KR910007890A - 아미노피리미딘의 제조방법 - Google Patents

아미노피리미딘의 제조방법 Download PDF

Info

Publication number
KR910007890A
KR910007890A KR1019900016952A KR900016952A KR910007890A KR 910007890 A KR910007890 A KR 910007890A KR 1019900016952 A KR1019900016952 A KR 1019900016952A KR 900016952 A KR900016952 A KR 900016952A KR 910007890 A KR910007890 A KR 910007890A
Authority
KR
South Korea
Prior art keywords
formula
alkyl
alcohol
process according
iii
Prior art date
Application number
KR1019900016952A
Other languages
English (en)
Inventor
라흐하인 스테펜
빌름스 로타르
Original Assignee
오일러, 라피체
훽스트 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오일러, 라피체, 훽스트 아크티엔게젤샤프트 filed Critical 오일러, 라피체
Publication of KR910007890A publication Critical patent/KR910007890A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

아미노피리미딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기일반식(Ⅳ)의 알콜중의 하기 일반식(Ⅱ) 및 (Ⅲ)의 화합물의 용액 또는 하기 일반식(Ⅳ)의 알콜중의 각각 하기 일반식(Ⅱ) 및 (Ⅲ) 화합물의 분리된 용액을 동시에 100℃이상의 온도에서 알콜에 비해 더 높은 온도에서 비등하는 불활성 유기 용매에 가하는 동시에 증류에 의해 상기 상기 일반식(Ⅳ)의 알콜을 제거하는 하기 일반식(Ⅱ)의 프로판디이미데이트 또는 그의 염을 하기 일반식(Ⅲ)의 시안아미드의 염과 반응시킴을 포함하는 하기 일반식
    (I)화합물의 제조방법.
    (R3)j(H-)k(N-C≡N)2- (Ⅲ)
    R4-OH (Ⅳ)
    상기식에서, X 및 Y는 각각의 경우에 산소 또는 황이고, R1, R2는 서로 독립적으로 (C1-C4)알킬, (C1-C4)알콕시 (C1-C2)알킬 또는 할로(C1-C4)알킬이며, R3은 알칼리 금속 또는 알칼리 토금속 양이온이고, R3가 알칼리 토금속 양이온인 경우 j=1 및 k=0이거나, 또는 R3가 알칼리 금속 양이온인 경우 j=1 및 k=1 또는 j=2 및 k=0이며 R4는 (C1-C4)알킬이다.
  2. 제1항에 있어서, 일반식(I)에서 X 및 Y가 각각의 경우에 산소원자이고 R1및 R2가 (C1-C4)알킬인 방법.
  3. 제1항 또는 제2항에 있어서, 일반식(I)에서 R1, 및 R2가 각각의 경우에 메틸 또는 에틸인 방법.
  4. 제1항 또는 제3항중 어느 한 항에 있어서, 사용된 일반식(Ⅱ) 화합물의 염이 블루오르화수소산, 염산 또는 브롬화수소산, 황산 또는 인산의 염인 방법.
  5. 제1항 내지 제4항에 어느 한 항에있어서, 임의로 할로겐화된 탄화수소를 불활성 유기 용매로서 사용하는 방법.
  6. 제5항에 있어서, 클로로벤젠, 톨루엔 또는 크실렌을 사용하는 방법.
  7. 제1항 내지 제6항중 어느 한 항에 있어서, 상기 일반식(Ⅳ)의 알콜이 메탄올 또는 에탄올인 방법.
  8. 제1항 내지 제7항중에 어느 한 항에 있어서, 상기일반식(Ⅳ)의 알콜중의 상기 일반식(Ⅱ)또는 (Ⅲ)화합물이 용액 또는 용액들을 -10내지 +10로 조절하는 방법.
  9. 제1항 내지 제8항에 어느 한 항에 있어서, 침전된 무기 염들을 반응시킨 후에 반응 용액으로 부터 여과하고 불활성 유기용매를 증류에 의해 제거하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900016952A 1989-10-24 1990-10-23 아미노피리미딘의 제조방법 KR910007890A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE39352781 1989-10-24
DE3935278A DE3935278A1 (de) 1989-10-24 1989-10-24 Verfahren zur herstellung von aminopyrimidinen

Publications (1)

Publication Number Publication Date
KR910007890A true KR910007890A (ko) 1991-05-30

Family

ID=6392022

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900016952A KR910007890A (ko) 1989-10-24 1990-10-23 아미노피리미딘의 제조방법

Country Status (7)

Country Link
US (1) US5070201A (ko)
EP (1) EP0424849B1 (ko)
JP (1) JPH03167177A (ko)
KR (1) KR910007890A (ko)
AT (1) ATE104285T1 (ko)
DE (2) DE3935278A1 (ko)
IL (1) IL96079A0 (ko)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100122351A (ko) * 2009-05-12 2010-11-22 파인텍스 주식회사 반도체용 닦음천 제조공정에서 사용되는 수축처리액 조성물
KR20220040841A (ko) * 2020-09-24 2022-03-31 (주)인터마루인더스트리 반도체 제조 클린룸용 친환경 고밀도 와이퍼의 제조 방법
KR20230053039A (ko) * 2021-10-13 2023-04-21 (주)인터마루인더스트리 반도체 제조 클린룸용 친환경 세섬도 고밀도 와이퍼의 제조 방법

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE913245A1 (en) * 1990-09-15 1992-02-25 Hoechst Ag Process for the preparation of aminopyrimidines
US5289056A (en) * 1992-06-12 1994-02-22 National Semiconductor Corporation BICMOS input buffer circuit with integral passgate
JP3269192B2 (ja) * 1992-08-05 2002-03-25 ロンザ リミテッド ２−ハロゲン−４，６−ジアルコキシ−ピリミジンの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2426913A1 (de) * 1974-06-04 1975-12-11 Ferring Arzneimittel Gmbh Malonsaeure- bzw. bernsteinsaeure-di- (imidoester),- verfahren zu ihrer herstellung und anwendung in der peptidchemie
US4169719A (en) * 1976-04-07 1979-10-02 E. I. Du Pont De Nemours And Co. Herbicidal sulfonamides
AR225772A1 (es) * 1979-08-14 1982-04-30 Du Pont Nuevo 3-amino-3-alcoxi-n-ciano-2-propenimidato de alquilo y procedimientos para su preparacion y de pirimidinas partiendo de aquellos
IL61185A (en) * 1980-09-30 1984-12-31 Du Pont Methyl 3-amino-3-methoxy-n-cyano-2-propenimidate,its preparation and rearrangement to the corresponding pyrimidine
DE3131489A1 (de) * 1981-08-08 1983-02-24 Hoechst Ag, 6000 Frankfurt Heterocyclisch substituierte sulfonylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung in der landwirtschaft

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100122351A (ko) * 2009-05-12 2010-11-22 파인텍스 주식회사 반도체용 닦음천 제조공정에서 사용되는 수축처리액 조성물
KR20220040841A (ko) * 2020-09-24 2022-03-31 (주)인터마루인더스트리 반도체 제조 클린룸용 친환경 고밀도 와이퍼의 제조 방법
KR20230053039A (ko) * 2021-10-13 2023-04-21 (주)인터마루인더스트리 반도체 제조 클린룸용 친환경 세섬도 고밀도 와이퍼의 제조 방법

Also Published As

Publication number Publication date
US5070201A (en) 1991-12-03
ATE104285T1 (de) 1994-04-15
EP0424849B1 (de) 1994-04-13
IL96079A0 (en) 1991-07-18
DE3935278A1 (de) 1991-04-25
JPH03167177A (ja) 1991-07-19
EP0424849A1 (de) 1991-05-02
DE59005349D1 (de) 1994-05-19

Similar Documents

Publication Publication Date Title
US4323570A (en) Substituted aminopyrimidines
KR910007890A (ko) 아미노피리미딘의 제조방법
KR890011904A (ko) 안드로스타-1,4, -디엔-3,17-디온의 6-메틸렌 유도체 합성방법
SU778710A3 (ru) Способ получени производных аминоалкоксибензофурана
ES8606857A1 (es) Procedimiento para preparar hidrocloruros de 2-hidrazino-1,3-diazacicloalqu-2-eno
US4665172A (en) Process for producing heterocyclic compound having nitromethylene group as the side chain group
KR930017875A (ko) 2-클로로-5-알킬아미노메틸-피리딘의 제조방법
US2867621A (en) Methyl triazines
US3900476A (en) 2(2'-pyrimidylamino)quinazolines and their preparation
KR860001060A (ko) 시클로헥세논 유도체의 제조방법
HU212611B (en) Process for the preparation of 2-substituted 4,6-dialkoxy-pyrimidine derivatives
KR860003212A (ko) 2-피리딘-티올 유도체 및 그의 산부가염의 제조 방법
KR940005619A (ko) 2-아미노-n-[[[4-(아미노카르보닐)피리미딘-2-일]아미노]알킬]피리미딘-4-카르복시아미드 유도체, 이것의 제법 및 치료에의 이용
US5286861A (en) Process for preparing uracil derivatives
KR920012048A (ko) 퀴녹살리닐옥시페녹시프로피온산의 광학적 활성 에스테르의 제조방법
GB2029414A (en) Process for preparing 4(5) - hydroxymethyl 5 (4)-alkyl imidazoles
US2856405A (en) Mecuration products of 1-(2-pyrimidyl)-3-allylurea
BR8203853A (pt) Processo para a obtencao de hidrazidinas
US5166397A (en) Process for producing optically active cyclobutylamines
BR8203989A (pt) Processo para a preparacao de hidrazidinas
KR880000178B1 (ko) 푸란유도체의 제조방법
KR830002349B1 (ko) 4-(5)-하이드록시메틸 5(4)-저급알킬이미다졸류의 제조방법
KR840006217A (ko) 4-아미노-5-디알콕시메틸피리미딘 유도체의 제조방법
GB2119788A (en) Process for removing 1-sulfonyl groups from benzimidazoles
PT98973A (pt) Processo para a preparacao de aminopirimidinas

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid