KR850006190A - 2-히드라지노-1,3-디아자시클로알크-2-엔히드로할라이드의 제조방법 - Google Patents

2-히드라지노-1,3-디아자시클로알크-2-엔히드로할라이드의 제조방법 Download PDF

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KR850006190A
KR850006190A KR1019850001451A KR850001451A KR850006190A KR 850006190 A KR850006190 A KR 850006190A KR 1019850001451 A KR1019850001451 A KR 1019850001451A KR 850001451 A KR850001451 A KR 850001451A KR 850006190 A KR850006190 A KR 850006190A
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South Korea
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sub
hydrogen
sup
alkyl
halide
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KR1019850001451A
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KR920002265B1 (ko
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패드매내든 서래레이저
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죤 제이 헤이간
아메리칸 사이아나밋드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/18—Nitrogen atoms not forming part of a nitro radical with hetero atoms attached to said nitrogen atoms, except nitro radicals, e.g. hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

2-히드라지노-1,3-디아자시클로알크-2-엔히드로할라이드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 하기 구조식(Ⅱ) 화합물 I 몰분율을 주위 온도 내지 환류 온도하에, C1-C4지방족 알콜, 물, 또는 그의 혼합물로 부터 선택되는 조성물 내에서, 등몰분율 정도의 암모늄 할라이드 또는 히드라조늄 할라이드 및 약 1-2 몰분율의 히드라진 수화물과 반응시킨 후, 구조식(I)의 화합물을 분리시키는 것으로 구성되는, 하기 구조식(I) 화합물의 제조방법.
    상기 식에서, R1은 수소, C1-C6알킬, C1-C6히드록시알킬, C1-C6알콕시알킬, 페닐, 치환된 페닐, 벤질 또는 치환된 벤질이고, R2와 R3는 독립적으로 수소, C1-C6알킬, C1-C6알콕시, C1-C6알콕시알킬, 히드록실, 아릴, 치환된아릴, 아르알킬 및 치환된 아르알킬이며, n은 0-3의 정수이다.
  2. 제1항에 있어서, R1, R2및 R3가 수소이고 n이 0인 방법.
  3. 제1항에 있어서, R1이 수소이고, R2및 R3가 메틸이며, n이 1인 방법.
  4. 제1항, 제2항 또는 제3항에 있어서, 반응 단계에서 상기 구조식(Ⅱ) 및 히드라진 수화물을 1 몰분율의 아민염과 반응시키며, 상기 염이 하기구조식(Ⅲ)에서 선택되는 방법.
    (상기식에서, R4는 수소 또는 C1-C4알킬이고, X는 할로겐 또는 설테이트이다.)
  5. 제4항에 있어서, X가 염소인 방법.
  6. 제5항에 있어서, 히드라진 수화물의 몰분율이 약 1.2-1.5인 방법.
  7. 제4항, 제5항 또는 제6항에 있어서, 상기 아민염이 염화암모늄인 방법.
  8. 제4항 내지 제7항중 어느 하나에 있어서, 지방족 알콜이 1-프로판올인 방법.
  9. 제8항에 있어서, 반응온도가 약 65-85℃인 방법.
  10. 제9항에 있어서, 상기 온도를 약 2-3시간동안 유지시키는 방법.
  11. 하기 구조식(I) 화합물을 약 0-30℃ 하에 C1-C4알킬알콜 내에서 할로겐화수소와 반응시킨 후, 상응되는 2-히드라지노-1,3-디아자시클로알크-2-엔 디히드로할라이드를 회수하는 것으로 구성되는 2-히드라지노-1,3-디아자시클로알크-2-엔 디히드로할라이드의 제조방법.
    상기식에서, R1은 수소, C1-C6알킬 또는 C1-C6히드록시 알킬이고, R2와 R3는 독립적으로 수소 또는 C1-C6알킬이며, n은 0-3, X는 할로겐 이온이다.
  12. 제11항에 있어서, R1, R2및 R3가 수소이고 n이 0인 방법.
  13. 제11항에 있어서, R1이 수소이고, R2및 R3가 메틸이며, n이 1인 방법.
  14. 제12항 또는 제13항에 있어서, X가 염소이온인 방법.
  15. 제14항에 있어서, 할로겐화수소가 염화수소인 방법.
  16. 제14항 또는 제15항에 있어서, 상기 알콜이 1-프로판올인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001451A 1984-03-08 1985-03-07 2-히드라지노-1,3-디아자시클로알크-2-엔 히드로할라이드의 제조방법 KR920002265B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/587,414 US4574155A (en) 1984-03-08 1984-03-08 Process for preparing 2-hydrazino-1,3-diazacycloalk-2-ene hydrohalides
US587,414 1984-03-08
US587414 2000-06-01

Publications (2)

Publication Number Publication Date
KR850006190A true KR850006190A (ko) 1985-10-02
KR920002265B1 KR920002265B1 (ko) 1992-03-20

Family

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KR1019850001451A KR920002265B1 (ko) 1984-03-08 1985-03-07 2-히드라지노-1,3-디아자시클로알크-2-엔 히드로할라이드의 제조방법

Country Status (19)

Country Link
US (1) US4574155A (ko)
EP (1) EP0158020B1 (ko)
JP (1) JPS60204768A (ko)
KR (1) KR920002265B1 (ko)
AT (1) ATE34571T1 (ko)
AU (1) AU578935B2 (ko)
DD (1) DD231786A5 (ko)
DE (1) DE3507579A1 (ko)
DK (1) DK166321C (ko)
ES (1) ES8606857A1 (ko)
FI (1) FI86300C (ko)
GR (1) GR850562B (ko)
HK (1) HK107290A (ko)
IE (1) IE58236B1 (ko)
IL (1) IL74431A (ko)
NO (1) NO170882C (ko)
NZ (1) NZ211278A (ko)
PT (1) PT80049B (ko)
ZA (1) ZA851731B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258381A (en) * 1984-03-19 1993-11-02 The Rockefeller University 2-substituted-2-imidazolines
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
US4983604A (en) * 1987-11-13 1991-01-08 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5612332A (en) * 1984-03-19 1997-03-18 Alteon Inc. Di- and triaminoguanidines, and methods of use
JPH0784461B2 (ja) * 1986-12-19 1995-09-13 日本バイエルアグロケム株式会社 殺虫性ニトロイミノ又はシアノイミノ化合物
US5850840A (en) * 1995-11-15 1998-12-22 Alteon Inc. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US6110968A (en) * 1995-12-26 2000-08-29 The Picower Institute For Medical Research Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5877217A (en) * 1995-12-26 1999-03-02 Alteon Inc. N-acylaminoalkyl-hydrazinecarboximidamides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2525927A (en) * 1947-09-26 1950-10-17 Honorary Advisory Council 2-nitramino delta 2-1, 3 diazacycloalkenes
FR1380402A (fr) * 1959-07-30 1964-12-04 Inst Chibret S A Perfectionnements apportés à la préparation d'imidazolines substituées en position 2
BE792606A (fr) * 1972-01-06 1973-03-30 Ferlux Nouveaux semicarbazides et thiosemicarbazides et leur preparation
JPS5222101B2 (ko) * 1973-05-09 1977-06-15
US3931152A (en) * 1974-01-29 1976-01-06 American Cyanamid Company 2-(1,3-Diazacycloalkenyl)-2-hydrazones of substituted chalcones
US4258181A (en) * 1978-09-05 1981-03-24 American Cyanamid Company Substituted 9,10-anthracenebishydrazones
US4262122A (en) * 1980-02-19 1981-04-14 American Cyanamid Company Preparation of 5,5-dimethyl-2-hydrazino-1,4,5,6-tetrahydro-pyrimidine hydrohalide

Also Published As

Publication number Publication date
DD231786A5 (de) 1986-01-08
NO850907L (no) 1985-09-09
NO170882B (no) 1992-09-14
ATE34571T1 (de) 1988-06-15
FI86300B (fi) 1992-04-30
PT80049A (en) 1985-04-01
AU3963485A (en) 1985-09-12
ZA851731B (en) 1985-11-27
NO170882C (no) 1992-12-23
HK107290A (en) 1990-12-28
IE850579L (en) 1985-09-08
NZ211278A (en) 1988-10-28
US4574155A (en) 1986-03-04
DK166321B (da) 1993-04-05
IE58236B1 (en) 1993-08-11
FI86300C (fi) 1992-08-10
ES541036A0 (es) 1986-05-16
FI850911A0 (fi) 1985-03-07
DK105385A (da) 1985-09-09
IL74431A0 (en) 1985-05-31
IL74431A (en) 1990-01-18
GR850562B (ko) 1985-07-03
ES8606857A1 (es) 1986-05-16
EP0158020B1 (en) 1988-05-25
EP0158020A1 (en) 1985-10-16
DE3507579A1 (de) 1985-09-12
FI850911L (fi) 1985-09-09
KR920002265B1 (ko) 1992-03-20
AU578935B2 (en) 1988-11-10
JPS60204768A (ja) 1985-10-16
DK105385D0 (da) 1985-03-07
PT80049B (pt) 1987-06-17
DK166321C (da) 1993-08-30
JPH0563470B2 (ko) 1993-09-10

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