KR930003121B1 - 세팔로스포린염의 제조방법 - Google Patents

세팔로스포린염의 제조방법 Download PDF

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Publication number
KR930003121B1
KR930003121B1 KR1019860006445A KR860006445A KR930003121B1 KR 930003121 B1 KR930003121 B1 KR 930003121B1 KR 1019860006445 A KR1019860006445 A KR 1019860006445A KR 860006445 A KR860006445 A KR 860006445A KR 930003121 B1 KR930003121 B1 KR 930003121B1
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KR
South Korea
Prior art keywords
methyl
aminothiazol
pyrrolidinio
carboxylate
methoxyiminoacetamido
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Expired - Lifetime
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KR1019860006445A
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English (en)
Korean (ko)
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KR880002530A (ko
Inventor
에이. 카플렌 머레이
더블유. 휴디마 토마스
에이. 립퍼 로버트
Original Assignee
브리스톨-마이어즈 스퀴브 캄파니
이삭 쟈코브스키
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Publication of KR880002530A publication Critical patent/KR880002530A/ko
Application granted granted Critical
Publication of KR930003121B1 publication Critical patent/KR930003121B1/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019860006445A 1985-08-05 1986-08-05 세팔로스포린염의 제조방법 Expired - Lifetime KR930003121B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05
US762235 1985-08-05
US762,235 1985-08-05

Publications (2)

Publication Number Publication Date
KR880002530A KR880002530A (ko) 1988-05-09
KR930003121B1 true KR930003121B1 (ko) 1993-04-19

Family

ID=25064475

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860006445A Expired - Lifetime KR930003121B1 (ko) 1985-08-05 1986-08-05 세팔로스포린염의 제조방법

Country Status (34)

Country Link
JP (1) JPH0615548B2 (cs)
KR (1) KR930003121B1 (cs)
AR (1) AR243894A1 (cs)
AT (1) AT390957B (cs)
AU (1) AU597262B2 (cs)
BE (1) BE905219A (cs)
CA (1) CA1284994C (cs)
CH (1) CH675581A5 (cs)
CS (2) CS276717B6 (cs)
CY (1) CY1614A (cs)
DD (2) DD254941A5 (cs)
DE (1) DE3626375A1 (cs)
DK (1) DK162053C (cs)
EG (1) EG18003A (cs)
ES (1) ES2002112A6 (cs)
FI (1) FI84484C (cs)
FR (1) FR2585705B1 (cs)
GB (1) GB2179936B (cs)
GR (1) GR862055B (cs)
HK (1) HK99691A (cs)
HU (1) HU196602B (cs)
IE (1) IE59222B1 (cs)
IL (1) IL79608A (cs)
IT (1) IT1197067B (cs)
LU (2) LU88574I2 (cs)
MY (1) MY102212A (cs)
NL (1) NL8601991A (cs)
OA (1) OA08672A (cs)
PT (1) PT83134B (cs)
SE (1) SE469633B (cs)
SG (1) SG79791G (cs)
SU (1) SU1516013A3 (cs)
YU (1) YU45793B (cs)
ZA (1) ZA865842B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
WO1988010263A1 (fr) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Composes cristallins de cephalosporine, procede de preparation et produits intermediaires pour la preparation de ces composes
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
ATE202109T1 (de) * 1993-03-12 2001-06-15 Upjohn Co Kristallines ceftiofur (freie säure)
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
ATE385500T1 (de) 2003-12-23 2008-02-15 Sandoz Ag Verfahren zur herstellung von zwischenprodukten für die verwendung bei der cefalosporinsynthese
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
GB8618989D0 (en) 1986-09-17
DD254941A5 (de) 1988-03-16
SE8603308D0 (sv) 1986-08-04
DK371886D0 (da) 1986-08-04
SE8603308L (sv) 1987-02-06
DE3626375A1 (de) 1987-02-12
FR2585705B1 (fr) 1989-01-13
OA08672A (en) 1989-03-31
YU137186A (en) 1987-12-31
AR243894A1 (es) 1993-09-30
CY1614A (en) 1992-07-10
PT83134B (pt) 1989-07-31
JPS62103090A (ja) 1987-05-13
AT390957B (de) 1990-07-25
DK162053B (da) 1991-09-09
SU1516013A3 (ru) 1989-10-15
GB2179936A (en) 1987-03-18
CA1284994C (en) 1991-06-18
CS276849B6 (en) 1992-08-12
FI84484B (fi) 1991-08-30
FR2585705A1 (fr) 1987-02-06
MY102212A (en) 1992-05-15
HK99691A (en) 1991-12-13
IL79608A (en) 1991-07-18
DK371886A (da) 1987-02-06
YU45793B (sh) 1992-07-20
ZA865842B (en) 1987-04-29
GB2179936B (en) 1989-04-26
HU196602B (en) 1988-12-28
AU6069486A (en) 1987-02-12
LU86540A1 (fr) 1987-03-06
JPH0615548B2 (ja) 1994-03-02
KR880002530A (ko) 1988-05-09
BE905219A (fr) 1987-02-04
FI863155A0 (fi) 1986-08-01
IE862078L (en) 1987-02-05
IT1197067B (it) 1988-11-25
LU88574I2 (fr) 1995-03-01
EG18003A (en) 1991-08-30
IT8621409A0 (it) 1986-08-04
CH675581A5 (cs) 1990-10-15
PT83134A (en) 1986-09-01
IE59222B1 (en) 1994-01-26
NL8601991A (nl) 1987-03-02
CS276717B6 (en) 1992-08-12
ES2002112A6 (es) 1988-07-16
FI84484C (fi) 1991-12-10
HUT41802A (en) 1987-05-28
FI863155A7 (fi) 1987-02-06
SG79791G (en) 1991-11-15
IT8621409A1 (it) 1988-02-04
SE469633B (sv) 1993-08-09
AU597262B2 (en) 1990-05-31
GR862055B (en) 1986-12-24
IL79608A0 (en) 1986-11-30
ATA211086A (de) 1990-01-15
DD268395A5 (de) 1989-05-31
DK162053C (da) 1992-02-10

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