patent/US8969336B2/en active Active
- 2010-05-06 CN CN201080020181.4A patent/CN102421761B/zh active Active
- 2010-05-06 PT PT107721771T patent/PT2428508E/pt unknown
- 2010-05-06 CA CA2760061A patent/CA2760061C/en active Active
- 2010-05-06 WO PCT/JP2010/057751 patent/WO2010128659A1/ja active Application Filing
- 2010-05-06 KR KR1020117026122A patent/KR101614572B1/ko active IP Right Review Request
- 2010-05-06 AU AU2010245545A patent/AU2010245545B2/en active Active
- 2010-05-06 EP EP15189570.3A patent/EP3009428B1/en active Active
- 2010-05-06 EP EP10772177.1A patent/EP2428508B9/en active Active
- 2010-05-06 LT LTEP15189570.3T patent/LT3009428T/lt unknown
- 2010-05-06 PL PL10772177T patent/PL2428508T3/pl unknown
- 2010-05-06 RS RS20180358A patent/RS57045B1/sr unknown
-
2011
- 2011-11-03 IL IL216132A patent/IL216132A/en active Protection Beyond IP Right Term
- 2011-11-24 ZA ZA2011/08642A patent/ZA201108642B/en unknown
-
2014
- 2014-08-29 US US14/472,959 patent/US9487491B2/en active Active
-
2015
- 2015-12-30 HR HRP20151435TT patent/HRP20151435T8/hr unknown
-
2016
- 2016-01-27 CY CY20161100072T patent/CY1117546T1/el unknown
- 2016-03-16 SM SM201600075T patent/SMT201600075B/xx unknown
- 2016-06-21 HK HK16107176.3A patent/HK1219105A1/zh unknown
-
2018
- 2018-03-01 HR HRP20180368TT patent/HRP20180368T1/hr unknown
- 2018-03-27 CY CY20181100350T patent/CY1120367T1/el unknown
-
2020
- 2020-01-16 NO NO2020001C patent/NO2020001I1/no unknown
- 2020-01-17 NL NL301028C patent/NL301028I2/nl unknown
- 2020-01-21 LT LTPA2020002C patent/LTC2428508I2/lt unknown
- 2020-01-22 CY CY2020004C patent/CY2020004I2/el unknown
- 2020-02-04 FR FR20C1003C patent/FR20C1003I2/fr active Active
- 2020-02-06 LU LU00147C patent/LUC00147I2/fr unknown
- 2020-02-20 HU HUS2000005C patent/HUS000511I2/hu unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LTPA2020002I1 (lt) | Heterociklinis diamino karboksamido junginys | |
BRPI0918045A2 (pt) | compostos de carboxamida heterocíclicos | |
BR112012006686A2 (pt) | composto amida substituído | |
ECSP12011986A (es) | Nebulizador | |
DK2540728T3 (da) | Heterocyklisk forbindelse | |
ECSP12011999A (es) | Derivados benzamida sustituidos | |
HK1190703A1 (zh) | 雜環胺衍生物 | |
BRPI0906705A2 (pt) | Composto heterocíclicos | |
DK2397480T3 (da) | Diazepindionderivat | |
BR112012005960A2 (pt) | n-fenil-1-(4-piridinil)-1h-pirazol-3-aminas substituídas | |
DK2387580T3 (da) | Deoxyactagardinderivater | |
BR112012010238A2 (pt) | compostos heterocíclicos pesticidas | |
FR2947556B1 (fr) | Composition polyamide modifiee | |
BRPI1009505A2 (pt) | poliamida | |
EP2632255A4 (en) | HETEROCYCLIC DIAZENIUM DIOLATE DERIVATIVES | |
ZA201306519B (en) | Primary amine diazeniumdiolate heterocyclic derivatives | |
BRPI0907519A2 (pt) | Antagonistas farmacoforos-pde4-muscarínicos duais | |
FR2947825B1 (fr) | Composition polyamide | |
TH104959B (th) | อนุพันธ์เฮทเทอโรแอริลแอไมด์ ไดแอซิพิโนพิริมิโดนที่ถูกแทนที่ | |
TH112738B (th) | อนุพันธ์เฮทเทอโรไซคลิก | |
TH104961B (th) | อนุพันธ์แอริลแอไมด์ ไดแอซีพิโนพิริมิโดนที่ถูกแทนที่ | |
TH126323B (th) | กรรมวิธีการสังเคราะห์ไดเอมีนและพอลีเอไมด์ | |
TH108043B (th) | อนุพันธ์ฟีนิลเอไมด์หรือไพริดิลเอไมด์ตัวใหม่ | |
ES1069418Y (es) | Pantalon | |
TH95725B (th) | กางเกง |