ATE217870T1 - Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4 - Google Patents

Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4

Info

Publication number
ATE217870T1
ATE217870T1 AT94909517T AT94909517T ATE217870T1 AT E217870 T1 ATE217870 T1 AT E217870T1 AT 94909517 T AT94909517 T AT 94909517T AT 94909517 T AT94909517 T AT 94909517T AT E217870 T1 ATE217870 T1 AT E217870T1
Authority
AT
Austria
Prior art keywords
compounds
functional groups
baccatin iii
new functional
iii analogues
Prior art date
Application number
AT94909517T
Other languages
English (en)
Inventor
Robert A Holton
Seocchan Kim
Yukio Suzuki
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/010,798 external-priority patent/US5399726A/en
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of ATE217870T1 publication Critical patent/ATE217870T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT94909517T 1993-01-29 1994-01-31 Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4 ATE217870T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/010,798 US5399726A (en) 1993-01-29 1993-01-29 Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US3485293A 1993-03-22 1993-03-22
US9471593A 1993-07-20 1993-07-20
PCT/US1994/001099 WO1994017051A1 (en) 1993-01-29 1994-01-31 Process for the preparation of baccatin iii analogs bearing new c2 and c4 functional groups

Publications (1)

Publication Number Publication Date
ATE217870T1 true ATE217870T1 (de) 2002-06-15

Family

ID=27359309

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94907959T ATE220064T1 (de) 1993-01-29 1994-01-28 C2-taxan-derivate sowie diese enthaltende arzneimittel
AT94909517T ATE217870T1 (de) 1993-01-29 1994-01-31 Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94907959T ATE220064T1 (de) 1993-01-29 1994-01-28 C2-taxan-derivate sowie diese enthaltende arzneimittel

Country Status (13)

Country Link
EP (2) EP0681573B1 (de)
JP (2) JP3452928B2 (de)
CN (1) CN1125061C (de)
AT (2) ATE220064T1 (de)
AU (2) AU685778B2 (de)
CA (2) CA2155013C (de)
DE (2) DE69430902T2 (de)
DK (1) DK0681573T3 (de)
ES (1) ES2176237T3 (de)
IL (1) IL108444A0 (de)
PT (1) PT681573E (de)
TW (2) TW360646B (de)
WO (2) WO1994017052A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
FR2702212B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
EP0868422A1 (de) * 1996-09-24 1998-10-07 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
HUP0101457A3 (en) * 1997-12-31 2003-01-28 Bristol Myers Squibb Co Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
BRPI0511109A (pt) * 2004-05-14 2007-11-27 Immunogen Inc método fácil para sintetizar compostos de baccatin iii
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN104250235B (zh) * 2014-09-24 2016-10-05 江苏红豆杉药业有限公司 一种紫杉醇的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol

Also Published As

Publication number Publication date
CA2155014C (en) 2007-06-26
JPH10502327A (ja) 1998-03-03
CA2155013A1 (en) 1994-08-04
CN1125061C (zh) 2003-10-22
CN1101346A (zh) 1995-04-12
IL108444A0 (en) 1994-04-12
TW402598B (en) 2000-08-21
JPH08506326A (ja) 1996-07-09
AU685778B2 (en) 1998-01-29
EP0681573A1 (de) 1995-11-15
CA2155014A1 (en) 1994-08-04
DE69430902T2 (de) 2002-10-24
DE69430661D1 (de) 2002-06-27
JP3452928B2 (ja) 2003-10-06
AU684268B2 (en) 1997-12-11
WO1994017052A1 (en) 1994-08-04
EP0681575A4 (de) 1995-12-13
EP0681573B1 (de) 2002-07-03
EP0681573A4 (de) 1995-12-06
AU6132794A (en) 1994-08-15
DK0681573T3 (da) 2002-10-28
DE69430661T2 (de) 2002-10-24
DE69430902D1 (de) 2002-08-08
TW360646B (en) 1999-06-11
ATE220064T1 (de) 2002-07-15
PT681573E (pt) 2002-11-29
EP0681575A1 (de) 1995-11-15
EP0681575B1 (de) 2002-05-22
AU6234094A (en) 1994-08-15
WO1994017051A1 (en) 1994-08-04
CA2155013C (en) 2006-04-11
ES2176237T3 (es) 2002-12-01
JP3741715B2 (ja) 2006-02-01

Similar Documents

Publication Publication Date Title
ATE217870T1 (de) Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4
NL350077I2 (nl) Cyprosulfamide
DE69430611D1 (de) Phosphonooxymethyl oder Methylthiomethylether von Taxanderivaten als Antitumormittel
DE69738740D1 (de) Verwendung von Oestrogen Antagonisten und Oestrogen Agonisten zur Behandlung von pathologischen Zuständen
FR2733244B1 (fr) Systeme de stabilisants a base de derives de polyalkylpiperidine
DE69420564D1 (de) Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)-homoserinlacton
DE69429438D1 (de) Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
KR927003540A (ko) 3-벤질리덴-1-카르바모일-2-피롤리돈 유사체
RU95108387A (ru) Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина
DE60234092D1 (de) Agonisten und antagonisten von sphingosin-1-phosphatrezeptoren
EA199900620A1 (ru) Фталазиноны
DK0863887T3 (da) Mellemprodukter til hemisyntese af taxaner og fremgangsmåder til deres fremstilling
EA200201083A1 (ru) Противоопухолевые производные эктейнасцидина
CO5050366A1 (es) Compuesto fungicida correspondiente a compuesto 7-bromo-3- metil-3,4-dihidrotienol[3,2-d]pirimidin-4-ona
MX9306606A (es) Procedimiento para la preparacion de derivados de taxano.
DE69102936D1 (de) Bis(alkyl-substituierte-4-hydroxyphenylthio)alkan-Analoga als Inhibitoren der Kataraktentstehung.
EA199800034A1 (ru) Способ получения n-монозамещенных и n,n'-дизамещенных асимметричных циклических мочевин
MX9203845A (es) Nuevos benzomorfanos, procedimieto para su preparacion y composiciones farmaceuticas que los contienen.
ES458557A1 (es) Un procedimiento de preparacion de derivados de quinazolina.
NO983691D0 (no) Forbindelser tilhörende amidiniumfamilien, farmasöytiske preparater inneholdende disse samt anvendelse derav
DE60032827D1 (de) Verfahren und Oxazolidin Zwischenprodukt zur Herstellung von Taxanen
NO20002600L (no) Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger
DE60031269D1 (de) Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen
BR9612242A (pt) Processo para a preparação de derivados de 7-(alcoxicarboniloxi-beta-substituidos)-10-hidroxi-tax anos e os respectivos derivados
ATE252381T1 (de) Neue cyanoaziridine zur behandlung von krebs

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties