KR920000772A - 2-테트라하이드로푸란 유도체의 에난티오머, 이들의 중간체 및 이들의 제조방법 - Google Patents
2-테트라하이드로푸란 유도체의 에난티오머, 이들의 중간체 및 이들의 제조방법 Download PDFInfo
- Publication number
- KR920000772A KR920000772A KR1019910010079A KR910010079A KR920000772A KR 920000772 A KR920000772 A KR 920000772A KR 1019910010079 A KR1019910010079 A KR 1019910010079A KR 910010079 A KR910010079 A KR 910010079A KR 920000772 A KR920000772 A KR 920000772A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- enantiomers
- tetrahydrofuran
- enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title claims 4
- 239000000543 intermediate Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 13
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- -1 2-octadecyloxymethyl tetrahydrofuran-2-ylmethoxy Chemical group 0.000 claims 1
- IXZHWGJCHBDVLV-UHFFFAOYSA-N C(CCC)(=O)O.C(CCC)(=O)O.OCC1(OCCC1)CO Chemical compound C(CCC)(=O)O.C(CCC)(=O)O.OCC1(OCCC1)CO IXZHWGJCHBDVLV-UHFFFAOYSA-N 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54043890A | 1990-06-19 | 1990-06-19 | |
| US540,438 | 1990-06-19 | ||
| US64739691A | 1991-01-29 | 1991-01-29 | |
| US647396 | 1991-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920000772A true KR920000772A (ko) | 1992-01-29 |
Family
ID=27066435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019910010079A Ceased KR920000772A (ko) | 1990-06-19 | 1991-06-18 | 2-테트라하이드로푸란 유도체의 에난티오머, 이들의 중간체 및 이들의 제조방법 |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0462935B1 (enExample) |
| JP (1) | JP2709330B2 (enExample) |
| KR (1) | KR920000772A (enExample) |
| AT (1) | ATE125261T1 (enExample) |
| AU (2) | AU649681B2 (enExample) |
| CA (1) | CA2044786A1 (enExample) |
| CS (1) | CS185191A3 (enExample) |
| DE (1) | DE69111311T2 (enExample) |
| DK (1) | DK0462935T3 (enExample) |
| ES (1) | ES2076502T3 (enExample) |
| FI (1) | FI912964A7 (enExample) |
| GR (1) | GR3017437T3 (enExample) |
| HK (1) | HK111996A (enExample) |
| HU (1) | HU210548B (enExample) |
| IE (1) | IE68417B1 (enExample) |
| IL (1) | IL98524A (enExample) |
| MY (1) | MY107022A (enExample) |
| NZ (1) | NZ238573A (enExample) |
| PL (1) | PL164981B1 (enExample) |
| PT (1) | PT97994B (enExample) |
| TW (1) | TW255897B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208352A (en) * | 1992-04-02 | 1993-05-04 | Sandoz Ltd. | Process for preparing the R- and S-isomers of 2-hydroxy-methyl-2-octadecyloxymethyl-tetrahydrofuran and their use in preparing stereoisomers of pharmacologically active compounds |
| EP0973181B1 (en) * | 1998-07-17 | 2002-10-09 | Fuji Photo Film Co., Ltd. | Photoelectric conversion device and photoelectrochemical cell |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0178261A3 (en) * | 1984-10-10 | 1986-12-30 | Sandoz Ag | Substituted 2-furanyl or 5-oxo-2-furanyl-alkoxy phosphoryl alkyl cyclimmonium salts |
| US4601987A (en) * | 1985-02-27 | 1986-07-22 | Massachusetts Institute Of Technology | Enzymatic production of optical isomers of 2-halopropionic acids |
| DE3666435D1 (en) * | 1985-08-30 | 1989-11-23 | Sandoz Ag | Substituted hydroxy-heterocyclyl-alkoxy phosphinyloxy trialkylaminium hydroxide inner salt oxides, processes for their preparation and their use as pharmaceuticals |
| US4673672A (en) * | 1985-10-28 | 1987-06-16 | Sandoz Pharmaceuticals Corp. | Substituted-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl)alkoxyphosphinyloxy]-alkanaminium hydroxide, inner salt oxides |
| US4868319A (en) * | 1987-12-22 | 1989-09-19 | Sandoz Pharm. Corp. | Process for the preparation of monoalkylcarbamate group-containing compounds |
-
1991
- 1991-06-06 HU HU911882A patent/HU210548B/hu not_active IP Right Cessation
- 1991-06-17 CS CS911851A patent/CS185191A3/cs unknown
- 1991-06-17 AU AU78439/91A patent/AU649681B2/en not_active Ceased
- 1991-06-17 NZ NZ238573A patent/NZ238573A/en unknown
- 1991-06-17 PT PT97994A patent/PT97994B/pt not_active IP Right Cessation
- 1991-06-17 CA CA002044786A patent/CA2044786A1/en not_active Abandoned
- 1991-06-17 IL IL9852491A patent/IL98524A/en not_active IP Right Cessation
- 1991-06-18 FI FI912964A patent/FI912964A7/fi not_active Application Discontinuation
- 1991-06-18 PL PL91290719A patent/PL164981B1/pl unknown
- 1991-06-18 JP JP3173245A patent/JP2709330B2/ja not_active Expired - Lifetime
- 1991-06-18 MY MYPI91001089A patent/MY107022A/en unknown
- 1991-06-18 KR KR1019910010079A patent/KR920000772A/ko not_active Ceased
- 1991-06-18 IE IE208191A patent/IE68417B1/en not_active IP Right Cessation
- 1991-06-19 ES ES91810477T patent/ES2076502T3/es not_active Expired - Lifetime
- 1991-06-19 DK DK91810477.9T patent/DK0462935T3/da active
- 1991-06-19 DE DE69111311T patent/DE69111311T2/de not_active Expired - Fee Related
- 1991-06-19 AT AT91810477T patent/ATE125261T1/de not_active IP Right Cessation
- 1991-06-19 EP EP91810477A patent/EP0462935B1/en not_active Expired - Lifetime
- 1991-07-09 TW TW080105309A patent/TW255897B/zh active
-
1994
- 1994-08-23 AU AU71407/94A patent/AU677403B2/en not_active Ceased
-
1995
- 1995-09-18 GR GR950402562T patent/GR3017437T3/el unknown
-
1996
- 1996-06-27 HK HK111996A patent/HK111996A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT97994A (pt) | 1992-03-31 |
| NZ238573A (en) | 1993-11-25 |
| FI912964A0 (fi) | 1991-06-18 |
| DK0462935T3 (da) | 1995-11-06 |
| FI912964L (fi) | 1991-12-20 |
| AU7843991A (en) | 1992-01-02 |
| HU911882D0 (en) | 1991-12-30 |
| GR3017437T3 (en) | 1995-12-31 |
| MY107022A (en) | 1995-08-30 |
| IL98524A0 (en) | 1992-07-15 |
| FI912964A7 (fi) | 1991-12-20 |
| PL290719A1 (en) | 1992-07-27 |
| JPH04270276A (ja) | 1992-09-25 |
| HK111996A (en) | 1996-07-05 |
| JP2709330B2 (ja) | 1998-02-04 |
| CS185191A3 (en) | 1992-01-15 |
| HU210548B (en) | 1995-05-29 |
| IL98524A (en) | 1995-12-31 |
| CA2044786A1 (en) | 1991-12-20 |
| DE69111311T2 (de) | 1996-03-14 |
| EP0462935A1 (en) | 1991-12-27 |
| DE69111311D1 (de) | 1995-08-24 |
| AU7140794A (en) | 1994-11-03 |
| ATE125261T1 (de) | 1995-08-15 |
| TW255897B (enExample) | 1995-09-01 |
| EP0462935B1 (en) | 1995-07-19 |
| AU649681B2 (en) | 1994-06-02 |
| ES2076502T3 (es) | 1995-11-01 |
| AU677403B2 (en) | 1997-04-24 |
| PT97994B (pt) | 1998-11-30 |
| PL164981B1 (pl) | 1994-10-31 |
| IE912081A1 (en) | 1992-01-01 |
| HUT58340A (en) | 1992-02-28 |
| IE68417B1 (en) | 1996-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19910618 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19960617 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19910618 Comment text: Patent Application |
|
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 19980227 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19980911 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19981223 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19980911 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |