KR930007938A - 시클릭 치환 이미다졸릴-프로펜산 유도체 - Google Patents

시클릭 치환 이미다졸릴-프로펜산 유도체 Download PDF

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Publication number
KR930007938A
KR930007938A KR1019920017893A KR920017893A KR930007938A KR 930007938 A KR930007938 A KR 930007938A KR 1019920017893 A KR1019920017893 A KR 1019920017893A KR 920017893 A KR920017893 A KR 920017893A KR 930007938 A KR930007938 A KR 930007938A
Authority
KR
South Korea
Prior art keywords
carbon atoms
straight
branched chain
hydrogen
chain alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019920017893A
Other languages
English (en)
Korean (ko)
Inventor
크래머 토마스
드레셀 위르겐
항코 루돌프
휘브쉬 발테르
뮐러 울리히
뮐러-글리만 마티아스
보익 마르틴
카즈다 스타니슬라프
스타쉬 요하네스-페터
크노르 안드레아스
볼파일 스테판
Original Assignee
만프레트 조벨
바이엘 악티엔게젤샤프트
요아힘 그렘
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 만프레트 조벨, 바이엘 악티엔게젤샤프트, 요아힘 그렘 filed Critical 만프레트 조벨
Publication of KR930007938A publication Critical patent/KR930007938A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019920017893A 1991-10-01 1992-09-30 시클릭 치환 이미다졸릴-프로펜산 유도체 Withdrawn KR930007938A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4132633.4 1991-10-01
DE4132633A DE4132633A1 (de) 1991-10-01 1991-10-01 Cyclisch substituierte imidazolyl-propensaeurederivate

Publications (1)

Publication Number Publication Date
KR930007938A true KR930007938A (ko) 1993-05-20

Family

ID=6441875

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920017893A Withdrawn KR930007938A (ko) 1991-10-01 1992-09-30 시클릭 치환 이미다졸릴-프로펜산 유도체

Country Status (14)

Country Link
US (1) US5225428A (enExample)
EP (1) EP0535465A1 (enExample)
JP (1) JPH05213937A (enExample)
KR (1) KR930007938A (enExample)
AU (1) AU646762B2 (enExample)
CA (1) CA2079266A1 (enExample)
CZ (1) CZ297792A3 (enExample)
DE (1) DE4132633A1 (enExample)
HU (1) HUT62578A (enExample)
IL (1) IL103292A0 (enExample)
MX (1) MX9205434A (enExample)
NO (1) NO923581L (enExample)
TW (1) TW206966B (enExample)
ZA (1) ZA927499B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
AU696868B2 (en) * 1994-03-29 1998-09-17 Merck & Co., Inc. Treatment of atherosclerosis with angiotensin II receptor blocking imidazoles
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
US6465502B1 (en) 1998-12-23 2002-10-15 Novartis Ag Additional therapeutic use
WO2006081807A2 (de) * 2005-02-03 2006-08-10 Ratiopharm Gmbh Verfahren zur herstellung von losartan
EP1741711A1 (en) * 2005-07-04 2007-01-10 KRKA, D.D., Novo Mesto A process for the preparation of losartan derivatives by chlorination and reduction of the respective 1H-imidazole-5-carbaldehydes
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
CN107325052B (zh) * 2017-06-19 2020-01-10 广东药科大学 一类具有抗癌活性的咪唑酯类化合物及其衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
DK0955294T3 (da) * 1989-06-14 2004-02-02 Smithkline Beecham Corp Imidazolylalkensyre
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
DE69025473T2 (de) * 1989-06-30 1996-10-17 Du Pont Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
JP2568315B2 (ja) * 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
CA2027937A1 (en) * 1989-10-25 1991-04-26 Richard M. Keenan Substituted 5-¬ (tetrazolyl)alkenyl|imidazoles
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate

Also Published As

Publication number Publication date
CZ297792A3 (en) 1993-04-14
IL103292A0 (en) 1993-02-21
MX9205434A (es) 1993-04-01
HU9203125D0 (en) 1992-12-28
EP0535465A1 (de) 1993-04-07
NO923581D0 (no) 1992-09-15
HUT62578A (en) 1993-05-28
TW206966B (enExample) 1993-06-01
JPH05213937A (ja) 1993-08-24
CA2079266A1 (en) 1993-04-02
DE4132633A1 (de) 1993-04-08
AU646762B2 (en) 1994-03-03
AU2602592A (en) 1993-04-08
ZA927499B (en) 1993-05-03
NO923581L (no) 1993-04-02
US5225428A (en) 1993-07-06

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19920930

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid