ES8606857A1 - Procedimiento para preparar hidrocloruros de 2-hidrazino-1,3-diazacicloalqu-2-eno - Google Patents

Procedimiento para preparar hidrocloruros de 2-hidrazino-1,3-diazacicloalqu-2-eno

Info

Publication number
ES8606857A1
ES8606857A1 ES541036A ES541036A ES8606857A1 ES 8606857 A1 ES8606857 A1 ES 8606857A1 ES 541036 A ES541036 A ES 541036A ES 541036 A ES541036 A ES 541036A ES 8606857 A1 ES8606857 A1 ES 8606857A1
Authority
ES
Spain
Prior art keywords
ene
alkyl
hydrazino
diazacycloalk
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541036A
Other languages
English (en)
Other versions
ES541036A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES8606857A1 publication Critical patent/ES8606857A1/es
Publication of ES541036A0 publication Critical patent/ES541036A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/18—Nitrogen atoms not forming part of a nitro radical with hetero atoms attached to said nitrogen atoms, except nitro radicals, e.g. hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE HIDROHALUROS DE 2-HIDRAZINO-1,3-DIAZACICLOALQU-2-ENO, DE FORMULA (I), EN LA QUE X ES UN HALOGENO, R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 0-3. COMPRENDE LA REACCION DE UN EQUIVALENTE MOLAR DE UN COMPUESTO DE FORMULA (R4)3N.HX, Y 1-2 EQUIVALENTES MOLARES DE HIDRATO DE HIDRAZINA; FORMULAS EN LAS QUE R4 REPRESENTA HIDROGENO O ALQUILO C1-4 Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN ALCOHOL ALIFATICO C1-4, EN AGUA, O UNA MEZCLA DE AMBOS, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DE LA MEZCLA. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS PARA LA SINTESIS DE AGENTES ANTICANCERIGENOS.
ES541036A 1984-03-08 1985-03-07 Procedimiento para preparar hidrocloruros de 2-hidrazino-1,3-diazacicloalqu-2-eno Expired ES8606857A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/587,414 US4574155A (en) 1984-03-08 1984-03-08 Process for preparing 2-hydrazino-1,3-diazacycloalk-2-ene hydrohalides

Publications (2)

Publication Number Publication Date
ES8606857A1 true ES8606857A1 (es) 1986-05-16
ES541036A0 ES541036A0 (es) 1986-05-16

Family

ID=24349708

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541036A Expired ES8606857A1 (es) 1984-03-08 1985-03-07 Procedimiento para preparar hidrocloruros de 2-hidrazino-1,3-diazacicloalqu-2-eno

Country Status (19)

Country Link
US (1) US4574155A (es)
EP (1) EP0158020B1 (es)
JP (1) JPS60204768A (es)
KR (1) KR920002265B1 (es)
AT (1) ATE34571T1 (es)
AU (1) AU578935B2 (es)
DD (1) DD231786A5 (es)
DE (1) DE3507579A1 (es)
DK (1) DK166321C (es)
ES (1) ES8606857A1 (es)
FI (1) FI86300C (es)
GR (1) GR850562B (es)
HK (1) HK107290A (es)
IE (1) IE58236B1 (es)
IL (1) IL74431A (es)
NO (1) NO170882C (es)
NZ (1) NZ211278A (es)
PT (1) PT80049B (es)
ZA (1) ZA851731B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258381A (en) * 1984-03-19 1993-11-02 The Rockefeller University 2-substituted-2-imidazolines
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
US5612332A (en) * 1984-03-19 1997-03-18 Alteon Inc. Di- and triaminoguanidines, and methods of use
US4983604A (en) * 1987-11-13 1991-01-08 The Rockefeller University Inhibitors of nonenzymatic cross-linking
JPH0784461B2 (ja) * 1986-12-19 1995-09-13 日本バイエルアグロケム株式会社 殺虫性ニトロイミノ又はシアノイミノ化合物
US5850840A (en) * 1995-11-15 1998-12-22 Alteon Inc. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US6110968A (en) * 1995-12-26 2000-08-29 The Picower Institute For Medical Research Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5877217A (en) * 1995-12-26 1999-03-02 Alteon Inc. N-acylaminoalkyl-hydrazinecarboximidamides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2525927A (en) * 1947-09-26 1950-10-17 Honorary Advisory Council 2-nitramino delta 2-1, 3 diazacycloalkenes
FR1380402A (fr) * 1959-07-30 1964-12-04 Inst Chibret S A Perfectionnements apportés à la préparation d'imidazolines substituées en position 2
BE792606A (fr) * 1972-01-06 1973-03-30 Ferlux Nouveaux semicarbazides et thiosemicarbazides et leur preparation
JPS5222101B2 (es) * 1973-05-09 1977-06-15
US3931152A (en) * 1974-01-29 1976-01-06 American Cyanamid Company 2-(1,3-Diazacycloalkenyl)-2-hydrazones of substituted chalcones
US4258181A (en) * 1978-09-05 1981-03-24 American Cyanamid Company Substituted 9,10-anthracenebishydrazones
US4262122A (en) * 1980-02-19 1981-04-14 American Cyanamid Company Preparation of 5,5-dimethyl-2-hydrazino-1,4,5,6-tetrahydro-pyrimidine hydrohalide

Also Published As

Publication number Publication date
AU3963485A (en) 1985-09-12
PT80049A (en) 1985-04-01
ES541036A0 (es) 1986-05-16
HK107290A (en) 1990-12-28
FI86300C (fi) 1992-08-10
DE3507579A1 (de) 1985-09-12
IE58236B1 (en) 1993-08-11
KR850006190A (ko) 1985-10-02
FI86300B (fi) 1992-04-30
DK105385D0 (da) 1985-03-07
US4574155A (en) 1986-03-04
ATE34571T1 (de) 1988-06-15
KR920002265B1 (ko) 1992-03-20
FI850911A0 (fi) 1985-03-07
PT80049B (pt) 1987-06-17
AU578935B2 (en) 1988-11-10
DD231786A5 (de) 1986-01-08
JPS60204768A (ja) 1985-10-16
GR850562B (es) 1985-07-03
NZ211278A (en) 1988-10-28
EP0158020A1 (en) 1985-10-16
IE850579L (en) 1985-09-08
EP0158020B1 (en) 1988-05-25
DK166321B (da) 1993-04-05
NO170882B (no) 1992-09-14
IL74431A (en) 1990-01-18
JPH0563470B2 (es) 1993-09-10
ZA851731B (en) 1985-11-27
DK166321C (da) 1993-08-30
FI850911L (fi) 1985-09-09
NO170882C (no) 1992-12-23
DK105385A (da) 1985-09-09
NO850907L (no) 1985-09-09
IL74431A0 (en) 1985-05-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505