LT3595B - Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents - Google Patents

Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents Download PDF

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Publication number
LT3595B
LT3595B LTIP1764A LTIP1764A LT3595B LT 3595 B LT3595 B LT 3595B LT IP1764 A LTIP1764 A LT IP1764A LT IP1764 A LTIP1764 A LT IP1764A LT 3595 B LT3595 B LT 3595B
Authority
LT
Lithuania
Prior art keywords
lower alkyl
phenyl
compound according
och
substituted
Prior art date
Application number
LTIP1764A
Other languages
English (en)
Lithuanian (lt)
Inventor
Sundeep Dugar
John W Clader
Duane A Burnett
Margaret E Browne
Harry R Davis
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of LTIP1764A publication Critical patent/LTIP1764A/xx
Publication of LT3595B publication Critical patent/LT3595B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTIP1764A 1993-01-21 1994-01-13 Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents LT3595B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US643993A 1993-01-21 1993-01-21

Publications (2)

Publication Number Publication Date
LTIP1764A LTIP1764A (en) 1995-02-27
LT3595B true LT3595B (en) 1995-12-27

Family

ID=21720894

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1764A LT3595B (en) 1993-01-21 1994-01-13 Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents

Country Status (26)

Country Link
US (1) US5698548A (fr)
EP (1) EP0681569B1 (fr)
JP (1) JP2719445B2 (fr)
KR (1) KR960700227A (fr)
CN (1) CN1118163A (fr)
AT (1) ATE199899T1 (fr)
AU (1) AU683048B2 (fr)
CA (1) CA2154257C (fr)
CZ (1) CZ180195A3 (fr)
DE (1) DE69426924T2 (fr)
DK (1) DK0681569T3 (fr)
EE (1) EE9400394A (fr)
ES (1) ES2155849T3 (fr)
FI (1) FI953497A (fr)
GR (1) GR3035963T3 (fr)
HU (1) HUT72592A (fr)
IL (1) IL108368A0 (fr)
LT (1) LT3595B (fr)
NO (1) NO952884L (fr)
NZ (1) NZ261714A (fr)
PL (1) PL309978A1 (fr)
PT (1) PT681569E (fr)
SI (1) SI9400022A (fr)
SK (1) SK91195A3 (fr)
WO (1) WO1994017038A1 (fr)
ZA (1) ZA94386B (fr)

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US6297268B1 (en) 1999-11-30 2001-10-02 Schering Corporation Imidazoles as cholesterol lowering agents
AR035611A1 (es) * 2000-12-20 2004-06-16 Schering Corp 2 -azetidinonas sustituidas con azucares, composicion farmaceutica, un kit, uso de dichos compuestos para la fabricacion de medicamentos utiles como agentes hipocolesterolemicos.
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US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
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AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
ATE485818T1 (de) 2002-07-30 2010-11-15 Karykion Inc Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004081002A1 (fr) 2003-03-07 2004-09-23 Schering Corporation Composes d'azetidinone substitues, leurs formulations et utilisations en vue du traitement de l'hypercholesterolemie
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CA2634940A1 (fr) * 2005-12-21 2007-07-05 Schering Corporation Traitement de la steatose hepatique non alcoolique au moyen d'agents hypocholesterolemiants et/ou dun agoniste inverse/antagoniste du recepteur h3
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JP2010503676A (ja) * 2006-09-15 2010-02-04 シェーリング コーポレイション 疼痛、糖尿病および脂質代謝の障害の治療
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CN101534818A (zh) * 2006-09-15 2009-09-16 先灵公司 用于治疗疼痛和脂类代谢疾病的氮杂环丁烷和氮杂环丁酮衍生物
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CN104496839B (zh) * 2014-12-03 2016-04-20 广东东阳光药业有限公司 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途
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EP0337549A1 (fr) 1988-04-11 1989-10-18 Merck & Co. Inc. Azétidinones nouvelles substituées comme agents anti-inflammatoires et anti-dégénératifs
US4983597A (en) 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
WO1993002048A1 (fr) 1991-07-23 1993-02-04 Schering Corporation Composes de beta-lactame substitues utilises comme agents d'hypocholesterolemie, et procedes de preparation

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Also Published As

Publication number Publication date
PT681569E (pt) 2001-06-29
LTIP1764A (en) 1995-02-27
NO952884L (no) 1995-09-20
JPH08501110A (ja) 1996-02-06
JP2719445B2 (ja) 1998-02-25
EE9400394A (et) 1996-06-17
ATE199899T1 (de) 2001-04-15
ES2155849T3 (es) 2001-06-01
GR3035963T3 (en) 2001-08-31
HU9502194D0 (en) 1995-09-28
ZA94386B (en) 1994-07-19
KR960700227A (ko) 1996-01-19
FI953497A0 (fi) 1995-07-20
DE69426924T2 (de) 2001-08-16
US5698548A (en) 1997-12-16
PL309978A1 (en) 1995-11-13
NZ261714A (en) 1997-02-24
DE69426924D1 (de) 2001-04-26
IL108368A0 (en) 1994-04-12
CA2154257A1 (fr) 1994-08-04
SI9400022A (en) 1995-02-28
NO952884D0 (no) 1995-07-20
FI953497A (fi) 1995-07-20
AU6087294A (en) 1994-08-15
AU683048B2 (en) 1997-10-30
DK0681569T3 (da) 2001-04-23
CN1118163A (zh) 1996-03-06
EP0681569A1 (fr) 1995-11-15
WO1994017038A1 (fr) 1994-08-04
EP0681569B1 (fr) 2001-03-21
CZ180195A3 (en) 1996-01-17
HUT72592A (en) 1996-05-28
CA2154257C (fr) 1999-05-25
SK91195A3 (en) 1995-12-06

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Effective date: 19970113