SK91195A3 - Azetidinones substituted with spirocycloalkyl group, their use and method of their production, pharmaceutical agent containing these substituted azetidinones substituted, method of its production and set containing this agent - Google Patents
Azetidinones substituted with spirocycloalkyl group, their use and method of their production, pharmaceutical agent containing these substituted azetidinones substituted, method of its production and set containing this agent Download PDFInfo
- Publication number
- SK91195A3 SK91195A3 SK911-95A SK91195A SK91195A3 SK 91195 A3 SK91195 A3 SK 91195A3 SK 91195 A SK91195 A SK 91195A SK 91195 A3 SK91195 A3 SK 91195A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- formula
- substituted
- lower alkyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US643993A | 1993-01-21 | 1993-01-21 | |
PCT/US1994/000421 WO1994017038A1 (fr) | 1993-01-21 | 1994-01-19 | Azetidinones a substitution spirocycloalkyle utilisees comme agents hypocholesterolemiques |
Publications (1)
Publication Number | Publication Date |
---|---|
SK91195A3 true SK91195A3 (en) | 1995-12-06 |
Family
ID=21720894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK911-95A SK91195A3 (en) | 1993-01-21 | 1994-01-19 | Azetidinones substituted with spirocycloalkyl group, their use and method of their production, pharmaceutical agent containing these substituted azetidinones substituted, method of its production and set containing this agent |
Country Status (26)
Country | Link |
---|---|
US (1) | US5698548A (fr) |
EP (1) | EP0681569B1 (fr) |
JP (1) | JP2719445B2 (fr) |
KR (1) | KR960700227A (fr) |
CN (1) | CN1118163A (fr) |
AT (1) | ATE199899T1 (fr) |
AU (1) | AU683048B2 (fr) |
CA (1) | CA2154257C (fr) |
CZ (1) | CZ180195A3 (fr) |
DE (1) | DE69426924T2 (fr) |
DK (1) | DK0681569T3 (fr) |
EE (1) | EE9400394A (fr) |
ES (1) | ES2155849T3 (fr) |
FI (1) | FI953497A (fr) |
GR (1) | GR3035963T3 (fr) |
HU (1) | HUT72592A (fr) |
IL (1) | IL108368A0 (fr) |
LT (1) | LT3595B (fr) |
NO (1) | NO952884L (fr) |
NZ (1) | NZ261714A (fr) |
PL (1) | PL309978A1 (fr) |
PT (1) | PT681569E (fr) |
SI (1) | SI9400022A (fr) |
SK (1) | SK91195A3 (fr) |
WO (1) | WO1994017038A1 (fr) |
ZA (1) | ZA94386B (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4226593A (en) * | 1992-06-26 | 1994-01-24 | Pfizer Inc. | Steroidal glycosides for treating hypercholesterolemia |
US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
US5648484A (en) * | 1995-03-07 | 1997-07-15 | Schering Corporation | Catalytic enantioselective synthesis of a spriofused azetidinone |
IL124268A (en) * | 1995-10-31 | 2005-08-31 | Schering Corp | Hypocholesterolemic (1-aryl-2-oxo-3-substituted-4-azetidinyl) phenylglucopyranose derivatives and pharmaceutical compositions containing them |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
WO2000063703A1 (fr) | 1999-04-16 | 2000-10-26 | Schering Corporation | Utilisation de composes a base d'azetodinone |
US6297268B1 (en) | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
AR035611A1 (es) * | 2000-12-20 | 2004-06-16 | Schering Corp | 2 -azetidinonas sustituidas con azucares, composicion farmaceutica, un kit, uso de dichos compuestos para la fabricacion de medicamentos utiles como agentes hipocolesterolemicos. |
PT1353694E (pt) * | 2001-01-26 | 2008-03-12 | Schering Corp | Combinações de ezetimiba com aspirina para o tratamento de doenças vasculares |
AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
EP1911462A3 (fr) | 2001-01-26 | 2011-11-30 | Schering Corporation | Combinaisons comprenant un inhibiteur d'absorption de stérol |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
PL205343B1 (pl) * | 2001-01-26 | 2010-04-30 | Schering Corp | Zastosowanie inhibitora wchłaniania sterolu |
SK287408B6 (sk) | 2001-03-28 | 2010-09-07 | Schering Corporation | Spôsob prípravy medziproduktov na výrobu azetidinónov |
EP1859796A3 (fr) * | 2001-09-21 | 2008-07-02 | Schering Corporation | Treatment de xanthoma avec des dérivés d'azétidines en tant qu'inhibiteurs d'absorption des stérols |
DK1429756T3 (da) * | 2001-09-21 | 2007-03-19 | Schering Corp | Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
JP2006501205A (ja) * | 2002-07-30 | 2006-01-12 | カリキオン インコーポレイテッド | エゼチミブ組成物、並びにコレステロールに関連した良性および悪性の腫瘍を治療する方法 |
EP1601668B1 (fr) * | 2003-03-07 | 2008-08-27 | Schering Corporation | Composes d'azetidinone substitues, leurs formulations et utilisations en vue du traitement de l'hypercholesterolemie |
ES2318274T3 (es) | 2003-03-07 | 2009-05-01 | Schering Corporation | Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia. |
WO2004096139A2 (fr) | 2003-04-24 | 2004-11-11 | Incyte Corporation | Derives d'aza spiro alcane en tant qu'inhibiteurs de metalloproteases |
JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
US20050096307A1 (en) * | 2003-11-05 | 2005-05-05 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
EP1918000A2 (fr) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinaisons d'agents de modulation lipide et azétidinones substitués et traitements pour conditions vasculaires |
SA04250427A (ar) | 2003-12-23 | 2005-12-03 | استرازينيكا ايه بي | مشتقات ثاني فينيل أزيتيدون |
WO2005062824A2 (fr) * | 2003-12-23 | 2005-07-14 | Merck & Co., Inc. | Composes anti-hypercholesterolemie |
CA2553769C (fr) * | 2004-01-16 | 2011-01-04 | Merck & Co., Inc. | Npc1l1 (npc3) et procedes pour identifier des ligands de ceux-ci |
US20080045726A1 (en) * | 2004-05-10 | 2008-02-21 | Laboratorios Del Dr. Esteve, S.A. | Spirolactams and Their Synthesis |
EP1598336A1 (fr) | 2004-05-20 | 2005-11-23 | Laboratorios Del Dr. Esteve, S.A. | Hydroxylation, fonctionnalisation et protection regioselective de spirolactames |
JP2007536328A (ja) * | 2004-05-10 | 2007-12-13 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | スピロラクタム類およびそれらの合成 |
US7291728B2 (en) | 2004-05-10 | 2007-11-06 | Laboratories Del Dr. Esteve, S.A. | Spirolactams and their synthesis |
EP1676836A1 (fr) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Hydroxylation, fonctionnalisation et protection regioselective de spirolactames |
CA2581596A1 (fr) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinaisons d'azetidinones substituees et d'antagonistes cb<sb>1</sb> |
CN102633730A (zh) | 2004-12-03 | 2012-08-15 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
EP1865947A1 (fr) * | 2005-04-04 | 2007-12-19 | Pontificia Universidad Catolica de Chile | Utilisation d'ezetimibe pour prevenir et traiter des calculs biliaires de cholesterol |
US7635705B2 (en) * | 2005-06-20 | 2009-12-22 | Schering Corporation | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
BRPI0620255A2 (pt) * | 2005-12-21 | 2011-11-08 | Schering Corp | uso de agentes redutores de colesterol e/ou antagonista/agonista inverso do receptor de h3 |
MX2008009354A (es) | 2006-01-18 | 2008-09-30 | Schering Corp | Moduladores de receptores cannabinoides. |
WO2007100807A2 (fr) | 2006-02-24 | 2007-09-07 | Schering Corporation | Orthologues de npc1l1 |
TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
MX2009002398A (es) * | 2006-09-05 | 2009-03-16 | Schering Corp | Combinaciones farmaceuticas para manejo de lipidos y en el tratamiento de aterosclerosis y estatosis hepatica. |
WO2008033447A1 (fr) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Dérivés d'azétidine et d'azétidone convenant dans le traitement de la douleur et des troubles du métabolisme des lipides |
CN101541805A (zh) * | 2006-09-15 | 2009-09-23 | 先灵公司 | 用于治疗疼痛和脂代射紊乱的氮杂环丁烷和氮杂环丁酮衍生物 |
MX2009002924A (es) * | 2006-09-15 | 2009-05-28 | Schering Corp | Derivados de azetidinona espirociclica para el tratamiento de trastornos del metabolismo de los lipidos, el dolor, la diabetes y otros trastornos. |
US20080070892A1 (en) * | 2006-09-15 | 2008-03-20 | Harris Joel M | Treating pain, diabetes, and disorders of lipid metabolism |
AR062790A1 (es) | 2006-09-15 | 2008-12-03 | Schering Corp | Derivados de azetidina utiles en el tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos |
JP2010503677A (ja) * | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 脂質代謝の障害を治療するためのアゼチジノン誘導体 |
CA2663503A1 (fr) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Derives d'azetidinone et procedes d'utilisation de ceux-ci |
US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
CA2694264A1 (fr) * | 2007-06-28 | 2009-01-08 | Intervet International B.V. | Piperazines a substitution servant d'antagonistes des recepteurs cb1 |
JP2010531361A (ja) | 2007-06-28 | 2010-09-24 | インターベット インターナショナル ベー. フェー. | Cb1アタゴニストとしての置換ピペラジン |
EP2403848A1 (fr) | 2009-03-06 | 2012-01-11 | Lipideon Biotechnology AG | Compositions pharmaceutiques hypocholestérolémiques |
CN101993403B (zh) * | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
AU2011228699B2 (en) | 2010-03-19 | 2016-05-19 | Pfizer Inc. | 2,3 dihydro-1H-inden-1-yl- 2,7-diazaspiro [3.5] nonane derivatives and their use as antagonists or inverse agonists of the Ghrelin receptor |
DK2844233T3 (da) | 2012-05-01 | 2020-07-13 | Althera Life Sciences Llc | Oral tabletformulering bestående af en fastsat kombination af rosuvastatin og ezetimib til behandling af hyperlipidæmi og kardiovaskulære sygdomme |
CN104496838B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
CN104496839B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
US11401273B2 (en) | 2018-11-20 | 2022-08-02 | Piramal Pharma Limited | Asymmetric synthesis of Azaspiro compounds |
WO2020191141A1 (fr) | 2019-03-20 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Traitement de niveaux de lipides accrus avec des inhibiteurs du facteur de transcription 1 de liaison à un élément régulateur de stérol (srebf1) |
CN113825839A (zh) | 2019-03-20 | 2021-12-21 | 雷杰纳荣制药公司 | 用固醇调节元件结合蛋白切割激活蛋白(scap)抑制剂治疗脂质水平升高 |
WO2023122662A1 (fr) * | 2021-12-22 | 2023-06-29 | The Regents Of The University Of California | Inhibiteurs de liaison covalente des mutants g12s, g12d et/ou g12e de k-ras gtpase |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2048080C3 (de) * | 1970-09-30 | 1979-11-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von N-substituierten 33-disubstituierten ß -Lactamen |
US4692515A (en) * | 1984-09-24 | 1987-09-08 | Pennwalt Corporation | Adamantane-spirolactams |
IL89835A0 (en) | 1988-04-11 | 1989-12-15 | Merck & Co Inc | Substituted azetidinones,their preparation and pharmaceutical compositions containing them |
US4983597A (en) | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
US5130425A (en) * | 1990-10-12 | 1992-07-14 | American Home Products Corporation | Spiro-lactams and analogs thereof useful as aldose reductase inhibitors |
ES2107548T3 (es) | 1991-07-23 | 1997-12-01 | Schering Corp | Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion. |
-
1994
- 1994-01-13 LT LTIP1764A patent/LT3595B/lt not_active IP Right Cessation
- 1994-01-19 DE DE69426924T patent/DE69426924T2/de not_active Expired - Lifetime
- 1994-01-19 AT AT94907200T patent/ATE199899T1/de not_active IP Right Cessation
- 1994-01-19 SK SK911-95A patent/SK91195A3/sk unknown
- 1994-01-19 HU HU9502194A patent/HUT72592A/hu unknown
- 1994-01-19 WO PCT/US1994/000421 patent/WO1994017038A1/fr not_active Application Discontinuation
- 1994-01-19 PL PL94309978A patent/PL309978A1/xx unknown
- 1994-01-19 ES ES94907200T patent/ES2155849T3/es not_active Expired - Lifetime
- 1994-01-19 IL IL10836894A patent/IL108368A0/xx unknown
- 1994-01-19 JP JP6517083A patent/JP2719445B2/ja not_active Expired - Fee Related
- 1994-01-19 CZ CZ951801A patent/CZ180195A3/cs unknown
- 1994-01-19 CA CA002154257A patent/CA2154257C/fr not_active Expired - Fee Related
- 1994-01-19 EP EP94907200A patent/EP0681569B1/fr not_active Expired - Lifetime
- 1994-01-19 ZA ZA94386A patent/ZA94386B/xx unknown
- 1994-01-19 AU AU60872/94A patent/AU683048B2/en not_active Expired - Fee Related
- 1994-01-19 DK DK94907200T patent/DK0681569T3/da active
- 1994-01-19 PT PT94907200T patent/PT681569E/pt unknown
- 1994-01-19 SI SI9400022A patent/SI9400022A/sl unknown
- 1994-01-19 CN CN94191245A patent/CN1118163A/zh active Pending
- 1994-01-19 NZ NZ261714A patent/NZ261714A/en unknown
- 1994-11-23 EE EE9400394A patent/EE9400394A/xx unknown
-
1995
- 1995-05-25 US US08/449,980 patent/US5698548A/en not_active Expired - Lifetime
- 1995-07-20 FI FI953497A patent/FI953497A/fi not_active Application Discontinuation
- 1995-07-20 NO NO952884A patent/NO952884L/no unknown
- 1995-07-21 KR KR1019950702988A patent/KR960700227A/ko active IP Right Grant
-
2001
- 2001-05-31 GR GR20010400814T patent/GR3035963T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EE9400394A (et) | 1996-06-17 |
GR3035963T3 (en) | 2001-08-31 |
EP0681569B1 (fr) | 2001-03-21 |
HUT72592A (en) | 1996-05-28 |
EP0681569A1 (fr) | 1995-11-15 |
PT681569E (pt) | 2001-06-29 |
DE69426924T2 (de) | 2001-08-16 |
CA2154257C (fr) | 1999-05-25 |
JPH08501110A (ja) | 1996-02-06 |
NZ261714A (en) | 1997-02-24 |
AU6087294A (en) | 1994-08-15 |
WO1994017038A1 (fr) | 1994-08-04 |
PL309978A1 (en) | 1995-11-13 |
KR960700227A (ko) | 1996-01-19 |
ZA94386B (en) | 1994-07-19 |
CN1118163A (zh) | 1996-03-06 |
HU9502194D0 (en) | 1995-09-28 |
DE69426924D1 (de) | 2001-04-26 |
CA2154257A1 (fr) | 1994-08-04 |
DK0681569T3 (da) | 2001-04-23 |
NO952884L (no) | 1995-09-20 |
NO952884D0 (no) | 1995-07-20 |
FI953497A0 (fi) | 1995-07-20 |
AU683048B2 (en) | 1997-10-30 |
LTIP1764A (en) | 1995-02-27 |
US5698548A (en) | 1997-12-16 |
JP2719445B2 (ja) | 1998-02-25 |
CZ180195A3 (en) | 1996-01-17 |
FI953497A (fi) | 1995-07-20 |
SI9400022A (en) | 1995-02-28 |
ES2155849T3 (es) | 2001-06-01 |
ATE199899T1 (de) | 2001-04-15 |
IL108368A0 (en) | 1994-04-12 |
LT3595B (en) | 1995-12-27 |
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