LT2064B - Pirimidininiu nukleozidu gavimo budas - Google Patents

Pirimidininiu nukleozidu gavimo budas

Info

Publication number
LT2064B
LT2064B LTRP271A LTRP271A LT2064B LT 2064 B LT2064 B LT 2064B LT RP271 A LTRP271 A LT RP271A LT RP271 A LTRP271 A LT RP271A LT 2064 B LT2064 B LT 2064B
Authority
LT
Lithuania
Prior art keywords
nucleosid
pyrimidin
price
reception
cytomegalovirus
Prior art date
Application number
LTRP271A
Other languages
English (en)
Lithuanian (lt)
Inventor
Saad George Rahin
Dorothy Jane Martin Purifoy
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LT2064B publication Critical patent/LT2064B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Silicon Polymers (AREA)
LTRP271A 1986-12-15 1992-12-30 Pirimidininiu nukleozidu gavimo budas LT2064B (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868629892A GB8629892D0 (en) 1986-12-15 1986-12-15 Antiviral compounds
SU874355176A SU1731064A3 (ru) 1986-12-15 1987-12-14 Способ получени пиримидиновых нуклеозидов

Publications (1)

Publication Number Publication Date
LT2064B true LT2064B (lt) 1993-06-15

Family

ID=10609013

Family Applications (1)

Application Number Title Priority Date Filing Date
LTRP271A LT2064B (lt) 1986-12-15 1992-12-30 Pirimidininiu nukleozidu gavimo budas

Country Status (30)

Country Link
US (1) US5079235A (hu)
EP (3) EP0417560A1 (hu)
JP (2) JPS63165397A (hu)
KR (1) KR880007521A (hu)
CN (2) CN87108265A (hu)
AT (1) ATE88713T1 (hu)
AU (2) AU601529B2 (hu)
CA (1) CA1319143C (hu)
CS (3) CS275398B2 (hu)
DD (2) DD264924A5 (hu)
DE (1) DE3785651T2 (hu)
DK (2) DK654287A (hu)
ES (1) ES2054693T3 (hu)
FI (2) FI875487A (hu)
GB (1) GB8629892D0 (hu)
HU (4) HU207735B (hu)
IE (2) IE930470L (hu)
IL (3) IL84810A (hu)
LT (1) LT2064B (hu)
LV (1) LV5273A3 (hu)
MC (1) MC1882A1 (hu)
MX (1) MX9203216A (hu)
NO (1) NO167576C (hu)
NZ (1) NZ222898A (hu)
PH (2) PH24104A (hu)
PL (3) PL160322B1 (hu)
PT (1) PT86356B (hu)
RU (1) RU2036199C1 (hu)
SU (1) SU1731064A3 (hu)
ZA (1) ZA879382B (hu)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340032C (en) * 1987-06-24 1998-09-08 Jim Haralambidis Lucleoside derivatives
US4954485A (en) * 1987-10-20 1990-09-04 Sanyo-Kokusaku Pulp Co., Ltd. 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
EP0346108A3 (en) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8827339D0 (en) * 1988-11-23 1988-12-29 Wellcome Found Antiviral compounds
US5006646A (en) * 1989-02-22 1991-04-09 Yuki Gosei Kogyo Co., Ltd. Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
GB8919607D0 (en) 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
GB9012899D0 (en) * 1990-06-09 1990-08-01 Wellcome Found Anti-hbv pyrimidine nucleoside
GB9014618D0 (en) * 1990-06-30 1990-08-22 Wellcome Found Process for the preparation of pyrimidine nucleosides
EP0711555A2 (en) * 1990-07-19 1996-05-15 The Wellcome Foundation Limited Enzyme inactivators
US5643913A (en) * 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
US5580858A (en) * 1991-06-10 1996-12-03 Alberta Research Council Immunosuppressive and tolerogenic modified Lewisx compounds
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
HU207524B (en) * 1991-11-22 1993-04-28 Mta Koezponti Kemiai Kutato In Industrial process for producing 5-alkyl-2'-deoxy-beta-uridines with stereoselective synthesis
DE637965T1 (de) * 1991-11-26 1995-12-14 Gilead Sciences Inc Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen.
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
JP2823358B2 (ja) * 1992-05-26 1998-11-11 アルバータ リサーチ カウンスル 免疫抑制性および寛容原性修飾ルイス▲上ｃ▼およびＬａｃＮＡｃ化合物
CA2119315A1 (en) * 1993-03-18 1994-09-19 Tsujiaki Hata Nucleoside derivatives and anti-herpes composition
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
RU98113785A (ru) * 1995-12-22 2000-06-10 Ист Каролина Юниверсити (US) Агент и способ лечения заболеваний, связанных с чрезмерной экспрессией цитидиндезаминазы или дезоксицитидинзаминазы
WO1997027849A1 (fr) * 1996-02-02 1997-08-07 Showa Shell Sekiyu K.K. Medicaments pour traiter les infections provoquees par le virus de l'herpes et compositions preventives pour empecher un retour de l'infection, contenant tous les deux des derives triterpeniques comme principe actif
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
WO2003053360A2 (en) 2001-12-20 2003-07-03 Pharmassett Ltd. Treatment of ebv and khsv infection and associated abnormal cellular proliferation
WO2006060697A1 (en) 2004-12-03 2006-06-08 Adherex Technologies, Inc. Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs
ES2633786T3 (es) 2008-04-01 2017-09-25 Biosearch Technologies, Inc. Sondas de fluoróforo atenuadoras oscuras de ácido nucleico estabilizado
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
EP2488182B1 (en) 2009-10-14 2017-07-19 Elion Oncology LLC Treating neurotoxicity associated with combinations of 5-FU or its prodrugs and DPD inhibitors
JP6574240B2 (ja) * 2014-03-30 2019-09-11 セフィエド 修飾シトシンポリヌクレオチドオリゴマーおよび方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4274544A (en) * 1980-03-11 1981-06-23 The Continental Group, Inc. Single-piece plastic closure having integral seal forming means
EP0082667A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc Pharmaceutical compositions
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections
GB8517402D0 (en) * 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
AU595832B2 (en) * 1985-09-17 1990-04-12 Wellcome Foundation Limited, The Therapeutic nucleosides
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds

Also Published As

Publication number Publication date
ATE88713T1 (de) 1993-05-15
IL95141A (en) 1992-05-25
US5079235A (en) 1992-01-07
CN87108265A (zh) 1988-07-13
JPH03141292A (ja) 1991-06-17
IE930470L (en) 1988-06-15
IL84810A (en) 1992-05-25
CS767588A3 (en) 1991-02-12
JPH0378370B2 (hu) 1991-12-13
ES2054693T3 (es) 1994-08-16
IE930471L (en) 1988-06-15
HU207735B (en) 1993-05-28
EP0417560A1 (en) 1991-03-20
IL84810A0 (en) 1988-06-30
CS275402B6 (en) 1992-02-19
PL160322B1 (pl) 1993-02-26
PH24870A (en) 1990-12-26
HUT46336A (en) 1988-10-28
DK168323B1 (da) 1994-03-14
EP0272065B1 (en) 1993-04-28
NO167576B (no) 1991-08-12
SU1731064A3 (ru) 1992-04-30
HU903829D0 (en) 1990-11-28
DK169991D0 (da) 1991-10-04
AU601529B2 (en) 1990-09-13
FI941523A0 (fi) 1994-03-31
EP0486477A2 (en) 1992-05-20
AU626041B2 (en) 1992-07-23
JPS63165397A (ja) 1988-07-08
CS916187A2 (en) 1991-02-12
PL277927A1 (en) 1989-08-21
DK169991A (da) 1991-10-04
CA1319143C (en) 1993-06-15
AU5989090A (en) 1990-11-08
FI875487A (fi) 1988-06-16
EP0272065A2 (en) 1988-06-22
MC1882A1 (fr) 1989-01-24
PL158050B1 (pl) 1992-07-31
CN1080292A (zh) 1994-01-05
IL95141A0 (en) 1991-06-10
PT86356B (pt) 1990-11-07
EP0486477A3 (en) 1992-06-17
CS275398B2 (en) 1992-02-19
PH24104A (en) 1990-03-05
GB8629892D0 (en) 1987-01-28
DE3785651D1 (de) 1993-06-03
DD264924A5 (de) 1989-02-15
HU200932B (en) 1990-09-28
DK654287D0 (da) 1987-12-14
FI875487A0 (fi) 1987-12-14
AU8252187A (en) 1988-06-16
FI941523A (fi) 1994-03-31
LV5273A3 (lv) 1993-10-10
NZ222898A (en) 1990-12-21
CS342591A3 (en) 1992-04-15
NO875209D0 (no) 1987-12-14
DD274766A5 (de) 1990-01-03
KR880007521A (ko) 1988-08-27
PT86356A (en) 1988-01-01
DE3785651T2 (de) 1993-11-11
NO875209L (no) 1988-06-16
PL277926A1 (en) 1989-08-21
PL269462A1 (en) 1989-06-26
EP0272065A3 (en) 1988-11-17
ZA879382B (en) 1989-08-30
PL160321B1 (pl) 1993-02-26
NO167576C (no) 1991-11-20
RU2036199C1 (ru) 1995-05-27
HU202112B (en) 1991-02-28
MX9203216A (es) 1992-07-01
HU199867B (en) 1990-03-28
DK654287A (da) 1988-06-16

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