ATE199899T1 - Spirocycloalkyl-substituierte azetidinone als hypocholesterolemische mittel - Google Patents

Spirocycloalkyl-substituierte azetidinone als hypocholesterolemische mittel

Info

Publication number
ATE199899T1
ATE199899T1 AT94907200T AT94907200T ATE199899T1 AT E199899 T1 ATE199899 T1 AT E199899T1 AT 94907200 T AT94907200 T AT 94907200T AT 94907200 T AT94907200 T AT 94907200T AT E199899 T1 ATE199899 T1 AT E199899T1
Authority
AT
Austria
Prior art keywords
optionally
alkenylene
sum
substituted
image
Prior art date
Application number
AT94907200T
Other languages
English (en)
Inventor
Sundeep Dugar
John W Clader
Duane A Burnett
Margaret E Browne
Harry R Davis
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE199899T1 publication Critical patent/ATE199899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT94907200T 1993-01-21 1994-01-19 Spirocycloalkyl-substituierte azetidinone als hypocholesterolemische mittel ATE199899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US643993A 1993-01-21 1993-01-21
PCT/US1994/000421 WO1994017038A1 (en) 1993-01-21 1994-01-19 Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents

Publications (1)

Publication Number Publication Date
ATE199899T1 true ATE199899T1 (de) 2001-04-15

Family

ID=21720894

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94907200T ATE199899T1 (de) 1993-01-21 1994-01-19 Spirocycloalkyl-substituierte azetidinone als hypocholesterolemische mittel

Country Status (26)

Country Link
US (1) US5698548A (de)
EP (1) EP0681569B1 (de)
JP (1) JP2719445B2 (de)
KR (1) KR960700227A (de)
CN (1) CN1118163A (de)
AT (1) ATE199899T1 (de)
AU (1) AU683048B2 (de)
CA (1) CA2154257C (de)
CZ (1) CZ180195A3 (de)
DE (1) DE69426924T2 (de)
DK (1) DK0681569T3 (de)
EE (1) EE9400394A (de)
ES (1) ES2155849T3 (de)
FI (1) FI953497A0 (de)
GR (1) GR3035963T3 (de)
HU (1) HUT72592A (de)
IL (1) IL108368A0 (de)
LT (1) LT3595B (de)
NO (1) NO952884L (de)
NZ (1) NZ261714A (de)
PL (1) PL309978A1 (de)
PT (1) PT681569E (de)
SI (1) SI9400022A (de)
SK (1) SK91195A3 (de)
WO (1) WO1994017038A1 (de)
ZA (1) ZA94386B (de)

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US7192944B2 (en) 2003-03-07 2007-03-20 Schering Corp. Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
HRP20160180T1 (hr) 2003-04-24 2016-03-25 Incyte Holdings Corp Derivati aza spiro alkana kao inhibitori metaloproteaza
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US8361999B2 (en) 2005-04-04 2013-01-29 Pontificia Universidad Catolica De Chile Methods of treating cholesterol gallstone disease with ezetimibe
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US20070161578A1 (en) * 2005-12-21 2007-07-12 Hwa Joyce J Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist
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US20080070888A1 (en) * 2006-09-15 2008-03-20 Mckittrick Brian A Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism
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Also Published As

Publication number Publication date
DE69426924T2 (de) 2001-08-16
JPH08501110A (ja) 1996-02-06
HUT72592A (en) 1996-05-28
EP0681569B1 (de) 2001-03-21
DK0681569T3 (da) 2001-04-23
SI9400022A (en) 1995-02-28
FI953497A7 (fi) 1995-07-20
CA2154257A1 (en) 1994-08-04
PL309978A1 (en) 1995-11-13
CA2154257C (en) 1999-05-25
KR960700227A (ko) 1996-01-19
AU6087294A (en) 1994-08-15
CN1118163A (zh) 1996-03-06
NZ261714A (en) 1997-02-24
EP0681569A1 (de) 1995-11-15
FI953497A0 (fi) 1995-07-20
GR3035963T3 (en) 2001-08-31
ES2155849T3 (es) 2001-06-01
DE69426924D1 (de) 2001-04-26
CZ180195A3 (en) 1996-01-17
US5698548A (en) 1997-12-16
HU9502194D0 (en) 1995-09-28
NO952884D0 (no) 1995-07-20
AU683048B2 (en) 1997-10-30
ZA94386B (en) 1994-07-19
LTIP1764A (en) 1995-02-27
SK91195A3 (en) 1995-12-06
JP2719445B2 (ja) 1998-02-25
IL108368A0 (en) 1994-04-12
NO952884L (no) 1995-09-20
LT3595B (en) 1995-12-27
WO1994017038A1 (en) 1994-08-04
PT681569E (pt) 2001-06-29
EE9400394A (et) 1996-06-17

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