KR950701625A - 항발작 치료용 gaba 및 l-글루탐산 동족체(gbab and l-glutamic acid analogs for antiseizure treatment) - Google Patents
항발작 치료용 gaba 및 l-글루탐산 동족체(gbab and l-glutamic acid analogs for antiseizure treatment)Info
- Publication number
- KR950701625A KR950701625A KR1019940704158A KR19940704158A KR950701625A KR 950701625 A KR950701625 A KR 950701625A KR 1019940704158 A KR1019940704158 A KR 1019940704158A KR 19940704158 A KR19940704158 A KR 19940704158A KR 950701625 A KR950701625 A KR 950701625A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- ester
- phenyl
- acid
- azide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
Abstract
본 발명의 하기 일반식의 화합물에서,
R1은 1~6개의 탄소원자를 갖는 직쇄형 알킬기 또는 측쇄형 알킬기, 페닐, 또는 3~6개의 탄소원자를 갖는 시클로알킬이고; R2는 수소 또는 메틸이며; R3는 수소, 메틸 또는 카르복실이다.
이 화합물은 발작성 질병 치료에 유용하다.
또한 본 발명은 상기 화합물의 제조방법에 대해서도 기술하였다. 상기 화합물의 합성시 제조된 중간물질에 대해서도 기술하였다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (16)
- 4-메틸-5-페닐-2-옥사졸리디논, 4-메틸-(2-메틸프로필)-2-디옥소-5-페닐-3-옥사졸리딘부탄산, 페닐메틸 에스테르, 4-메틸-펜타노일 클로라이드, 4-메틸-3-(4-메틸-1-옥소펜틸)-5-페닐-2-옥사졸리디논, 2-(2-메틸프로필)-부탄디산, 4-(페닐메틸)에스테르, 3-(아지도메틸)-5-메틸-헥산산, 페닐메틸 에스테르, 3-(히드록시메틸)-5-메틸-헥산산, 페닐메틸 에스테르, 5-메틸-3-[[[(4-메틸페닐)술포닐]옥시]-메틸]-헥산산, 페닐메틸 에스테르, 3-(아지도메틸)-5-메틸-헥산산, 2-(2-메틸프로필)-1,4-부틴디산, 4-(1,1-디메틸에틸)에스테르, 3-(아지도메틸)-5-메틸-1, 1-디메틸에틸에스테르, 3-(히드록시 메틸)-5-메틸-헥산산, 1, 1-디메틸에스테르, 5-메틸-3[[[(4-메틸(페닐)술포닐]옥시]-메틸-헥산산, 1,1-디메틸에틸에스테르, 또는 4-메틸-(2-메틸프필)-2-디옥소-5-페닐-3-옥사졸리딘부탄산, 1,1-디메틸에틸에스테르인 화합물.
- (S)-3-(아지도메틸)-5-메틸-헥산산인 화합물.
- (S)-3-(아지도메틸)-5-메틸-헥산산, 1,1-디메틸에틸에스테르인 화합물.
- (S)-5-메틸-3-[[[(4-메틸(페닐)술포닐]-옥시]메틸-헥산산, 1,1-디메틸에틸 에스테르, (S)-3-(히드록시메틸)-5-메틸-, 1,1-디-메틸에틸 에스테르, (S)-2-(2-메틸프로필)-1,4-부탄디산, 4-(1,1-디메틸에틸) 에스테르, 또는 (S)-4-메틸-(2-메틸프로필)-2-디옥소-5-페닐-3-옥사졸리딘부탄산, 1,1-디메틸에틸에스테르인 화합물.
- R1은 1~6개의 탄소원자를 갖는 직쇄형 알킬 또는 측쇄형 알킬, 페닐, 또는 3~6개의 탄소원자를 갖는 시클로알킬이고; R2가 수소 또는 메틸이며; R3가 수소, 메틸 또는 카르복실인 상기 일반식 Ⅰ의 비대칭 화합물의 제조 방법에 있어서, 다음 일반식의 아지드를 가수분해시켜다음 일반식의 중간물질 아지드를 만들고,중간물질 아지드를 환원시켜 다음 일반식의 아민을 제조함을 특징으로 하는 제조방법:위 식에서, R1과 R2는 제1항에 정의한 바와 같고, Ph는 페닐, Me는 메틸, Bn은 벤질을 나타낸다.
- 제5항에 있어서, 상기 아지드를 수산화나트륨으로 처리하여 가수분해 시킴을 특징으로 하는 제조방법.
- 제5항에 있어서, 상기 중간물질 아지드를 수성염기에서 추출하는 단계를 더 포함함을 특징으로 하는 제조방법.
- 제7항에 있어서, 상기 수성 추출물을 산성화시키는 단계를 더 포함함을 특징으로 하는 제조방법.
- 제5항에 있어서, 상기 중간물질 아지드를 중성 조건하에서 환원시켜 아미노산을 제공함을 특징으로 하는 제조방법.
- 제5항에 제조 방법으로 제조된 아미노산.
- ⅠR1은 1~6개의 탄소원자를 갖는 직쇄형 알킬이고; R2가 수소 또는 메틸이며; R3가 수소,메틸 또는 카르복실인 상기 일반식의 비대칭 화합물의 제조 방법에 있어서, 다음 일반식의 아지드를 가수분해시켜다음 일반식의 중간물질 아지드를 만들고,중간물질 아지드를 환원시켜 다음 일반식의 아민을 제조함을 특징으로 하는 제조방법:위 식에서, R1과 R2는 제1항에 정의한 바와 같고, ph는 페닐, Me는 메틸을 나타낸다.
- 제11항에 있어서, 상기 아지드를 수산화나트륨으로 처리하여 가수분해 시킴을 특징으로 하는 제조방법.
- 제11항에 있어서, 상기 중간물질 아지드를 수성염기에서 추출하는 단계를 더 포함함을 특징으로 하는 제조방법.
- 제13항에 있어서, 상기 수성 추출물을 산성화시키는 단계를 더 포함함을 특징으로 하는 제조방법.
- 제11항에 있어서, 상기 중간물질 아지드를 중성 조건하에서 환원시켜 아미노산을 제공함을 특징으로 하는 제조방법.
- 제11항의 제조 방법으로 제조된 아미노산.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88608092A | 1992-05-20 | 1992-05-20 | |
US886,080 | 1992-05-20 | ||
PCT/US1993/004680 WO1993023383A1 (en) | 1992-05-20 | 1993-05-18 | Gaba and l-glutamic acid analogs for antiseizure treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
KR950701625A true KR950701625A (ko) | 1995-04-28 |
Family
ID=25388336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940704158A KR950701625A (ko) | 1992-05-20 | 1993-05-18 | 항발작 치료용 gaba 및 l-글루탐산 동족체(gbab and l-glutamic acid analogs for antiseizure treatment) |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0641330B1 (ko) |
JP (2) | JP3856816B2 (ko) |
KR (1) | KR950701625A (ko) |
AT (1) | ATE207052T1 (ko) |
AU (1) | AU677008B2 (ko) |
CA (1) | CA2134674C (ko) |
CZ (1) | CZ286106B6 (ko) |
DE (2) | DE122004000039I2 (ko) |
DK (1) | DK0641330T3 (ko) |
ES (1) | ES2165857T3 (ko) |
FI (1) | FI945426A0 (ko) |
HK (1) | HK1011022A1 (ko) |
HU (2) | HU222776B1 (ko) |
LU (1) | LU91112I2 (ko) |
NL (1) | NL300164I2 (ko) |
NO (1) | NO944370L (ko) |
NZ (1) | NZ253459A (ko) |
PT (1) | PT641330E (ko) |
RU (2) | RU2140901C1 (ko) |
SG (1) | SG48288A1 (ko) |
SK (1) | SK283281B6 (ko) |
WO (1) | WO1993023383A1 (ko) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL113052A0 (en) * | 1994-03-23 | 1995-06-29 | Rhone Poulenc Rorer Sa | Recombinant viruses, their preparation and their use in gene therapy |
US5792796A (en) * | 1994-07-27 | 1998-08-11 | Warner-Lambert Company | Methods for treating anxiety and panic |
HU223841B1 (hu) * | 1994-07-27 | 2005-02-28 | Warner-Lambert Company | Gabepentin alkalmazása szorongás és pánik kezelésére alkalmazható gyógyszerkészítmények előállítására |
US5616793A (en) * | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US6372792B1 (en) * | 1996-04-26 | 2002-04-16 | Guy Chouinard | Method for treating anxiety, anxiety disorders and insomnia |
PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
ATE361909T1 (de) * | 1996-10-23 | 2007-06-15 | Warner Lambert Co | Substituierte gamma-aminobuttersäurederivate als arzneimittel |
WO1999008670A1 (en) * | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Gaba analogs to prevent and treat gastrointestinal damage |
DK1011658T3 (da) | 1997-09-08 | 2006-04-03 | Warner Lambert Co | Analgesiske præparater, der omfatter antiepileptiske forbindelser, og fremgangsmåder til anvendelse af samme |
PT1077692E (pt) * | 1998-05-15 | 2004-12-31 | Warner Lambert Co | Preparacoes farmaceuticas estabilizadas de derivados do acido aminobutirico e processos para a sua preparacao |
CA2344407C (en) * | 1998-10-16 | 2007-01-09 | Warner-Lambert Company | Method for the treatment of mania and bipolar disorder |
US6627771B1 (en) | 1998-11-25 | 2003-09-30 | Pfizer Inc | Gamma amino butyric and acid analogs |
WO2000061135A1 (en) * | 1999-04-08 | 2000-10-19 | Warner-Lambert Company | Method for the treatment of incontinence |
US6992109B1 (en) * | 1999-04-08 | 2006-01-31 | Segal Catherine A | Method for the treatment of incontinence |
US6642398B2 (en) | 1999-06-10 | 2003-11-04 | Warner-Lambert Company | Mono-and disubstituted 3-propyl gamma-aminobutyric acids |
RS50352B (sr) * | 1999-06-10 | 2009-11-10 | Warner-Lambert Company Llc., | Monosupstituisane 3-propil gama-aminobuterne kiseline |
US7164034B2 (en) | 1999-06-10 | 2007-01-16 | Pfizer Inc. | Alpha2delta ligands for fibromyalgia and other disorders |
AU2002213422A1 (en) | 2000-09-13 | 2002-03-26 | Georgetown University | Synthesis of 2-hydroxymethylglutamic acid and congeners thereof |
EP1343805A4 (en) | 2000-10-06 | 2005-07-20 | Xenoport Inc | COMPOUNDS DERIVED FROM GALLENIC ACIDS FOR THE PROVISION OF CONTINUING SYSTEMIC CONCENTRATIONS OF MEDICINAL PRODUCTS AFTER ORAL ADMINISTRATION |
AU2002230398A1 (en) | 2000-10-06 | 2002-04-29 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
US6462084B1 (en) * | 2001-05-14 | 2002-10-08 | Brookhaven Science Associates, Llc | Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG |
JP2005501013A (ja) | 2001-06-11 | 2005-01-13 | ゼノポート,インコーポレイテッド | Gaba類似体の全身濃度が持続するアミノ酸コンジュゲート |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
HUP0400167A3 (en) * | 2001-06-11 | 2012-09-28 | Xenoport Inc | Prodrugs of gaba analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
EP1485082A4 (en) | 2002-02-19 | 2009-12-30 | Xenoport Inc | PROCESS FOR THE SYNTHESIS OF PROMEDICAMENTS FROM 1-ACYL-ALKYL DERIVATIVES AND CORRESPONDING COMPOSITIONS |
AU2003222033A1 (en) | 2002-03-20 | 2003-10-08 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
US20030225149A1 (en) * | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
WO2003099338A2 (en) | 2002-05-17 | 2003-12-04 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
US7419981B2 (en) | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
US7071339B2 (en) | 2002-08-29 | 2006-07-04 | Warner Lambert Company Llc | Process for preparing functionalized γ-butyrolactones from mucohalic acid |
WO2004052360A1 (en) | 2002-12-11 | 2004-06-24 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
RU2353358C2 (ru) | 2002-12-13 | 2009-04-27 | Уорнер-Ламберт Компани Ллс | Производные прегабалина для лечения приливов |
NZ567457A (en) | 2002-12-13 | 2009-08-28 | Warner Lambert Co | Alpha-2-delta ligand to treat lower urinary tract symptoms |
CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
EP1670451A4 (en) | 2003-09-11 | 2009-10-21 | Xenoport Inc | TREATMENT AND / OR PREVENTION OF URINARY INCONTINENCE AND PROMOTERS OF GABA ANALOGS |
WO2005025675A1 (en) | 2003-09-12 | 2005-03-24 | Pfizer Limited | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
RU2377234C2 (ru) * | 2003-09-17 | 2009-12-27 | Ксенопорт, Инк. | Лечение или предупреждение синдрома беспокойных ног с использованием пролекарств аналогов гамк |
SG146643A1 (en) | 2003-09-17 | 2008-10-30 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
SG147437A1 (en) | 2003-10-14 | 2008-11-28 | Xenoport Inc | Crystalline form of gamma-aminobutyric acid analog |
AU2004305563C1 (en) | 2003-12-11 | 2011-07-07 | Sunovion Pharmaceuticals Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
BRPI0517227B8 (pt) | 2004-11-04 | 2021-05-25 | Xenoport Inc | comprimido oral de liberação prolongada do ácido 1-{[alfa-isobutanoiloxietoxi)carbonil]amino metil}-1-cicloexano acético, e, uso do comprimido |
EP1820502A1 (en) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
RS51940B (en) | 2006-12-22 | 2012-02-29 | Recordati Ireland Limited | Combined TH2δ LIGANAD THERAPY AND NSAID FOR LOWER URINARY TRACT DISORDERS |
CA2710152A1 (en) * | 2007-12-26 | 2009-07-02 | Generics (Uk) Limited | Processes to pregabalin |
US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
EP2250148B1 (en) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use |
JP5291123B2 (ja) | 2008-01-25 | 2013-09-18 | ゼノポート,インコーポレイティド | (3s)−アミノメチル−5−ヘキサン酸プロドラッグの結晶形態及びその使用 |
EP2110372A1 (en) | 2008-04-16 | 2009-10-21 | Chemo Ibérica, S.A. | Intermediates for the preparation of Pregabalin and process for their preparation |
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
EP2123626A1 (en) | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Co-crystals of duloxetine and co-crystal formers for the treatment of pain |
ES2589915T3 (es) | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
ES2362913B1 (es) | 2009-12-24 | 2012-05-24 | Moehs Iberica S.L. | Nuevo método para la preparación de (s)-pregabalina. |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
JP5778133B2 (ja) | 2010-03-18 | 2015-09-16 | 第一三共株式会社 | シクロプロパンカルボン酸誘導体 |
MX358628B (es) | 2010-03-18 | 2018-08-28 | Daiichi Sankyo Co Ltd | Derivado de imidazol sustituido con cicloalquilo. |
EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
PL2599487T3 (pl) | 2010-07-30 | 2015-09-30 | Toray Industries | Środek terapeutyczny lub środek profilaktyczny przeciwko bólowi neuropatycznemu |
EP2415460A1 (de) | 2010-08-03 | 2012-02-08 | ratiopharm GmbH | Orale Darreichungsform von Pregabalin |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
US8212072B2 (en) | 2010-08-13 | 2012-07-03 | Divi's Laboratories, Ltd. | Process for the preparation of pregabalin |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
EP2527319A1 (en) | 2011-05-24 | 2012-11-28 | Laboratorios Del. Dr. Esteve, S.A. | Crystalline forms of pregabalin and co-formers in the treatment of pain |
WO2013100873A1 (en) | 2011-12-19 | 2013-07-04 | Mahmut Bilgic | Pharmaceutical formulation of pregabalin (particle size 300-2500 micrometer) |
ES2423254B1 (es) | 2012-02-15 | 2014-03-26 | Laboratec, S.L. | Composición farmacéutica para el tratamiento de incontinencia urinaria y enuresis |
US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
CA2903000C (en) | 2013-01-28 | 2021-10-12 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor |
CN105873580B (zh) | 2013-12-17 | 2020-08-25 | 埃斯蒂维制药有限公司 | 加巴喷丁类化合物与σ受体配体的组合物 |
CN105873578A (zh) | 2013-12-17 | 2016-08-17 | 埃斯蒂维实验室股份有限公司 | 血清素-去甲肾上腺素再摄取抑制剂(SNRIs)和σ受体配体组合物 |
WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
AU2019271799B2 (en) | 2018-05-14 | 2023-10-12 | Xgene Pharmaceutical Inc. | Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin |
DE202018105573U1 (de) | 2018-09-27 | 2018-10-19 | Laboratec | Pharmazeutische Zusammensetzung zur Behandlung der Harninkontinenz und Enuresis |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4840460B1 (ko) * | 1969-02-05 | 1973-11-30 | ||
US4173541A (en) * | 1978-06-05 | 1979-11-06 | Cincinnati Milacron Chemicals Inc. | Polynuclear hindered phenols and stabilized organic materials containing the phenols |
US4322440A (en) * | 1980-06-25 | 1982-03-30 | New York University | Anticonvulsive compositions and method of treating convulsive disorders |
US4479005A (en) * | 1982-12-16 | 1984-10-23 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
US4771038A (en) * | 1986-01-21 | 1988-09-13 | Ici Americas Inc. | Hydroxamic acids |
US4814342A (en) * | 1986-10-31 | 1989-03-21 | Pfizer Inc. | Nor-statine and nor-cyclostatine polypeptides |
KR930003864B1 (ko) * | 1990-10-19 | 1993-05-14 | 한국과학기술연구원 | d-2-(6-메톡시-2-나프틸)-프로피온산의 제조방법 |
AU9137091A (en) * | 1990-11-27 | 1992-06-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
US5198548A (en) * | 1992-01-30 | 1993-03-30 | Warner-Lambert Company | Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof |
-
1993
- 1993-05-18 SK SK1395-94A patent/SK283281B6/sk not_active IP Right Cessation
- 1993-05-18 ES ES93925173T patent/ES2165857T3/es not_active Expired - Lifetime
- 1993-05-18 AU AU43794/93A patent/AU677008B2/en not_active Ceased
- 1993-05-18 AT AT93925173T patent/ATE207052T1/de active
- 1993-05-18 NZ NZ253459A patent/NZ253459A/en not_active IP Right Cessation
- 1993-05-18 HU HU9702482A patent/HU222776B1/hu active IP Right Grant
- 1993-05-18 JP JP50380794A patent/JP3856816B2/ja not_active Expired - Lifetime
- 1993-05-18 DK DK93925173T patent/DK0641330T3/da active
- 1993-05-18 CA CA002134674A patent/CA2134674C/en not_active Expired - Lifetime
- 1993-05-18 WO PCT/US1993/004680 patent/WO1993023383A1/en active IP Right Grant
- 1993-05-18 KR KR1019940704158A patent/KR950701625A/ko not_active Application Discontinuation
- 1993-05-18 SG SG1996008718A patent/SG48288A1/en unknown
- 1993-05-18 RU RU96124481A patent/RU2140901C1/ru active
- 1993-05-18 RU RU94046105/04A patent/RU94046105A/ru unknown
- 1993-05-18 CZ CZ19942849A patent/CZ286106B6/cs not_active IP Right Cessation
- 1993-05-18 PT PT93925173T patent/PT641330E/pt unknown
- 1993-05-18 EP EP93925173A patent/EP0641330B1/en not_active Expired - Lifetime
- 1993-05-18 HU HU9403310A patent/HU222339B1/hu active Protection Beyond IP Right Term
- 1993-05-18 DE DE1993630949 patent/DE122004000039I2/de active Active
- 1993-05-18 DE DE69330949T patent/DE69330949T2/de not_active Expired - Lifetime
-
1994
- 1994-11-16 NO NO944370A patent/NO944370L/no unknown
- 1994-11-18 FI FI945426A patent/FI945426A0/fi not_active Application Discontinuation
-
1998
- 1998-11-17 HK HK98112078A patent/HK1011022A1/xx not_active IP Right Cessation
-
2004
- 2004-03-16 JP JP2004075406A patent/JP4297814B2/ja not_active Expired - Lifetime
- 2004-10-06 LU LU91112C patent/LU91112I2/fr unknown
- 2004-11-22 NL NL300164C patent/NL300164I2/nl unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR950701625A (ko) | 항발작 치료용 gaba 및 l-글루탐산 동족체(gbab and l-glutamic acid analogs for antiseizure treatment) | |
KR930703305A (ko) | 5-헤테로일 인돌 유도체 | |
AU515774B2 (en) | Benzopyran derivatives | |
KR910021366A (ko) | 4-(4-알콕시페닐)-2-부틸아민 유도체 및 그의 제조방법 | |
KR960017648A (ko) | 옥사졸리딘디온 유도체, 그의 제법 및 용도 | |
CY1107238T1 (el) | Παρασκευη μιας πολυμορφικης μορφης ενος παραγωγου θειαζολιδινοδιονης | |
ATE319702T1 (de) | Verfahren zur herstellung von benzothiophen- derivaten | |
DK1395263T3 (da) | 3, 7 eller 3 og 7 thia- eller oxaprostansyrederivater som midler til at sænke intraokulært tryk | |
KR920701177A (ko) | 3-아릴옥사졸리디논 유도체, 그의 제조 방법 및 그의 치료 용도 | |
KR950032276A (ko) | 내부기생충 구제제로서의 18 환 원자를 갖는 락트산- 함유 사이클릭 뎁시펩타이드, 및 이의 제조방법 | |
ATE265541T1 (de) | Verfahren zur fermentativen herstellung von nicht-proteinogenen l-aminosäuren | |
KR870005985A (ko) | 구아니디노벤조 에스테르유도체 및 그의 제조방법 | |
KR930702339A (ko) | 에폭시숙시남산 유도체 | |
KR850000455A (ko) | 세팔로스포린 에스테르 유도체의 제조방법 | |
KR880007528A (ko) | [3s(z)]-2[[[1-(2-아미노-4-티아졸릴)-2-[[2,2-디메틸-4-옥소-1-(술포옥시)-3-아제티디닐]아미노]-2-옥소에틸리덴]아미노]옥시]아세트산의 결정질 염류 | |
KR950702638A (ko) | 입체 특이적 γ-아미노부티르산 트란스아미나제 억제제의 라세미 혼합물의 효소적 분할 방법(Enzymatic Resolution of a Racemic Mixture of Stereopecific GABA-T Inhibitors) | |
BR0008586A (pt) | Processo de preparação de aminoácidos quirais e processo de preparação de compostos a partir destes | |
PT91145A (pt) | Processo para a sintese de amino-acidos opticamente activos | |
KR920701232A (ko) | 신규 9α-히드록시-3-옥소-4,24(25)-스티그마스타디엔-26-산 유도체, 이의 제조법 및 이를 함유하는 약학 조성물 | |
BR9815967A (pt) | Processo para a preparação de um derivado de amino-5-cloro de 3(2h)-piridazinona-4-substituìdo | |
KR870002153A (ko) | α-시아노-(디)티오포스폰산 에스테르의 제조 방법 | |
KR860003250A (ko) | 위치 2에 α-히드록실쇄가 치환된 4-히드록시-3-퀴놀린 카르복실산으로 부터 유도된 에스테르의 제조방법 | |
KR920002564A (ko) | N-알킬 티아졸리딘 유도체 | |
KR890009860A (ko) | 광학적 활성 카르복실산 유도체 l-리진염 및 그의 제조방법 | |
KR960701832A (ko) | Ng-모노알킬-l-아르기닌 및 관련 화합물의 제조 방법(process for preparing ng-monoalkyl-l-arginine and related compounds) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |