IL108368A0 - Spirocycloalkyl-substituted azetidinones useful as hypocholestrerolemic agents - Google Patents
Spirocycloalkyl-substituted azetidinones useful as hypocholestrerolemic agentsInfo
- Publication number
- IL108368A0 IL108368A0 IL10836894A IL10836894A IL108368A0 IL 108368 A0 IL108368 A0 IL 108368A0 IL 10836894 A IL10836894 A IL 10836894A IL 10836894 A IL10836894 A IL 10836894A IL 108368 A0 IL108368 A0 IL 108368A0
- Authority
- IL
- Israel
- Prior art keywords
- optionally
- alkenylene
- sum
- substituted
- image
- Prior art date
Links
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 3
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical class C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical class 0.000 abstract 2
- 125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 abstract 2
- 125000003454 indenyl group Chemical class C1(C=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000001624 naphthyl group Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001712 tetrahydronaphthyl group Chemical class C1(CCCC2=CC=CC=C12)* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 125000002047 benzodioxolyl group Chemical class O1OC(C2=C1C=CC=C2)* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US643993A | 1993-01-21 | 1993-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL108368A0 true IL108368A0 (en) | 1994-04-12 |
Family
ID=21720894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10836894A IL108368A0 (en) | 1993-01-21 | 1994-01-19 | Spirocycloalkyl-substituted azetidinones useful as hypocholestrerolemic agents |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5698548A (de) |
| EP (1) | EP0681569B1 (de) |
| JP (1) | JP2719445B2 (de) |
| KR (1) | KR960700227A (de) |
| CN (1) | CN1118163A (de) |
| AT (1) | ATE199899T1 (de) |
| AU (1) | AU683048B2 (de) |
| CA (1) | CA2154257C (de) |
| CZ (1) | CZ180195A3 (de) |
| DE (1) | DE69426924T2 (de) |
| DK (1) | DK0681569T3 (de) |
| EE (1) | EE9400394A (de) |
| ES (1) | ES2155849T3 (de) |
| FI (1) | FI953497A0 (de) |
| GR (1) | GR3035963T3 (de) |
| HU (1) | HUT72592A (de) |
| IL (1) | IL108368A0 (de) |
| LT (1) | LT3595B (de) |
| NO (1) | NO952884L (de) |
| NZ (1) | NZ261714A (de) |
| PL (1) | PL309978A1 (de) |
| PT (1) | PT681569E (de) |
| SI (1) | SI9400022A (de) |
| SK (1) | SK91195A3 (de) |
| WO (1) | WO1994017038A1 (de) |
| ZA (1) | ZA94386B (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU94046294A (ru) * | 1992-06-26 | 1996-10-10 | Пфайзер Инк. (US) | Стероидные гликозиды для лечения гиперхолестеринэмии |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| US5648484A (en) * | 1995-03-07 | 1997-07-15 | Schering Corporation | Catalytic enantioselective synthesis of a spriofused azetidinone |
| CA2235943C (en) * | 1995-10-31 | 2002-10-01 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6593078B1 (en) | 1999-04-16 | 2003-07-15 | Schering Corporation | Use of azetidinone compounds |
| US6297268B1 (en) | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| IL155771A0 (en) * | 2000-12-20 | 2003-12-23 | Schering Corp | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| KR20080067717A (ko) * | 2001-01-26 | 2008-07-21 | 쉐링 코포레이션 | 스테롤 흡수 억제제와 혈액 조절제를 포함하는 혈관 질환의치료 또는 예방용 약제학적 조성물 |
| AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
| ME00145B (me) * | 2001-01-26 | 2010-10-10 | Merck Sharp & Dohme | Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije |
| IL156445A0 (en) | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| WO2002079174A2 (en) | 2001-03-28 | 2002-10-10 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| EP1859796A3 (de) * | 2001-09-21 | 2008-07-02 | Schering Corporation | Behandlung von xanthom mit azetidinon-derivaten als hemmer der sterol absorption |
| ES2272776T3 (es) | 2001-09-21 | 2007-05-01 | Schering Corporation | Tratamiento de xantomas con derivados de azetidinona como inhibidores de la absorcion de esterol. |
| US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
| CA2493614C (en) * | 2002-07-30 | 2011-09-13 | Karykion Inc. | Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors |
| WO2004043457A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| DE602004016123D1 (de) | 2003-03-07 | 2008-10-09 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| DE602004018617D1 (de) | 2003-03-07 | 2009-02-05 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| US7192944B2 (en) | 2003-03-07 | 2007-03-20 | Schering Corp. | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| HRP20160180T1 (hr) | 2003-04-24 | 2016-03-25 | Incyte Holdings Corp | Derivati aza spiro alkana kao inhibitori metaloproteaza |
| JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
| EP1918000A2 (de) | 2003-11-05 | 2008-05-07 | Schering Corporation | Verbindungen aus lipidverändernden Wirkstoffen und substituierten Azetidinonen und Behandlungen für Gefäßzustände |
| EP1680189A2 (de) * | 2003-11-05 | 2006-07-19 | Schering Corporation | Kombinationen von lipidmodulierenden mitteln mit substituierten azetidinonen zur behandlung von vaskularen erkrankungen |
| WO2005062824A2 (en) * | 2003-12-23 | 2005-07-14 | Merck & Co., Inc. | Anti-hypercholesterolemic compounds |
| BRPI0418004A (pt) | 2003-12-23 | 2007-04-17 | Astrazeneca Ab | composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis, métodos para tratar ou prevenir condições hiperlipidêmicas, aterosclerose, mal de alzheimer, e tumores associados com colesterol, formulação farmacêutica, combinação, e, processo para preparar um composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis |
| US7901893B2 (en) * | 2004-01-16 | 2011-03-08 | Merck Sharp & Dohme Corp. | NPC1L1 (NPC3) and methods of identifying ligands thereof |
| EP1676836A1 (de) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Regioselektive Hydroxylierung, Funktionalisierung und Schutz von Spirolactamen |
| EP1598336A1 (de) * | 2004-05-20 | 2005-11-23 | Laboratorios Del Dr. Esteve, S.A. | Regioselektive Hydroxylierung, Funktionalisierung und Schutz von Spirolactamen |
| CA2566417A1 (en) * | 2004-05-10 | 2005-11-17 | Laboratorios Del Dr. Esteve, S.A. | Spirolactams and their synthesis |
| US7291728B2 (en) | 2004-05-10 | 2007-11-06 | Laboratories Del Dr. Esteve, S.A. | Spirolactams and their synthesis |
| US20080045726A1 (en) * | 2004-05-10 | 2008-02-21 | Laboratorios Del Dr. Esteve, S.A. | Spirolactams and Their Synthesis |
| CA2581596A1 (en) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinations of substituted azetidonones and cb1 antagonists |
| CN101115726A (zh) | 2004-12-03 | 2008-01-30 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
| US8361999B2 (en) | 2005-04-04 | 2013-01-29 | Pontificia Universidad Catolica De Chile | Methods of treating cholesterol gallstone disease with ezetimibe |
| US7635705B2 (en) * | 2005-06-20 | 2009-12-22 | Schering Corporation | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| US20070161578A1 (en) * | 2005-12-21 | 2007-07-12 | Hwa Joyce J | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist |
| PE20071320A1 (es) | 2006-01-18 | 2007-12-29 | Schering Corp | Moduladores de receptores cannabinoides |
| EP1986489A2 (de) * | 2006-02-24 | 2008-11-05 | Schering Corporation | Npc1l1-orthologe |
| TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| JP2010502702A (ja) * | 2006-09-05 | 2010-01-28 | シェーリング コーポレイション | 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物 |
| CA2663502A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
| US20080070888A1 (en) * | 2006-09-15 | 2008-03-20 | Mckittrick Brian A | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
| WO2008033456A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabilism |
| WO2008033468A2 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
| CA2663501A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Treating pain, diabetes, and disorders of lipid metabolism |
| MX2009002918A (es) * | 2006-09-15 | 2009-03-31 | Schering Corp | Derivados azetidinona y sus metodos de uso. |
| WO2008033431A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders |
| WO2008130616A2 (en) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| JP2010531874A (ja) * | 2007-06-28 | 2010-09-30 | インターベット インターナショナル ベー． フェー． | Ｃｂ１アンタゴニストとしての置換ピペラジン |
| CN101796033A (zh) | 2007-06-28 | 2010-08-04 | 英特维特国际股份有限公司 | 作为cb1拮抗剂的取代的哌嗪 |
| EP2403848A1 (de) | 2009-03-06 | 2012-01-11 | Lipideon Biotechnology AG | Pharmazeutische hypocholesterinemische zusammensetzungen |
| CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| BR112012023664B1 (pt) | 2010-03-19 | 2020-01-28 | Pfizer | Compostos derivados de 2,3-di-hidro-1hinden-1-il-2,7- diazaspiro [3,5] nonano e composiçãofarmacêutica compreendendo os mesmos |
| HUE052300T2 (hu) | 2012-05-01 | 2021-04-28 | Althera Life Sciences Llc | Orális tablettakészítmény, amely a rozuvastatin és az ezetimib rögzített kombinációjából áll, hiperlipidémia és kardiovaszkuláris betegségek kezelésére |
| CN104496839B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
| CN104496838B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
| US11401273B2 (en) | 2018-11-20 | 2022-08-02 | Piramal Pharma Limited | Asymmetric synthesis of Azaspiro compounds |
| CN116889627A (zh) | 2019-03-20 | 2023-10-17 | 雷杰纳荣制药公司 | 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高 |
| EP3942047A1 (de) | 2019-03-20 | 2022-01-26 | Regeneron Pharmaceuticals, Inc. | Behandlung von erhöhten lipidspiegeln mit sterol-regulator-bindenden protein bindenden protein (scap) inhibitoren |
| EP4452416A1 (de) * | 2021-12-22 | 2024-10-30 | The Regents Of The University Of California | Kovalent bindende inhibitoren von g12s-, g12d- und/oder g12e-mutanten von k-ras-gtpase |
| WO2025049568A1 (en) | 2023-08-29 | 2025-03-06 | Regeneron Pharmaceuticals, Inc. | Treatment of muscle disorder with folliculin interacting protein 1 (fnip1) inhibitors and/or folliculin (flcn) inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2048080C3 (de) * | 1970-09-30 | 1979-11-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von N-substituierten 33-disubstituierten ß -Lactamen |
| US4692515A (en) * | 1984-09-24 | 1987-09-08 | Pennwalt Corporation | Adamantane-spirolactams |
| NZ228600A (en) | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
| US4983597A (en) | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
| US5130425A (en) * | 1990-10-12 | 1992-07-14 | American Home Products Corporation | Spiro-lactams and analogs thereof useful as aldose reductase inhibitors |
| DE69222532T2 (de) * | 1991-07-23 | 1998-02-26 | Schering Corp | Substituierte beta-lactam-verbindungen als hypocholesterolemische mittel und verfahren zu deren herstellung |
-
1994
- 1994-01-13 LT LTIP1764A patent/LT3595B/lt not_active IP Right Cessation
- 1994-01-19 CN CN94191245A patent/CN1118163A/zh active Pending
- 1994-01-19 ZA ZA94386A patent/ZA94386B/xx unknown
- 1994-01-19 NZ NZ261714A patent/NZ261714A/en unknown
- 1994-01-19 CZ CZ951801A patent/CZ180195A3/cs unknown
- 1994-01-19 DK DK94907200T patent/DK0681569T3/da active
- 1994-01-19 DE DE69426924T patent/DE69426924T2/de not_active Expired - Lifetime
- 1994-01-19 WO PCT/US1994/000421 patent/WO1994017038A1/en not_active Ceased
- 1994-01-19 SI SI9400022A patent/SI9400022A/sl unknown
- 1994-01-19 CA CA002154257A patent/CA2154257C/en not_active Expired - Fee Related
- 1994-01-19 FI FI953497A patent/FI953497A0/fi not_active Application Discontinuation
- 1994-01-19 AU AU60872/94A patent/AU683048B2/en not_active Expired - Fee Related
- 1994-01-19 PT PT94907200T patent/PT681569E/pt unknown
- 1994-01-19 PL PL94309978A patent/PL309978A1/xx unknown
- 1994-01-19 IL IL10836894A patent/IL108368A0/xx unknown
- 1994-01-19 JP JP6517083A patent/JP2719445B2/ja not_active Expired - Fee Related
- 1994-01-19 ES ES94907200T patent/ES2155849T3/es not_active Expired - Lifetime
- 1994-01-19 SK SK911-95A patent/SK91195A3/sk unknown
- 1994-01-19 HU HU9502194A patent/HUT72592A/hu unknown
- 1994-01-19 AT AT94907200T patent/ATE199899T1/de not_active IP Right Cessation
- 1994-01-19 EP EP94907200A patent/EP0681569B1/de not_active Expired - Lifetime
- 1994-11-23 EE EE9400394A patent/EE9400394A/xx unknown
-
1995
- 1995-05-25 US US08/449,980 patent/US5698548A/en not_active Expired - Lifetime
- 1995-07-20 NO NO952884A patent/NO952884L/no unknown
- 1995-07-21 KR KR1019950702988A patent/KR960700227A/ko not_active Abandoned
-
2001
- 2001-05-31 GR GR20010400814T patent/GR3035963T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69426924T2 (de) | 2001-08-16 |
| JPH08501110A (ja) | 1996-02-06 |
| HUT72592A (en) | 1996-05-28 |
| EP0681569B1 (de) | 2001-03-21 |
| DK0681569T3 (da) | 2001-04-23 |
| SI9400022A (en) | 1995-02-28 |
| FI953497A7 (fi) | 1995-07-20 |
| ATE199899T1 (de) | 2001-04-15 |
| CA2154257A1 (en) | 1994-08-04 |
| PL309978A1 (en) | 1995-11-13 |
| CA2154257C (en) | 1999-05-25 |
| KR960700227A (ko) | 1996-01-19 |
| AU6087294A (en) | 1994-08-15 |
| CN1118163A (zh) | 1996-03-06 |
| NZ261714A (en) | 1997-02-24 |
| EP0681569A1 (de) | 1995-11-15 |
| FI953497A0 (fi) | 1995-07-20 |
| GR3035963T3 (en) | 2001-08-31 |
| ES2155849T3 (es) | 2001-06-01 |
| DE69426924D1 (de) | 2001-04-26 |
| CZ180195A3 (en) | 1996-01-17 |
| US5698548A (en) | 1997-12-16 |
| HU9502194D0 (en) | 1995-09-28 |
| NO952884D0 (no) | 1995-07-20 |
| AU683048B2 (en) | 1997-10-30 |
| ZA94386B (en) | 1994-07-19 |
| LTIP1764A (en) | 1995-02-27 |
| SK91195A3 (en) | 1995-12-06 |
| JP2719445B2 (ja) | 1998-02-25 |
| NO952884L (no) | 1995-09-20 |
| LT3595B (en) | 1995-12-27 |
| WO1994017038A1 (en) | 1994-08-04 |
| PT681569E (pt) | 2001-06-29 |
| EE9400394A (et) | 1996-06-17 |
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