LT2545939T - Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiu - Google Patents
Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiuInfo
- Publication number
- LT2545939T LT2545939T LTEP12005352.5T LT12005352T LT2545939T LT 2545939 T LT2545939 T LT 2545939T LT 12005352 T LT12005352 T LT 12005352T LT 2545939 T LT2545939 T LT 2545939T
- Authority
- LT
- Lithuania
- Prior art keywords
- tetrahydrobiopterin
- conditions associated
- treating conditions
- phenylalanine levels
- elevated phenylalanine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61P3/02—Nutrients, e.g. vitamins, minerals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92282107P | 2007-04-11 | 2007-04-11 | |
US1975308P | 2008-01-08 | 2008-01-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2545939T true LT2545939T (lt) | 2021-03-10 |
Family
ID=39620159
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP12005352.5T LT2545939T (lt) | 2007-04-11 | 2008-04-11 | Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiu |
LTEP18205446.0T LT3461503T (lt) | 2007-04-11 | 2008-04-11 | Tetrahidrobiopterino, susijusių kompozicijų įvedimo būdai ir matavimo būdai |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP18205446.0T LT3461503T (lt) | 2007-04-11 | 2008-04-11 | Tetrahidrobiopterino, susijusių kompozicijų įvedimo būdai ir matavimo būdai |
Country Status (23)
Country | Link |
---|---|
US (6) | US7612073B2 (lt) |
EP (4) | EP2545939B1 (lt) |
JP (2) | JP2010523708A (lt) |
KR (5) | KR20170037676A (lt) |
CN (1) | CN101678025A (lt) |
AU (1) | AU2008240259C1 (lt) |
BR (1) | BRPI0809470A2 (lt) |
CA (1) | CA2682598C (lt) |
CY (3) | CY1113543T1 (lt) |
DE (1) | DE22154751T1 (lt) |
DK (3) | DK3461503T3 (lt) |
ES (3) | ES2906582T3 (lt) |
HK (1) | HK1139864A1 (lt) |
HR (3) | HRP20220188T3 (lt) |
HU (2) | HUE058030T2 (lt) |
IL (1) | IL201101A (lt) |
LT (2) | LT2545939T (lt) |
MX (1) | MX2009010977A (lt) |
PL (3) | PL2545939T3 (lt) |
PT (3) | PT2545939T (lt) |
RU (1) | RU2486899C2 (lt) |
SI (2) | SI3461503T1 (lt) |
WO (1) | WO2008128049A2 (lt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0416566A (pt) | 2003-11-17 | 2007-01-23 | Biomarin Pharm Inc | tratamento de fenilcetonúrias com bh4 |
PL2545939T3 (pl) | 2007-04-11 | 2021-05-17 | Biomarin Pharmaceutical Inc. | Tetrahydrobiopteryna do leczenia stanów związanych z podwyższonymi poziomami fenyloalaniny |
ES2736730T3 (es) * | 2008-08-12 | 2020-01-07 | Orpha Swiss Gmbh | Forma de administración farmacéutica que contiene tetrahidrobiopterina |
US9089573B2 (en) | 2009-07-22 | 2015-07-28 | University Of Massachusetts | Methods and compositions to reduce oxidative stress |
JP5066756B2 (ja) * | 2010-04-22 | 2012-11-07 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
KR102391511B1 (ko) * | 2010-12-03 | 2022-04-26 | 오렉시젠 세러퓨틱스 인크. | 날트렉손 요법에서 약물 생체이용률의 증가 |
KR20140021585A (ko) * | 2011-03-01 | 2014-02-20 | 루비콘 리서치 피브이티. 엘티디. | 테트라하이드로바이옵테린의 안정한 조성물 |
WO2013063163A1 (en) * | 2011-10-24 | 2013-05-02 | Kickass Candy, Llc | Sweet tart energy tablet |
US9216178B2 (en) * | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
CA2862076C (en) | 2012-01-23 | 2020-04-21 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
KR20190006598A (ko) | 2012-01-26 | 2019-01-18 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
CN102650621B (zh) * | 2012-05-02 | 2014-06-25 | 安徽农业大学 | 一种从蚕体提取的墨蝶呤的鉴定方法 |
EP2954324B1 (en) | 2013-02-08 | 2019-07-31 | University of Iowa Research Foundation | Method using copeptin to predict onset of preeclampsia |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
US20150204834A1 (en) * | 2014-01-22 | 2015-07-23 | Sarfaraz K. Niazi | Thermodynamic equivalence surrogate test (test) for bioequivalence |
HUE030221T2 (en) * | 2014-03-31 | 2017-04-28 | Vasopharm Gmbh | Solid pharmaceutical composition containing biopterin derivatives and uses of such compositions |
MA41124A (fr) * | 2014-12-05 | 2017-10-10 | Sun Pharmaceutical Ind Ltd | Compositions en suspension à libération prolongée à rétention gastrique |
JP6996713B2 (ja) | 2015-10-06 | 2022-02-04 | エイチエルビー・セラピューティクス・カンパニー・リミテッド | チモシンベータ4を含む眼科用製剤の製造方法 |
JOP20170059B1 (ar) | 2016-03-08 | 2021-08-17 | Sage Therapeutics Inc | ستيرويدات وتركيبات نشطة عصبيًا واستخداماتها |
KR20230117467A (ko) * | 2016-11-29 | 2023-08-08 | 피티씨 테라퓨틱스 엠피, 인크. | 세피아프테린의 다형체 및 그의 염 |
WO2018102314A1 (en) * | 2016-11-29 | 2018-06-07 | Censa Pharmaceuticals Inc. | Polymorphic form of sepiapterin |
CN108627576A (zh) * | 2017-03-17 | 2018-10-09 | 武汉宏韧生物医药科技有限公司 | 一种人血浆中他达拉非的定量分析方法 |
CA3066361A1 (en) | 2017-06-07 | 2018-12-13 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
EP3648760A1 (en) * | 2017-07-06 | 2020-05-13 | Treeway TW001 B.V. | Use of edaravone in oral treatment of oxidative-stress mediated neurodegenerative disorders |
WO2019055118A2 (en) * | 2017-07-13 | 2019-03-21 | Tab Protein, Llc | COMPLEMENTARY FOOD TABLE AND PACKAGING |
BR112020003865A8 (pt) | 2017-09-01 | 2022-08-16 | Censa Pharmaceuticals Inc | Composições farmacêuticas compreendendo sepiapterina e seus usos |
EP3710076B1 (en) | 2017-11-13 | 2023-12-27 | Shifamed Holdings, LLC | Intravascular fluid movement devices, systems, and methods of use |
AU2018369913B2 (en) * | 2017-11-20 | 2020-08-20 | Medibeacon Inc. | Method for preparing and analyzing fluorescent compounds in plasma |
CN109946412B (zh) * | 2017-12-21 | 2021-10-15 | 上海产业技术研究院 | 一种体液蝶呤谱检测试剂盒及其使用 |
EP3746149A4 (en) | 2018-02-01 | 2021-10-27 | Shifamed Holdings, LLC | INTRAVASCULAR BLOOD PUMPS AND METHODS OF USE AND METHODS OF MANUFACTURING |
WO2019024509A1 (zh) * | 2018-03-16 | 2019-02-07 | 共生地球生物科技有限公司 | 多重pH缓冲配方与蛋白质消化助剂的组合物及其用途 |
CN110269099B (zh) * | 2018-03-16 | 2023-01-31 | 共生地球生物科技有限公司 | 多重pH缓冲配方与蛋白质消化助剂的组合物及其用途 |
JP2021525746A (ja) * | 2018-05-30 | 2021-09-27 | ピーティーシー セラピューティクス エムピー,インコーポレイテッド | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
CN112543758A (zh) * | 2018-05-30 | 2021-03-23 | Ptc医疗Mp公司 | 墨蝶呤的药学上可接受的盐 |
US11617752B2 (en) | 2018-05-30 | 2023-04-04 | Ptc Therapeutics Mp, Inc. | Methods for increasing sepiapterin plasma exposure |
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