WO1993024166A2 - Inhalation device - Google Patents
Inhalation device Download PDFInfo
- Publication number
- WO1993024166A2 WO1993024166A2 PCT/EP1993/001410 EP9301410W WO9324166A2 WO 1993024166 A2 WO1993024166 A2 WO 1993024166A2 EP 9301410 W EP9301410 W EP 9301410W WO 9324166 A2 WO9324166 A2 WO 9324166A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stack
- containers
- powder
- container
- holding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- This invention relates to an inhalation device t for use in the inhalation of material in powder form. More particularly, it relates to a device by means of which medicament in powder form can be inhaled, and it is so described below.
- an inhalation device by means of which material in powder form can be inhaled, comprising means for holding a stack of powder containers, means for feeding the containers individually to a use station, and . means for enabling the powder to be inhaled from a container at the use station.
- the invention further provides an inhalation device by means of which material in powder form can be inhaled, comprising means for holding a stack of powder containers, means for resiliently urging the stack in a direction from a first end thereof to a second end thereof, a use station at or operatively connected to the said second end, and means for enabling powder to be inhaled from a container at the use station.
- the invention also provides an inhalation device by means of which material in powder form can be inhaled, comprising means holding a stack of powder containers each of which has a powder-containing depression therein, means for feeding each of the containers to a use station, and inhalation means for enabling the powder to be inhaled from a container at a use station, said inhalation means comprising wall means which cooperate with the said depression to define a venturi.
- the invention additionally provides an inhalation device by means of which material in powder form can be inhaled, comprising means for holding said material therein, means for actuating the device to permit inhalation, and a safety catch which in an operative position prevents actuation of the device and which in an inoperative position permits operation of the device. .
- a cartridge for use in an inhalation device comprising means containing a first stack of unused powder containers, means for receiving at a first end used containers from a first end of the first stack, to form a second stack, and a force-applying means, one end of the force-applying means applying a substantially constant force to a second end of the first stack and the other end of the force-applying means applying a substantially constant force to a second end of the second stack.
- Figure 1 is an isometric view of a first embodiment of the invention
- Figures 2a and 2b show details of the embodiment of Figure 1, namely part of a stack of powder containers and a helical ramp;
- Figure 3 is an isometric view of a second embodiment of the invention.
- Figures 4a and 4b show, in diagrammatic form, and by way of example, two air flow patterns which may be generated to empty the powder from the containers;
- Figure 5 is a side view, partly in section, showing diagrammatically another embodiment of the present invention.
- Figure 6 is an underplan view of the upper portion of the embodiment shown in Figure 5, on a larger scale;
- Figure 7 is a section on line III-III in Figure 6, but showing only one of the components shown in Figure 6;
- Figure 8 is a perspective view of a device embodying the principles of Figures 5 to 7;
- Figure 8a is a view from above showing part of the device of Figure 8;
- Figure 8b is a vertical section through part of the device of Figure 8, showing in more detail the design of the mouthpiece thereof;
- Figure 9 shows a single powder container
- Figures 10a and 10b show part of an embodiment employing a rotary slider, with Figure 10a being a section on line X-X in Figure 10b;
- Figures 11a and lib, and 12a and 12b are views corresponding to Figures 10a and 10b, with the components in other positions;
- Figure 13 is a longitudinal section, with portions cut away, showing a further embodiment
- Figure 13a shows a detail of the embodiment of Figure 13
- Figures 14a and 14b show, diagram atically and in section, the upper portion of the embodiment of Figures 13 and 13a in its inoperative and operative positions, respectively;
- Figure 15 is a section through the portion shown in Figure 14b, taken at right angles thereto.
- each cup 2 has a shallow depression 4 in its upper surface, the depression 4 being circular in plan view and smoothly curved in vertical section.
- the depression terminates at its upper end in an annular bead 6 which acts as a sealing ring to provide a seal between each cup and the cup above it, thereby sealing the volume within the depression.
- a pre- metered quantity of medicament 8 is provided in each depression.
- the medicament is shown as occupying only part of the volume of the depression, but it could be such as to occupy the whole volume.
- FIG. 1a shows three cups, but it is to be understood that in practice a much larger number of cups would normally be stacked one above the other.
- Figure l shows an inhalation device which comprises a feed magazine 14 having four cylindrical bores 16 which are spaced at 90° from one another round the circumference of the magazine.
- Each bore 16 contains a stack of cups 2, each with a respective disk 10 and spring 12 at its upper end.
- the feed magazine 14 is rotatable about its longitudinal axis, and carries at its lower end a starwheel 18.
- the starwheel 18 has four arcuate cut-outs 20 which receive, respectively, the lowest cup of a given stack.
- a non-rotating disk 22 Immediately below the starwheel 18 is a non-rotating disk 22 having an upper surface 24 in the form of a ramp. The amount by which the ramp descends over a complete turn, as represented by the step 26, is equal to the vertical height of a single cup.
- the device further comprises a collection magazine 28 having four bores 30 arranged therein in a similar manner to the way in * which the bores 16 are arranged in the feed magazine 14.
- the collection magazine 28 is rotatable about its longitudinal axis, and carries, at its lower end, a starwheel 32 having four arcuate cut ⁇ outs 34.
- a non-rotating disk 36 is located beneath the starwheel 32, the disk 36 being the mirror image of the disk 22.
- an indexing starwheel 38 Located between the starwheels 18 and 32, and coplanar therewith, is an indexing starwheel 38. This also has four arcuate cut-outs, denoted as 40. The cut-outs in the three starwheels are so arranged that, as can be seen in Figure 1, a cup can be engaged between the starwheels 18 and 38 or between the starwheels 32 and 38.
- the necessary alignment between the starwheels can be achieved by providing gear wheels 42, 44 and 46 on the underside of the starwheels, the gear wheels meshing with one another. However, if the cups are sufficiently rigid the gear wheels may be dispensed with, since the cups themselves, when engaged between adjacent starwheels, can provide the necessary alignment.
- Figure 1 further shows a mouthpiece 48 through which the user can inhale.
- the device is provided with an air inlet 50, shown by way of example in the form of a grille.
- a lever 52 is pivotally mounted on the underside of the device for movement through 90° between an inoperative position and an operative position (shown) . In the inoperative position the lever covers the mouthpiece and covers the air inlet 50. It uncovers both of these in the operative position.
- the manner in which the device operates is as follows.
- the user desires to inhale medicament, the user moves the lever 52 from the inoperative position to the operative position.
- the lever is connected by suitable means, which include a ratchet mechanism, (not shown) to one or other of the magazines via its respective starwheel or gear wheel (if provided) or to the indexing starwheel 38.
- suitable means include a ratchet mechanism, (not shown) to one or other of the magazines via its respective starwheel or gear wheel (if provided) or to the indexing starwheel 38.
- the device is provided with suitable air flow guide means (not shown) so that when the user then inhales, air is caused to flow in through the air inlet 50, through the depression 4 in the cup, and out through the mouthpiece 48 carrying the powder with it.
- a suitable air flow guide means may comprise a venturi, with the throat of the venturi being located adjacent the depression 4.
- Figures 4a and 4b show two forms of air flow which may be established with a view to emptying the powder from the depression 4.
- Figure 4a shows a laminar flow
- Figure 4b shows a turbulent flow induced by a sharp edge 54.
- the above described rotation of the lever through 90° from the inoperative position to the operative position also causes the empty cup (if any) at the use station to be moved to the bottom of one of the stacks in the collection magazine 28.
- Each stack in the collection magazine may be lightly compressed by a spring 56, or any other suitable means, to prevent the empty cups rattling in the magazine 28.
- the springs 12 in the feed magazine 14 serve.a similar purpose, but in general need to be stronger than the springs 56, since they must ensure that the cups at the bottom of the stacks in the feed magazine successively engage in the space defined between the starwheels 18 and 38.
- the ramp 24 ensures that the stacks of cups in the bores 16 are progressively lowered as the magazine 14 rotates. Thus, when a cup reaches the position in which it is engaged between the starwheels 18 and 38 it can then be carried to the use . station without being impeded by the downward force of the caps above it in the stack. This is because the lower surface of the lowest of those other caps engages the upper surface of the ramp 24 at the upper end of the ramp immediately that movement to the use station commences.
- FIG 3 shows an alternative embodiment.
- This comprises a feed magazine 114, similar in function to the magazine 14 of Figure 1, and having a starwheel 118.
- An indexing starwheel 138 similar in function to the starwheel 38 of Figure 1, brings a cup from which powder is to be dispensed to a use station, where the cup is denoted by reference 2a.
- the user inhales through a mouthpiece 148, which is covered when not in use by a dust cover 149, and air enters the device through an air inlet 150.
- the feed magazine is indexed through successive steps of 90° by an indexing wheel 152.
- the wheel 152 is connected to the magazine 114 via a ratchet mechanism (not shown) to ensure that the magazine can only be turned in the correct direction.
- the device of Figure 3 has a storage chamber 128. This is provided internally with a helical ramp down which empty cups travel as they are pushed by the cups behind them. Adjacent turns of the ramp are spaced from one another by a distance such that the cups have a slight friction fit in the ramp and are therefore prevented from rattling.
- cups which are each hermetically sealed, for example, by a foil lid, and which do not rely on being sealed by the cup or disk immediately above them. In that case some means for removing or opening the hermetic seal is required at the use station.
- the device of the invention may be used to dispense an active ingredient either with or without a carrier.
- the powder containers are taken from a separate stack of unused containers and, after the powder has been inhaled therefrom, are transferred to a separate stack of used containers (in the case of Figure 1) or a storage chamber in the case of Figure 3) .
- the stacks are kept in a state of compression. In the case of the stack of unused containers this is for two reasons. Firstly, it assists in feeding the powder containers in turn to the use station. Secondly, in the preferred embodiments the containers are open-topped, each container being closed by the container above it, and so the containers need to be pressed together to prevent powder escaping and to prevent the ingress of moisture and contaminants.
- an inhalation device by means of which material in powder form can be inhaled, comprising means for holding a first stack of unused powder containers, means for holding a second stack of used powder containers, means for feeding each of the containers from a first end of the first stack to the use station and thence to a first end of the second stack, means for enabling the powder to be inhaled from a container at the use station, and a force- applying means, one end of the force-applying means, applying a substantially constant force to a second end of the first stack and the other end of the force-applying means applying a substantially constant force to a second end of the second stack.
- FIG. 5 to 9 a body 201 within which is formed a generally U-shaped passage 202.
- This passage comprises a first straight portion 203 which contains a stack 204 of unused powder containers 205, and a second straight portion 206 which contains a stack 207 of used powder containers.
- At the lower end of the stack 204 is a piston 208, and at the lower end of the stack 207 is a piston 209.
- a coil spring 210 is located, in a state of compression, within the U-shaped passage 201, with one end of the spring bearing against the piston 208 and the other end of the spring bearing against the piston 209.
- the spring 210 has end portions 210a and 210b in which adjacent turns of the spring are spaced somewhat from one another, whilst over the rest of the length of the spring the coils are located tightly against one another. The effect of this is that the spring 210 provides a flexible member of substantially constant length, with a substantially constant spring force being generated only by the end portions 210a and 210b.
- a cover 211 is secured to the top of the body 201, and has a recess 212, which is rectangular both in vertical section and plan view on the underside thereof.
- a slider 213 is slidably mounted in the recess 212.
- the cover 211 has an air inlet passage 214 and an outlet passage 215 for air and powder.
- the passage 215 is connected to a mouthpiece or nosepiece for inhalation, though this is not shown in Figure 5.
- the slider 213 has a passage 216 which opens into the lower face of the slider 213. When the slider is in its left hand position (it is shown in an intermediate position in Figure 5) the opening in the passage communicates with the upper end of the stack 204 and the ends of the passage 216 communicate respectively with the passages 214 and 215.
- passage 215 when the slider is in the left hand position, inhalation by the user through the mouthpiece or nosepiece attached to passage 215 causes air to flow in through passage 214 and thence through passage 216, entraining powder from the topmost of the containers 205 in the stack 204, and thence, with the powder entrained therein, out through the passage 215.
- Each of the containers 205 has a depression in its upper surface to hold the powder, and the shape of this depression is preferably such that it forms a smooth continuation with the adjacent wall of the passage 216, thereby to improve the efficiency with which powder is scoured from the depression by the air flow.
- the combination of the passages 214, 215 and 216, and the depression in the container 205 preferably forms a venturi.
- the slider 213 operates to transfer each powder container, as it is used, from the top of stack 204 to the top of stack 207.
- the slider can be seen in more detail in Figures 6 and 7. It will be seen there that it has a recess 217 on the underside thereof, the recess being defined by a shoulder 218 at one end and a ramp 219 at the other end.
- the shoulder 218 engages the left hand edge of the container 205 which is at the top of the stack 204.
- the slider moves this container onto the top of the existing stack 207 of used containers.
- the leading lower edge portion 220 of the slider 213 stays in contact with the top of the existing stack 207 until after the leading edge of the new used container 205 is over the edge of the stack 207. This ensures that the new used container is free to assume its desired position on the top of the existing stack.
- the stack 207 is progressively compressed as the right hand edge of the top container in the stack is engaged by the ramp 219, until the leading edge portion 220 is over the top of the stack 207.
- the top container in the stack 207 is prevented from moving leftwardly by a non-return catch which is provided by a pair of pins 221.
- the pins pass through apertures 223 in the cover 211 and are biased towards one another, and in Figure 6 this is shown as being achieved by flexible resilient members 222.
- any suitable alternative biasing means could be used instead.
- the inner ends of the pins 221 are bevelled so that although they prevent the slider carrying containers from right to left they do not prevent the slider carrying containers from left to right.
- One of the containers, with its depression 205a, is shown on a larger scale in Figure 9, and it can be seen to be generally rectangular in plan, but with two opposite bevelled edges. It will be appreciated that these are convenient from the point of view of the operation of the non-return catch in Figure 6.
- the slider 213 may be moved back and forth, for example, by a lever 224, part of which is indicated in broken lines in Figure 7.
- the lever is pivotally mounted on the body 201 by a shaft 225, which passes through a bore 226 indicated in Figure 5.
- the lever itself is not shown in Figure 5.
- the lever has an arcuate slot 227 which receives the end of a pin 228 which is fixedly secured in the slider 213.
- the lever 224 is shown moving clockwise, so as to carry the pin 228, and hence the slider 213, rightwardly.
- the device is closed by a pivotally mounted mouthpiece cap 234 which . provides the lever to move the slider apart against the resilient force of the spring.
- the cap 234 is pivotally mounted on the body 231 by shafts 237, and has arcuate slots 238 in which pins 239 engage, the pins 239 being attached to the slider.
- the device has a mouthpiece 235.
- the mouthpiece 235 is hollow and has within it a venturi passage 240.
- the passage 240 has an air inlet 241 which air reaches preferably via an aperture 242 in the mouthpiece.
- the aperture 242 is sealed when the cap 234 is in its closed position, as illustrated.
- the slider 213 and a container 205 define together part of the wall of the venturi passage.
- the principle of operation of the slider is substantially the same as in Figures 5 to 7, except that the pins 221 and resilient members 222 are replaced by a single U-shaped spring 236.
- the containers 205 are modified in that they are provided with cutouts 205b, and the ends of spring 236 engage in the cutouts of the used containers in stack 207. As each container moves from stack 204 to stack 207, it forces the ends of spring 236.
- FIG. 5 to 7 and Figure 8 employ a linearly moving slider.
- the slider is moved arcuately by a pivotally mounted member, and this is shown in Figures 10a, 10b, 11a, lib, 12a and 12b.
- the "slider" is constituted by a portion of the mouthpiece adjacent the body within which the stacks of powder containers are held.
- the body is denoted by reference 250, the mouthpiece by reference 251, the stack of unused containers by reference 252 and the stack of used containers by reference 253.
- the mouthpiece 251 and body 250 are rotatable relative to one another through an angle of 90° about an axis which is the longitudinal axis of the device, i.e. an axis which is perpendicular to the plane of the paper in Figures 10b, lib and 12b.
- the description will be given on the basis that the body is fixed and the mouthpiece rotates, but it will be understood that all that matters is the relative rotation between these two components.
- Rotation is limited to 90° by means of a stud 259 which is formed on the upper surface of the body 250 and which runs in an arcuate track 260 formed in the lower portion of the mouthpiece 251.
- This 90° rotation correlates with the fact that the stack 252 and the stack 253 are disposed at 90° with respect to one another about the axis of rotation of the mouthpiece. It must be understood, however, that the stacks could be at other angles with respect to one another, in which case the angle of rotation would be correspondingly different.
- the container at the top of the full stack 252 sits in a cutout 254 on the underside of the mouthpiece. This cannot be seen in Figures 10a and 10b, but is visible in Figure 11a.
- the cup at the top of the empty stack 253 is held down by a portion of an inclined ramp 255, also formed on the lower portion of the mouthpiece 251.
- the cup at the top of the empty stack 253 is held in line with the rest of the stack by a resilient non-return catch 256 formed on the top of the body 250.
- the mouthpiece 251 is rotated anticlockwise with respect to the body 250, as viewed in Figures 10b, lib and 12b. This is indicated by arrows in each of the Figures lib and 12b.
- the container at the top of the stack 252 is an empty container, this being the container from which the user last inhaled.
- this container denoted there by reference 257, starts to move over the top of the stack 253 of empty containers, holding what was previously the top container of the stack 253 down while the ramp 255 moves away from the stack 253.
- the mouthpiece is rotated clockwise through 90° to bring the device back to the position shown in Figures 10a and 10b.
- the transferred container 257 is forced down into the stack 253 of empty containers by the ramp 255, and the catch 256 prevents the container 257 being drawn back towards the stack 252.
- the newly emptied container on top of stack 252 snaps up into the cutout 254 in the mouthpiece 251, ready for the next operation.
- Figures 13 and 13a show a further embodiment in which, like the embodiments of Figures 5 to 12, there is a U-shaped passage containing a stack of unused containers and a stack of used containers. As in the case of the embodiments of Figures 5 to 8, containers are shifted from the top of one stack to the top of the other stack by a translational movement.
- the device comprises a body 300 in which there is an outlet spout in the form of a mouthpiece 302. It would alternatively be possible for the device to be adapted for nasal use instead of oral use, in which case a nasal outlet would replace the mouthpiece. The same is true of the other embodiments described herein.
- the outlet end of the mouthpiece is closed by a cap 304 which is pivotally mounted on the body by means of a pivot 306 for pivotal movement with respect thereto.
- the powder containers are held in two stacks within a cartridge 307. Initially, all the containers are in a stack 308, which consists of a number of unused (i.e. full) containers surmounted by one empty container which acts as an initial lid to close off the top of the stack.
- the “top” for this purpose is the end of the stack nearer the mouthpiece 302.
- a stack of used (i.e empty) containers is formed during operation of the device in the chamber indicated by reference numeral 310.
- a window 311 is provided in the body 300, through which the stack of empty containers can be viewed when there are sufficient containers. therein to fill the chamber 310 almost completely. This gives warning to the user when the full containers have almost all been used.
- a spring member 312 which comprises a top member 314, a base member 316 and a compression spring 318 which urges the members 314 and 316 away from one another.
- One end of a U-shaped pusher member 320 bears against the base member 316.
- the pusher member 320 passes round a guide surface 322, over which it can slide, and the other end thereof bears against a pad 324 which can be seen in Figure 13a and which is slidable in the chamber 310.
- the pusher 322 is in the form of a flexible plate, for example of a plastics material.
- the guide surface 322 is formed on one end of a rod 326, the other end of which, as can be seen in Figure 13a, provides a surface against which one end of a compression spring 328 can bear.
- the other end of the spring 328 bears against the end of a blade 330, the purpose of which is described below.
- the shaft 306 which provides pivotal movement between the cap 304 and the body 300, carries a crank arm 332.
- crank arm 332 Preferably, there is a pair of crank arms, one at each end of the shaft 306, only one of these arms being visible in Figure 13.
- the crank arm 302 and shaft 306 rotate with the cap 304, and thus with respect to the body 300.
- a slider 336 which is movable transversely with respect to the longitudinal axis of the mouthpiece 302, i.e. in a direction which is upward and downward as viewed in Figure 13.
- the slider has a lug 338 which is engaged by the end of the crank arm 332 after the arm has rotated clockwise from its illustrated position through an angle of about 45°. If a second crank arm 332 is provided there is a corresponding second lug 338 for it to engage.
- the slider also defines a bearing surface 340 with which a curved surface on the crank arm 332 can engage. The purpose of this is described below in connection with the operation of the device.
- the slider has a bead 342 on one end thereof.
- the end of a safety catch 344 operable by a button 346 engages behind the bead 342, and is urged into the engaging position by a compression spring 348. So long as the catch 344 engages behind the bead 342 the slider 336 cannot move.
- the empty container at the top of the stack 308 is in a recess 350 on the underside of the slider.
- the lateral movement of the slider transfers the empty container at the top of the stack 308 past the blade 330, which is depressed against the force of the spring 328, so that the empty container is on the end of the pad 324.
- the pad is thereby depressed, and movement of the pad is transmitted by the pusher 320 to the spring member 312.
- the spring top 314 cannot move any further, so the result is that the compression spring 316 is compressed by an amount equal to the thickness of one container.
- the empty container which is now bearing against the pad 324 forms the start of the stack of used containers.
- a pair of passages 354, 356 with which the opening 352 communicates are in alignment respectively with an aperture which communicates with the interior of the mouthpiece 302 and an aperture 358 in the plate 334 through which air can enter from the exterior of the device. Accordingly, when the user now inhales through the mouthpiece, air flows in through the aperture 358 and passage 356, entrains powder from the container, and flows out through the passage 354 into the mouthpiece and thence to the patient.
- the device could comprise a replaceable cartridge having the stacks of unused and used containers therein, with the cartridge being replaced once all the containers had been used.
- the cartridge could include all or part of a slider mechanism for transferring containers from one stack to the other.
Abstract
Description
Claims
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929211801A GB9211801D0 (en) | 1992-06-04 | 1992-06-04 | Device |
GB9211801.7 | 1992-06-04 | ||
GB9219282.2 | 1992-09-11 | ||
GB929219282A GB9219282D0 (en) | 1992-09-11 | 1992-09-11 | Device |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1993024166A2 true WO1993024166A2 (en) | 1993-12-09 |
WO1993024166A3 WO1993024166A3 (en) | 1994-06-23 |
Family
ID=26300994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1993/001410 WO1993024166A2 (en) | 1992-06-04 | 1993-06-02 | Inhalation device |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4295993A (en) |
WO (1) | WO1993024166A2 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995016483A1 (en) * | 1993-12-18 | 1995-06-22 | Merck Patent Gmbh | Powder inhalator |
US5647347A (en) * | 1994-10-21 | 1997-07-15 | Glaxo Wellcome Inc. | Medicament carrier for dry powder inhalator |
US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
US6048857A (en) * | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
US6792945B2 (en) * | 1990-03-02 | 2004-09-21 | Glaxo Group Limited | Inhalation device |
US6886560B1 (en) | 1999-09-17 | 2005-05-03 | Orion Corporation | Moisture protected powder inhaler |
GB2426202A (en) * | 2005-05-18 | 2006-11-22 | Alfred John Bailey | Inhaler |
WO2007089477A2 (en) | 2006-01-31 | 2007-08-09 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
JP2014516682A (en) * | 2011-05-16 | 2014-07-17 | ザ テクノロジー パートナーシップ パブリック リミテッド カンパニー | Dose container |
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GB2061735A (en) * | 1979-10-30 | 1981-05-20 | Riker Laboratories Inc | Breath actuated device for administration of powdered medicaments by inhalation |
WO1990013328A1 (en) * | 1989-04-28 | 1990-11-15 | Riker Laboratories, Inc. | Dry powder inhalation device |
US5048514A (en) * | 1989-07-07 | 1991-09-17 | Somova S.P.A. | Inhaler for medicaments contained in capsules |
-
1993
- 1993-06-02 WO PCT/EP1993/001410 patent/WO1993024166A2/en active Application Filing
- 1993-06-02 AU AU42959/93A patent/AU4295993A/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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GB2061735A (en) * | 1979-10-30 | 1981-05-20 | Riker Laboratories Inc | Breath actuated device for administration of powdered medicaments by inhalation |
WO1990013328A1 (en) * | 1989-04-28 | 1990-11-15 | Riker Laboratories, Inc. | Dry powder inhalation device |
US5048514A (en) * | 1989-07-07 | 1991-09-17 | Somova S.P.A. | Inhaler for medicaments contained in capsules |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6048857A (en) * | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
US6792945B2 (en) * | 1990-03-02 | 2004-09-21 | Glaxo Group Limited | Inhalation device |
AU687489B2 (en) * | 1993-12-18 | 1998-02-26 | Merck Patent Gmbh | Powder inhalator |
US5769073A (en) * | 1993-12-18 | 1998-06-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Powder inhalator |
WO1995016483A1 (en) * | 1993-12-18 | 1995-06-22 | Merck Patent Gmbh | Powder inhalator |
CN1133470C (en) * | 1993-12-18 | 2004-01-07 | 默克专利股份有限公司 | Powder inhalator |
US5823182A (en) * | 1994-10-21 | 1998-10-20 | Glaxo Wellcome Inc. | Medicament carrier for dry powder inhalator |
US5647347A (en) * | 1994-10-21 | 1997-07-15 | Glaxo Wellcome Inc. | Medicament carrier for dry powder inhalator |
US6591833B2 (en) | 1996-06-10 | 2003-07-15 | Delsys Pharmaceutical Corp. | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
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US7987845B2 (en) | 2006-01-31 | 2011-08-02 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
US8375941B2 (en) | 2006-01-31 | 2013-02-19 | Oriel Therapeutics, Inc. | Methods of operating dry powder inhalers having spiral travel paths with microcartridges of dry powder |
JP2014516682A (en) * | 2011-05-16 | 2014-07-17 | ザ テクノロジー パートナーシップ パブリック リミテッド カンパニー | Dose container |
Also Published As
Publication number | Publication date |
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AU4295993A (en) | 1993-12-30 |
WO1993024166A3 (en) | 1994-06-23 |
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