KR970702269A - 7-하이드록시 택산의 제조 방법(process for the preparation of 7-hydroxytaxanes) - Google Patents
7-하이드록시 택산의 제조 방법(process for the preparation of 7-hydroxytaxanes)Info
- Publication number
- KR970702269A KR970702269A KR1019960705643A KR19960705643A KR970702269A KR 970702269 A KR970702269 A KR 970702269A KR 1019960705643 A KR1019960705643 A KR 1019960705643A KR 19960705643 A KR19960705643 A KR 19960705643A KR 970702269 A KR970702269 A KR 970702269A
- Authority
- KR
- South Korea
- Prior art keywords
- radicals
- radical
- carbon atoms
- alkyl
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract 5
- -1 heterocyclyl radical Chemical class 0.000 claims abstract 64
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 11
- 125000000217 alkyl group Chemical group 0.000 claims abstract 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 7
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 37
- 150000003254 radicals Chemical class 0.000 claims 15
- 125000005843 halogen group Chemical group 0.000 claims 7
- 125000004429 atom Chemical group 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- WPWHSFAFEBZWBB-UHFFFAOYSA-N 1-butyl radical Chemical group [CH2]CCC WPWHSFAFEBZWBB-UHFFFAOYSA-N 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical compound [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 150000005840 aryl radicals Chemical class 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- GPKUICFDWYEPTK-UHFFFAOYSA-N methoxycyclohexatriene Chemical compound COC1=CC=C=C[CH]1 GPKUICFDWYEPTK-UHFFFAOYSA-N 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000006633 tert-butoxycarbonylamino group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9403980A FR2718135B1 (fr) | 1994-04-05 | 1994-04-05 | Procédé de préparation d'hydroxy-7 taxanes. |
| FR94/03,980 | 1994-04-05 | ||
| PCT/FR1995/000420 WO1995026961A1 (fr) | 1994-04-05 | 1995-04-03 | Procede de preparation d'hydroxy-7 taxanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR970702269A true KR970702269A (ko) | 1997-05-13 |
Family
ID=9461748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019960705643A Abandoned KR970702269A (ko) | 1994-04-05 | 1995-04-03 | 7-하이드록시 택산의 제조 방법(process for the preparation of 7-hydroxytaxanes) |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5750738A (enExample) |
| EP (1) | EP0754181B1 (enExample) |
| JP (1) | JPH09511245A (enExample) |
| KR (1) | KR970702269A (enExample) |
| CN (1) | CN1066144C (enExample) |
| AT (1) | ATE168109T1 (enExample) |
| AU (1) | AU691916B2 (enExample) |
| BG (1) | BG62731B1 (enExample) |
| BR (1) | BR9507443A (enExample) |
| CA (1) | CA2186917A1 (enExample) |
| CZ (1) | CZ284725B6 (enExample) |
| DE (1) | DE69503366T2 (enExample) |
| DK (1) | DK0754181T3 (enExample) |
| EE (1) | EE03239B1 (enExample) |
| ES (1) | ES2118592T3 (enExample) |
| FI (1) | FI964002A7 (enExample) |
| FR (1) | FR2718135B1 (enExample) |
| GE (1) | GEP19991535B (enExample) |
| HU (1) | HU214157B (enExample) |
| LT (1) | LT4186B (enExample) |
| LV (1) | LV11685B (enExample) |
| NO (1) | NO314145B1 (enExample) |
| NZ (1) | NZ284491A (enExample) |
| PL (1) | PL316589A1 (enExample) |
| RO (1) | RO115727B1 (enExample) |
| RU (1) | RU2127730C1 (enExample) |
| SK (1) | SK281075B6 (enExample) |
| TW (1) | TW285669B (enExample) |
| UA (1) | UA45332C2 (enExample) |
| WO (1) | WO1995026961A1 (enExample) |
| ZA (1) | ZA952732B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732968B1 (fr) * | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2750989B1 (fr) * | 1996-07-09 | 1998-09-25 | Rhone Poulenc Rorer Sa | Procede de monoacylation d'hydroxy taxanes |
| AU761389B2 (en) * | 1999-05-17 | 2003-06-05 | Bristol-Myers Squibb Company | Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol) and paclitaxel analogues |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| AU2010319483B2 (en) | 2009-11-13 | 2015-03-12 | Amgen Inc. | Material and methods for treating or preventing HER-3 associated diseases |
| WO2012018404A2 (en) | 2010-08-06 | 2012-02-09 | U3 Pharma Gmbh | Use of her3 binding agents in prostate treatment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
| FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
-
1994
- 1994-04-05 FR FR9403980A patent/FR2718135B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-22 TW TW084102786A patent/TW285669B/zh active
- 1995-04-03 UA UA96093733A patent/UA45332C2/uk unknown
- 1995-04-03 EP EP95916697A patent/EP0754181B1/fr not_active Expired - Lifetime
- 1995-04-03 CN CN95192428A patent/CN1066144C/zh not_active Expired - Fee Related
- 1995-04-03 AU AU23097/95A patent/AU691916B2/en not_active Ceased
- 1995-04-03 AT AT95916697T patent/ATE168109T1/de not_active IP Right Cessation
- 1995-04-03 HU HU9602736A patent/HU214157B/hu not_active IP Right Cessation
- 1995-04-03 RO RO96-01922A patent/RO115727B1/ro unknown
- 1995-04-03 SK SK1264-96A patent/SK281075B6/sk unknown
- 1995-04-03 ES ES95916697T patent/ES2118592T3/es not_active Expired - Lifetime
- 1995-04-03 EE EE9600141A patent/EE03239B1/xx not_active IP Right Cessation
- 1995-04-03 DE DE69503366T patent/DE69503366T2/de not_active Expired - Fee Related
- 1995-04-03 RU RU96120193A patent/RU2127730C1/ru active
- 1995-04-03 KR KR1019960705643A patent/KR970702269A/ko not_active Abandoned
- 1995-04-03 DK DK95916697T patent/DK0754181T3/da active
- 1995-04-03 PL PL95316589A patent/PL316589A1/xx unknown
- 1995-04-03 CA CA002186917A patent/CA2186917A1/fr not_active Abandoned
- 1995-04-03 WO PCT/FR1995/000420 patent/WO1995026961A1/fr not_active Ceased
- 1995-04-03 NZ NZ284491A patent/NZ284491A/en unknown
- 1995-04-03 BR BR9507443A patent/BR9507443A/pt not_active IP Right Cessation
- 1995-04-03 CZ CZ962899A patent/CZ284725B6/cs not_active IP Right Cessation
- 1995-04-03 GE GEAP19953432A patent/GEP19991535B/en unknown
- 1995-04-03 US US08/722,106 patent/US5750738A/en not_active Expired - Fee Related
- 1995-04-03 ZA ZA952732A patent/ZA952732B/xx unknown
- 1995-04-03 JP JP7525467A patent/JPH09511245A/ja not_active Ceased
-
1996
- 1996-09-24 LT LT96-138A patent/LT4186B/lt not_active IP Right Cessation
- 1996-09-27 NO NO19964104A patent/NO314145B1/no not_active IP Right Cessation
- 1996-10-04 FI FI964002A patent/FI964002A7/fi unknown
- 1996-10-04 BG BG100887A patent/BG62731B1/bg unknown
- 1996-10-07 LV LVP-96-393A patent/LV11685B/lv unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19961005 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20000403 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20020530 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20030519 |
|
| NORF | Unpaid initial registration fee | ||
| PC1904 | Unpaid initial registration fee |