FI953497A - Spirosykloalkyylisubstituoidut atsetidinonit, jotka ovat käyttökelpoisia hypokolesteroleemisina aineina - Google Patents
Spirosykloalkyylisubstituoidut atsetidinonit, jotka ovat käyttökelpoisia hypokolesteroleemisina aineina Download PDFInfo
- Publication number
- FI953497A FI953497A FI953497A FI953497A FI953497A FI 953497 A FI953497 A FI 953497A FI 953497 A FI953497 A FI 953497A FI 953497 A FI953497 A FI 953497A FI 953497 A FI953497 A FI 953497A
- Authority
- FI
- Finland
- Prior art keywords
- optionally
- alkenylene
- sum
- substituted
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US643993A | 1993-01-21 | 1993-01-21 | |
PCT/US1994/000421 WO1994017038A1 (fr) | 1993-01-21 | 1994-01-19 | Azetidinones a substitution spirocycloalkyle utilisees comme agents hypocholesterolemiques |
Publications (2)
Publication Number | Publication Date |
---|---|
FI953497A true FI953497A (fi) | 1995-07-20 |
FI953497A0 FI953497A0 (fi) | 1995-07-20 |
Family
ID=21720894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI953497A FI953497A0 (fi) | 1993-01-21 | 1995-07-20 | Spirosykloalkyylisubstituoidut atsetidinonit, jotka ovat käyttökelpoisia hypokolesteroleemisina aineina |
Country Status (26)
Country | Link |
---|---|
US (1) | US5698548A (fr) |
EP (1) | EP0681569B1 (fr) |
JP (1) | JP2719445B2 (fr) |
KR (1) | KR960700227A (fr) |
CN (1) | CN1118163A (fr) |
AT (1) | ATE199899T1 (fr) |
AU (1) | AU683048B2 (fr) |
CA (1) | CA2154257C (fr) |
CZ (1) | CZ180195A3 (fr) |
DE (1) | DE69426924T2 (fr) |
DK (1) | DK0681569T3 (fr) |
EE (1) | EE9400394A (fr) |
ES (1) | ES2155849T3 (fr) |
FI (1) | FI953497A0 (fr) |
GR (1) | GR3035963T3 (fr) |
HU (1) | HUT72592A (fr) |
IL (1) | IL108368A0 (fr) |
LT (1) | LT3595B (fr) |
NO (1) | NO952884L (fr) |
NZ (1) | NZ261714A (fr) |
PL (1) | PL309978A1 (fr) |
PT (1) | PT681569E (fr) |
SI (1) | SI9400022A (fr) |
SK (1) | SK91195A3 (fr) |
WO (1) | WO1994017038A1 (fr) |
ZA (1) | ZA94386B (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
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BR9306619A (pt) * | 1992-06-26 | 1998-12-08 | Pfizer | Glicosídeos esteroidais para o tratamento da hipercolesterolemia |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
US5648484A (en) * | 1995-03-07 | 1997-07-15 | Schering Corporation | Catalytic enantioselective synthesis of a spriofused azetidinone |
WO1997016455A1 (fr) * | 1995-10-31 | 1997-05-09 | Schering Corporation | 2-azetidinones substituees par un sucre, utiles comme agents hypocholesterolemiants. |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
WO2000063703A1 (fr) | 1999-04-16 | 2000-10-26 | Schering Corporation | Utilisation de composes a base d'azetodinone |
US6297268B1 (en) | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
CN100475829C (zh) * | 2000-12-20 | 2009-04-08 | 先灵公司 | 作为降血胆甾醇剂的糖取代的2-氮杂环丁烷酮 |
PT1353694E (pt) * | 2001-01-26 | 2008-03-12 | Schering Corp | Combinações de ezetimiba com aspirina para o tratamento de doenças vasculares |
AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
EP1911462A3 (fr) | 2001-01-26 | 2011-11-30 | Schering Corporation | Combinaisons comprenant un inhibiteur d'absorption de stérol |
RU2756946C2 (ru) * | 2001-01-26 | 2021-10-07 | Мерк Шарп И Доум Корп. | Применение замещенных азетидинонов для лечения ситостеролемии |
RS50386B (sr) | 2001-03-28 | 2009-12-31 | Schering Corporation, | Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
EP1429756B1 (fr) * | 2001-09-21 | 2006-11-22 | Schering Corporation | Methodes et combinaisons therapeutiques utiles pour le traitement du xanthome effectue avec des inhibiteurs d'absorption du sterol |
EP1859796A3 (fr) * | 2001-09-21 | 2008-07-02 | Schering Corporation | Treatment de xanthoma avec des dérivés d'azétidines en tant qu'inhibiteurs d'absorption des stérols |
US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) * | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
US6933292B2 (en) * | 2002-07-30 | 2005-08-23 | Children's Medical Center Corporation | Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors |
EP1601668B1 (fr) | 2003-03-07 | 2008-08-27 | Schering Corporation | Composes d'azetidinone substitues, leurs formulations et utilisations en vue du traitement de l'hypercholesterolemie |
ES2318274T3 (es) | 2003-03-07 | 2009-05-01 | Schering Corporation | Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia. |
EP1622569B1 (fr) | 2003-04-24 | 2015-12-02 | Incyte Corporation | Derives d'aza spiro alcane en tant qu'inhibiteurs de metalloproteases |
JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
EP1918000A2 (fr) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinaisons d'agents de modulation lipide et azétidinones substitués et traitements pour conditions vasculaires |
CA2544309A1 (fr) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinaisons de modulateurs lipidiques et d'azetidinones substituees et traitements d'affections vasculaires |
WO2005061452A1 (fr) | 2003-12-23 | 2005-07-07 | Astrazeneca Ab | Derives diphenylazetidinone a activite inhibitrice de l'absorption du cholesterol |
EP1699760B1 (fr) * | 2003-12-23 | 2017-05-17 | Merck Sharp & Dohme Corp. | Composes anti-hypercholesterolemie |
US7901893B2 (en) * | 2004-01-16 | 2011-03-08 | Merck Sharp & Dohme Corp. | NPC1L1 (NPC3) and methods of identifying ligands thereof |
EP1747197A1 (fr) * | 2004-05-10 | 2007-01-31 | Laboratorios Del Dr. Esteve, S.A. | Fonctionnalisation stereoselective et protection de spirolactames |
EP1598336A1 (fr) | 2004-05-20 | 2005-11-23 | Laboratorios Del Dr. Esteve, S.A. | Hydroxylation, fonctionnalisation et protection regioselective de spirolactames |
US20080045726A1 (en) * | 2004-05-10 | 2008-02-21 | Laboratorios Del Dr. Esteve, S.A. | Spirolactams and Their Synthesis |
EP1676836A1 (fr) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Hydroxylation, fonctionnalisation et protection regioselective de spirolactames |
US7291728B2 (en) | 2004-05-10 | 2007-11-06 | Laboratories Del Dr. Esteve, S.A. | Spirolactams and their synthesis |
EP1807070A1 (fr) * | 2004-09-29 | 2007-07-18 | Schering Corporation | Combinaisons d'azetidinones substituees et d'antagonistes cb1 |
CA2589483C (fr) | 2004-12-03 | 2013-10-29 | Schering Corporation | Piperazines substituees en tant qu'antagonistes de cb1 |
US8361999B2 (en) | 2005-04-04 | 2013-01-29 | Pontificia Universidad Catolica De Chile | Methods of treating cholesterol gallstone disease with ezetimibe |
AU2006262441A1 (en) * | 2005-06-20 | 2007-01-04 | Schering Corporation | Piperidine derivatives useful as histamine H3 antagonists |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
MX2008008340A (es) * | 2005-12-21 | 2008-09-03 | Schering Corp | Tratamiento de enfermedad de higado graso no alcoholica usando agentes reductores de colesterol y/o antagonista/agonista inverso de receptor de histamina 3. |
CA2637565A1 (fr) | 2006-01-18 | 2007-07-26 | Schering Corporation | Modulateurs de recepteurs de cannibinoides |
US7910698B2 (en) | 2006-02-24 | 2011-03-22 | Schering Corporation | NPC1L1 orthologues |
AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
US20080103122A1 (en) * | 2006-09-05 | 2008-05-01 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
EP2061462A2 (fr) * | 2006-09-15 | 2009-05-27 | Schering Corporation | Procédé de traitement de la douleur, du diabète et des troubles du métabolisme lipidique |
US20080070890A1 (en) * | 2006-09-15 | 2008-03-20 | Burnett Duane A | Spirocyclic Azetidinone Compounds and Methods of Use Thereof |
WO2008033447A1 (fr) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Dérivés d'azétidine et d'azétidone convenant dans le traitement de la douleur et des troubles du métabolisme des lipides |
CN101583612A (zh) * | 2006-09-15 | 2009-11-18 | 先灵公司 | 治疗脂质代谢障碍的氮杂环丁酮衍生物 |
US7902157B2 (en) | 2006-09-15 | 2011-03-08 | Schering Corporation | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
US20080076750A1 (en) * | 2006-09-15 | 2008-03-27 | Aslanian Robert G | Azetidinone Derivatives and Methods of Use Thereof |
AR062790A1 (es) | 2006-09-15 | 2008-12-03 | Schering Corp | Derivados de azetidina utiles en el tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos |
US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
WO2009005671A2 (fr) * | 2007-06-28 | 2009-01-08 | Schering Corporation | Pipérazines à substitution servant d'antagonistes des récepteurs cb1 |
RU2010102478A (ru) | 2007-06-28 | 2011-08-10 | Интэрвэт Интэрнэшнл Б.Ф. (NL) | Замещенные пиперазины как антагонисты св1 |
WO2010100255A1 (fr) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Compositions pharmaceutiques hypocholestérolémiques |
CN101993403B (zh) * | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
KR101455917B1 (ko) | 2010-03-19 | 2014-11-03 | 화이자 인코포레이티드 | 2,3-디히드로-1h-인덴-1-일-2,7-디아자스피로[3.5]노난 유도체 및 그렐린 수용체의 길항제 또는 역 작용제로서의 그 용도 |
MX365046B (es) | 2012-05-01 | 2019-05-17 | Althera Life Sciencies Llc | Formulacion de tableta oral que consiste de una combinacion fija de rosuvastatina y ezetimiba para el tratamiento de hiperlipidemia y enfermedades cardiovasculares. |
CN104496839B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
CN104496838B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
US11401273B2 (en) | 2018-11-20 | 2022-08-02 | Piramal Pharma Limited | Asymmetric synthesis of Azaspiro compounds |
WO2020191141A1 (fr) | 2019-03-20 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Traitement de niveaux de lipides accrus avec des inhibiteurs du facteur de transcription 1 de liaison à un élément régulateur de stérol (srebf1) |
EP3942047A1 (fr) | 2019-03-20 | 2022-01-26 | Regeneron Pharmaceuticals, Inc. | Traitement de niveaux de lipides accrus avec des inhibiteurs de protéine d'activation de clivage de protéine de liaison d'élément régulateur de stérol (scap) |
TW202340202A (zh) * | 2021-12-22 | 2023-10-16 | 美國加利福尼亞大學董事會 | Gtp酶抑制劑及其用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2048080C3 (de) * | 1970-09-30 | 1979-11-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von N-substituierten 33-disubstituierten ß -Lactamen |
US4692515A (en) * | 1984-09-24 | 1987-09-08 | Pennwalt Corporation | Adamantane-spirolactams |
NZ228600A (en) | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
US4983597A (en) | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
US5130425A (en) * | 1990-10-12 | 1992-07-14 | American Home Products Corporation | Spiro-lactams and analogs thereof useful as aldose reductase inhibitors |
EP0524595A1 (fr) | 1991-07-23 | 1993-01-27 | Schering Corporation | Dérivés de bêta-lactame substitués comme agents hypocholestérolémiques et leurs procédés de préparation |
-
1994
- 1994-01-13 LT LTIP1764A patent/LT3595B/lt not_active IP Right Cessation
- 1994-01-19 HU HU9502194A patent/HUT72592A/hu unknown
- 1994-01-19 AT AT94907200T patent/ATE199899T1/de not_active IP Right Cessation
- 1994-01-19 DK DK94907200T patent/DK0681569T3/da active
- 1994-01-19 CA CA002154257A patent/CA2154257C/fr not_active Expired - Fee Related
- 1994-01-19 EP EP94907200A patent/EP0681569B1/fr not_active Expired - Lifetime
- 1994-01-19 CZ CZ951801A patent/CZ180195A3/cs unknown
- 1994-01-19 SI SI9400022A patent/SI9400022A/sl unknown
- 1994-01-19 NZ NZ261714A patent/NZ261714A/en unknown
- 1994-01-19 SK SK911-95A patent/SK91195A3/sk unknown
- 1994-01-19 ZA ZA94386A patent/ZA94386B/xx unknown
- 1994-01-19 WO PCT/US1994/000421 patent/WO1994017038A1/fr not_active Application Discontinuation
- 1994-01-19 JP JP6517083A patent/JP2719445B2/ja not_active Expired - Fee Related
- 1994-01-19 DE DE69426924T patent/DE69426924T2/de not_active Expired - Lifetime
- 1994-01-19 CN CN94191245A patent/CN1118163A/zh active Pending
- 1994-01-19 PT PT94907200T patent/PT681569E/pt unknown
- 1994-01-19 IL IL10836894A patent/IL108368A0/xx unknown
- 1994-01-19 AU AU60872/94A patent/AU683048B2/en not_active Expired - Fee Related
- 1994-01-19 ES ES94907200T patent/ES2155849T3/es not_active Expired - Lifetime
- 1994-01-19 PL PL94309978A patent/PL309978A1/xx unknown
- 1994-11-23 EE EE9400394A patent/EE9400394A/xx unknown
-
1995
- 1995-05-25 US US08/449,980 patent/US5698548A/en not_active Expired - Lifetime
- 1995-07-20 FI FI953497A patent/FI953497A0/fi not_active Application Discontinuation
- 1995-07-20 NO NO952884A patent/NO952884L/no unknown
- 1995-07-21 KR KR1019950702988A patent/KR960700227A/ko active IP Right Grant
-
2001
- 2001-05-31 GR GR20010400814T patent/GR3035963T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU683048B2 (en) | 1997-10-30 |
ZA94386B (en) | 1994-07-19 |
CN1118163A (zh) | 1996-03-06 |
DE69426924D1 (de) | 2001-04-26 |
LTIP1764A (en) | 1995-02-27 |
SK91195A3 (en) | 1995-12-06 |
NO952884L (no) | 1995-09-20 |
AU6087294A (en) | 1994-08-15 |
GR3035963T3 (en) | 2001-08-31 |
CA2154257A1 (fr) | 1994-08-04 |
DK0681569T3 (da) | 2001-04-23 |
NO952884D0 (no) | 1995-07-20 |
FI953497A0 (fi) | 1995-07-20 |
JPH08501110A (ja) | 1996-02-06 |
SI9400022A (en) | 1995-02-28 |
EP0681569A1 (fr) | 1995-11-15 |
ES2155849T3 (es) | 2001-06-01 |
CZ180195A3 (en) | 1996-01-17 |
CA2154257C (fr) | 1999-05-25 |
EP0681569B1 (fr) | 2001-03-21 |
KR960700227A (ko) | 1996-01-19 |
PT681569E (pt) | 2001-06-29 |
NZ261714A (en) | 1997-02-24 |
DE69426924T2 (de) | 2001-08-16 |
ATE199899T1 (de) | 2001-04-15 |
HUT72592A (en) | 1996-05-28 |
EE9400394A (et) | 1996-06-17 |
JP2719445B2 (ja) | 1998-02-25 |
PL309978A1 (en) | 1995-11-13 |
WO1994017038A1 (fr) | 1994-08-04 |
HU9502194D0 (en) | 1995-09-28 |
LT3595B (en) | 1995-12-27 |
US5698548A (en) | 1997-12-16 |
IL108368A0 (en) | 1994-04-12 |
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