LT3808B - Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies - Google Patents

Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies Download PDF

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Publication number
LT3808B
LT3808B LTIP1747A LTIP1747A LT3808B LT 3808 B LT3808 B LT 3808B LT IP1747 A LTIP1747 A LT IP1747A LT IP1747 A LTIP1747 A LT IP1747A LT 3808 B LT3808 B LT 3808B
Authority
LT
Lithuania
Prior art keywords
hcv
domain
antigen
cvh
avh
Prior art date
Application number
LTIP1747A
Other languages
English (en)
Lithuanian (lt)
Inventor
Michael Houghton
Qui-Lim Choo
George Kuo
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24005897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3808(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of LTIP1747A publication Critical patent/LTIP1747A/xx
Publication of LT3808B publication Critical patent/LT3808B/lt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pinball Game Machines (AREA)
  • Thermistors And Varistors (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LTIP1747A 1990-04-04 1993-12-30 Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies LT3808B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50435290A 1990-04-04 1990-04-04

Publications (2)

Publication Number Publication Date
LTIP1747A LTIP1747A (en) 1995-07-25
LT3808B true LT3808B (en) 1996-03-25

Family

ID=24005897

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1747A LT3808B (en) 1990-04-04 1993-12-30 Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies

Country Status (25)

Country Link
EP (2) EP0450931B1 (bg)
JP (1) JP2733138B2 (bg)
KR (1) KR100206150B1 (bg)
AT (2) ATE139343T1 (bg)
BG (1) BG61291B1 (bg)
BR (1) BR9106309A (bg)
CY (1) CY1881A (bg)
DE (2) DE69120138T2 (bg)
DK (2) DK0450931T3 (bg)
ES (2) ES2088465T3 (bg)
FI (1) FI106317B (bg)
GB (1) GB2257784B (bg)
GR (2) GR3020964T3 (bg)
HU (1) HU217025B (bg)
IE (1) IE911105A1 (bg)
IL (2) IL170719A (bg)
LT (1) LT3808B (bg)
LV (2) LV10344A (bg)
MY (1) MY107499A (bg)
NO (1) NO310241B1 (bg)
PL (1) PL172133B1 (bg)
RO (1) RO109916B1 (bg)
RU (1) RU2130969C1 (bg)
UA (1) UA41266C2 (bg)
WO (1) WO1991015771A1 (bg)

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US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
KR940000755B1 (ko) * 1990-02-16 1994-01-29 유나이티드 바이오메디칼 인코오포레이티드 Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드
US6194140B1 (en) 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
WO1991015516A2 (en) * 1990-04-06 1991-10-17 Genelabs Incorporated Hepatitis c virus epitopes
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
US6274148B1 (en) 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
CA2095521C (en) * 1990-11-08 2009-06-30 Robert O. Ralston Hepatitis c virus asialoglycoproteins
US5910404A (en) * 1990-12-14 1999-06-08 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
EP0489968B1 (en) * 1990-12-14 1996-11-06 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
US6007982A (en) * 1990-12-14 1999-12-28 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
DE4041304A1 (de) * 1990-12-21 1992-06-25 Mikrogen Molekularbiol Entw Von strukturproteinen des hepatitis c-virus abgeleitete polypeptide, testkits, die diese polypeptide enthalten und impfstoffe gegen infektionen von hepatitis c-viren
US5574132A (en) * 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
CA2099883A1 (en) * 1991-11-07 1993-05-08 John A. Kink Epitope mapping of the c33c region of hcv
AU671967B2 (en) * 1991-11-21 1996-09-19 Common Services Agency Hepatitis-C virus testing
EP0625204B1 (en) * 1992-02-04 2002-06-19 Chiron Corporation Hepatitis therapeutics
GB9203803D0 (en) * 1992-02-21 1992-04-08 Wellcome Found A recombinant polypeptide
UA39944C2 (uk) * 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
EP0593291A3 (en) * 1992-10-16 1995-03-15 Evernew Biotech Inc Non-structural protein of the hepatitis C virus, as well as diagnostic procedure and test kit.
JP2778886B2 (ja) * 1992-10-16 1998-07-23 エバーニュー バイオテック インコーポレイティド C型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット
US6153378A (en) * 1992-10-16 2000-11-28 Bionova Corporation Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus
WO1994013164A1 (en) 1992-12-10 1994-06-23 Nike International Ltd. Bonding of rubber to plastic in footwear
RO115471B1 (ro) 1993-05-10 2000-02-28 Chiron Corp Emeryville Metoda pentru stabilirea unuia sau a mai multor tipuri de virus al hepatitei c
DE4428705A1 (de) * 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
JPH0862219A (ja) * 1994-08-19 1996-03-08 Dainabotsuto Kk 還元型抗原に対する抗体アッセイ試薬及びそれを使用した測定方法
JP3665371B2 (ja) * 1994-08-31 2005-06-29 株式会社先端生命科学研究所 C型肝炎ウイルス感染又はグループ判定のためのエピトープキメラ抗原ペプチド、その製法、及びそれを使用する感染又はグループ判定法
CA2172305A1 (en) * 1995-03-30 1996-10-01 Muneo Aoyama Multiple antigenic peptide comprising at least two hepatitis c virus-associated peptides
WO1996037606A1 (en) * 1995-05-22 1996-11-28 Bionova Corporation Compositions and methods for the diagnosis of, and vaccination against, hepatitis c virus (hcv)
FR2734639B1 (fr) * 1995-05-26 1997-10-03 Parteurop Methode de pronostic de l'evolution d'une infection par le virus de l'hepatite c, et necessaire pour sa mise en oeuvre
FR2737209B1 (fr) 1995-07-25 1997-09-19 Bio Merieux Peptide capable d'etre reconnu par des anticorps reconnaissant l'antigene c33 du virus de l'hepatite c
US6127116A (en) 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
JP3715027B2 (ja) 1996-05-07 2005-11-09 シスメックス株式会社 C型肝炎ウイルス感染症診断薬
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
ATE354800T1 (de) * 1997-09-22 2007-03-15 Novartis Vaccines & Diagnostic Verfahren zum nachweiss von antikörpern in einer probe
JP2003512598A (ja) * 1999-07-15 2003-04-02 デパートマント、アヴ、ヘルス、アンド、ヒューマン、サーヴィセズ C型肝炎に続く肝不全の予測
CA2389206C (en) 1999-10-27 2011-01-04 Chiron Corporation Activation of hcv-specific t cells
AU2574601A (en) * 1999-11-24 2001-06-04 Chiron Corporation Novel hcv non-structural polypeptide
US6986892B1 (en) 1999-11-24 2006-01-17 Chiron Corporation Immunogenic Hepatitis C virus non-structural polypeptides
ES2288969T3 (es) 2000-06-15 2008-02-01 Novartis Vaccines And Diagnostics, Inc. Inmunoensayos para anticuerpos anti-hcv.
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6858590B2 (en) 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
ATE517184T1 (de) 2000-08-17 2011-08-15 Tripep Ab Hcv ns3/4a kodierende nukleinsäure
FR2839722A1 (fr) 2002-05-17 2003-11-21 Bio Merieux Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c
MXPA05002641A (es) 2002-09-09 2005-05-05 Chiron Corp Ensayo del virus de la hepatitis c.
NZ551646A (en) 2004-06-09 2010-11-26 Pathogen Removal & Diagnostic Technologies Inc Particles embedded in a porous substrate for removing target analyte from a sample
JP2005274584A (ja) * 2005-05-25 2005-10-06 Sysmex Corp C型肝炎ウイルス感染症診断薬の製造方法
EP1888751A2 (en) 2005-05-25 2008-02-20 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
JP4005093B2 (ja) * 2005-05-25 2007-11-07 シスメックス株式会社 C型肝炎ウイルス感染症診断薬および抗hcv抗体検出方法
ATE556136T1 (de) * 2006-03-09 2012-05-15 Transgene Sa Nichtstrukturelles hcv-fusionsprotein
US20080227111A1 (en) 2007-03-16 2008-09-18 Sysmex Corporation Reagent kit and method for measuring hcv antibody
EP2185195A2 (en) 2007-08-16 2010-05-19 Tripep Ab Immunogen platform
US20090214593A1 (en) 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
KR102441636B1 (ko) 2014-10-29 2022-09-13 아보트 러보러터리즈 Ns3 포획 펩타이드를 사용한 대상체 항-hcv 항체 검출 검정
JP2018124277A (ja) * 2017-02-02 2018-08-09 三洋化成工業株式会社 粒子含有組成物、免疫測定用試薬、免疫測定方法及び粒子の保存方法

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US456637A (en) 1891-07-28 Fence
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
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Patent Citations (6)

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US456637A (en) 1891-07-28 Fence
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
EP0318216A1 (en) 1987-11-18 1989-05-31 Chiron Corporation NANBV diagnostics and vaccines

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Title
HOUGHTON M ET AL.: "Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome", SCIENCE, 1989, pages 359 - 362, XP000051654, DOI: doi:10.1126/science.2523562

Also Published As

Publication number Publication date
GR3020964T3 (en) 1996-12-31
BR9106309A (pt) 1993-04-20
FI924349A0 (fi) 1992-09-28
NO310241B1 (no) 2001-06-11
KR100206150B1 (ko) 1999-07-01
MY107499A (en) 1995-12-30
HU9203146D0 (en) 1992-12-28
EP0450931B1 (en) 1996-06-12
PL172133B1 (pl) 1997-08-29
DK0693687T3 (da) 1999-11-29
HU217025B (hu) 1999-11-29
FI106317B (fi) 2001-01-15
IL170719A (en) 2011-04-28
AU639560B2 (en) 1993-07-29
ATE139343T1 (de) 1996-06-15
DE69131488T2 (de) 1999-11-18
EP0693687A1 (en) 1996-01-24
DK0693687T4 (da) 2008-09-22
DE69120138T2 (de) 1996-11-14
GB2257784B (en) 1995-01-04
HUT62706A (en) 1993-05-28
ES2134388T5 (es) 2008-12-01
IL97741A0 (en) 1992-06-21
DE69120138D1 (de) 1996-07-18
LV10344A (en) 1994-10-20
EP0693687B1 (en) 1999-07-28
EP0693687B2 (en) 2008-06-04
NO923839D0 (no) 1992-10-01
JPH05508219A (ja) 1993-11-18
UA41266C2 (uk) 2001-09-17
NO923839L (no) 1992-11-19
ES2134388T3 (es) 1999-10-01
RO109916B1 (ro) 1995-07-28
DE69131488D1 (de) 1999-09-02
LTIP1747A (en) 1995-07-25
BG61291B1 (en) 1997-04-30
ES2088465T3 (es) 1996-08-16
RU2130969C1 (ru) 1999-05-27
GB9220480D0 (en) 1992-11-25
LV10344B (en) 1996-02-20
FI924349A (fi) 1992-09-28
IE911105A1 (en) 1991-10-09
ATE182684T1 (de) 1999-08-15
GR3031361T3 (en) 2000-01-31
EP0450931A1 (en) 1991-10-09
GB2257784A (en) 1993-01-20
AU7651091A (en) 1991-10-30
BG96943A (bg) 1993-12-24
CY1881A (en) 1996-04-05
WO1991015771A1 (en) 1991-10-17
JP2733138B2 (ja) 1998-03-30
DK0450931T3 (da) 1996-07-01

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PD9A Change of patent owner

Owner name: NOVARTIS VACCINES & DIAGNOSTICS, INC, US

Effective date: 20071228

MK9A Expiry of a patent

Effective date: 20131230