LT3595B - Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents - Google Patents
Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents Download PDFInfo
- Publication number
- LT3595B LT3595B LTIP1764A LTIP1764A LT3595B LT 3595 B LT3595 B LT 3595B LT IP1764 A LTIP1764 A LT IP1764A LT IP1764 A LTIP1764 A LT IP1764A LT 3595 B LT3595 B LT 3595B
- Authority
- LT
- Lithuania
- Prior art keywords
- lower alkyl
- phenyl
- compound according
- och
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US643993A | 1993-01-21 | 1993-01-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP1764A LTIP1764A (en) | 1995-02-27 |
LT3595B true LT3595B (en) | 1995-12-27 |
Family
ID=21720894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP1764A LT3595B (en) | 1993-01-21 | 1994-01-13 | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
Country Status (26)
Country | Link |
---|---|
US (1) | US5698548A (fr) |
EP (1) | EP0681569B1 (fr) |
JP (1) | JP2719445B2 (fr) |
KR (1) | KR960700227A (fr) |
CN (1) | CN1118163A (fr) |
AT (1) | ATE199899T1 (fr) |
AU (1) | AU683048B2 (fr) |
CA (1) | CA2154257C (fr) |
CZ (1) | CZ180195A3 (fr) |
DE (1) | DE69426924T2 (fr) |
DK (1) | DK0681569T3 (fr) |
EE (1) | EE9400394A (fr) |
ES (1) | ES2155849T3 (fr) |
FI (1) | FI953497A (fr) |
GR (1) | GR3035963T3 (fr) |
HU (1) | HUT72592A (fr) |
IL (1) | IL108368A0 (fr) |
LT (1) | LT3595B (fr) |
NO (1) | NO952884L (fr) |
NZ (1) | NZ261714A (fr) |
PL (1) | PL309978A1 (fr) |
PT (1) | PT681569E (fr) |
SI (1) | SI9400022A (fr) |
SK (1) | SK91195A3 (fr) |
WO (1) | WO1994017038A1 (fr) |
ZA (1) | ZA94386B (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU94046294A (ru) * | 1992-06-26 | 1996-10-10 | Пфайзер Инк. (US) | Стероидные гликозиды для лечения гиперхолестеринэмии |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
US5648484A (en) * | 1995-03-07 | 1997-07-15 | Schering Corporation | Catalytic enantioselective synthesis of a spriofused azetidinone |
JP3385031B2 (ja) * | 1995-10-31 | 2003-03-10 | シェーリング コーポレイション | 低コレステロール血症剤として有用な糖−置換2−アゼチジノン |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
AU4343500A (en) | 1999-04-16 | 2000-11-02 | Schering Corporation | Use of azetidinone compounds |
US6297268B1 (en) | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
AR035611A1 (es) * | 2000-12-20 | 2004-06-16 | Schering Corp | 2 -azetidinonas sustituidas con azucares, composicion farmaceutica, un kit, uso de dichos compuestos para la fabricacion de medicamentos utiles como agentes hipocolesterolemicos. |
AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
CZ305202B6 (cs) * | 2001-01-26 | 2015-06-10 | Merck Sharp & Dohme Corp. | Farmaceutický prostředek |
EP1911462A3 (fr) | 2001-01-26 | 2011-11-30 | Schering Corporation | Combinaisons comprenant un inhibiteur d'absorption de stérol |
KR20080067717A (ko) * | 2001-01-26 | 2008-07-21 | 쉐링 코포레이션 | 스테롤 흡수 억제제와 혈액 조절제를 포함하는 혈관 질환의치료 또는 예방용 약제학적 조성물 |
BRPI0208384B1 (pt) | 2001-03-28 | 2016-05-31 | Merck Sharp & Dohme | síntese enantiosseletiva de compostos intermediários de azetidinona |
JP2005504091A (ja) * | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
EP1859796A3 (fr) * | 2001-09-21 | 2008-07-02 | Schering Corporation | Treatment de xanthoma avec des dérivés d'azétidines en tant qu'inhibiteurs d'absorption des stérols |
US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
ATE485818T1 (de) | 2002-07-30 | 2010-11-15 | Karykion Inc | Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren |
US7208486B2 (en) | 2003-03-07 | 2007-04-24 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
WO2004081002A1 (fr) | 2003-03-07 | 2004-09-23 | Schering Corporation | Composes d'azetidinone substitues, leurs formulations et utilisations en vue du traitement de l'hypercholesterolemie |
DK1622569T3 (en) | 2003-04-24 | 2015-12-14 | Incyte Holdings Corp | AZA-SPIRO-alkane derivatives as inhibitors of metalloproteases |
JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
EP1918000A2 (fr) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinaisons d'agents de modulation lipide et azétidinones substitués et traitements pour conditions vasculaires |
EP1680189A2 (fr) * | 2003-11-05 | 2006-07-19 | Schering Corporation | Combinaisons de modulateurs lipidiques et d'azetidinones substituees et traitements d'affections vasculaires |
CA2550373C (fr) * | 2003-12-23 | 2012-01-31 | Merck & Co., Inc. | Composes anti-hypercholesterolemie |
WO2005061452A1 (fr) | 2003-12-23 | 2005-07-07 | Astrazeneca Ab | Derives diphenylazetidinone a activite inhibitrice de l'absorption du cholesterol |
JP4590417B2 (ja) * | 2004-01-16 | 2010-12-01 | メルク・シャープ・エンド・ドーム・コーポレイション | Npc1l1(npc3)およびこのリガンドの同定方法 |
EP1598336A1 (fr) | 2004-05-20 | 2005-11-23 | Laboratorios Del Dr. Esteve, S.A. | Hydroxylation, fonctionnalisation et protection regioselective de spirolactames |
EP1676836A1 (fr) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Hydroxylation, fonctionnalisation et protection regioselective de spirolactames |
US7291728B2 (en) | 2004-05-10 | 2007-11-06 | Laboratories Del Dr. Esteve, S.A. | Spirolactams and their synthesis |
WO2005108356A1 (fr) * | 2004-05-10 | 2005-11-17 | Laboratorios Del Dr. Esteve, S.A. | Spirolactames et leur synthese |
US20080045726A1 (en) * | 2004-05-10 | 2008-02-21 | Laboratorios Del Dr. Esteve, S.A. | Spirolactams and Their Synthesis |
US20060069080A1 (en) * | 2004-09-29 | 2006-03-30 | Veltri Enrico P | Combinations of substituted azetidinones and CB1 antagonists |
CN102633730A (zh) | 2004-12-03 | 2012-08-15 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
US8361999B2 (en) | 2005-04-04 | 2013-01-29 | Pontificia Universidad Catolica De Chile | Methods of treating cholesterol gallstone disease with ezetimibe |
US7635705B2 (en) * | 2005-06-20 | 2009-12-22 | Schering Corporation | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
CA2634940A1 (fr) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Traitement de la steatose hepatique non alcoolique au moyen d'agents hypocholesterolemiants et/ou dun agoniste inverse/antagoniste du recepteur h3 |
PE20071320A1 (es) | 2006-01-18 | 2007-12-29 | Schering Corp | Moduladores de receptores cannabinoides |
EP1986489A2 (fr) * | 2006-02-24 | 2008-11-05 | Schering Corporation | Orthologues de npc1l1 |
AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
EP2059241A1 (fr) * | 2006-09-05 | 2009-05-20 | Schering Corporation | Compositions pharmaceutiques pour un traitement des lipides et dans le traitement de l'athérosclérose et de la stéatose hépatique |
JP2010503676A (ja) * | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 疼痛、糖尿病および脂質代謝の障害の治療 |
US20080076750A1 (en) * | 2006-09-15 | 2008-03-27 | Aslanian Robert G | Azetidinone Derivatives and Methods of Use Thereof |
MX2009002921A (es) * | 2006-09-15 | 2009-04-01 | Schering Corp | Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico. |
CN101541795A (zh) | 2006-09-15 | 2009-09-23 | 先灵公司 | 用于治疗疼痛、糖尿病和脂类代谢紊乱的螺-稠合氮杂环丁烷衍生物 |
CN101534818A (zh) * | 2006-09-15 | 2009-09-16 | 先灵公司 | 用于治疗疼痛和脂类代谢疾病的氮杂环丁烷和氮杂环丁酮衍生物 |
US7902157B2 (en) | 2006-09-15 | 2011-03-08 | Schering Corporation | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
EP2066668A1 (fr) * | 2006-09-15 | 2009-06-10 | Schering Corporation | Dérivés d'azétidinone spirocyclique traitant les troubles du métabolisme des lipides, la douleur, le diabète et d'autres troubles |
WO2008130616A2 (fr) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines comme modulateurs des récepteurs cb1 |
EP2170846A2 (fr) | 2007-06-28 | 2010-04-07 | Intervet International BV | Pipérazines à substitution servant d'antagonistes des récepteurs cb1 |
JP2010531874A (ja) * | 2007-06-28 | 2010-09-30 | インターベット インターナショナル ベー. フェー. | Cb1アンタゴニストとしての置換ピペラジン |
CA2754384A1 (fr) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Compositions pharmaceutiques hypocholesterolemiques |
CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
RU2524341C2 (ru) | 2010-03-19 | 2014-07-27 | Пфайзер Инк. | Производные 2,3-дигидро-1н-инден-1-ил-2,7-диазаспиро[3.5]нонана и их применение в качестве антагонистов или обратных агонистов грелинового рецептора |
WO2013166117A1 (fr) | 2012-05-01 | 2013-11-07 | Althera Life Sciences, Llc | Formulation de comprimé oral constituée d'une combinaison fixe de rosuvastatine et d'ézétimibe pour le traitement de l'hyperlipidémie et de maladies cardiovasculaires |
CN104496838B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
CN104496839B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
WO2020104930A1 (fr) | 2018-11-20 | 2020-05-28 | Piramal Enterprises Limited | Synthèse asymétrique améliorée de composés azaspiro |
US11504390B2 (en) | 2019-03-20 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors |
US11331332B2 (en) | 2019-03-20 | 2022-05-17 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (SCAP) inhibitors |
WO2023122662A1 (fr) * | 2021-12-22 | 2023-06-29 | The Regents Of The University Of California | Inhibiteurs de liaison covalente des mutants g12s, g12d et/ou g12e de k-ras gtpase |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0337549A1 (fr) | 1988-04-11 | 1989-10-18 | Merck & Co. Inc. | Azétidinones nouvelles substituées comme agents anti-inflammatoires et anti-dégénératifs |
US4983597A (en) | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
WO1993002048A1 (fr) | 1991-07-23 | 1993-02-04 | Schering Corporation | Composes de beta-lactame substitues utilises comme agents d'hypocholesterolemie, et procedes de preparation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2048080C3 (de) * | 1970-09-30 | 1979-11-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von N-substituierten 33-disubstituierten ß -Lactamen |
US4692515A (en) * | 1984-09-24 | 1987-09-08 | Pennwalt Corporation | Adamantane-spirolactams |
US5130425A (en) * | 1990-10-12 | 1992-07-14 | American Home Products Corporation | Spiro-lactams and analogs thereof useful as aldose reductase inhibitors |
-
1994
- 1994-01-13 LT LTIP1764A patent/LT3595B/lt not_active IP Right Cessation
- 1994-01-19 DE DE69426924T patent/DE69426924T2/de not_active Expired - Lifetime
- 1994-01-19 HU HU9502194A patent/HUT72592A/hu unknown
- 1994-01-19 SI SI9400022A patent/SI9400022A/sl unknown
- 1994-01-19 WO PCT/US1994/000421 patent/WO1994017038A1/fr not_active Application Discontinuation
- 1994-01-19 ZA ZA94386A patent/ZA94386B/xx unknown
- 1994-01-19 EP EP94907200A patent/EP0681569B1/fr not_active Expired - Lifetime
- 1994-01-19 CN CN94191245A patent/CN1118163A/zh active Pending
- 1994-01-19 IL IL10836894A patent/IL108368A0/xx unknown
- 1994-01-19 CA CA002154257A patent/CA2154257C/fr not_active Expired - Fee Related
- 1994-01-19 DK DK94907200T patent/DK0681569T3/da active
- 1994-01-19 NZ NZ261714A patent/NZ261714A/en unknown
- 1994-01-19 SK SK911-95A patent/SK91195A3/sk unknown
- 1994-01-19 ES ES94907200T patent/ES2155849T3/es not_active Expired - Lifetime
- 1994-01-19 AT AT94907200T patent/ATE199899T1/de not_active IP Right Cessation
- 1994-01-19 PT PT94907200T patent/PT681569E/pt unknown
- 1994-01-19 PL PL94309978A patent/PL309978A1/xx unknown
- 1994-01-19 AU AU60872/94A patent/AU683048B2/en not_active Expired - Fee Related
- 1994-01-19 JP JP6517083A patent/JP2719445B2/ja not_active Expired - Fee Related
- 1994-01-19 CZ CZ951801A patent/CZ180195A3/cs unknown
- 1994-11-23 EE EE9400394A patent/EE9400394A/xx unknown
-
1995
- 1995-05-25 US US08/449,980 patent/US5698548A/en not_active Expired - Lifetime
- 1995-07-20 NO NO952884A patent/NO952884L/no unknown
- 1995-07-20 FI FI953497A patent/FI953497A/fi not_active Application Discontinuation
- 1995-07-21 KR KR1019950702988A patent/KR960700227A/ko active IP Right Grant
-
2001
- 2001-05-31 GR GR20010400814T patent/GR3035963T3/el not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0337549A1 (fr) | 1988-04-11 | 1989-10-18 | Merck & Co. Inc. | Azétidinones nouvelles substituées comme agents anti-inflammatoires et anti-dégénératifs |
US4983597A (en) | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
WO1993002048A1 (fr) | 1991-07-23 | 1993-02-04 | Schering Corporation | Composes de beta-lactame substitues utilises comme agents d'hypocholesterolemie, et procedes de preparation |
Non-Patent Citations (2)
Title |
---|
ILLINGWORTH DR: "An overview of lipid-lowering drugs.", DRUGS, 1988, pages 63 - 71, XP000617212, DOI: doi:10.2165/00003495-198800363-00015 |
J L WITZTUM: "Current approaches to drug therapy for the hypercholesterolemic patient", CIRCULATION, 1989, pages 1101 - 1114, XP000617211 |
Also Published As
Publication number | Publication date |
---|---|
PT681569E (pt) | 2001-06-29 |
LTIP1764A (en) | 1995-02-27 |
NO952884L (no) | 1995-09-20 |
JPH08501110A (ja) | 1996-02-06 |
JP2719445B2 (ja) | 1998-02-25 |
EE9400394A (et) | 1996-06-17 |
ATE199899T1 (de) | 2001-04-15 |
ES2155849T3 (es) | 2001-06-01 |
GR3035963T3 (en) | 2001-08-31 |
HU9502194D0 (en) | 1995-09-28 |
ZA94386B (en) | 1994-07-19 |
KR960700227A (ko) | 1996-01-19 |
FI953497A0 (fi) | 1995-07-20 |
DE69426924T2 (de) | 2001-08-16 |
US5698548A (en) | 1997-12-16 |
PL309978A1 (en) | 1995-11-13 |
NZ261714A (en) | 1997-02-24 |
DE69426924D1 (de) | 2001-04-26 |
IL108368A0 (en) | 1994-04-12 |
CA2154257A1 (fr) | 1994-08-04 |
SI9400022A (en) | 1995-02-28 |
NO952884D0 (no) | 1995-07-20 |
FI953497A (fi) | 1995-07-20 |
AU6087294A (en) | 1994-08-15 |
AU683048B2 (en) | 1997-10-30 |
DK0681569T3 (da) | 2001-04-23 |
CN1118163A (zh) | 1996-03-06 |
EP0681569A1 (fr) | 1995-11-15 |
WO1994017038A1 (fr) | 1994-08-04 |
EP0681569B1 (fr) | 2001-03-21 |
CZ180195A3 (en) | 1996-01-17 |
HUT72592A (en) | 1996-05-28 |
CA2154257C (fr) | 1999-05-25 |
SK91195A3 (en) | 1995-12-06 |
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