KR920004342A - 아세트아미드 유도체 - Google Patents

아세트아미드 유도체 Download PDF

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KR920004342A
KR920004342A KR1019910013360A KR910013360A KR920004342A KR 920004342 A KR920004342 A KR 920004342A KR 1019910013360 A KR1019910013360 A KR 1019910013360A KR 910013360 A KR910013360 A KR 910013360A KR 920004342 A KR920004342 A KR 920004342A
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acetyl
methoxy
phenyl
hydrogen
dimethyl
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데이비드 로버트 브리태인
스티븐 폴 브라운
앤토니 로렌 코퍼
제트로 라우렌스 론 그리쥐
제프리 제임스 모리스
존 프레스톤
린다 슬레이터
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존 린들레이 렝
임페리얼 케미칼 인더스트리즈 피엘씨
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Abstract

내용 없음

Description

아세트아미드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅰ)의 (4-아미노-2,6-디메틸페닐술포닐)니트로 메탄화합물의 페닐 아세틸유도체 또는 그 약학적 허용염:
    상기 식중, R0및 R1은 각각 수소, (1-4C)알킬, (1-4C)알콕시, 시아노 또는 트리플루오르메틸이거나 함께(2-6)알킬렌을 이루거나, R1이 인접 벤젠고리 A의 R2와 함께 메틸렌, 에틸렌, 옥시에틸렌, 에틸렌옥시, 메틸렌옥시메탈렌, 비닐렌, 트리메틸렌 또는 테트라메틸렌을 이루고 벤젠고리 A에서의 R1,R3,R4R5및 R6중의 1개, 2개 또는 3개가 각각 수소원자, 할로게노, 트리플루오로메틸, 니트로, 시아노, (1-4C)알킬 및 (1-4C)알콕시로 부터 선택되고, R2내지 R6의 나머지가 수소이거나, R2,R3,R4,R5및 R6의 인접 쌍(인접탄소원자들과 함께)이 할로게노, (1-4C)알킬 또는 (1-4C)알콕시 치환제를 임의로 가질 수 있는 추가 벤젠고리를 만들며, R2내지 R6중의 또 다른 하나는 수소, 할로게노, 트리플루오로메틸, 니트로, 시아노, (1-4C)알킬 또는 (1-4C)알콕시이고 R2내지 R6중의 또 다른 하나는 수소이다.
  2. 제1항에 있어서, R0및 R1이 수소, 메톡시, 에톡시, 이소프로폭시, 시아노 또는 트리플루오로메틸로 부터 선택되거나 R0및 R1이 함께 에틸렌, 1,1-디메틸,에틸렌, 트리메틸렌, 테트라메틸렌 또는 펜타메틸렌을 이루거나 R1이 인접 벤젠고리 A의 R2와 함께 메틸렌, 에틸렌, 옥시에틸렌, 에틸렌옥시. 메틸렌옥시메틸렌, 비닐렌트리메틸렌 또는 테트라메틸렌을 이루며, 벤젠고리 A상의 R2,R3,R4,R5및 R6중의 1개, 2개 또는 3개가 각각 수소, 플루오로, 클로로, 브로모, 트리플루오로메틸, 니트로, 시아노, 메틸, 에틸, 프로필, 이소프로필,이소부틸, 메톡시 및 에톡시로 부터 선택되고 R2내지 R6중 그 나머지는 수소이거나, R2,R3,R4,R5및 R6의 인접쌍이 플루오로, 클로로, 메틸 또는 메톡시 치환체를 임의로 갖는 추가 벤젠고리를 만들고(인접 탄소원자와 함께), R2내지 R6중 하나가 수소, 플루오로, 클로로, 브로모, 트리플루오로메틸, 니트로, 시아노, 메틸, 에틸, 프로필, 이소프로필, 이소부틸, 메톡시 및 에톡시이고 그 나머지는 수소인 화합물.
  3. 제1항 또는 제2항에 있어서, R0및 R1이 하기 (a)내지(f)중의 하나인 화합물: (a)R0및 R1은 둘다 수소이거나 ; (b) R0은 수소이고 R1은 에틸이거나 ;(d)R0는 수소 또는 메틸이고 R1은 시아노이거나 ; (e) R0는 수소 또는 트리플루오로메틸이고 R1은 메톡시 또는 에톡시이거나 ; (f) R0및 R1이 함께 에틸렌을 이룬다.
  4. 하기 일반식(Ⅰa)의 바이-또는 트리-시클릭아미드 또는 그 약학적 허용염 :
    상기 식중, Q는 메틸렌, 에틸렌, 옥시에틸렌, 에틸렌옥시, 비닐렌 또는 트리메틸렌이고 벤젠고리 A상의 R3내지 R6치환체는 제1항 또는 제2항에서 정의한 바와 같다.
  5. 하기 일반식(Ⅱ)의 화합물 또는 그 약학적 허용염 :
    상기 식중, Ra 및 Rb는 수소, 메틸, 에틸 및 시아노로 부터 선택되거나, Ra및 Rb중 하나는 수소 또는 트리플루오로메틸이고, 그 다른 하나는 메톡시, 에톡시 또는 이소프로폭시이고, 벤젠고리 B는 페닐, 2-할로게노 페닐, 2-(1-4C)알콕시 페닐, 4-(1-4C)알콕시페닐 및 2,4,6-트리[(1-4C)알킬]페닐로 부터 선택된다.
  6. 하기 일반식(Ⅱa)의 화합물 또는 그 약학적 허용염 :
    상기 식중, 아실(Acyl)은 페닐아세틸, (2,4,6-트리메틸페닐)아세틸, (2-메틸페닐)아세틸, (2-플루오로페닐)아세틸, (2-클로로페닐)아세틸, (2-메톡시페닐)-아세틸, 1-(4-클로로페닐)-1-시클로프로판 카르보닐, 1-(페닐)-1-시클로프로판카르보닐, (4-에톡시페닐)아세틸, (R,S)-2-(페닐)-프로피오닐, (4-메톡시페닐)아세틸, (R,S)-벤조시클로부탄카르보닐, (2-브로모페닐)아세틸, (2-니트로페닐)아세틸, 2-(4-클로로페닐)-2-메틸프로피오닐, (4-메톡시-3-메틸페닐)아세틸, (3-플루오로페닐)아세틸, (R,S)-2-메톡시-2-(2-플루오로페닐)아세틸, (2-트리플루오로메틸페닐)아세틸, (3,4-디플루오로페닐)아세틸, (2,6-디클로로페닐)아세틸, (4-트리플루오로메틸페닐)아세틸, (4-클로로페닐)아세틸, (3-메틸페닐)아세틸, (3-메톡시페닐)-아세틸, 1-페닐 시클로펜탈카르보닐, 1-(4-메톡시페닐)-시클로프로판카르보닐, (2-나프틸)아세틸, (R,S)-1-(4-클로로페닐)-시클로부탄카르보닐, (1-나프틸)아세틸, (2-메틸-6-니트로페닐)-아세틸, (4-플루오로페닐)아세틸, (3,4-디클로로페닐)아세틸, (2,4-디클로로페닐)아세틸, (R,S)-2-(4-이소부틸페닐)프로피오닐, (R)-3,3,3-트리플루오로-2-메톡시-2-페닐프로피오닐, (S)-3,3,3-트리플루오로2-메톡시-2-페닐프로피오닐, (R,S)-2-메톡시-2-(메틸페닐)아세틸, (S)-2-메톡시-2-페닐-아세틸, (R,S)-1,2,3,4-테트라하드로-1-나프토일, (R)-2-메톡시-2-페닐아세틸, (R,S)-2-메톡시-2-페닐아세틸, (R,S)-2-(2-클로로페닐)-2-메톡시아세틸, (R,S)-2-(2-클로로페닐)-2-이소프로폭시아세틸, 3-인데닐카르보닐, (R,S)-1-인다닐카르보닐, (R,S)-2-(3-플루오로-2-메틸페닐)-2-메톡시아세틸, (R,S)-2-(2,6-디플루오로페닐)-2-메톡시아세틸, (2,6-디플루오로페닐)아세틸, (1-이소크로마닐)카르보닐, (R,S)-2-시아노-2-(페닐)프로피오닐, (R,S)-2-메톡시-2-(2-메톡시페닐)아세틸, (R,S)-2-(2,3-디플루오로-페닐)-2-메톡시아세틸, (S)-2-페닐프로피오닐, (R)-2-페닐프로피오닐, (R,S)-2-(2-메닐페닐)프로피오닐, (R,S)-2-페닐부티릴, (R,S)-2-에톡시-2-(페닐)아세틸 및 (R,S)-2-에톡시-2-(2-메틸-2-페닐)아세틸로 부터 선택된다.
  7. 아실기가(R)-2-메톡시-2-(2-메틸페닐)아세틸,(R,S)-2-에톡시-2-(2-플루오로-페닐)아세틸, 2-(2,3-디메틸페닐)아세틸, 2-(2,6-디메틸페닐)아세틸,(R,S)-2-(2,6-디플루오로페닐)프로피오닐, (S)-2-메톡시-2-(2-메틸페닐)아세틸, 2-(4-메틸페닐)아세틸, 2-(2-플루오로-페닐)프로피오닐, 2-(2,4-디메틸페닐)아세틸, (R)-1,2,3,4-테트라-히드로-1-나프토일, (S)-1,2,3,4-테트라히드로-1-나프토일, (R)-2-메톡시-2-(2-케톡시페닐)아세틸 및 (S)-2-메톡시-2-(2-메톡시페닐)아세틸로 부터 선택된 일반식(Ⅱa)의 화합물 또는 그 약학적 허용염.
  8. (2-6-디메틸-4-[2-(2,4,6-트리메틸페닐)아세트아미노]페닐술포닐)-니프로메탄, (2,6-디메틸-4-[2-(2-메틸페닐)아세트아미노]페닐술포닐)-니트로메탄,(S)-(2,6-디메틸-4-[3,3,3-트리플루오로-2-메톡시-2-페닐프로피온아미도]-페닐술포닐)니트로메탄, (R,S)-(2,6-디메틸-4-[2-메톡시-2-(2-메틸페닐)아세트아미노]-페닐술포닐)니트로메탄, (S)-(2,6-디메틸-4-[2-메톡시-2-페닐아세트아미노]페닐술포닐)-니트로메탄, (R,S)-(2,6-디메틸-4-[1,2,3,4-테트라히드로-1-나프노일아미노]페닐-술로닐)니트로메탄, (R,S)-(2,6-디메틸-4-[2-메톡시-2-)2-메톡시페닐)아세트아미노]페닐-술포닐)니트로메탄, (R,S)-(2,6-디메틸-4-[2-에톡시-2-(2-페닐아세트아미노]페닐-술포닐)니트로메탄, (+)-(2,6-디메틸-4-[2-메톡시-2-(2-메틸페닐)아세트아미노]페닐-니트로메탄, (-)--(2,6-디메틸-4-[1,2,3,4-테트라히드로-1-나프토일아미노]페닐-술포닐, 니트로메탄 및 (-)-(2,6-디메틸-4-[2-메톡시-2-(2-메톡시페닐)아세트아미노]페닐-술포닐)니트로 메탄으로 부터 선택되는 일반식(Ⅰ)의 화합물 또는 그 약학적 허용염.
  9. 제1항 내지 제8항중 어느 한 항에 있어서, 알칼리금속염, 알칼리토금속염, 암모늄염, 또는 생리적으로 허용 가능한 양이온을 제고하는 유기염기를 갖는 염인 약학적 허용염.
  10. 약학적으로 허용 가능한 부형제 또는 담체와 함께 제1항 내지 제9항중 어느 한 항에 의한 상기 일반식(Ⅰ)(Ⅰa),(Ⅱ),(Ⅱa)또는 그 약학적 허용염을 포함하는 약학적 조성물.
  11. (a)하기 일반식(Ⅲ)의 카르복릴산의 반응에 의해 또는 그것으로 부터 유도된 반응성 아실화제로(4-아미노-2,6-디메틸페닐술포닐)니트로메탄올 알킬화시키거나; (b)하기 일반식(Ⅳ)의 티오에테르를 산화시키거나 ; (c)알칼리금속(1-6C)알콕사이드의 존재하에 일반식(Ⅷ)의 4-N-아실아미노-2,6-디메틸벤젠술핀산의 알칼리 금속염를 니트로 메탄 및 요오드와 반응시킨 뒤 약학적 허용염이 필요하다면 일반식(Ⅰ)의 화합물을 생리적 허용 가능한 양이온을 가진 적당한 염기와 반응시키고, 일반식(Ⅰ)화합물이 비대칭탄소를 포함한다면, 방법(a),(b)또는 (c)를 일반식(Ⅲ),(Ⅳ)또는 (Ⅶ)의 적당한 광학활성 출발물질로 수행하거나 또는 라세믹 형태의 일반식(Ⅰ)화합물을 분할하는 것을 특징으로 하는 일반식(Ⅰ)의 화합물 또는 그 약학적 허용염의 제조방법 :
    상기 식중 R0,R1및 벤젠고리 A와 그것위의 치환체들은 제1항, 제2항 또는 제3항에서 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9016984D0 (en) * 1990-08-02 1990-09-19 Ici Plc Aniline derivatives
GB9016978D0 (en) * 1990-08-02 1990-09-19 Ici Plc Acetamide derivatives
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
FR2757509B1 (fr) 1996-12-23 1999-03-26 Lipha Nouveaux derives de sulfonamides et sulfonylurees, leurs preparations et medicaments les contenant
KR100891756B1 (ko) * 1997-04-15 2009-04-07 씨에스아이알 식욕 억제 활성을 갖는 약학 조성물
GB9714274D0 (en) 1997-07-08 1997-09-10 Zeneca Ltd Pharmaceutical composition
EP1052994A2 (en) * 1998-02-02 2000-11-22 Trustees Of Tufts College Use of dipeptidylpetidase inhibitors to regulate glucose metabolism
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IL155710A0 (en) 2000-11-30 2003-11-23 Pfizer Prod Inc Combination of gaba agonists and aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
WO2006118322A1 (en) * 2005-04-28 2006-11-09 Shiratori Pharmaceutical Co., Ltd. Method for producing hydrazone derivatives
NZ569327A (en) * 2005-12-28 2011-09-30 Vertex Pharma 1-(benzo [d] [1,3] dioxol-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-binding cassette transporters for the treatment of cystic fibrosis
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
ATE518544T1 (de) 2007-03-12 2011-08-15 Zadec Aps Rotbusch-extrakt gegen diabetes
WO2008118844A1 (en) 2007-03-23 2008-10-02 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibitors
FR2914188B1 (fr) * 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
CA2822672C (en) 2010-12-23 2018-06-05 The Board Of Regents Of The University Of Texas System Methods for treating copd

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229653A (ko) * 1968-03-14 1971-04-28
US3882247A (en) * 1972-04-21 1975-05-06 Du Pont Fungicidal nitro organic sulfur compounds
SU479761A1 (ru) * 1973-07-18 1975-08-05 Институт Органической Химии Им. Н.Д.Зелинского Ан Ссср Способ получени -динитроалкилсульфонов
US4053633A (en) * 1976-06-24 1977-10-11 The Dow Chemical Company Aryl dibromonitromethyl sulfones
US4058633A (en) * 1976-09-15 1977-11-15 Fairmont Foods Company Meat product, and process for preparing same
FR2432316A1 (fr) * 1978-08-02 1980-02-29 Choay Sa Nouveaux medicaments contenant, a titre de substance active, des composes de type benzenesulfone, nouveaux composes de ce type et procede pour leur preparation
US4670470A (en) * 1979-08-15 1987-06-02 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US4309554A (en) * 1980-04-28 1982-01-05 The Dow Chemical Company 3-(2-Thiophenesulfonyl)-2-halopropanenitriles
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
DE3326635A1 (de) * 1983-07-23 1985-01-31 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von monomethylsubstituierten methylen-verbindungen
EP0169887B1 (en) * 1984-02-01 1990-06-27 BAXTER INTERNATIONAL INC. (a Delaware corporation) Clinical analysis systems and methods
DE3768352D1 (de) * 1986-06-30 1991-04-11 Merck & Co Inc Alkansulfonamide als antiglaucoma-mittel.
GB8718619D0 (en) * 1987-08-06 1987-09-09 Ici Plc Pharmaceutical compositions
GB8810203D0 (en) * 1988-04-29 1988-06-02 Ici Plc Heterocyclic compounds
IE63463B1 (en) * 1989-02-06 1995-04-19 Zeneca Ltd Phenylsulphone derivatives
GB9016978D0 (en) * 1990-08-02 1990-09-19 Ici Plc Acetamide derivatives

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