KR920700715A - 건조 분말 흡입 장치 - Google Patents

건조 분말 흡입 장치

Info

Publication number
KR920700715A
KR920700715A KR1019910701474A KR910701474A KR920700715A KR 920700715 A KR920700715 A KR 920700715A KR 1019910701474 A KR1019910701474 A KR 1019910701474A KR 910701474 A KR910701474 A KR 910701474A KR 920700715 A KR920700715 A KR 920700715A
Authority
KR
South Korea
Prior art keywords
drug
patient
aerosolization
deagglomeration
means comprises
Prior art date
Application number
KR1019910701474A
Other languages
English (en)
Inventor
페터 데이비드 호드슨
데이비드 케이쓰 스미드
앤터니 차알즈 램먼드 와스
Original Assignee
원본미기재
라이커 레보러토리즈 인코오포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 라이커 레보러토리즈 인코오포레이티드 filed Critical 원본미기재
Priority claimed from PCT/GB1990/000670 external-priority patent/WO1990013327A1/en
Publication of KR920700715A publication Critical patent/KR920700715A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0078—Mechanical counters having a display or indicator on a strip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

내용 없음

Description

건조 분말 흡입 장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 탈집괴/에어로졸화용 전지식 전동 수단을 지니는 본 발명의 흡입기의 단면도이다. 제2도는 탈집괴/에어로졸화용 전지식 충격 수단을 지니는 본 발명의 흡입기의 단면도이, 제3a도 내지 제3b도는 탈집괴/에어로졸화용 용수철 충격 수단을 지니는 본 발명의 흡입기를 도시하고 있다. 제3a도는 전면도이고 제3b도는 후면도이고 제3c도는 장치의 외부의 배면도이다. 제3d도는 측 A-A를 따라 흡입기를 절단한 단면도이다.

Claims (15)

  1. 입에 무는 부분 또는 코적용부의 형태로 환자의 흡입구와 연결되어 있는 1회분의 분말 약물 수용 챔버를 분할 하는 하우징을 포함하며, 상기 투여량의 분말 약물을 탈집괴시키고/거나 에어로졸화를 돕고 환자에 비의존적인 에너지 출력원에 의해 작동되는 탈집괴/에어로졸화 수단; 환자의 흡입구를 통한 환자 호흡을 감지하기 위한 감지수단 및 상기 감지수단에 의해 환자 호흡을 감지하여 상기 탈집외/에어로졸화 수단을 작동시키는 조절 수단을 부가로 포함하는 건조 분말 흡입장치.
  2. 제1항에 있어서, 상기 분말 약물이 가늘고 긴 캐리어상에서 운반되고 상기 캐리어의 소정 면적과 크기가 상기 챔버내에 순차적으로 노출되도록 구성되고 배열된 장치.
  3. 제1항또는 제2항에 있어서, 상기 가늘고 긴 캐리어가 약물로 예비 하중되어 있고 테이프의 형태인 장치.
  4. 제1항에 있어서, 분말약물 저장소와 분말 이동 부재를 부가로 포함하고, 이동 배주가 상기 저장소를 통과 하거나 지나서 소정양의 약물이 상기 챔버를 통과하기 전에 상기 부재의 표면위에 피복되도록 구성되고 배열된 장치.
  5. 제1항에 있어서, 상기 분말 약물이 파열 가능한 캅셀속에 밀봉되어 있고 상기 캅셀 수용부와 상기 캅셀 파괴 수단을 포함하는 장치.
  6. 제1항 내지 5항중 어느 한 항에 있어서, 환자에 비의존 적인 상기 에너지 출력원이 스프링 또는 다른 비스듬하게 되튀는 에너지 저장 수단, 전지, 압축가스원 또는 액화 가스원에서 발생되는 장치.
  7. 제1항 내지 제6항중 어느 한 항에 있어서, 상가 탈집괴/에어로졸화 수단이 1회분의 약물을 충격, 타격 또는 진동시키는 수단을 포함하는 장치.
  8. 제6항에 있어서, 상기 충격 또는 타격 수단이 비스듬하게 배열된 헤머 또는 솔레노이드 및 플런저 막대를 포함하는 장치.
  9. 제7항에 있어서, 상기 수단이 주파수가 5내지 250,000헤르쯔인 진동을 생성하고, 전기적, 압전적, 전자기적 또는 기계적인 장치.
  10. 제7항 또는 제9항에 있어서, 상기 진동 수단이 솔레노이드형 진동기, 회전캠 또는 톱날 휠을 포함하는 장치.
  11. 제3항 또는 제4항에 있어서, 상기 탈집괴/에어로졸화 수단이 (i)테이프 또는 회전 운동 또는 왕복운동을 하는 분말 이동 부재의 노출면을 브러싱 또는 스크레핑하는수단; (ii)분말 약물을 지니는 가늘고 긴 캐리어 물질의 표면이 모나고 볼록한 굴곡면이 되도록 작은 지름을 가지고 있는 가장자리 또는 코오너, 또는 불규칙면을 지니는 표면을 가로질러 테이프 또는 분말 이동 부재를 견인하는 수단; (iii)환자가 흡입하고 있는 동안 가늘고 긴 캐리어 또는 분말 이동 부재의 비노출면을 재빨리 챔버로 전전시켜 갑자기 멈추게하여 약물을 방출시키는 수단 또는 (iv)가늘고 긴 캐리어의 비노출된 길이를 느슨한 루프 형태로 하여 흡입시 재빨리 팽팽해져 약물을 방출시키는 수단을 포함하는 장치.
  12. 제1항 내지 제6항중 어느 한 항에 있어서, 상기 탈집괴/에어로졸화 수단이 난류를 발생시켜 약물을 방출시키는 프로펠러 또는 임펠러를 포함하는 장치.
  13. 제1항 내지 제12항중 어느 한항에 있어서, 상기 감지 수단이 움직일 수 있는 날개를 포함하고 상기 탈집괴/에어로졸화 수단을 작동시키는 상기 조절 수단이 작동되기 전에 환자가 흡입구를 통해 흡입할때 상기 날개가 움직이는 장치.
  14. 제1항 내지 제13항중 어느 한항에 있어서, 상기 분말 약물은 입자 크기가 약 1내지 10㎛이고, 기관지확장제, 코티코스테로이드, 식용감퇴제, 항 우울제, 항고혈압제, 항종양제, 항콜린성약물, 도파민성 약물, 마약성 진통제, β-아드레날린성 봉쇄제, 프로스타글란딘, 교감신경흥분제, 정온제, 스테로이드, 단백질, 펩티드, 비타민, 성호르몬 및 천식 예방약으로 이루어진 군중에서 선택된 하나 또는 그 이상의 약을 포함하는 장치.
  15. 제14항에 있어서, 상기 약물이 살부타몰, 테르부탈린, 리미테롤, 펜타닐, 페노테롤, 피르부테롤, 레프로테롤, 아드레날린, 이소프레날린, 오시프레날린 이프라트로피움, 베클로메타존, 베탄메타존, 부데소나이드, 디소듐 크로모글레시이트 네도크로밀 소듐, 에르고타민, 살메테롤, 플루티카존, 포르모테롤, 인슐린, 아트로핀, 프레드니졸론, 벤즈페타민, 클로르펜테르민, 아미트립틸린, 이미프라민, 클로라딘, 액티노마이신 C, 브로모크립틴, 부프레노르핀, 프로프라놀롤, 라시코르톤, 히드로코르티존, 플루오시놀론, 트리암신 클록, 디노프로스트, 크실로메타졸린, 디아제팜, 로사제팜, 엽산, 니코틴아미도, 클렌부테롤, 비롤테롤, 에틸닐리에스트라디올 및 레보노르게스트렐 및 이들의 약학적 허용 염인 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910701474A 1989-04-28 1990-04-30 건조 분말 흡입 장치 KR920700715A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB898909891A GB8909891D0 (en) 1989-04-28 1989-04-28 Device
GB89098917 1989-04-28
GB90002619 1990-01-05
GB909000261A GB9000261D0 (en) 1989-04-28 1990-01-05 Device
PCT/GB1990/000670 WO1990013327A1 (en) 1989-04-28 1990-04-30 Dry powder inhalation device

Publications (1)

Publication Number Publication Date
KR920700715A true KR920700715A (ko) 1992-08-10

Family

ID=10655980

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019910701474A KR920700715A (ko) 1989-04-28 1990-04-30 건조 분말 흡입 장치
KR1019910701473A KR0178798B1 (ko) 1989-04-28 1990-04-30 건조 분말 흡입 장치

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019910701473A KR0178798B1 (ko) 1989-04-28 1990-04-30 건조 분말 흡입 장치

Country Status (13)

Country Link
US (2) US5619984A (ko)
EP (1) EP0472598B1 (ko)
JP (1) JP3130925B2 (ko)
KR (2) KR920700715A (ko)
AU (1) AU644790B2 (ko)
CA (2) CA2354096A1 (ko)
DE (1) DE69027679T2 (ko)
DK (1) DK0472598T3 (ko)
ES (1) ES2091825T3 (ko)
GB (2) GB8909891D0 (ko)
HK (1) HK1006546A1 (ko)
NZ (2) NZ248275A (ko)
WO (1) WO1990013328A1 (ko)

Families Citing this family (233)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0470154B1 (en) * 1989-04-28 1996-06-05 Riker Laboratories, Inc. Dry powder inhalation device
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
US5176132A (en) * 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
US6536427B2 (en) * 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
UA26230A (uk) * 1990-03-02 1999-07-19 Глексо Груп Лімітед Іhгалятор для спільhого використаhhя з лікувальhим блоком і лікувальhий блок
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SK280967B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Inhalačný prístroj
US5192548A (en) * 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
KR0179375B1 (ko) * 1990-06-28 1999-04-01 디이터 라우디인, 루돌프 호프만 분말 투여 방법 및 이를 위한 장치
FR2667509B1 (fr) * 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
FR2667790A1 (fr) * 1990-10-04 1992-04-17 Valois Cassette de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et son procede de fabrication.
GB9024760D0 (en) * 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
US5479948A (en) * 1993-08-10 1996-01-02 Philip Morris Incorporated Electrical smoking article having continuous tobacco flavor web and flavor cassette therefor
FR2676929B1 (fr) * 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
DE4142238A1 (de) * 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen
WO1993024166A2 (en) * 1992-06-04 1993-12-09 Glaxo Group Limited Inhalation device
SE9203570D0 (sv) * 1992-11-27 1992-11-27 Astra Ab Inhaler for multiple use
US6250300B1 (en) 1992-12-11 2001-06-26 Ab Astra System for dispensing pharmaceutically active compounds
SE9203743D0 (sv) * 1992-12-11 1992-12-11 Astra Ab Efficient use
WO1994014490A1 (de) * 1992-12-23 1994-07-07 Bernhard Hugemann Verfestigter arzneistoffvorrat für die mechanische erzeugung inhalierbarer wirkstoffpartikel
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
FR2701653B1 (fr) * 1993-02-18 1995-04-07 Valois Dispositif doseur pour l'inhalation de poudre sèche.
EP0691864A4 (en) * 1993-03-03 1996-07-03 Tenax Corp POWDER DRUG HOLDER, FOR INHALER
GB9314614D0 (en) * 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
GB9324391D0 (en) * 1993-11-26 1994-01-12 Minnesota Mining & Mfg Device for transmission of one-way torque
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
SE9400257D0 (sv) * 1994-01-27 1994-01-27 Astra Ab Spacer
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
EP1462096B1 (en) * 1994-03-07 2008-12-10 Nektar Therapeutics Methods and compositions for pulmonary delivery of insulin
DE69505266T2 (de) * 1994-08-30 1999-05-06 Pharmacia & Upjohn Ab Verfahren zur Erzeugung eines gezielten Tropfenstrahls
GB9417399D0 (en) 1994-08-30 1994-10-19 Scherer Corp R P Ocular treatment device
ES2148578T3 (es) * 1994-10-21 2000-10-16 Glaxo Wellcome Inc Soporte de medicamento para un inhalador de polvo seco y procedimiento de fabricacion del mismo.
US5647347A (en) * 1994-10-21 1997-07-15 Glaxo Wellcome Inc. Medicament carrier for dry powder inhalator
US5642727A (en) * 1995-07-25 1997-07-01 David Sarnoff Research Center, Inc. Inhaler apparatus using a tribo-electric charging technique
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US5694920A (en) * 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
US6026809A (en) * 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
US5858099A (en) 1996-04-09 1999-01-12 Sarnoff Corporation Electrostatic chucks and a particle deposition apparatus therefor
US5871010A (en) * 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
WO1997047347A1 (en) * 1996-06-10 1997-12-18 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
US5857456A (en) * 1996-06-10 1999-01-12 Sarnoff Corporation Inhaler apparatus with an electronic means for enhanced release of dry powders
GB2320489A (en) * 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6192882B1 (en) * 1997-02-24 2001-02-27 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
SE9700936D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Inhalation device
US6006747A (en) * 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
CA2212430A1 (en) * 1997-08-07 1999-02-07 George Volgyesi Inhalation device
US6237590B1 (en) * 1997-09-18 2001-05-29 Delsys Pharmaceutical Corporation Dry powder delivery system apparatus
NZ506640A (en) 1998-03-04 2003-01-31 Delsys Pharmaceutical Corp Medicament dry powder inhaler dispensing device
US6149774A (en) * 1998-06-10 2000-11-21 Delsys Pharmaceutical Corporation AC waveforms biasing for bead manipulating chucks
DE69928928T2 (de) * 1998-06-12 2006-08-03 Microdose Technologies Inc. Vorrichtung zur abgabe von arzneimitteln
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6062213A (en) * 1998-06-16 2000-05-16 Fuisz Technologies Ltd. Single unit dose inhalation therapy device
AU2281300A (en) 1999-01-22 2000-08-07 Glaxo Group Limited Inhalation device
US6752148B1 (en) 1999-02-10 2004-06-22 Delsys Pharmaceutical Company Medicament dry powder inhaler dispensing device
US6223744B1 (en) 1999-03-16 2001-05-01 Multi-Vet Ltd. Wearable aerosol delivery apparatus
EP1169053A1 (en) 1999-04-13 2002-01-09 Inhale Therapeutic Systems, Inc. Pulmonary administration of dry powder formulations for treating infertility
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6730066B1 (en) 1999-08-03 2004-05-04 Pharmacia Ab Liquid delivery container
WO2001026720A1 (en) * 1999-10-12 2001-04-19 Shl Medical Ab Inhaler
EP1666028B1 (en) 1999-10-29 2010-03-24 Novartis AG Dry powder compositions having improved dispersivity
SE517806C2 (sv) * 1999-11-11 2002-07-16 Microdrug Ag Doseringsanordning för inhalator
GB9929486D0 (en) 1999-12-15 2000-02-09 Glaxo Group Ltd Inhalation delivery apparatus and method
WO2001045731A1 (en) 1999-12-21 2001-06-28 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
US6761909B1 (en) 1999-12-21 2004-07-13 Rxkinetix, Inc. Particulate insulin-containing products and method of manufacture
US7080642B2 (en) * 1999-12-22 2006-07-25 3M Innovative Properties Company Refillable device with counting means
GB9930602D0 (en) * 1999-12-24 2000-02-16 Glaxo Group Ltd Inhalation device
US6427688B1 (en) * 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
US7171965B2 (en) * 2000-02-01 2007-02-06 Valois S.A.S. Breath actuated dry powder inhaler and tape dose strip
US6971383B2 (en) 2001-01-24 2005-12-06 University Of North Carolina At Chapel Hill Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods
CA2400349C (en) * 2000-03-10 2009-11-10 University Of North Carolina At Chapel Hill Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
GB0015034D0 (en) * 2000-06-21 2000-08-09 Glaxo Group Ltd Inhalation device
GB0015043D0 (en) * 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
GB2381461C (en) * 2000-07-24 2015-12-30 Clinical Designs Ltd Dispenser
GB0019715D0 (en) * 2000-08-10 2000-09-27 Pa Consulting Services Device for delivering physiologically active agent in powdered form
DE10040528A1 (de) * 2000-08-18 2002-02-28 Pari Gmbh Inhalationsvorrichtung und Verfahren zur Erzeugung eines Partikelnebels für Inhalationszwecke
US6626173B2 (en) * 2001-01-08 2003-09-30 Iep Pharmaceutical Devices Inc. Dry powder inhaler
US6443152B1 (en) * 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
US6782887B2 (en) * 2001-01-12 2004-08-31 Becton, Dickinson And Company Medicament respiratory delivery device and cartridge
EP2366420B1 (en) * 2001-03-20 2015-05-06 Trudell Medical International Nebulizer apparatus
WO2002092154A1 (en) * 2001-04-26 2002-11-21 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
GB0125132D0 (en) * 2001-10-19 2001-12-12 Glaxo Group Ltd Medicament dispenser
GB0125134D0 (en) * 2001-10-19 2001-12-12 Glaxo Group Ltd Medicament dispenser
EP1458360B1 (en) 2001-12-19 2011-05-11 Novartis AG Pulmonary delivery of aminoglycosides
ATE385193T1 (de) * 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
SI2143458T1 (sl) * 2002-03-22 2017-09-29 Clinical Designs Limited Vpenjalo vsebnika
GB0209528D0 (en) * 2002-04-26 2002-06-05 Glaxo Group Ltd Medicament dispenser
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US6985798B2 (en) 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7118010B2 (en) 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US6904908B2 (en) * 2002-05-21 2005-06-14 Trudell Medical International Visual indicator for an aerosol medication delivery apparatus and system
SI1535349T1 (sl) * 2002-06-27 2014-10-30 Oriel Therapeutics, Inc. Naprave, sistemi in ustrezni postopki za predelavo, izdajo in/ali vrednotenje nefarmacevtskih suhih praškov
GB0216831D0 (en) * 2002-07-19 2002-08-28 Glaxo Group Ltd Medicament dispenser
GB0221493D0 (en) * 2002-09-17 2002-10-23 Glaxo Group Ltd Method for loading a medicament dispenser with a medicament carrier
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
GB0303870D0 (en) * 2003-02-20 2003-03-26 Norton Healthcare Ltd Pre-metered dose magazine for breath-actuated dry powder inhaler
GB0304000D0 (en) * 2003-02-21 2003-03-26 Clinical Designs Ltd Dispenser
US7360537B2 (en) * 2003-04-16 2008-04-22 Trudell Medical International Antistatic medication delivery apparatus
CA2526432A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
GB0317374D0 (en) * 2003-07-24 2003-08-27 Glaxo Group Ltd Medicament dispenser
JP2007505136A (ja) * 2003-09-10 2007-03-08 マツプ・フアーマシユーテイカルズ・インコーポレーテツド ジヒドロエルゴタミンを肺吸入により体循環に送達するためのエアゾール製剤
GB2407042B (en) * 2003-10-17 2007-10-24 Vectura Ltd Inhaler
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
WO2005049449A1 (en) * 2003-11-18 2005-06-02 Yansong Shan Healthy pleasurable inhalation device
GB0327112D0 (en) * 2003-11-21 2003-12-24 Clincial Designs Ltd Dispenser and reservoir
GB0328859D0 (en) * 2003-12-12 2004-01-14 Clinical Designs Ltd Dispenser and counter
WO2005067898A2 (en) 2004-01-07 2005-07-28 Nektar Therapeutics Improved sustained release compositions for pulmonary administration of insulin
CN100589849C (zh) * 2004-02-24 2010-02-17 微计量技术有限公司 基于合成射流的药物输送方法和装置
US7861712B2 (en) * 2004-04-23 2011-01-04 Manta Product Development Sealed capsule including an integrated puncturing mechanism
US7727962B2 (en) 2004-05-10 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
US7611709B2 (en) 2004-05-10 2009-11-03 Boehringer Ingelheim Pharma Gmbh And Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US7723306B2 (en) 2004-05-10 2010-05-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2006002178A1 (en) 2004-06-18 2006-01-05 Novartis Vaccines And Diagnostics Inc. Methods of treatment of endobronchial infections
GB0418278D0 (en) * 2004-08-16 2004-09-15 Glaxo Group Ltd Medicament dispenser
AU2005277208B2 (en) 2004-08-20 2011-11-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
DK1791542T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte for pharmaceutical delivery
ATE458518T1 (de) * 2004-11-10 2010-03-15 Cipla Ltd Inhalator
WO2006062448A1 (en) * 2004-12-10 2006-06-15 Ernst Hörlins Ingenjörsbyrå Ab Dose inhaler with a dose counter
GB0507711D0 (en) 2005-04-15 2005-05-25 Vectura Group Plc Improved blister piercing
JP5339328B2 (ja) * 2005-07-21 2013-11-13 独立行政法人物質・材料研究機構 薬物吸入デバイス
GB0515584D0 (en) * 2005-07-28 2005-09-07 Glaxo Group Ltd Medicament dispenser
BRPI0615819B8 (pt) 2005-09-14 2021-05-25 Mannkind Corp processo para preparar uma composição de distribuição de fármaco compreendendo um agente ativo e uma micropartícula fumaril dicetopiperazina cristalina.
JP5096363B2 (ja) 2005-12-16 2012-12-12 ネクター セラピューティックス Ｇｌｐ−１のポリマ複合体
CA2635622C (en) 2006-01-31 2015-03-31 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
CA2642745A1 (en) * 2006-02-20 2007-08-30 Boehringer Ingelheim International Gmbh Inhaler
CN101389348A (zh) 2006-02-22 2009-03-18 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
US8127763B2 (en) * 2006-03-03 2012-03-06 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
AU2007224178B2 (en) * 2006-03-03 2013-03-07 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
GB0605723D0 (en) * 2006-03-23 2006-05-03 3M Innovative Properties Co Powder filling processes
US20070286814A1 (en) * 2006-06-12 2007-12-13 Medispray Laboratories Pvt. Ltd. Stable aerosol pharmaceutical formulations
EP2037999B1 (en) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Smart parenteral administration system
FR2904229B1 (fr) * 2006-07-25 2008-10-10 Valois Sas Dispositif de distribution de produit fluide.
EP2059309B1 (en) 2006-08-21 2013-07-03 Trudell Medical International Respiratory muscle endurance training device and method for the use thereof
DE102006044756A1 (de) * 2006-09-20 2008-04-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006044755A1 (de) * 2006-09-20 2008-04-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
WO2008042951A2 (en) * 2006-10-03 2008-04-10 Manta Product Development Inhalation devices and related methods
GB0622827D0 (en) * 2006-11-15 2006-12-27 Glaxo Group Ltd Sheet driver for use in a drug dispenser
HUE026884T2 (en) * 2007-02-11 2016-08-29 Map Pharmaceuticals Inc DHE is a therapeutic method of administration for the rapid relief of migraine while minimizing side effects
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
CA2681299C (en) * 2007-03-21 2015-02-17 Cipla Limited Multi-dose inhaler device
US20090151722A1 (en) * 2007-07-06 2009-06-18 Vectura Delivery Devices Limited Inhaler
EP2011537A1 (en) * 2007-07-06 2009-01-07 Vectura Delivery Devices Limited Inhaler
EP2011538B1 (en) * 2007-07-06 2016-02-17 Vectura Delivery Devices Limited Inhaler
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US8419638B2 (en) 2007-11-19 2013-04-16 Proteus Digital Health, Inc. Body-associated fluid transport structure evaluation devices
GB0800457D0 (en) 2008-01-11 2008-02-20 Innovata Biomed Ltd Improvements in or relating to inhalers
GB0800459D0 (en) * 2008-01-11 2008-02-20 Innovata Biomed Ltd Improvements in or relating to inhalers
EP2082772A1 (en) * 2008-01-24 2009-07-29 Vectura Delivery Devices Limited Inhaler
CA2884941C (en) 2008-02-21 2017-03-14 Martin P. Foley Respiratory muscle endurance training device
IL191190A0 (en) * 2008-05-01 2009-08-03 Dan Adler Dry powder inhaler
US8485180B2 (en) * 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA3086027C (en) 2008-06-13 2022-05-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
AU2009292643B2 (en) 2008-09-19 2016-02-18 Nektar Therapeutics Polymer conjugates of therapeutic peptides
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
WO2010115032A1 (en) 2009-04-01 2010-10-07 Promedior, Inc. Pulmonary and nasal delivery of serum amyloid p
WO2010135253A2 (en) * 2009-05-18 2010-11-25 3M Innovative Properties Company Dry powder inhaler dose counters
ES2650862T3 (es) * 2009-05-18 2018-01-22 Adamis Pharmaceuticals Corporation Inhaladores de polvo seco
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
MY159925A (en) * 2009-05-21 2017-02-15 Microdose Therapeutx Inc Rotary cassette system for dry powder inhaler
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US9345848B2 (en) 2009-10-20 2016-05-24 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Dry powder inhaler
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2010319328A1 (en) 2009-11-12 2012-05-31 Stc.Unm Dry powder inhaler with flutter dispersion member
EP3431128A1 (en) 2010-01-05 2019-01-23 MicroDose Therapeutx, Inc. Inhalation device and method
CA2788336C (en) 2010-02-01 2018-05-01 Proteus Digital Health, Inc. Data gathering system
SG182824A1 (en) 2010-02-01 2012-09-27 Proteus Biomedical Inc Two-wrist data gathering system
KR20130117755A (ko) 2010-06-21 2013-10-28 맨카인드 코포레이션 건조 분말 약물 운반 시스템 및 방법
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
WO2012135765A2 (en) 2011-04-01 2012-10-04 Mannkind Corporation Blister package for pharmaceutical cartridges
US8486002B2 (en) * 2011-04-19 2013-07-16 Palo Alto Research Center Incorporated Drug delivery devices and methods with collimated gas stream and release-activatable tape
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013059631A1 (en) 2011-10-21 2013-04-25 Rigel Pharmaceuticals, Inc. Method and device for administering xinafoate salt of n4-(2,2-difluoro-4h-benzo [1,4] oxazin-3-one) -6-yl] -5-fluoro-n2- [3- (methylaminocarbonylmethyleneoxy) phenyl] 2,4-pyrimidinediamine
MX2014004983A (es) 2011-10-24 2014-09-22 Mannkid Corp Metodos y composiciones para tratar dolor.
EA026450B1 (ru) 2011-11-25 2017-04-28 Махмут Билджик Ингалятор
EP2617448A1 (en) * 2012-01-20 2013-07-24 Almirall S.A. Inhalation device for powdered drugs
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
US10525216B2 (en) 2012-02-21 2020-01-07 Respira Therapeutics, Inc. Powder dispersion methods and devices
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
MX354365B (es) 2012-07-19 2018-02-28 Adamis Pharmaceuticals Corp Aparato alimentador de polvo.
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
GB201301192D0 (en) 2013-01-23 2013-03-06 Vectura Delivery Devices Ltd A blister piercing element for a dry powder inhaler
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
JP6491658B2 (ja) 2013-07-18 2019-03-27 マンカインド コーポレイション 熱安定性乾燥粉末医薬組成物及び方法
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
ES2848300T3 (es) * 2013-08-07 2021-08-06 Bristol Myers Squibb Co Elemento de ayuda de inyección para su uso con un dispositivo de inyección y método de uso
ES2691806T3 (es) 2013-10-01 2018-11-28 Novartis Ag Dispositivo inhalador para el recorrido de un blíster que tiene una trayectoria final bifurcada
EP3054948B1 (en) 2013-10-08 2020-08-12 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
EP3125875B1 (en) 2014-04-04 2023-06-07 AI Therapeutics, Inc. An inhalable rapamycin formulation for treating age-related conditions
CN106999681B (zh) 2014-08-28 2021-02-02 诺顿（沃特福特）有限公司 吸入器的依从性辅助模块
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
AU2015330905B2 (en) 2014-10-07 2021-02-25 AI Therapeutics, Inc. An inhalable rapamycin formulation for the treatment of pulmonary hypertension
US10765821B2 (en) * 2015-03-19 2020-09-08 Altria Client Services Llc Vaporizer for vaporizing a constituent of a plant material
US10179215B2 (en) 2015-03-19 2019-01-15 Altria Client Services Llc Vaporizer for vaporizing a constituent of a plant material
TWI597079B (zh) * 2015-04-10 2017-09-01 微劑量醫療公司 泡殼帶進給機構
ES2949155T3 (es) * 2015-06-14 2023-09-26 Tobe Influence Innovation Ltd Aparato para desinfestar colmenas y método para controlar el mismo
EP3458132B1 (en) 2016-05-19 2021-06-30 Trudell Medical International Smart valved holding chamber
EP3984579A1 (en) 2016-07-08 2022-04-20 Trudell Medical International Smart oscillating positive expiratory pressure device
US10786638B2 (en) 2016-07-08 2020-09-29 Trudell Medical International Nebulizer apparatus and method
WO2018071427A1 (en) 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
CA3036631A1 (en) 2016-12-09 2018-06-14 Trudell Medical International Smart nebulizer
MX2020007026A (es) 2018-01-04 2020-12-03 Trudell Medical Int Dispositivo de presión espiratoria positiva oscilante inteligente.
US20210085897A1 (en) * 2018-04-06 2021-03-25 Lupin Inc. Medicament dispenser
US11458262B2 (en) 2019-06-25 2022-10-04 Altria Client Services Llc Capsules, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol
USD916361S1 (en) 2019-06-25 2021-04-13 Altria Client Services Llc Aerosol-generating capsule
JP2022547826A (ja) 2019-08-27 2022-11-16 トゥルーデル メディカル インターナショナル 振動型呼気陽圧器具
US12011034B2 (en) 2021-01-18 2024-06-18 Altria Client Services Llc Capsules including embedded heaters and heat-not-burn (HNB) aerosol-generating devices
US11910826B2 (en) 2021-01-18 2024-02-27 Altria Client Services Llc Heat-not-burn (HNB) aerosol-generating devices and capsules
US11789476B2 (en) 2021-01-18 2023-10-17 Altria Client Services Llc Heat-not-burn (HNB) aerosol-generating devices including intra-draw heater control, and methods of controlling a heater

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE25422C (de) * J. HASSLER in Baden - Soden, Reg.-Bez. Wiesbaden Apparat zum Zerstäuben pulverförmiger Stoffe für Inhalationszwecke
GB1479283A (en) * 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
DE2346730C3 (de) * 1973-09-17 1980-10-16 Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems Einrichtung zur Aerosolbehandlung von Menschen, Tieren, Gegenständen, Stoffen u.dgl. in einem Behandlungsraum
US3971377A (en) * 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
US4147166A (en) * 1977-05-02 1979-04-03 American Cyanamid Company Oral inhalator powder dispenser
DE2837040C2 (de) * 1978-08-24 1982-10-21 Siemens AG, 1000 Berlin und 8000 München Flüssigkeitstransportsystem für ein Inhalationsgerät
GB2061735B (en) * 1979-10-30 1983-11-30 Riker Laboratories Inc Breath actuated device for administration of powdered medicaments by inhalation
DE3023648A1 (de) * 1980-06-24 1982-01-21 Jaeger, Erich, 8700 Würzburg Einrichtung zur untersuchung der atemwege auf reizstoff-ueberempfindlichkeit
SE438261B (sv) * 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
CY1492A (en) * 1981-07-08 1990-02-16 Draco Ab Powder inhalator
JPS5876038A (ja) * 1981-10-28 1983-05-09 高森　正之 殺虫剤や芳香剤の蒸発装置
EP0079478A1 (en) * 1981-11-03 1983-05-25 Miles Laboratories, Inc. Medicament inhalation device
FR2516387A1 (fr) * 1981-11-16 1983-05-20 Fabre Sa Pierre Inhalateur liberant des quantites pre-dosees de principe actif volatil ou entrainable par un excipient volatil contenu dans des microcapsules reparties periodiquement sur un support, ainsi que ledit support et son procede de fabrication
GB2122903B (en) * 1982-06-22 1986-11-05 Masayuki Takamori Vaporizers for vaporisable substances and support media for substances usable therewith
SE432054B (sv) * 1982-09-10 1984-03-19 Anders Tamsen Programmerbart injektions-och infusionsaggregat
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
GB8328808D0 (en) * 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
AU572322B2 (en) * 1984-07-27 1988-05-05 N.J. Phillips Pty. Limited Tape dispenser
US4712460A (en) * 1985-11-18 1987-12-15 Biotrack, Inc. Integrated drug dosage form and metering system
JPS62204756A (ja) * 1986-03-04 1987-09-09 大研医工株式会社 薬剤揮散方法および装置
US5204113A (en) * 1987-04-09 1993-04-20 Fisons Plc Pharmaceutical compositions containing pentamidine
EP0290683A3 (en) * 1987-05-01 1988-12-14 Diva Medical Systems B.V. Diabetes management system and apparatus
JP2845887B2 (ja) * 1987-05-12 1999-01-13 セプラコール、インコーポレーテッド 吸入装置
US4933873A (en) * 1988-05-12 1990-06-12 Healthtech Services Corp. Interactive patient assistance device
GB2218831A (en) * 1988-05-17 1989-11-22 Mark John Newland Personal medical apparatus
US4984158A (en) * 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
US5153827A (en) * 1989-01-30 1992-10-06 Omni-Flow, Inc. An infusion management and pumping system having an alarm handling system
EP0470154B1 (en) * 1989-04-28 1996-06-05 Riker Laboratories, Inc. Dry powder inhalation device
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
US4899839A (en) * 1989-06-14 1990-02-13 Dessertine Albert L Compliance and patient status monitoring system and method
US5036462A (en) * 1989-09-29 1991-07-30 Healthtech Services Corp. Interactive patient assistance and medication delivery systems responsive to the physical environment of the patient
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9016789D0 (en) * 1990-07-31 1990-09-12 Lilly Industries Ltd Medicament administering devices
FR2667509B1 (fr) * 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
DK0592540T3 (da) * 1991-07-02 2000-06-26 Inhale Inc Fremgangsmåde og indretning til aflevering af aerosoliserede medikamenter
EP0526166A2 (en) * 1991-07-29 1993-02-03 Albert L. Dessertine Patient compliance monitoring method and system
US5363842A (en) * 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional

Also Published As

Publication number Publication date
GB9000261D0 (en) 1990-03-07
AU644790B2 (en) 1993-12-23
EP0472598B1 (en) 1996-07-03
DK0472598T3 (da) 1996-07-29
ES2091825T3 (es) 1996-11-16
CA2354096A1 (en) 1990-11-15
HK1006546A1 (en) 1999-03-05
US5740793A (en) 1998-04-21
US5619984A (en) 1997-04-15
DE69027679T2 (de) 1996-11-14
CA2050298C (en) 2001-09-04
CA2050298A1 (en) 1990-10-29
NZ233486A (en) 1995-05-26
NZ248275A (en) 1995-05-26
JPH04504671A (ja) 1992-08-20
KR0178798B1 (ko) 1999-04-01
WO1990013328A1 (en) 1990-11-15
GB8909891D0 (en) 1989-06-14
JP3130925B2 (ja) 2001-01-31
AU5558890A (en) 1990-11-29
DE69027679D1 (de) 1996-08-08
EP0472598A1 (en) 1992-03-04

Similar Documents

Publication Publication Date Title
KR920700715A (ko) 건조 분말 흡입 장치
US20200316317A1 (en) Nebulizer device
AU2006283113B2 (en) Drug containment systems with sticks, related kits, dry powder inhalers and methods
EP0470154B1 (en) Dry powder inhalation device
US5875776A (en) Dry powder inhaler
US5349947A (en) Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
US7377277B2 (en) Blister packages with frames and associated methods of fabricating dry powder drug containment systems
CA2635622C (en) Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
ZIERENBERG Optimizing the in vitro performance of Respimat
US7318434B2 (en) Synthetic jet based medicament delivery method and apparatus
JP3708964B2 (ja) インシュリンのエアロゾル化製剤の製造
US20100059049A1 (en) Dry-Powder Inhaler
JP2007530671A5 (ko)
DE69528912T2 (de) Inhalator
JP2005522494A (ja) 治療用乾燥粉末調製物
GB2433207A (en) Breath actuated dry powder inhaler
JP2003516824A (ja) パッケージ化粉体を処理するシステムおよび方法
US20130025593A1 (en) Dry powder inhaler
US20050039744A1 (en) Delivery of dispersed powders
CA2150923A1 (en) Inhaler
CA2551561A1 (en) Dry-powder inhaler
JP2004256416A (ja) 吸入用製剤

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid