KR960700227A - 저콜레스테린혈증제로서 유용한 스피로사이클로알킬 치환된 아제티디논(Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents) - Google Patents
저콜레스테린혈증제로서 유용한 스피로사이클로알킬 치환된 아제티디논(Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents)Info
- Publication number
- KR960700227A KR960700227A KR1019950702988A KR19950702988A KR960700227A KR 960700227 A KR960700227 A KR 960700227A KR 1019950702988 A KR1019950702988 A KR 1019950702988A KR 19950702988 A KR19950702988 A KR 19950702988A KR 960700227 A KR960700227 A KR 960700227A
- Authority
- KR
- South Korea
- Prior art keywords
- optionally
- alkenylene
- sum
- substituted
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US643993A | 1993-01-21 | 1993-01-21 | |
PCT/US1994/000421 WO1994017038A1 (en) | 1993-01-21 | 1994-01-19 | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960700227A true KR960700227A (ko) | 1996-01-19 |
Family
ID=21720894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950702988A KR960700227A (ko) | 1993-01-21 | 1995-07-21 | 저콜레스테린혈증제로서 유용한 스피로사이클로알킬 치환된 아제티디논(Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents) |
Country Status (26)
Country | Link |
---|---|
US (1) | US5698548A (ko) |
EP (1) | EP0681569B1 (ko) |
JP (1) | JP2719445B2 (ko) |
KR (1) | KR960700227A (ko) |
CN (1) | CN1118163A (ko) |
AT (1) | ATE199899T1 (ko) |
AU (1) | AU683048B2 (ko) |
CA (1) | CA2154257C (ko) |
CZ (1) | CZ180195A3 (ko) |
DE (1) | DE69426924T2 (ko) |
DK (1) | DK0681569T3 (ko) |
EE (1) | EE9400394A (ko) |
ES (1) | ES2155849T3 (ko) |
FI (1) | FI953497A0 (ko) |
GR (1) | GR3035963T3 (ko) |
HU (1) | HUT72592A (ko) |
IL (1) | IL108368A0 (ko) |
LT (1) | LT3595B (ko) |
NO (1) | NO952884L (ko) |
NZ (1) | NZ261714A (ko) |
PL (1) | PL309978A1 (ko) |
PT (1) | PT681569E (ko) |
SI (1) | SI9400022A (ko) |
SK (1) | SK91195A3 (ko) |
WO (1) | WO1994017038A1 (ko) |
ZA (1) | ZA94386B (ko) |
Families Citing this family (68)
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CZ331094A3 (en) * | 1992-06-26 | 1995-09-13 | Pfizer | Steroidal glycosides and their use for treating hypercholesterolemia and atherosclerosis |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
US5648484A (en) * | 1995-03-07 | 1997-07-15 | Schering Corporation | Catalytic enantioselective synthesis of a spriofused azetidinone |
TW448181B (en) * | 1995-10-31 | 2001-08-01 | Schering Corp | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
US6593078B1 (en) | 1999-04-16 | 2003-07-15 | Schering Corporation | Use of azetidinone compounds |
US6297268B1 (en) | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
SI1593670T1 (sl) * | 2000-12-20 | 2007-12-31 | Schering Corp | S hidroksi substituirani 2-azetidinoni, uporabni kot sredstva za zniĹľevanje holesterola |
US7417039B2 (en) * | 2001-01-26 | 2008-08-26 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
ATE381347T1 (de) * | 2001-01-26 | 2008-01-15 | Schering Corp | Kombinationen von ezetimibe und aspirin zur behandlung von kardiovaskulären erkrankungen |
EE05453B1 (et) | 2001-03-28 | 2011-08-15 | Schering Corporation | Protsess asetidinoonvahehendite valmistamiseks |
MXPA04002573A (es) * | 2001-09-21 | 2004-06-18 | Schering Corp | Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol. |
SI1429756T1 (sl) * | 2001-09-21 | 2007-02-28 | Schering Corp | Zdravljenje ksantomov z azetidinonskimi derivati kot inhibitorji absorpcije sterola |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
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US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
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AU2003254261B2 (en) * | 2002-07-30 | 2008-04-17 | Children's Medical Center Corporation | Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors |
ATE406364T1 (de) | 2003-03-07 | 2008-09-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
ES2563304T3 (es) | 2003-04-24 | 2016-03-14 | Incyte Holdings Corporation | Derivados azaespiro alcano como inhibidores de metaloproteasas |
JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
JP2007510659A (ja) * | 2003-11-05 | 2007-04-26 | シェーリング コーポレイション | 脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置 |
EP1699759B1 (en) | 2003-12-23 | 2010-10-20 | AstraZeneca AB | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
AU2004308332B2 (en) * | 2003-12-23 | 2008-04-10 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
WO2005069900A2 (en) * | 2004-01-16 | 2005-08-04 | Merck & Co., Inc. | Npc1l1 (npc3) and methods of identifying ligands thereof |
EP1676836A1 (en) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Regioselective hydroxylation, functionalisation and protection of spirolactams II |
WO2005108356A1 (en) * | 2004-05-10 | 2005-11-17 | Laboratorios Del Dr. Esteve, S.A. | Spirolactams and their synthesis |
US20080045726A1 (en) * | 2004-05-10 | 2008-02-21 | Laboratorios Del Dr. Esteve, S.A. | Spirolactams and Their Synthesis |
EP1598336A1 (en) * | 2004-05-20 | 2005-11-23 | Laboratorios Del Dr. Esteve, S.A. | Regioselective hydroxylation, functionalisation and protection of spirolactams |
US7291728B2 (en) | 2004-05-10 | 2007-11-06 | Laboratories Del Dr. Esteve, S.A. | Spirolactams and their synthesis |
WO2006039334A1 (en) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinations of substituted azetidonones and cb1 antagonists |
MX2007006695A (es) | 2004-12-03 | 2007-08-14 | Schering Corp | Piperazinas sustituidas como antagonistas de cb1. |
US8361999B2 (en) | 2005-04-04 | 2013-01-29 | Pontificia Universidad Catolica De Chile | Methods of treating cholesterol gallstone disease with ezetimibe |
KR20080021082A (ko) * | 2005-06-20 | 2008-03-06 | 쉐링 코포레이션 | 히스타민 h3 길항제로서 유용한 피페리딘 유도체 |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
WO2007075702A2 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist |
NZ569814A (en) | 2006-01-18 | 2011-10-28 | Schering Corp | Cannibinoid receptor modulators |
US7910698B2 (en) * | 2006-02-24 | 2011-03-22 | Schering Corporation | NPC1L1 orthologues |
AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
JP2010502702A (ja) * | 2006-09-05 | 2010-01-28 | シェーリング コーポレイション | 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物 |
AR062841A1 (es) * | 2006-09-15 | 2008-12-10 | Schering Corp | Tratamiento del dolor, diabetes, y trastornos del metabolismo de los lipidos |
CA2663500A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism |
CN101541805A (zh) * | 2006-09-15 | 2009-09-23 | 先灵公司 | 用于治疗疼痛和脂代射紊乱的氮杂环丁烷和氮杂环丁酮衍生物 |
JP2010503677A (ja) | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 脂質代謝の障害を治療するためのアゼチジノン誘導体 |
JP2010503678A (ja) * | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | アゼチジノン誘導体およびその使用方法 |
US20080070890A1 (en) * | 2006-09-15 | 2008-03-20 | Burnett Duane A | Spirocyclic Azetidinone Compounds and Methods of Use Thereof |
US20080070888A1 (en) * | 2006-09-15 | 2008-03-20 | Mckittrick Brian A | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
MX2010000334A (es) | 2007-06-28 | 2010-04-22 | Intervet Int Bv | Piperazinas sustituidas como antagonistas de cannabinoides 1. |
CA2694264A1 (en) * | 2007-06-28 | 2009-01-08 | Intervet International B.V. | Substituted piperazines as cb1 antagonists |
CA2754384A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
CN101993403B (zh) * | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
WO2011114271A1 (en) | 2010-03-19 | 2011-09-22 | Pfizer Inc. | 2,3 dihydro-1h-inden-1-yl- 2,7-diazaspiro [3.6] nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor |
PL2844233T3 (pl) | 2012-05-01 | 2020-09-07 | Althera Life Sciences, Llc | Preparat w postaci tabletki do stosowania doustnego składający się ze stałego połączenia rosuwastatyny i ezetymibu w leczeniu hiperlipidemii i chorób sercowo-naczyniowych |
CN104496838B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
CN104496839B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
WO2020104930A1 (en) | 2018-11-20 | 2020-05-28 | Piramal Enterprises Limited | An improved asymmetric synthesis of azaspiro compounds |
WO2020191163A1 (en) | 2019-03-20 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors |
US11504390B2 (en) | 2019-03-20 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors |
TW202340202A (zh) * | 2021-12-22 | 2023-10-16 | 美國加利福尼亞大學董事會 | Gtp酶抑制劑及其用途 |
Family Cites Families (6)
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DE2048080C3 (de) * | 1970-09-30 | 1979-11-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von N-substituierten 33-disubstituierten ß -Lactamen |
US4692515A (en) * | 1984-09-24 | 1987-09-08 | Pennwalt Corporation | Adamantane-spirolactams |
NZ228600A (en) | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
US4983597A (en) | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
US5130425A (en) * | 1990-10-12 | 1992-07-14 | American Home Products Corporation | Spiro-lactams and analogs thereof useful as aldose reductase inhibitors |
HUT67341A (en) * | 1991-07-23 | 1995-03-28 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof |
-
1994
- 1994-01-13 LT LTIP1764A patent/LT3595B/lt not_active IP Right Cessation
- 1994-01-19 NZ NZ261714A patent/NZ261714A/en unknown
- 1994-01-19 DE DE69426924T patent/DE69426924T2/de not_active Expired - Lifetime
- 1994-01-19 CZ CZ951801A patent/CZ180195A3/cs unknown
- 1994-01-19 EP EP94907200A patent/EP0681569B1/en not_active Expired - Lifetime
- 1994-01-19 CN CN94191245A patent/CN1118163A/zh active Pending
- 1994-01-19 AU AU60872/94A patent/AU683048B2/en not_active Expired - Fee Related
- 1994-01-19 IL IL10836894A patent/IL108368A0/xx unknown
- 1994-01-19 HU HU9502194A patent/HUT72592A/hu unknown
- 1994-01-19 AT AT94907200T patent/ATE199899T1/de not_active IP Right Cessation
- 1994-01-19 ES ES94907200T patent/ES2155849T3/es not_active Expired - Lifetime
- 1994-01-19 WO PCT/US1994/000421 patent/WO1994017038A1/en not_active Application Discontinuation
- 1994-01-19 CA CA002154257A patent/CA2154257C/en not_active Expired - Fee Related
- 1994-01-19 PL PL94309978A patent/PL309978A1/xx unknown
- 1994-01-19 ZA ZA94386A patent/ZA94386B/xx unknown
- 1994-01-19 SK SK911-95A patent/SK91195A3/sk unknown
- 1994-01-19 PT PT94907200T patent/PT681569E/pt unknown
- 1994-01-19 JP JP6517083A patent/JP2719445B2/ja not_active Expired - Fee Related
- 1994-01-19 DK DK94907200T patent/DK0681569T3/da active
- 1994-01-19 SI SI9400022A patent/SI9400022A/sl unknown
- 1994-11-23 EE EE9400394A patent/EE9400394A/xx unknown
-
1995
- 1995-05-25 US US08/449,980 patent/US5698548A/en not_active Expired - Lifetime
- 1995-07-20 FI FI953497A patent/FI953497A0/fi not_active Application Discontinuation
- 1995-07-20 NO NO952884A patent/NO952884L/no unknown
- 1995-07-21 KR KR1019950702988A patent/KR960700227A/ko active IP Right Grant
-
2001
- 2001-05-31 GR GR20010400814T patent/GR3035963T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
LT3595B (en) | 1995-12-27 |
NO952884L (no) | 1995-09-20 |
NZ261714A (en) | 1997-02-24 |
JP2719445B2 (ja) | 1998-02-25 |
CA2154257C (en) | 1999-05-25 |
DE69426924T2 (de) | 2001-08-16 |
CZ180195A3 (en) | 1996-01-17 |
ZA94386B (en) | 1994-07-19 |
NO952884D0 (no) | 1995-07-20 |
GR3035963T3 (en) | 2001-08-31 |
HUT72592A (en) | 1996-05-28 |
SK91195A3 (en) | 1995-12-06 |
JPH08501110A (ja) | 1996-02-06 |
PL309978A1 (en) | 1995-11-13 |
FI953497A (fi) | 1995-07-20 |
WO1994017038A1 (en) | 1994-08-04 |
ATE199899T1 (de) | 2001-04-15 |
AU683048B2 (en) | 1997-10-30 |
CN1118163A (zh) | 1996-03-06 |
CA2154257A1 (en) | 1994-08-04 |
EP0681569B1 (en) | 2001-03-21 |
EP0681569A1 (en) | 1995-11-15 |
PT681569E (pt) | 2001-06-29 |
ES2155849T3 (es) | 2001-06-01 |
SI9400022A (en) | 1995-02-28 |
EE9400394A (et) | 1996-06-17 |
HU9502194D0 (en) | 1995-09-28 |
IL108368A0 (en) | 1994-04-12 |
FI953497A0 (fi) | 1995-07-20 |
US5698548A (en) | 1997-12-16 |
LTIP1764A (en) | 1995-02-27 |
DE69426924D1 (de) | 2001-04-26 |
AU6087294A (en) | 1994-08-15 |
DK0681569T3 (da) | 2001-04-23 |
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