LT3604B - Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids - Google Patents

Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids Download PDF

Info

Publication number
LT3604B
LT3604B LTIP872A LTIP872A LT3604B LT 3604 B LT3604 B LT 3604B LT IP872 A LTIP872 A LT IP872A LT IP872 A LTIP872 A LT IP872A LT 3604 B LT3604 B LT 3604B
Authority
LT
Lithuania
Prior art keywords
formula
compound
crr
alkyl
pharmaceutically acceptable
Prior art date
Application number
LTIP872A
Other languages
English (en)
Lithuanian (lt)
Inventor
Bruno Silvestrini
Leandro Baiocchi
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of LTIP872A publication Critical patent/LTIP872A/xx
Publication of LT3604B publication Critical patent/LT3604B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LTIP872A 1989-02-07 1993-08-17 Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids LT3604B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8947620A IT1230441B (it) 1989-02-07 1989-02-07 Eteri della serie dell'indazolo

Publications (2)

Publication Number Publication Date
LTIP872A LTIP872A (en) 1995-03-27
LT3604B true LT3604B (en) 1995-12-27

Family

ID=11261479

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP872A LT3604B (en) 1989-02-07 1993-08-17 Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids

Country Status (36)

Country Link
US (2) US4999367A (sk)
EP (1) EP0382276B1 (sk)
JP (1) JP2870925B2 (sk)
KR (1) KR0145525B1 (sk)
CN (2) CN1046505C (sk)
AR (1) AR247386A1 (sk)
AT (1) ATE127115T1 (sk)
AU (1) AU624895B2 (sk)
BG (1) BG50273A3 (sk)
CA (1) CA2009503C (sk)
CZ (1) CZ280121B6 (sk)
DD (2) DD291995A5 (sk)
DE (2) DE69021902T2 (sk)
DK (1) DK0382276T3 (sk)
EG (1) EG19170A (sk)
ES (1) ES2020171T3 (sk)
FI (1) FI102678B (sk)
GE (1) GEP19971030B (sk)
GR (2) GR910300073T1 (sk)
HU (1) HU204793B (sk)
IL (1) IL93132A (sk)
IN (1) IN170957B (sk)
IT (1) IT1230441B (sk)
LT (1) LT3604B (sk)
LV (1) LV10612B (sk)
NZ (1) NZ232258A (sk)
PE (1) PE25091A1 (sk)
PH (1) PH26552A (sk)
PL (2) PL163720B1 (sk)
PT (1) PT93067B (sk)
RO (1) RO106252B1 (sk)
RU (3) RU2066318C1 (sk)
SK (1) SK278441B6 (sk)
UA (1) UA26852C2 (sk)
YU (1) YU47943B (sk)
ZA (1) ZA90644B (sk)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253703B (it) * 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) * 1997-11-26 1999-08-24 Intel Corporation Two-transistor DRAM cell for logic process technology
US7514463B2 (en) * 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
MX2010009624A (es) 2008-03-07 2010-09-28 Acraf Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1.
ES2569330T3 (es) * 2008-03-07 2016-05-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Derivados del 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de MCP-1, CX3CR1
SI2262778T1 (sl) 2008-03-07 2019-12-31 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzil-3-hidroksimetilindazolni derivati in njihova uporaba pri zdravljenju bolezni, na osnovi izražanja MCP-1, CXCR1 in P40
SG176885A1 (en) * 2009-08-03 2012-01-30 Acraf Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates
UA108742C2 (uk) * 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
ES2656292T3 (es) 2012-05-01 2018-02-26 Translatum Medicus Inc. Métodos de tratamiento y diagnóstico de enfermedades oculares que causan ceguera
JP6257596B2 (ja) 2012-05-18 2018-01-10 サノフイ ピラゾール誘導体およびｌｐａｒ５アンタゴニストとしてのその使用
WO2013171316A1 (en) 2012-05-18 2013-11-21 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
CN108047136B (zh) * 2017-12-20 2021-07-09 长春普华制药股份有限公司 一种苄达酸的精制方法
WO2020261158A1 (en) * 2019-06-25 2020-12-30 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470194A (en) 1966-08-29 1969-09-30 Acraf (indazole-3-yl)-oxyalkanoic acids
US4352813A (en) 1980-07-29 1982-10-05 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. [(1-Benzyl-1H-indazol-3-yl)oxy] acetic acid salt with L. lysine
US4451477A (en) 1981-11-27 1984-05-29 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Bendazac treatment of cataract
EP0131317A2 (en) 1983-04-18 1985-01-16 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. Use of Benzadac and of its salts for the manufacture of a medicament for the treatment of retinitis pigmentosa
EP0255967A1 (en) 1986-08-01 1988-02-17 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. Method of treating contact lenses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470194A (en) 1966-08-29 1969-09-30 Acraf (indazole-3-yl)-oxyalkanoic acids
US4352813A (en) 1980-07-29 1982-10-05 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. [(1-Benzyl-1H-indazol-3-yl)oxy] acetic acid salt with L. lysine
US4451477A (en) 1981-11-27 1984-05-29 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Bendazac treatment of cataract
EP0131317A2 (en) 1983-04-18 1985-01-16 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. Use of Benzadac and of its salts for the manufacture of a medicament for the treatment of retinitis pigmentosa
EP0255967A1 (en) 1986-08-01 1988-02-17 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. Method of treating contact lenses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. MARCH: "Advanced Organic Chemistry"
WOOLFE G, MACDONALD AD: "The evaluation of the analgesic action of pethidine hydrochloride", J PHARMACOL EXPER THER, 1944, pages 300 - 307

Also Published As

Publication number Publication date
DD291995A5 (de) 1991-07-18
AU4906690A (en) 1990-08-16
RU2044729C1 (ru) 1995-09-27
FI900577A0 (fi) 1990-02-06
CZ56390A3 (en) 1995-06-14
IT1230441B (it) 1991-10-23
IL93132A0 (en) 1990-11-05
IN170957B (sk) 1992-06-20
ZA90644B (en) 1991-01-30
EG19170A (en) 1994-11-30
IT8947620A0 (it) 1989-02-07
YU47943B (sh) 1996-07-24
US5112986A (en) 1992-05-12
CN1046505C (zh) 1999-11-17
DE69021902D1 (de) 1995-10-05
KR0145525B1 (ko) 1998-08-17
RU2066318C1 (ru) 1996-09-10
EP0382276A2 (en) 1990-08-16
HUT53088A (en) 1990-09-28
UA26852C2 (uk) 1999-12-29
IL93132A (en) 1994-05-30
CZ280121B6 (cs) 1995-11-15
SK56390A3 (en) 1997-05-07
HU204793B (en) 1992-02-28
LV10612B (en) 1995-08-20
GR3018165T3 (en) 1996-02-29
EP0382276A3 (en) 1990-12-12
ES2020171A4 (es) 1991-08-01
HU900689D0 (en) 1990-04-28
FI102678B1 (fi) 1999-01-29
GEP19971030B (en) 1997-06-13
CA2009503C (en) 2000-04-11
FI102678B (fi) 1999-01-29
GR910300073T1 (en) 1991-11-15
NZ232258A (en) 1991-06-25
YU20690A (sh) 1992-07-20
JPH02240065A (ja) 1990-09-25
RO106252B1 (ro) 1993-03-31
CN1034016C (zh) 1997-02-12
DE382276T1 (de) 1991-11-28
PL163730B1 (pl) 1994-04-29
LTIP872A (en) 1995-03-27
PH26552A (en) 1992-08-19
ATE127115T1 (de) 1995-09-15
JP2870925B2 (ja) 1999-03-17
BG50273A3 (en) 1992-06-15
ES2020171T3 (es) 1995-12-01
CN1088201A (zh) 1994-06-22
PT93067A (pt) 1990-08-31
RU2055071C1 (ru) 1996-02-27
PL163720B1 (pl) 1994-04-29
KR900012913A (ko) 1990-09-03
PE25091A1 (es) 1991-08-17
US4999367A (en) 1991-03-12
SK278441B6 (en) 1997-05-07
DE69021902T2 (de) 1996-05-23
EP0382276B1 (en) 1995-08-30
AU624895B2 (en) 1992-06-25
CN1044810A (zh) 1990-08-22
CA2009503A1 (en) 1990-08-07
DD295363A5 (de) 1991-10-31
AR247386A1 (es) 1994-12-29
PT93067B (pt) 1995-12-29
DK0382276T3 (da) 1996-01-15
LV10612A (lv) 1995-04-20

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Effective date: 19980817